Assessing the risk of chemotherapy toxicity and hospital admission due to toxicity.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e14508-e14508
Author(s):  
Samuel Robert Malton
Keyword(s):  
Length Of Stay ◽  
Hospital Admission ◽  
Outcome Measures ◽  
Anticancer Agents ◽  
Toxicity Assessment ◽  
Health Economy ◽  
Secondary Outcome ◽  
University Hospitals ◽  
Lung Cancers ◽  
Chemotherapy Toxicity

e14508 Background: Acute chemotherapy toxicity can have negative effects for the patient and the health economy. Finding overall toxicity incidence for a typical teaching hospital population proved difficult, although the 2008 report in to deaths within 30 days of chemotherapy found that 43% of patients who died reported a grade 3 or 4 toxicity1. At Nottingham University Hospitals (NUH) a Cancer Admissions and Triage Team was established, who undertake a proactive telephone toxicity assessment 24 hours following the administration of a first cycle of chemotherapy. This had the aim of reducing hospital admission due to toxicity through timely advice and intervention and allowed the accrual of data regarding reported toxicity. Methods: Data was obtained from the telephone assessment of acute toxicity 24 hours after administration of a first cycle of chemotherapy, once the service had been in use for 1 year. Descriptive statistics were produced to establish toxicity incidence and severity and hospital admission rates as well as length of stay. Regression modelling was used to identify predictors of the four outcome measures. The commonest toxicities were explored as secondary outcome measures. Results: 1539 patients were studied and the overall incidence of toxicity was 35.6%. Disease site and number of chemotherapy agents given were shown to predict toxicity, with breast and upper gastrointestinal cancers having a higher likelihood of toxicity. The more anticancer agents used, the higher the risk of toxicity. Disease was predictive of toxicity grade, with urology, gynaecology and lung patients experiencing higher grades of toxicity than other tumour sites. The rate of hospital admission due to toxicity was 13.1% and median length of stay 3 days. The risk of admission had some risk factors in common with toxicity. Disease and the number of drugs in the regimen affected the risk of admission, with gynaecology, head and neck and lung patients and patients who received 3 drugs having a higher likelihood of admission. No predictors could be reliably identified for length of stay. Predictors in the sub-groups of breast, lower gastrointestinal and lung cancers did not differ greatly from the whole population and the number of drugs was shown to be a predictor of nausea, vomiting and fatigue when explored as secondary outcomes. Conclusions: Predictors were identified for occurrence of toxicity, severity of toxicity, risk of hospital admission but not for length of stay. Sub-group analyses were undertaken. The overall burden of acute chemotherapy toxicity of a heterogeneous population was elucidated.

CLO19-043: Assessing the Risk of Chemotherapy Toxicity and Hospital Admission Due to Toxicity

2019 ◽  
Vol 17 (3.5) ◽  
pp. CLO19-043
Author(s):  
Samuel Malton
Keyword(s):  
Length Of Stay ◽  
Hospital Admission ◽  
Outcome Measures ◽  
Anticancer Agents ◽  
Toxicity Assessment ◽  
Health Economy ◽  
Secondary Outcome ◽  
University Hospitals ◽  
Lung Cancers ◽  
Chemotherapy Toxicity

