scholarly journals Association between Primary Hyperparathyroidism and Increased Body Weight: A Meta-Analysis

2005 ◽  
Vol 90 (3) ◽  
pp. 1525-1530 ◽  
Author(s):  
Mark J. Bolland ◽  
Andrew B. Grey ◽  
Greg D. Gamble ◽  
Ian R. Reid
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Primary Hyperparathyroidism ◽  
Body Mass ◽  
English Language ◽  
Meta Analysis ◽  
Control Group ◽  
Language Studies ◽  
Standard Mean Difference ◽  
Age And Sex

Although primary hyperparathyroidism is frequently asymptomatic, it has been associated with an increased prevalence of hypertension, insulin resistance, dyslipidemia, cardiovascular mortality, and cancer. Previously we reported that patients with primary hyperparathyroidism are heavier than age-matched controls. Increased body weight could contribute to the association between primary hyperparathyroidism and these extraskeletal complications. We searched MEDLINE for English language studies published between 1975 and 2003 that reported body weight or body mass index in subjects with primary hyperparathyroidism and a healthy age- and sex-comparable eucalcemic control group. Seventeen eligible studies were identified. Subjects with primary hyperparathyroidism were 3.34 kg (95% confidence interval, 1.97–4.71; P < 0.00001) heavier than controls in 13 studies reporting body weight. In four studies reporting body mass index, subjects with primary hyperparathyroidism had an increased body mass index of 1.13 kg/m2 (−0.29 to 2.55; P = 0.12) compared with controls. Standard mean difference analysis showed that subjects with primary hyperparathyroidism had an increased weight or body mass index of 0.3 sd (0.19–0.40; P < 0.00001) compared with controls. We conclude that patients with primary hyperparathyroidism are heavier than their eucalcemic peers, and that increased body weight may contribute to the reported associations between primary hyperparathyroidism and some extraskeletal complications.

scholarly journals CHARACTERISTICS OF METABOLIC PROCESSES IN THE FORMATION OF MENSTRUAL FUNCTION DISORDERS IN ADOLESCENT GIRLS WITH OBESITY

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 28-33
Author(s):  
A. Borshuliak ◽  
O. Andriets ◽  
A. Andriets ◽  
A. Semeniak
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Weight ◽  
Menstrual Cycle ◽  
Body Mass ◽  
Adolescent Girls ◽  
Main Group ◽  
Leptin Resistance ◽  
Control Group ◽  
Menstrual Dysfunction

Іntroduction. Today, a quarter of the population of economically developed countries has a body weight that is 15% larger than the norm. According to various authors, the timely onset of menarche in women with various forms of obesity and reproductive dysfunction is observed in 31% of cases only. Obesity results in insulin resistance, which in its turn results in hyperinsulinemia. The main reason of the connection of insulin resistance with reproductive function disorders consists in the specific influence of insulin on ovaries. Insulin suppresses apoptosis, binding to receptors of various growth factors that promotes long existence of atresizing follicles. In the pathogenesis of the metabolic syndrome, along with the development of hyperinsulinemia and insulin resistance, a significant role belongs to the imbalance of adipocytokines, one of which is adiponectin. The aim is to analyze metabolic processes in the formation of menstrual dysfunction in adolescent girls with obesity to improve diagnostic methods of menstrual disorders. Material and methods. Clinical and laboratory examination of adolescent girls aged 12-18 years was held, among which 79 had obesity and complaints about menstrual dysfunction (the main group); 31 with normal body weight and regular menstrual cycle (the control group). Research methods: general clinical, biochemical (indicators of lipid and carbohydrate metabolism were determined), instrumental (ultrasound), statistical. Results. It was found that 53.3% of the girls from the main group had the beginning of the first menstruation after 14 years, delayed menstruation from 42 days to 6 days, duration 2.1 ± 0.05 days, which was significantly shorter, the volume of 10.2 ± 0.05; 0.4 points (average 1-2 pads per day) was significantly lower (p <0.05). Ultrasound showed uterine hypoplasia in almost every second girl in the main group - 36 (45.46%). Hyperleptinemia and leptin resistance was found in obesity of the first degree 34.8 ± 1.75, in obesity of the second degree 37.15 ± 2.12, in obesity of the third degree 40.64 ± 2.0. It was 14.35 ng / ml in the control group, p<0,01. Hyperleptinemia in the main group was accompanied by hyperinsulinemia in 26% of cases and insulin resistance. The relationship between low values of adiponectin and elevated body mass index in patients of the main group was established, which was confirmed by the results of correlation analysis (adiponectin & body mass index: ρ = -0.74). Analysis of the results revealed a decrease of A/L level in the main group by 4.3 times. Based on our own results, the A/L and HOMA-AD models can be considered more accurate for determining insulin resistance. Conclusions. 1. Changes of the menstrual cycle in overweight girls were found. The association of adipokines secretion disorders is characterized by hyperleptinemia, leptin resistance, decreased Adiponectin / Leptin index and hypoadiponectinemia, which, in combination with insulin resistance, indicates the participation of adipokines in the genesis of oligomenorrhea. The algorithm of adolescents’ treatment with menstrual dysfunction on the background of obesity must include the calculation of Adiponectin/Leptin and HOMA-AD, which will make it possible to avoid overdiagnosis of insulin resistance.

