scholarly journals The Use of Liraglutide in Obese Patients With COVID-19: A Case Report

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A38-A39
Author(s):  
Taliê Zanchetta Buani Hanada ◽  
Rafael Silvestre Knack ◽  
Renata Silvestre Knack
Keyword(s):  
Case Report ◽  
General Condition ◽  
Interleukin 6 ◽  
Laboratory Tests ◽  
Low Grade ◽  
Obese Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Good General Condition ◽  
Anti Inflammatory

Abstract Introduction: In December 2019, a new type of coronavirus was discovered in Wuhan, China, characterized by a picture of atypical pneumonia composed of fever, dry cough and progressive dyspnea. Autopsy analyzes of patients with Covid-19 were performed, and hyperactivation of cytotoxic T cells was observed, suggesting an increase in humoral-type immunological signaling, where interleukin 6 (IL-6) is a mediator present that can fit as a potential critical agent for exacerbation of inflammatory conditions. In addition, not only interleukin-6, but also serum C-reactive protein (CRP) and ferritin have been recognized as strong predictors of COVID-19 severity. Recent studies have shown that the use of liraglutide has antioxidant and anti-inflammatory effects in vitro. Thus, the present case report discusses the possible anti-inflammatory properties of the antidiabetic drug liraglutide (Saxenda), in Covid-19. Clinical Case: JCMS, 45 years, male, married, obese grade 2 (BMI: 38.2), sought medical service on August 18, 2020, bringing a positive result of the RT-PCR test for Covid-19, performed in last day. The patient was in good general condition, reporting mild headache and adynamia. He was prescribed to start a treatment with Saxenda (6mg/ml - started 0.6mg/day at week 1, with a gradual increase up to 3mg/day at week 5); Jardiance (25mg / day); Fluimicil (600mg); Ivermectin (6mg) and Colchicine (0.5mg every 12 hours). In addition, collection of laboratory tests was requested. Examination results: IL6: <1.5 pg/mL; Ferritin: 819 ng/ml; C-reactive protein: 5.1mg/L. On August 24, the patient was tachycardic (HR 120–140 bpm) associated with headache and fever (38 °C). Azithromycin (500mg), dexamethasone (4mg) and dipyrone (1g) were prescribed. Collection of laboratory tests was requested. Examination results: IL6: 9.3 pg/mL; Ferritin: 1085 ng/ml; C-reactive protein:23.9mg/L. On September 3, the patient was in good general condition, eupneic, afebrile, with no complaints to declare. On September 6, the collection of laboratory tests was requested. Examination results: IL6: <1.5 pg/mL; Ferritin: 687 ng/ml; C-reactive protein: 1.7mg/L. Conclusion: Based on the described report, it is possible to observe a good clinical and laboratory evolution of the patient with Covid-19 who, among the drugs used, made use of liraglutida. Diabetes and obesity are considered significant risk factors for morbidity and mortality by COVID-19, since they are a condition of low-grade chronic inflammation and in these conditions, inflammatory markers such as CRP, IL-6 and ferritin have strong signs of alteration. Thus, the possible beneficial effect of the administration of liraglutide in obese patients is highlighted, as a potential anti-inflammatory effect, especially in the COVID-19 era.

scholarly journals Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers

2021 ◽  
Vol 5 (1) ◽  
pp. 40
Author(s):  
Livia Kurniati Saputra ◽  
Dian Novita Chandra ◽  
Ninik Mudjihartini
Keyword(s):  
Body Weight ◽  
High Sensitivity ◽  
The Body ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Dietary Fiber Intake ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 

scholarly journals Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

2019 ◽  
pp. 1-10
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
Daniel U. Owu
Keyword(s):  
Body Weight ◽  
Interleukin 6 ◽  
Leaf Extract ◽  
Serum Levels ◽  
Diabetic Rats ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa.  And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin.  Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

C-reactive protein and ART outcomes: a systematic review

2020 ◽  
Vol 26 (5) ◽  
pp. 753-773
Author(s):  
Sophie Brouillet ◽  
Guilaine Boursier ◽  
Margaux Anav ◽  
Bertille Du Boulet De La Boissière ◽  
Anna Gala ◽  
...  
Keyword(s):  
Systematic Review ◽  
Embryo Implantation ◽  
Clinical Pregnancy ◽  
Successful Outcome ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Concentration Changes ◽  
Art Outcome ◽  
Anti Inflammatory