Background: Acute chemotherapy toxicity is common and can have negative effects for the patient and the health economy. Finding overall toxicity incidence for a typical teaching hospital population proved difficult, although a 2008 report into deaths within 30 days of chemotherapy found that 43% of patients who died reported a grade 3 or 4 toxicity (Mort D et al, available at: http://www.ncepod.org.uk/2008report3/Downloads/SACT_report.pdf). At Nottingham University Hospitals (NUH), a Cancer Admissions and Triage Team was established, who undertake a telephone assessment 24 hours following the administration of a first cycle of chemotherapy, in which a proactive toxicity assessment is completed. This had the aim of reducing hospital admission due to toxicity through timely advice and intervention and allowed the accrual of data regarding reported toxicity. Methods: Data was obtained from the telephone assessment of acute toxicity 24 hours after administration of a first cycle of chemotherapy, once the service had been in use for 1 year. Descriptive statistics were produced to establish toxicity incidence and severity and hospital admission rates as well as length of stay. Regression modelling was used to identify predictors of the 4 outcome measures. The commonest toxicities were explored as secondary outcome measures. Results: 1,539 patients were studied, and the overall incidence of toxicity was 35.6%. Disease site and number of chemotherapy agents given were shown to predict toxicity, with breast and upper gastrointestinal cancers having a higher likelihood of toxicity. The more anticancer agents used, the higher the risk of toxicity. Disease was predictive of toxicity grade, with urology, gynecology, and lung patients experiencing higher grades of toxicity than other tumor sites. The rate of hospital admission due to toxicity was 13.1% and mean length of stay 4.4 days. The risk of admission had some risk factors in common with toxicity. Disease and the number of drugs in the regimen affected the risk of admission, with gynecology, head and neck, and lung cancer patients and patients who received 3 drugs having a higher likelihood of admission. No predictors could be reliably identified for length of stay. Predictors in the subgroups of breast, lower gastrointestinal, and lung cancers did not differ greatly from the whole population, and the number of drugs was shown to be a predictor of nausea, vomiting, and fatigue when explored as secondary outcomes. Conclusion: Predictors were identified for occurrence of toxicity, severity of toxicity, risk of hospital admission, but not for length of stay. Subgroup analyses were undertaken. The overall burden of acute chemotherapy toxicity of a heterogeneous population was elucidated.

scholarly journals Inpatient hypoglycaemia in older people is associated with a doubling in the increased length of stay compared with the younger population

2020 ◽  
Author(s):  
Yue Ruan ◽  
Zuzana Moysova ◽  
Garry D Tan ◽  
Alistair Lumb ◽  
Jim Davies ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Older People ◽  
Hospital Admission ◽  
Hospital Admissions ◽  
Age Groups ◽  
University Hospitals ◽  
Clinical Consequences ◽  
Level 1 ◽  
Poor Outcomes ◽  
Level 2

Abstract Background Hypoglycaemia during hospital admission is associated with poor outcomes including increased length of stay. In this study, we compared the incidence of inpatient hypoglycaemia and length of stays among people of three age groups: ≤65 years, 65–80 years and >80 years old. Methods The study was conducted using a 4-year electronic patient record dataset from Oxford University Hospitals NHS Foundation Trust. The dataset contains hospital admission data for people with diabetes. We analysed the blood glucose (BG) measurements and identified all level 1 (BG <4 mmol/l) and level 2 (BG <3 mmol/l) hypoglycaemic episodes. We compared the length of stays between different age groups and with different levels of hypoglycaemia. Results We analysed data obtained from 17,658 inpatients with diabetes who underwent 32,758 hospital admissions. The length of stays for admissions with no hypoglycaemia were 3[1,6], 3[1,8] and 4[2,11] (median[interquartile range]) days for age groups ≤65 years, 65–80 years and >80 years, respectively. These were statistically significantly lower (P < 0.01 for all pairwise comparisons) than the length of stays for admissions with level 1 hypoglycaemia, which were 6[3,13], 10[5,20] and 12[6,22] days, and level 2 hypoglycaemia, which were 7[3,14], 11[5,24] and 13[6,24] days. Conclusions In all age groups, admissions with either level 1 or level 2 hypoglycaemia were associated with an increased length of stay. However, in both the older groups, the length of stay increments were much higher (double) than the younger counterparts. The clinical consequences of hypoglycaemia were more severe in older people compared with the younger population.

The Use of Cryotherapy in the Early Postoperative Period after Total Hip Arthroplasty

2019 ◽  
Vol 21 (5) ◽  
pp. 339-348 ◽  
Author(s):  
Tosan Okoro ◽  
Yousef Ibrahim ◽  
Nadia Mansour ◽  
Phillip Alderman ◽  
Aled Evans
Keyword(s):  
Total Hip Arthroplasty ◽  
Length Of Stay ◽  
Blood Loss ◽  
Outcome Measures ◽  
Hip Arthroplasty ◽  
Early Period ◽  
Postoperative Blood Loss ◽  
Secondary Outcome ◽  
Postoperative Phase ◽  
Total Hip

