scholarly journals Metrics of Diabetes Risk Are Only Minimally Improved by Exercise Training in Postmenopausal Breast Cancer Survivors

2019 ◽  
Vol 105 (5) ◽  
pp. e1958-e1966
Author(s):  
Richard Viskochil ◽  
Jennifer M Blankenship ◽  
Grace Makari-Judson ◽  
John Staudenmayer ◽  
Patty S Freedson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer ◽  
Sensitivity Index ◽  
Supervised Exercise ◽  
Glucose Ingestion

Abstract Context Insulin resistance is a risk factor for breast cancer recurrence. How exercise training changes fasting and postglucose insulin resistance in breast cancer survivors is unknown. Objective To evaluate exercise-induced changes in postglucose ingestion insulin concentrations, insulin resistance, and their associations with cancer-relevant biomarkers in breast cancer survivors. Setting The University of Massachusetts Kinesiology Department. Participants 15 postmenopausal breast cancer survivors not meeting the physical activity guidelines (150 min/week of exercise). Intervention A supervised 12-week aerobic exercise program (60 min/day, 3–4 days/week). Main outcome measures Postglucose ingestion insulin was determined by peak insulin and area under the insulin curve (iAUC) during a 5-sample oral glucose tolerance test. Insulin sensitivity was estimated from the Matsuda composite insulin sensitivity index (C-ISI). Changes in fitness and body composition were determined from submaximal VO2peak and dual energy X-ray absorptiometry. Results Participants averaged 156.8 ± 16.6 min/week of supervised exercise. Estimated VO2peak significantly increased (+2.8 ± 1.4 mL/kg/min, P < .05) and body weight significantly decreased (–1.1 ± 0.8 kg, P < .05) following the intervention. There were no differences in fasting insulin, iAUC, C-ISI, or peak insulin following the intervention. Insulin was only significantly lower 120 min following glucose consumption (68.8 ± 34.5 vs 56.2 ± 31.9 uU/mL, P < .05), and there was a significant interaction with past/present aromatase inhibitor (AI) use for peak insulin (–11.99 non-AI vs +13.91 AI uU/mL) and iAUC (-24.03 non-AI vs +32.73 AI uU/mL). Conclusions Exercise training had limited overall benefits on insulin concentrations following glucose ingestion in breast cancer survivors but was strongly influenced by AI use.

Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment

Cancer ◽  
2007 ◽  
Vol 110 (4) ◽  
pp. 918-925 ◽  
Author(s):  
Carole M. Schneider ◽  
City C. Hsieh ◽  
Lisa K. Sprod ◽  
Susan D. Carter ◽  
Reid Hayward
Keyword(s):  
Breast Cancer ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Cardiopulmonary Function ◽  
Supervised Exercise

Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

2003 ◽  
Vol 21 (9) ◽  
pp. 1660-1668 ◽  
Author(s):  
Kerry S. Courneya ◽  
John R. Mackey ◽  
Gordon J. Bell ◽  
Lee W. Jones ◽  
Catherine J. Field ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxygen Consumption ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer ◽  
Exercise Group ◽  
Peak Oxygen Consumption ◽  
Control Group