Abstract BACKGROUND A dynamic balance between pro- and anti-inflammatory factors contributes to regulating human female reproduction. Chronic low-grade inflammation has been detected in several female reproductive conditions, from anovulation to embryo implantation failure. C-reactive protein (CRP) is a reliable marker of inflammation that is extensively used in clinical practice. Recent studies quantified CRP in the serum of infertile women undergoing ART and suggested its potential for the prediction of ART reproductive outcomes. OBJECTIVE AND RATIONALE The first objective of this systematic review of the available literature was to evaluate the association between pre-implantation circulating CRP concentration and pregnancy rates in women undergoing ART. The second objective was to describe serum CRP concentration changes after early embryo implantation. The changes in circulating CRP throughout the ART cycle, clinical implications of CRP quantification for the management of women undergoing ART, and future therapeutic options will also be discussed. SEARCH METHODS The MEDLINE database was systematically searched from inception to March 2019 using the following key words: (C-reactive protein) AND (assisted reproductive techniques OR ovulation induction OR insemination OR in vitro fertilization). Only articles in English were considered. Studies were selected based on title and abstract. The full text of potentially relevant articles was retrieved and assessed for inclusion by two reviewers (S.B. and S.H.). The protocol was registered in the International prospective register of systematic reviews (PROSPERO; registration number: CRD148687). OUTCOMES In total, 10 studies were included in this systematic review. Most of these studies reported lower circulating CRP values before the window of implantation and higher circulating CRP values during the peri-implantation period in women with successful ART outcome (biochemical or clinical pregnancy) compared to women without a successful outcome. Several lifestyle factors and/or drugs that reduce the concentration of circulating CRP significantly improve ART outcomes. Subgroup analyses according to female BMI and baseline circulating CRP concentration are highly recommended in future analyses. WIDER IMPLICATIONS These findings highlight a possible detrimental impact of preconception high circulating CRP concentration on ART outcomes. However, the biochemical or clinical pregnancy rate endpoints used in the studies examined here are insufficient (there were no data on live birth outcome), and the impact of major variables that can influence CRP and/or ART, for example maternal age, BMI, number of transferred embryos, and use of anti-inflammatory drugs, were not considered in the analyses. CRP quantification may be a potential marker of ART outcome, but its predictive value still needs to be investigated in large prospective studies. In future, the quantification of circulating CRP before starting ART could help to identify patients with a poor ART prognosis, leading to ART cycle cancellation or to preconception treatment to minimize the medical risks and costs.

Is there any role of interleukin-6 and high sensitive C-reactive protein in predicting IVF/ICSI success? A prospective cohort study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
A. Seval Ozgu-Erdinc ◽  
Ilay Gozukara ◽  
Serkan Kahyaoglu ◽  
Saynur Yilmaz ◽  
Omer Hamit Yumusak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Interleukin 6 ◽  
Prospective Cohort ◽  
Clinical Pregnancy ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Icsi Cycle ◽  
Hs Crp

Abstract Objectives Studies have established a relationship between proinflammatory factors and implantation failure in IVF/ICSI cycles. Likewise, low-grade chronic inflammation is generally blamed for predisposing infertility. In the present study, we aimed to find a relationship between serum IL-6 and hs-CRP levels and IVF/ICSI cycle outcomes. Methods A total of 129 patients who consented to participate and attended the IVF unit of our department for the treatment of infertility have been enrolled in this prospective cohort study. Serum levels of high sensitive C-reactive protein and interleukin 6 have been detected at the beginning of the IVF/ICSI ovulation induction cycle. Cycle outcomes have been compared between patients with and without clinical pregnancy achievement following ART treatments. IVF/ICSI cycle outcomes of these two groups were also comparable except the number of >14 mm follicles, retrieved oocytes, metaphase II oocytes, and fertilized oocytes (2 pronuclei) which were in favor of the clinical pregnancy group. Results Mean serum hs-CRP levels were 3.08 mg/L (0.12–35.04) and 2.28 mg/L (0.09–22.52) patients with and without clinical pregnancy respectively. Mean serum IL-6 levels were 2 pg/mL (1–10.2) and 2 pg/mL (1–76.9) patients with and without clinical pregnancy respectively. Both tests were found to be statistically insignificant in predicting the success of the ART cycle in terms of implantation, clinical pregnancy, miscarriage, and live birth. Conclusions In the present study, we have not found any significant effect of hs-CRP and IL-6 levels in the IVF cycle. However, in the light of this and previous studies, large-scale research may prove the exact influence of these markers on IVF success.