Background. Recent evidence suggests that cryotherapy may be beneficial in reducing postoperative pain and blood loss in joint arthroplasty. The objective of this study was to review the use of cryotherapy in the early postoperative phase after total hip arthroplasty to assess the benefits in terms of pain relief and reduction in postoperative blood loss. Material and methods. A prospective cohort study of the use of a cryotherapy device (Hilotherm) was performed in patients following total hip arthroplasty. The primary outcome measures were visual analogue score (VAS) for pain (at 24 and 48 hours postoperatively), and amount of postoperative blood loss, measured by change in haemoglobin (g/L). The secondary outcome measures were length of stay (days), duration of patient controlled analgesia (PCA) administered postoperatively (hours) and amount of analgesia used (mg) in the first 48 hours. Results. 28 patients were recruited (n=13 Hilotherm; n= 15 non-Hilotherm). Hilotherm application reduced pain in the first 24 hours, non-significantly, (3.50±2.41 vs 4.90±2.95; p=0.185). This effect was not carried through at 48 hours postoperatively (5.68±1.94 vs 3.72±2.46; p=0.029). Hilotherm application significantly reduced postoperative blood loss (22.38±5.71 g/L vs 29.13±10.22 g/L; p=0.045). Hilotherm reduced length of stay by almost 1 day; however, this was not statistically significant (4.46±2.33 vs 5.20±3.55; p=0.528). There was no difference in the length of time PCA was administered (22.30±0.75 vs 22.02±3.26; p=0.763). Patients in the non-Hilotherm group required more paracetamol on average (p=0.001). Conclusions. 1. Hilotherm application does not appear to significantly reduce pain postoperatively but re­sults in less postoperative blood loss. 2. There may be a role for the continued use of cryotherapy in the early period of rehabilitation following total hip arthroplasty, as it appears to result in more rapid ambulatory rehabilitation in patients, resulting in reduced length of stay.

scholarly journals A ‘hot clinic’ for cold limbs: the benefit of urgent clinics for patients with critical limb ischaemia

2020 ◽  
Vol 102 (6) ◽  
pp. 412-417
Author(s):  
A Khan ◽  
M Hughes ◽  
M Ting ◽  
G Riding ◽  
J Simpson ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Outcome Measures ◽  
Odds Ratio ◽  
Smoking Status ◽  
Emergency Admission ◽  
Major Amputation ◽  
Critical Limb Ischaemia ◽  
Secondary Outcome ◽  
Limb Ischaemia ◽  
Emergency General Surgery

Introduction The national reconfiguration of vascular surgery means that arterial centres serve larger populations with increased demand on resources. Emergency general surgery ambulatory clinics facilitate timely review and intervention, avoiding admission; a critical limb ischaemia (CLI) ‘hot clinic’ (HC) was implemented to achieve similar for vascular patients. The aim of the study was to determine HC efficacy. Methods This was a prospective cohort study comparing HC patients with emergency admission (EA) patients between 1 May and 1 December 2017. Age, sex, comorbidities, CLI severity and smoking status were noted. HC patients were provided with satisfaction surveys. Primary outcome measures were freedom from reintervention and major amputation. Secondary outcome measures included time to procedure, length of stay, returns to theatre and 30-day readmission. Results A total of 147 patients (72 HC, 75 EA) were enrolled in the study. No statistical difference was found in age, sex, smoking status, severity of CLI or prevalence of comorbidities between the groups except that diabetes was more prevalent in EA patients (p=0.028). The median length of stay for the HC cohort was shorter (3 days vs 17 days, p<0.001), with no difference between time to procedure, return to theatre or 30-day readmission. HC patients were nearly 6 times more likely to experience freedom from reintervention (odds ratio: 5.824, p<0.001) and 2.5 times less likely to undergo amputation (odds ratio: 2.616, p=0.043). HC utilisation saved a total of 441 bed days. Over 90% of attendees responded with 100% positive feedback. Conclusions A vascular HC facilitates urgent review and revascularisation. It provides comparable in-hospital outcomes and better long-term outcomes, with greater efficiency than hospital admission, demonstrating its value in treating CLI.

scholarly journals Caesarean sections in teaching hospitals: systematic review and meta-analysis of hospitals in 22 countries

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e042076
Author(s):  
Ilir Hoxha ◽  
Esra Zhubi ◽  
Krenare Grezda ◽  
Blerta Kryeziu ◽  
Jeta Bunjaku ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Outcome Measures ◽  
Teaching Hospital ◽  
Population Characteristics ◽  
Teaching Hospitals ◽  
Cochrane Library ◽  
Secondary Outcome ◽  
University Hospitals ◽  
Lower Odds ◽  
Significant Difference