Effect of Obesity and Family History on the Risk of Breast Cancer: Meta Analysis

2020 ◽  
Author(s):  
Enge Surabina Ketaren ◽  
◽  
Bhisma Murti ◽  
Vitri widyaningsih ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Body Mass ◽  
English Language ◽  
Meta Analysis ◽  
Random Effect ◽  
Positive Family History ◽  
Random Effect Model ◽  
Central Java

Background: Breast cancer is the most common cancer among women worldwide and currently ranked as the fifth leading cause of death from cancer in general. Studies have indicated that breast cancer was strongly associated with a positive family history of breast cancer.The risk of breast cancer also increased with the increasing levels of body‐mass index. This study aimed to examine the effect of obesity and family history on the risk of breast cancer. Subjects and Method: Meta analysis and systematic review was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, DOAJ, and Science Direct databases.Keywords used “breast cancer” AND “risk factors” AND “BMI” OR “body mass index” AND “obesity”AND “family history” AND “cohort” AND “Asia”. The inclusion criteria were full text, using English language, using cohort study design, and reporting adjusted hazard ratio.The study population was Asian women. Intervention was obesity and family history with comparison non-obesity and no family history. The study outcome was breast cancer. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed by random effect model using Revman 5.3. Results: 6 studies fromTaiwan, Israel, Japan, Malaysia, Thailand, and Korea were selected for this study. This study showed that obesity (aHR= 1.01; 95% CI= 0.67 to 1.52; p= 0.96), with I²= 90% and family history (aHR= 1.69; 95% CI= 1.09 to 2.62; p= 0.02), with I²= 57%, were associated with breast cancer. Conclusion: Obesity and family history are associated with breast cancer. Keywords: breast cancer, obesity, family history Correspondence: Enge Surabina Ketaren. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 087838583646. DOI: https://doi.org/10.26911/the7thicph.05.56

scholarly journals Body Mass Index and Risk of Gastric Cancer in Asian Adults: A Meta-Epidemiological Meta-Analysis of Population-Based Cohort Studies

2020 ◽  
Vol 52 (2) ◽  
pp. 369-373 ◽  
Author(s):  
Jong-Myon Bae
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Body Weight ◽  
Cohort Studies ◽  
Body Mass ◽  
Meta Analysis ◽  
Population Based ◽  
Overweight And Obesity ◽  
Excess Body Weight ◽  
Inverse Association

PurposeA previous meta-analysis (MA) published in 2009 reported that excess body weight was associated with an increased risk of gastric cancer in non-Asians, but not in Asians. The aim was to conduct a meta-epidemiological MA (MEMA) to evaluate association between excess body weight and the risk of gastric cancer in Asian adults with using the proposed classification of weight by body mass index (BMI) in Asian adults.Materials and MethodsThe selection criteria were population-based prospective cohort studies that measured BMI of cohort participants and evaluated a risk of gastric cancer. Overweight group (OW) and obesity group (OB) were defined as 23.0-24.9 and ≥ 25.0, respectively. A group only showing results for BMI over 23.0 was defined as overweight and obesity group (OWB). Random effect model was applied if I<sup>2</sup> value was over 50%.ResultsAfter four new studies were added through citation discovery tools, seven cohort studies with 21 datasets were selected finally for MEMA. The I<sup>2</sup> value of OW, OB, and OWB were 76.1%, 83.5%, and 97.1%, respectively. Only OWB in men had a I<sup>2</sup> value below 50% (22.5%) and showed a statistical significance with inverse association (summary relative risk, 0.79; 95% confidence interval, 0.77 to 0.81).ConclusionThis MEMA supported the hypothesis that OW might be a protective factor in gastric cancer risk in Asian adults. It will be necessary to conduct additional cohort studies with lengthening follow-up periods and re-analyzing the effect of overweight and obesity classified by the Asian criteria.