PSV-B-28 Late-Breaking: Development and validation of a Total Inflammation Index™ for identifying inflammation in Labrador Retrievers using a pressure walkway

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 383-384
Author(s):  
Jessica L Varney ◽  
Craig N Coon
Keyword(s):  
Creatine Kinase ◽  
Gait Analysis ◽  
Interleukin 6 ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Low Grade ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Labrador Retrievers

Abstract The objective of this trial was to develop an index system to identify inflammation in Labrador Retrievers using a pressure walkway system. Gait analysis data can be difficult to interpret between treatment groups or for identifying low grade inflammation. To calculate the Total Inflammation Index™, the distance away from the ideal score was calculated for four parameters for each dog, including gait lameness score, total pressure index, step/stride ratio, and hind reach. These values were equally weighted and added together to produce the Total Inflammation Index™. For validation, the Total Inflammation Index™ values were compared to biomarker data for inflammation including cartilage oligomeric matrix protein, interleukin-6, creatine kinase, and c-reactive protein. Forty Labrador Retrievers (20 male/20 female) were used in this trial. All dogs were passed over the pressure walkway (Gait4Dogs; CIR Systems, Inc) to obtain gait analysis at baseline, 24h prior to the first 5km run, 24h after the first 5km run, 24h prior to the final 16km run, and 24h after the final 16km run. All biomarkers and the Total Inflammation Index™ were both significantly lower at the pre-exercise timepoints and elevated after post-exercise timepoints (P &lt; 0.01). The Total Inflammation Index™ had significant correlation between timepoints and all biomarkers, including cartilage oligomeric matrix protein (P &lt; 0.01), interleukin-6 (P &lt; 0.05), creatine kinase (P &lt; 0.01), and c-reactive protein (P &lt; 0.05). The Total Inflammation Index™ appears to be a valid assay to evaluate generalized inflammation in Labrador Retrievers, and is in agreement with inflammatory biomarker values.

scholarly journals Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Birgitte Tholin ◽  
Marit Teigen Hauge ◽  
Pål Aukrust ◽  
Lutz Fehrle ◽  
Tor Henrik Tvedt
Keyword(s):  
Case Report ◽  
Interleukin 6 ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Specific Treatment ◽  
Respiratory Illness ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Interleukin 6 Receptor

Abstract Background The understanding of coronavirus disease 2019 (COVID-19) is rapidly evolving. Although it is primarily a respiratory illness, other manifestations, such as Guillain-Barré syndrome, immune thrombocytopenia, and immune-mediated thrombotic thrombocytopenic purpura, have been described. We present a case of a patient with hemophagocytic lymphohistiocytosis secondary to COVID-19 treated with tocilizumab with a marked biochemical improvement. Case presentation In this case report we present a Caucasian patient with COVID-19 who developed a marked elevation of inflammatory parameters with ferritin 36,023 μg/L, but also elevated C-reactive protein 334 mg/L and lactate dehydrogenase 1074 U/L, 1 week after admission to the intensive care unit. He met five of eight criteria for hemophagocytic lymphohistiocytosis, but he lacked the high fever and cytopenia seen in the majority of cases. He was treated with tocilizumab, a monoclonal antibody targeting the interleukin-6 receptor, and over the next days, a rapid decrease in ferritin and C-reactive protein levels was observed. However, his respiratory failure only improved gradually, and he was weaned off the respirator 11 days later. Conclusion COVID-19 may induce a hyperinflammatory clinical picture and in some cases develop into hemophagocytic lymphohistiocytosis. In our patient’s case, therapeutic interleukin-6 blockade abrogated signs of hyperinflammation but did not seem to improve pulmonary function. Measurement of ferritin and C-reactive protein, as well as quantification of interleukin-6 on indication, should be performed in patients with severe COVID-19. Specific treatment in such patients must also be contemplated, preferably in randomized controlled trials.