ObjectiveThe aim of this study is to determine the odds of caesarean section in all births in teaching hospitals as compared with non-teaching hospitals.SettingOver 3600 teaching and non-teaching hospitals in 22 countries. We searched CINAHL, The Cochrane Library, PubMed, sciELO, Scopus and Web of Science from the beginning of records until May 2020.ParticipantsWomen at birth. Over 18.5 million births.InterventionCaesarean section.Primary and secondary outcome measuresThe primary outcome measures are the adjusted OR of caesarean section in a variety of teaching hospital comparisons. The secondary outcome is the crude OR of caesarean section in a variety of teaching hospital comparisons.ResultsIn adjusted analyses, we found that university hospitals have lower odds than non-teaching hospitals (OR=0.66, 95% CI 0.56 to 0.78) and other teaching hospitals (OR=0.46, 95% CI 0.24 to 0.89), and no significant difference with unspecified teaching status hospitals (OR=0.92, 95% CI 0.80 to 1.05, τ2=0.009). Other teaching hospitals had higher odds than non-teaching hospitals (OR=1.23, 95% CI 1.12 to 1.35). Comparison between unspecified teaching hospitals and non-teaching hospitals (OR=0.91, 95% CI 0.50 to 1.65, τ2=1.007) and unspecified hospitals (OR=0.95, 95% CI 0.76 to 1.20), τ2<0.001) showed no significant difference. While the main analysis in larger sized groups of analysed studies reveals no effect between hospitals, subgroup analyses show that teaching hospitals carry out fewer caesarean sections in several countries, for several study populations and population characteristics.ConclusionsWith smaller sample of participants and studies, in clearly defined hospitals categories under comparison, we see that university hospitals have lower odds for caesarean. With larger sample size and number of studies, as well as less clearly defined categories of hospitals, we see no significant difference in the likelihood of caesarean sections between teaching and non-teaching hospitals. Nevertheless, even in groups with no significant effect, teaching hospitals have a lower or higher likelihood of caesarean sections in several analysed subgroups. Therefore, we recommend a more precise examination of forces sustaining these trends.PROSPERO registration numberCRD42020158437.

Abstract TP376: Infections in Patients With Spontaneous Intraventricular Hemorrhage- Results From the Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage (CLEAR) III Trial

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Jharna N Shah ◽  
Santosh B Murthy ◽  
Nichol McBee ◽  
Rachel Dlugash ◽  
Malathi Ram ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Intracerebral Hemorrhage ◽  
Outcome Measures ◽  
Intraventricular Hemorrhage ◽  
External Ventricular Drain ◽  
Randomized Study ◽  
Multivariable Analysis ◽  
Hospital Length Of Stay ◽  
Secondary Outcome ◽  
Clot Lysis

Introduction: Intraventricular hemorrhage (IVH) occurs in about 40% of patients with intracerebral hemorrhage (ICH) and is associated with higher mortality and worse outcomes than ICH patients without IVH. Infections are common in ICH patients but data in IVH patients are limited. Methods: Prospective analysis of adjudicated adverse event infection reporting during first 180 days in 500 patients enrolled in the CLEAR III trial, a multicenter, double-blind, randomized study comparing external ventricular drain (EVD) + intraventricular recombinant tissue plasminogen activator (rtPA) vs. EVD + placebo for treatment of obstructive IVH and intracerebral hemorrhage (ICH) volume <30cc. Primary outcome measures were 90-day and 180-day mortality. Secondary outcome measures were hospital length of stay (LOS). We constructed binary logistic and linear regression models for multivariable analysis. Results: Infection was reported in 269 patients (53.8%). Pneumonia was the most common infection (33%), followed by UTI (16%), and bacterial ventriculitis (4.4%). Overall 180-day mortality was 20%. Patients with infection were more likely to have older age (p=0.012), lower admission GCS (p=0.007), higher ICH volume (8.8 vs 6.7ml, p=0.001), and higher ICH+IVH volume (37.7 vs 31.7 ml, p=0.002). In the regression model, IVH volume was associated with higher odds of 90-day or 180-day mortality, but presence of any infection was not a significant predictor of mortality. Infection was however associated with longer length of stay (26 vs 22 days, p<0.001). Subgroup analysis of individual infections, showed only bacterial ventriculitis to be associated with 90-day (OR: 3.84, CI: 1.36-10.82), and 180-day mortality (OR: 2.9, CI: 1.05-8.06), while pneumonia and UTI were not. Conclusion: Patients with IVH have a high incidence of infections, which is associated with longer hospitalization but does not appear to influence mortality. Of the infections, bacterial ventriculitis is a significant predictor of mortality in our 7-factor model. IVH volume did not predict infections but predicted mortality.These results form a basis for future correlation of infectious complications with treatment rendered (thrombolysis versus placebo), with upcoming unblinding of the trial.

