Uncoupling Protein-2 Decreases the Lipogenic Actions of Ghrelin

The exact mechanisms through which ghrelin promotes lipogenesis are unknown. Uncoupling protein (UCP)-2 is a mitochondrial protein important in regulating reactive oxygen species; however, recent research shows that it may play an important role fat metabolism. Given that ghrelin increases UCP2 mRNA in white adipose tissue, we examined whether the lipogenic actions of ghrelin are modulated by UCP2 using ucp2+/+ and ucp2−/− mice. Chronic ghrelin treatment either via osmotic minipumps or daily ip injections induced body weight gain in both ucp2+/+ and ucp2−/− mice; however, body weight gain was potentiated in ucp2−/− mice. Increased body weight gain was completely due to increased body fat as a result of decreased fat oxidation in ucp2−/− mice. Ghrelin treatment of ucp2−/− mice resulted in a gene expression profile favoring lipogenesis. In a calorie-restriction model of negative energy balance, ghrelin to ucp2+/+ mice did not increase body weight; however, ghrelin to ucp2−/− mice still induced body weight. These results show that UCP2 plays an important role in fat metabolism by promoting fat oxidation and restricts ghrelin-induced lipogenesis.

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Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbaa038 ◽

2021 ◽

Vol 85 (2) ◽

pp. 421-429

Author(s):

Sachiko Okue ◽

Eimi Ishikawa ◽

Ren Nakahara ◽

Tsubasa Ito ◽

Takumi Okura ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Fish Oil ◽

High Fat Diet ◽

Body Weight Gain ◽

Uncoupling Protein ◽

Liver Steatosis ◽

Obese Mice ◽

Food Efficiency ◽

Lard Diet

ABSTRACT This study sought to clarify the antiobesity effects of fish oil (FO) in terms of prevention and amelioration. An isocaloric diet composed of lard or FO was given to lean C57BL/6J mice for the study of prevention and high-fat diet-induced obese (DIO) mice for the study of amelioration for 4 weeks. Body weight gain and food efficiency were potently suppressed by FO in lean mice compared to lard diet-fed mice. Uncoupling protein-1 (UCP-1) expression in inguinal white adipose tissue (WAT) was also significantly induced by FO in lean mice. FO also suppressed body weight gain and food efficiency in DIO mice but did not reduce body weight. FO ameliorated liver steatosis in DIO mice by mildly inducing UCP-1 in inguinal WAT. FO suppressed obesity more potently in lean mice than in DIO mice but ameliorated steatosis in the DIO mice.

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Effect on Body Weight and Adipose Tissue by Cariprazine: A Head-to-Head Comparison Study to Olanzapine and Aripiprazole in Rats

Scientia Pharmaceutica ◽

10.3390/scipharm88040050 ◽

2020 ◽

Vol 88 (4) ◽

pp. 50

Author(s):

László-István Bába ◽

Zsolt Gáll ◽

Melinda Kolcsár ◽

Zsuzsánna Pap ◽

Zoltán V. Varga ◽

...

Keyword(s):

Body Weight ◽

Adipose Tissue ◽

Weight Gain ◽

Partial Agonist ◽

Body Weight Gain ◽

Uncoupling Protein ◽

Regulatory Element ◽

Receptor Subtypes ◽

Limited Information ◽

Pharmacodynamic Profile

Cariprazine (Car) is a recently approved second generation antipsychotic (SGA) with unique pharmacodynamic profile, being a partial agonist at both dopamine D2/3 receptor subtypes, with almost 10 times greater affinity towards D3. SGAs are known to increase body weight, alter serum lipids, and stimulate adipogenesis but so far, limited information about the adverse effects is available with this drug. In order to study this new SGA with such a unique mechanism of action, we compared Car to substances that are considered references and are well characterized: olanzapine (Ola) and aripiprazole (Ari). We studied the effects on body weight and also assessed the adipogenesis in rats. The drugs were self-administered in two different doses to female, adult, Wistar rats for six weeks. Weekly body weight change, vacuole size of adipocytes, Sterol Regulatory Element Binding Protein-1 (SREBP-1) and Uncoupling Protein-1 (UCP-1) expression were measured from the visceral adipose tissue (AT). The adipocyte’s vacuole size, and UCP-1 expression were increased while body weight gain was diminished by Car. by increasing UCP-1 might stimulate the thermogenesis, that could potentially explain the weight gain lowering effect through enhanced lipolysis.