scholarly journals Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study

2012 ◽  
Vol 43 (8) ◽  
pp. 1773-1783 ◽  
Author(s):  
H. J. Cho ◽  
M. Kivimäki ◽  
J. E. Bower ◽  
M. R. Irwin
Keyword(s):  
Cohort Study ◽  
Interleukin 6 ◽  
Large Scale ◽  
Short Form ◽  
Low Grade ◽  
Continuous Variables ◽  
C Reactive Protein ◽  
Phase 3 ◽  
Reactive Protein ◽  
New Onset

BackgroundAlthough basic research on neuroimmune interactions suggests that inflammatory processes may play a role in the development of fatigue, population-based evidence on this association is limited. This study examined whether plasma C-reactive protein (CRP) and interleukin-6 (IL-6), biomarkers of systemic inflammation, predict fatigue onset.MethodThe Whitehall II study is a large-scale cohort study conducted in 20 civil service departments in London. Plasma CRP and IL-6 were measured in 4847 non-fatigued participants at phase 3 (1991–1993, aged 39–63 years). Fatigue was assessed using the Vitality subscale of the 36-item Short Form Health Survey (SF-36) at phase 3 and phase 4 (1995–1996).ResultsDuring a mean follow-up of 3.1 years, 957 new fatigue cases (19.7%) were identified using the pre-established cut-off score of ⩽50 on the Vitality subscale. CRP values were dichotomized as low (<1.0 mg/l ) or high (⩾1.0 mg/l) using the Centers for Disease Control/American Heart Association recommendations. Similarly, IL-6 values were also dichotomized as low (<1.5 pg/ml) or high (⩾1.5 pg/ml). After full adjustment for sociodemographic and biobehavioral covariates, the odds ratios for new-onset fatigue were 1.28 [95% confidence interval (CI) 1.09–1.49,p = 0.003] for high CRP and 1.24 (95% CI 1.06–1.45,p = 0.008) for high IL-6. Similar results were found when CRP and IL-6 were treated as continuous variables.ConclusionsPlasma CRP and IL-6 were prospectively associated with new-onset fatigue, supporting the hypothesis that low-grade inflammation has a role in the development of fatigue.

scholarly journals Interleukin-6 and highly sensitive C-reactive protein in obese adolescents

2012 ◽  
Vol 52 (4) ◽  
pp. 219
Author(s):  
Michael Kasenda ◽  
Suryadi Tantura ◽  
Sarah Warouw
Keyword(s):  
Interleukin 6 ◽  
Cross Sectional Study ◽  
Low Grade ◽  
C Reactive Protein ◽  
Tissue Mass ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Inflammatory State

Background Childhood obesity is a major health concern.Obesity is due to an expansion of adipose tissue mass. This tissueproduces pro􀁞inflarmnatory cytokines, such as interleukin􀁞6 (IL--6).IL􀁞6 is considered to be the chief stimulator of the production ofhighly sensitive C􀁞reactive protein (hsCRP) in the liver. Bothmolecules are responsible for the chronic low􀁞grade inflammatorystate in obese individuals.Objective To assess a correlation between IL􀁞6 and hsCRP inobese adolescents.Methods This cross􀁞sectional study was conducted from Marchto June 2011 in Manado. Subjects were obese and normal bodymass index (BMI) teens aged 13􀁞18 years. Serum glutamicoxaloacetic transaminase (SOOT) and serum glutamic pyruvictransaminase (SOPT) levels were measured to rule out liverimpairment. IL􀁞6 and hsCRP levels were also measured. Data wasanalyzed by Pearson's correlation and linear regression to test forcorrelation between IL--6 and hsCRP levels.Results There was a strongly positive correlation between IL􀁞6and hsCRP levels in obese adolescents (r=0.79 with P<O.OOl).IL--6 and hsCRP levels were not significantly associated in subjectswith normal BMI.Conclusions There was a strongly positive correlation betweenIL--6 and hsCRP levels in obese adolescents, suggestive of anongoing, chronic, low􀁞grade inflammatory state. [PaediatrIndanes.2012;52:219-22].

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