scholarly journals Impact of the implementation of a fast-track on emergency department length of stay and quality of care indicators in the Champagne-Ardenne region: a before–after study

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e026200 ◽  
Author(s):  
Jan Chrusciel ◽  
Xavier Fontaine ◽  
Arnaud Devillard ◽  
Aurélien Cordonnier ◽  
Lukshe Kanagaratnam ◽  
...  
Keyword(s):  
Emergency Department ◽  
Quality Of Care ◽  
Length Of Stay ◽  
Outcome Measures ◽  
Fast Track ◽  
Secondary Outcome ◽  
Large Hospital ◽  
Intervention Hospital ◽  
Hospital Bed

ObjectivesWe aimed to evaluate the effect of the implementation of a fast-track on emergency department (ED) length of stay (LOS) and quality of care indicators.DesignAdjusted before–after analysis.SettingA large hospital in the Champagne-Ardenne region, France.ParticipantsPatients admitted to the ED between 13 January 2015 and 13 January 2017.InterventionImplementation of a fast-track for patients with small injuries or benign medical conditions (13 January 2016).Primary and secondary outcome measuresProportion of patients with LOS ≥4 hours and proportion of access block situations (when patients cannot access an appropriate hospital bed within 8 hours). 7-day readmissions and 30-day readmissions.ResultsThe ED of the intervention hospital registered 53 768 stays in 2016 and 57 965 in 2017 (+7.8%). In the intervention hospital, the median LOS was 215 min before the intervention and 186 min after the intervention. The exponentiated before–after estimator for ED LOS ≥4 hours was 0.79; 95% CI 0.77 to 0.81. The exponentiated before–after estimator for access block was 1.19; 95% CI 1.13 to 1.25. There was an increase in the proportion of 30 day readmissions in the intervention hospital (from 11.4% to 12.3%). After the intervention, the proportion of patients leaving without being seen by a physician decreased from 10.0% to 5.4%.ConclusionsThe implementation of a fast-track was associated with a decrease in stays lasting ≥4 hours without a decrease in access block. Further studies are needed to evaluate the causes of variability in ED LOS and their connections to quality of care indicators.

Admission Ambulation Velocity Predicts Length of Stay and Discharge Disposition Following Stroke in an Acute Rehabilitation Hospital

2005 ◽  
Vol 19 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Meheroz H. Rabadi ◽  
Alan Blau
Keyword(s):  
Length Of Stay ◽  
Outcome Measures ◽  
Stroke Rehabilitation ◽  
Secondary Outcome ◽  
Rehabilitation Unit ◽  
Chi Square ◽  
Predictive Values ◽  
Female Ratio ◽  
Discharge Disposition ◽  
Sensitivity Specificity

Poststroke functional outcome and discharge disposition are influenced by age, lesion location and size, severity of neurological insult, prior functional ability, and social support. The effect of admission ambulation velocity on length of stay and discharge disposition has not been previously reported. Design. Prospective, cohort study. Setting. Designated acute stroke rehabilitation unit. Method. 373 patients consecutively admitted to a designated inpatient stroke rehabilitation unit were studied. The study sample was divided into 2 groups, based on admission ambulation velocity (meters/second) during a 2-min timed walk test. Fast ambulators had an ambulation velocity of greater than 0.15 m/s, whereas slow ambulators had an ambulation velocity of 0.15 m/s or less, and also included nonambulators. Interventions. None. Outcome Measures. Primary outcome measures were length of stay and discharge disposition. Secondary outcome measures were change in the Functional Independence Measure (FIM) scores and change in ambulation velocity per week. Continuous, ordinal, and nominal variables were analyzed using the Student t test, Mann-Whitney U test, and chi-square test, respectively. Sensitivity, specificity, and positive and negative predictive values assessed admission ambulation velocity as a predictor of discharge disposition. Results. Patient variables for slow ambulators (n = 226) versus fast ambulators (n = 147) were as follows: age (68 ± 13 SD vs. 69 ± 12, P = 0.32), male-female ratio (100:126 vs. 78:69, P = 0.09), admission total FIM score (52 ± 17 vs. 77 ± 16, P < 0.0001), change in total FIM score (20 ± 12 vs. 16 ± 12, P < 0.003), change in ambulation velocity per week (0.05 ± 0.06 vs. 0.13 ± 0.30, P < 0.0001), length of stay in days (30 ± 28 vs. 17 ± 19, P < 0.0001), and discharge disposition: home/skilled nursing facility (133/91 vs. 133/13, P < 0.0001). Sensitivity, specificity, and positive and negative predictive values (based on chi-square analyses) for admission fast ambulators as a predictor of home discharge were 0.5, 0.87, 0.91, and 0.41, respectively. Admission ambulation velocity alone correctly identified discharge disposition in 78% of the patient population, based on logistic regression analysis (P < 0.0001). Conclusion. Admission ambulation velocity can predict length of stay and discharge disposition poststroke. This effect is independent of age and admission total FIM score.