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Pengaruh pemanfaatan ampas kedelai dan onggok terfermentasi rhizopus sp dalam konsentrat domba Merino terhadap pertambahan bobot badan dan konsumsi pakan

Jurnal Sains Peternakan ◽

10.21067/jsp.v6i2.2887 ◽

2018 ◽

Vol 6 (2) ◽

pp. 34-41

Author(s):

Dwi Fiky Evavianto ◽

Dimas Puri Astuti Hadiyani ◽

Waluyo Edi Susanto

Keyword(s):

Body Weight ◽

Weight Gain ◽

Feed Intake ◽

Body Weight Gain ◽

Feed Consumption ◽

Increase Body Weight ◽

Merino Sheep ◽

Good Nutrition ◽

Materials Used ◽

Rhizopus Sp

ABSTRACT This study aims to determine the benefits of soybean husk and onggok fermented rhizopus sp in feed merino sheep concentrate of body weight gain and feed intake. Materials used in the study is as much as 12 merino sheep and the methods used by the randomized trial (RAK) using the PO as controls (100% concentrate); P1 (AOT concentrate 90% + 10%); P2 (AOT concentrate 80% + 20%); P3 (AOT Concentrate 70% + 30%). The results of the study with 30% of AOT gift giving weight increase of 25.3 g / tail significantly different (F count> F table) and feed consumption P0 :. 215, 27g / tail, P1 : 203, 13g / eco, P2: 219,24g / tail, P3: 190.72 not significantly different (F arithmetic <F table 0.05), it can be concluded that the AOT replace concentrate when substituted have the same content to concentrate on P0 , P1, P2, and P3. From the results of this study cuncluded that the addition soybean husk and onggok fermented rhizopus sp in feed merino sheep concentrate can increase body weight gain and low consumption level but have a good nutrition with the level of gift 30%. ABSTRAK Penelitian ini bertujuan untuk mengetahui manfaat dari kulit kedelai dan onggok fermentasi Rhizopus sp dalam pakan merino domba konsentrat dari bobot badan dan konsumsi pakan. Bahan yang digunakan dalam penelitian ini adalah sebanyak 12 domba dan metode yang digunakan oleh uji coba secara acak (RAK) dengan menggunakan PO sebagai kontrol (100% konsentrat); P1 (AOT berkonsentrasi 90% + 10%); P2 (AOT berkonsentrasi 80% + 20%); P3 (AOT Konsentrat 70% + 30%). Hasil penelitian dengan 30% dari hadiah AOT memberikan peningkatan berat 25,3 g / ekor yang berbeda secara signifikan (F hitung> F tabel) dan pakan P0 konsumsi:. 215, 27g / ekor, P1: 203, 13 g / eco, P2: 219,24g / ekor, P3: 190,72 tidak berbeda nyata (F hitung <F tabel 0,05), dapat disimpulkan bahwa AOT menggantikan konsentrat ketika diganti memiliki konten yang sama untuk berkonsentrasi pada P0, P1, P2, dan P3. Dari hasil penelitian ini diaimpilkan bahwa penambahan kulit kedelai dan onggok fermentasi Rhizopus sp dalam pakan konsentrat domba merino dapat meningkatkan bobot badan dan tingkat konsumsi yang rendah tetapi memiliki gizi yang baik dengan tingkat pemberian 30%.

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Does increased sexual activity increase body weight gain?