Purpose: To determine the effects of exercise training on cardiopulmonary function and quality of life (QOL) in postmenopausal breast cancer survivors who had completed surgery, radiotherapy, and/or chemotherapy with or without current hormone therapy use. Methods: Fifty-three postmenopausal breast cancer survivors were randomly assigned to an exercise (n = 25) or control (n = 28) group. The exercise group trained on cycle ergometers three times per week for 15 weeks at a power output that elicited the ventilatory equivalent for carbon dioxide. The control group did not train. The primary outcomes were changes in peak oxygen consumption and overall QOL from baseline to postintervention. Peak oxygen consumption was assessed by a graded exercise test using gas exchange analysis. Overall QOL was assessed by the Functional Assessment of Cancer Therapy–Breast scale. Results: Fifty-two participants completed the trial. The exercise group completed 98.4% of the exercise sessions. Baseline values for peak oxygen consumption (P = .254) and overall QOL (P = .286) did not differ between groups. Peak oxygen consumption increased by 0.24 L/min in the exercise group, whereas it decreased by 0.05 L/min in the control group (mean difference, 0.29 L/min; 95% confidence interval [CI], 0.18 to 0.40; P < .001). Overall QOL increased by 9.1 points in the exercise group compared with 0.3 points in the control group (mean difference, 8.8 points; 95% CI, 3.6 to 14.0; P = .001). Pearson correlations indicated that change in peak oxygen consumption correlated with change in overall QOL (r = 0.45; P < .01). Conclusion: Exercise training had beneficial effects on cardiopulmonary function and QOL in postmenopausal breast cancer survivors.

Exercise Training Lowers Postmeal Insulin Concentrations And Cancer-relevant Adipokines In Postmenopausal Breast Cancer Survivors

2017 ◽  
Vol 49 (5S) ◽  
pp. 346
Author(s):  
Richard Viskochil ◽  
Jennifer Blankenship ◽  
John Staudenmayer ◽  
Susan E. Hankinson ◽  
Patty Freedson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer

scholarly journals Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors

2012 ◽  
Vol 21 (4) ◽  
pp. 456-462 ◽  
Author(s):  
Claire F. Friedman ◽  
Angela DeMichele ◽  
H. Irene Su ◽  
Rui Feng ◽  
Shiv Kapoor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Deficiency ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer

scholarly journals Updated systematic review of exercise studies in breast cancer survivors: attention to the principles of exercise training

2017 ◽  
Vol 53 (8) ◽  
pp. 504-512 ◽  
Author(s):  
Sarah E Neil-Sztramko ◽  
Kerri M Winters-Stone ◽  
Kelcey A Bland ◽  
Kristin L Campbell
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Randomised Controlled Trials ◽  
Breast Cancer Survivors ◽  
Exercise Prescription ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomised Controlled

ObjectivesTo update our previous evaluation of the exercise interventions used in randomised controlled trials of breast cancer survivors in relation to (1) the application of the principles of exercise training in the exercise prescription; (2) the reporting of the components of the exercise prescription; and (3) the reporting of adherence of participants to the prescribed interventions.DesignSystematic review.Data sourcesThe OVID Medline, Embase, CINAHL and SPORTDiscus electronic databases were searched from January 2010 to January 2017.Eligibility criteriaRandomised controlled trials of at least 4 weeks of aerobic and/or resistance exercise in women diagnosed with breast cancer, reporting on physical fitness or body composition outcomes.ResultsSpecificity was appropriately applied by 84%, progression by 29%, overload by 38% and initial values by 67% of newly identified studies. Reversibility was reported by 3% anddiminishing returns by 22% of newly identified studies. No studies reported all components of the exercise prescription in the methods, or adherence to the prescribed intervention in the results. Reporting of reversibility has increased from 2010, but no other improvements in reporting were noted from the previous review.Summary/ConclusionNo studies of exercise in women with breast cancer attended to all principles of exercise training, or reported all components of the exercise prescription in the methods, or adherence to the prescription in the results. Full reporting of the exercise prescribed and completed is essential for study replication in research and translating research findings into the community, and should be prioritised in future trials.

scholarly journals Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors

2018 ◽  
Vol 15 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sheri J. Hartman ◽  
Catherine R. Marinac ◽  
Lisa Cadmus-Bertram ◽  
Jacqueline Kerr ◽  
Loki Natarajan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Survivors ◽  
Sedentary Behavior ◽  
Breast Cancer Survivors ◽  
Sitting Time ◽  
Sedentary Behaviors ◽  
Sit To Stand

Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = −5.52; 95% CI, −9.79 to −1.24) and a lower HOMA-IR value (β = −0.22; 95% CI, −0.42 to −0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

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