Reducing ICU Length of Stay: The Impact of a Multidisciplinary Perioperative Pathway in Vestibular Schwannoma

2021 ◽  
Author(s):  
Robert J. Yawn ◽  
Ashley M. Nassiri ◽  
Jacqueline E. Harris ◽  
Nauman F. Manzoor ◽  
Saniya Godil ◽  
...  
Keyword(s):  
Nursing Education ◽  
Postoperative Complications ◽  
Length Of Stay ◽  
Outcome Measures ◽  
Vestibular Schwannoma ◽  
Quality Care ◽  
Secondary Outcome ◽  
Readmission Rates ◽  
Postoperative Rehabilitation ◽  
The Impact

Abstract Objective This study was aimed to evaluate the impact of a multidisciplinary perioperative pathway on length of stay (LOS) and postoperative outcomes after vestibular schwannoma surgery. Setting This study was conducted in a tertiary skull base center. Main Outcome Measures The impact of the pathway on intensive care unit (ICU) LOS was evaluated as the primary outcome measure of the study. Overall resource LOS, postoperative complications, and readmission rates were also evaluated as secondary outcome measures. Methods Present study is a retrospective review. Results A universally adopted perioperative pathway was developed to include standardization of preoperative education and expectations, intraoperative anesthetic delivery, postoperative nursing education, postoperative rehabilitation, and utilization of stepdown and surgical floor units after ICU stay. Outcomes were measured for 95 consecutive adult patients who underwent surgical resection for vestibular schwannoma (40 cases before implementation of the perioperative pathway and 55 cases after implementation). There were no significant differences in the two groups with regard to tumor size, operative time, or medical comorbidities. The mean ICU LOS decreased from 2.1 in the preimplementation group to 1.6 days in the postimplementation group (p = 0.02). There were no significant differences in overall resource LOS postoperative complications or readmission rates between groups. Conclusion Multidisciplinary, perioperative neurotologic pathways can be effective in lowering ICU LOS in patients undergoing vestibular schwannoma surgery without compromising quality of care. Further research is needed to continue to sustain and continuously improve these and other measures, while continuing to provide high-quality care to this patient population.

Dexamethasone-Chemical Structure and Mechanisms of Action in Prophylaxis of Postoperative Side Effects

2019 ◽  
Vol 70 (3) ◽  
pp. 843-847 ◽  
Author(s):  
Oana Roxana Ciobotaru ◽  
Mary-Nicoleta Lupu ◽  
Laura Rebegea ◽  
Octavian Catalin Ciobotaru ◽  
Oana Monica Duca ◽  
...  
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Length Of Stay ◽  
Hospital Admission ◽  
Postoperative Period ◽  
Analgesic Effect ◽  
Chemical Structure ◽  
Mechanisms Of Action ◽  
Good Recovery ◽  
Synthetic Glucocorticoid

Dexamethasone is a synthetic glucocorticoid used for its anti-inflammatory and analgesic effect. In addition to these therapeutic indications, it is also recommended for nausea and vomiting treatment which may occur during the postoperative period, with impact on postoperative evolution, regarding the evolution of wound healing and length of stay (LOS), with a reflection on the costs of hospital admission. Therefore, their prevention is very important for both patients� comfort and a good recovery.

Sign in / Sign up

Export Citation Format

Share Document