Medical Hypotheses ◽

10.1016/j.mehy.2008.04.019 ◽

2008 ◽

Vol 71 (4) ◽

pp. 601-602 ◽

Cited By ~ 3

Author(s):

Ritesh G. Menezes ◽

Anurag J. Shetty ◽

Stany W. Lobo ◽

Tanuj Kanchan ◽

B. Suresh Kumar Shetty ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Sexual Activity ◽

Body Weight Gain ◽

Increase Body Weight ◽

Activity Increase

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The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice

Bioscience Biotechnology and Biochemistry ◽

10.1080/09168451.2020.1792268 ◽

2020 ◽

Vol 84 (11) ◽

pp. 2367-2373

Author(s):

Tomoki Sato ◽

Neo Sayama ◽

Mizuki Inoue ◽

Akihito Morita ◽

Shinji Miura

Keyword(s):

Body Weight ◽

Weight Gain ◽

Body Weight Gain ◽

Active Phase ◽

Fat Oxidation ◽

Glycerol 3 Phosphate Dehydrogenase ◽

Deficient Mice

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Purified Chicken Growth Hormone (GH) and a Human Pancreatic GH-Releasing Hormone Increase Body Weight Gain in Chickens

Endocrinology ◽

10.1210/endo-118-5-1961 ◽

1986 ◽

Vol 118 (5) ◽

pp. 1961-1965 ◽

Cited By ~ 60

Author(s):

F. C. LEUNG ◽

J. E. TAYLOR ◽

S. WIEN ◽

A. VAN IDERSTINE

Keyword(s):

Growth Hormone ◽

Body Weight ◽

Weight Gain ◽

Body Weight Gain ◽

Increase Body Weight ◽

Releasing Hormone

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Novel human resistin antagonist (monomeric C6A mutant) reduced body weight gain and restored insulin responsiveness in mice fed high fat diet

Endocrine Abstracts ◽

10.1530/endoabs.37.gp.15.04 ◽

2015 ◽

Author(s):

Yacir Benomar ◽

Gili Solomon ◽

Hamza Amine ◽

Ahlem Othmane ◽

Arieh Gertler ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

High Fat Diet ◽

Body Weight Gain ◽

High Fat ◽

Reduced Body ◽

Insulin Responsiveness ◽

Human Resistin

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PENGEMBANGAN TANAMAN RAMI (Boehmeria nivea L. Gaud) DAN PEMANFAATAN LIMBAH DAUN RAMI UNTUK PENGGEMUKKAN DOMBA WONOSOBO

Jurnal Litbang Provinsi Jawa Tengah ◽

10.36762/litbangjateng.v16i2.766 ◽

2018 ◽

Vol 16 (2) ◽

pp. 201-210

Author(s):

Muryanto Muryanto ◽

Pita Sudrajad ◽

Amrih Prasetyo

Keyword(s):

Body Weight ◽

Weight Gain ◽

Plant Development ◽

Body Weight Gain ◽

Survey Methods ◽

The Body ◽

Boehmeria Nivea ◽

Central Java ◽

Potential Capacity ◽

The Given

The aim of the study was to determine the development of ramie plants (Boehmeria nivea L. Gaud) and the effect of using ramie leaves on feed on the body weight gain of Wonosobo Sheep (Dombos). Research on the development of ramie plants using survey methods in the area of ramie plant development in Wonosobo Regency. While the research on the use of ramie leaves for fattening was carried out in Butuh Village, Kalikajar District, Wonosobo Regency in 2018. 21 male Dombos were divided into 3 feed treatments with forage proportions of 70%, 50% and 30 ramie leaves respectively. %. The results showed that currently ramie plants were being developed in Wonosobo Regency by CV. Ramindo Berkah Persada Sejahtera in Gandok Village, Kalikajar District, Wonosobo Regency, Central Java. Until now the area of the crop has reached 13 ha. Of this area will produce ramie leaves 195,000 kg / year. If one sheep needs 4 kg of ramie / tail / day leaves, then the potential capacity of sheep is 135 heads / year, if the given one is 50% then the Jurnal Litbang Provinsi Jawa Tengah, Volume 16 202 Nomor 2 – Desember 2018potential capacity is 270 heads / year and if it is reduced again to 25% of ramie leaves then the potential capacity 440 heads / year. The use of ramie leaves as a feed for Wonosobo Sheep fattening can be given as much as 30% in fresh form.

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