Effects of Aerobic Plus Resistance Exercise on Body Composition Related Variables in Pediatric Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2015 ◽  
Vol 27 (4) ◽  
pp. 431-440 ◽  
Author(s):  
Antonio García-Hermoso ◽  
Mairena Sánchez-López ◽  
Vicente Martínez-Vizcaíno
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Weight ◽  
Resistance Exercise ◽  
Body Mass ◽  
Fat Mass ◽  
Meta Analysis ◽  
Fat Free Mass ◽  
Exercise Interventions ◽  
Obese Youth

The purpose of this meta-analysis of randomized trials was to determine the effectiveness of aerobic plus resistance exercise interventions on body composition related to variables in overweight and obese youth. A computerized search was made of 7 databases. The analysis was restricted to randomized controlled trials that examined the effect of aerobic and resistance exercise on body composition (body weight, body mass index, fat mass, fat-free mass, and waist circumference) in obese youth. Two independent reviewers screened studies and extracted data. Weighted mean differences (WMD) and 95% confidence intervals were calculated. Nine studies were selected for meta-analysis as they fulfilled the inclusion criteria (n = 365). Aerobic plus resistance exercise interventions (8–24 weeks duration) produced a decrease in body weight (WMD=-3.31 kg), body mass index (WMD=-1.05 kg/m2), and fat mass (WMD=-1.93% and 5.05 kg), but changes in fatfree mass and waist circumference were not observed. These changes were accentuated through programs of at least 60 min of exercise per session, generating greater reductions in body weight (WMD=-4.11 kg), fat mass (WMD=-4.07%), and increase in fat-free mass (WMD = 2.45 kg). This meta-analysis provides insight into the effectiveness of short-term aerobic plus resistance exercise interventions for decreasing body weight, body mass index, and fat mass in pediatric obesity.

scholarly journals The effect of women’s body mass index on pelvic organ prolapse: a systematic review and meta analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Chernet Baye Zenebe ◽  
Wagaye Fentahun Chanie ◽  
Aster Berhe Aregawi ◽  
Tamiru Minwuye Andargie ◽  
Muhabaw Shumye Mihret
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Body Weight ◽  
Pelvic Organ Prolapse ◽  
Body Mass ◽  
Meta Analysis ◽  
Grey Literature ◽  
Experimental Studies ◽  
Pelvic Organ ◽  
Cross Sectional

Abstract Background Pelvic organ prolapse remains the public health challenge globally. Existing evidences report the effect of woman’s weight on the pelvic organ prolapse inconsistently and this urges the need of pooled body weight effect on the pelvic organ prolapse. Although there was a previous work on this regard, it included papers reported before June 18/2015. Thus, updated and comprehensive evidence in this aspect is essential to devise strategies for interventions. Objective This review aimed at synthesizing evidence regarding the pooled effect of body weight on the pelvic organ prolapsed. Methods For this review, we searched all available articles through databases including PubMed, Web of Sciences, CINAHL, JBI library, Cochran library, PsycInfo and EMBASE as well as grey literature including Mednar, worldwide science, PschEXTRA and Google scholar. We included cohort, case–control, cross-sectional and experimental studies which had been reported between March 30, 2005 to March 30, 2020. In the effect analysis, we utilized random model. The heterogeneity of the studies was determined by I2 statistic and the publication bias was checked by Egger’s regression test. Searching was limited to studies reported in the English language. Results A total of 14 articles with 53,797 study participants were included in this systematic review (SR) and meta analysis (MA). The pooled result of this Meta analyses depict that body mass index (BMI) doesn’t have statistical significant association with pelvic organ prolapse. Conclusion This review point out that women’s body mass index has no significant effect on the development of pelvic organ prolapse. However, the readers should interpret the result with cautions due to the presence of considerable limitations in this work. Trial registration The protocol of this systematic review (SR) and meta analysis (MA) has been registered in PROSPERO databases with the Registration number of CRD42020186951

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