scholarly journals The Hypothalamic-Pituitary-Testicular Axis in Exceptionally Old Men

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A727-A727
Author(s):  
Sandra Aleksic ◽  
Dimpi Desai ◽  
Kenny Ye ◽  
Sally Duran ◽  
Tina Gao ◽  
...  
Keyword(s):  
Linear Regression ◽  
Change Point ◽  
Linear Regression Analysis ◽  
Community Dwelling ◽  
Metabolic Parameters ◽  
Inverse Association ◽  
Metabolic Dysfunction ◽  
Exceptional Longevity ◽  
Hpt Axis ◽  
Secondary Hypogonadism

Abstract Introduction: As life expectancy continues to increase and more men reach the extremes of age, it is important to understand the physiology of the aging hypothalamic-pituitary-testicular (HPT) axis and its role in health. While prior studies primarily focused on men younger than age ninety, we studied a unique cohort enriched for men with exceptional longevity to characterize the age-related trends in male sex-hormones, the etiology of the observed changes in the HPT axis, and its relationship with metabolic dysfunction and survival at the extremes of age. Methods: This is a cross-sectional study of community-dwelling Ashkenazi Jewish men (n = 427), age range 50-106 years. Longitudinal follow-up for vital status was conducted for men age ≥ 88 at enrollment (n = 86). Measurements included serum total testosterone (TT) by LC/MS, LH, SHBG, lipids, glucose and BMI. Free testosterone (FT) was calculated according to Vermeulen et. al. A change-point linear regression model was applied to describe the age trend of TT. Multivariable linear regression adjusted for comorbidities tested the associations between metabolic parameters and TT. The association between survival and TT was evaluated with the age-adjusted Cox proportional hazards model. Age-specific cutoffs for TT and LH were used to define primary and secondary hypogonadism. Results: The change point model was a significantly better fit for the data compared to the straight-line model (p = 0.004), indicating that TT significantly declines after age 88 years. Men age < 88 years had higher average TT (401 ± 162 vs. 278 ± 178 ng/dL, p < 0.001), FT (6.3 ± 2.0 vs. 3.3± 2.1 pg/mL, p < 0.001), and lower LH (4.3 [3.0 - 6.1] vs. 14.6 [7.2 - 25.5] mIU/mL, p < 0.001), compared to men age ≥ 88 years. The prevalence of primary and secondary hypogonadism was 2% and 11%, respectively, in men age < 88 years, and 30% and 11%, among men age ≥ 88 years (p < 0.001). A multivariable linear regression analysis revealed interactions between age, dichotomized at the change-point of 88 years, and metabolic parameters. Models stratified at age 88 demonstrated an inverse association between TT and BMI (p = 0.02), serum triglycerides (p = 0.007), and random glucose levels (p = 0.02) among men age < 88; whereas a positive association was noted between TT and HDL cholesterol (p = 0.009) in this group. In men age ≥ 88 years, TT was not associated with any of the metabolic parameters or overall survival. Conclusions: Low testosterone in men with exceptional longevity is largely a result of primary testicular failure that occurs around age 88 and is accompanied by preserved hypothalamic-pituitary response with no associated metabolic dysfunction or effect on survival. This is in contrast to younger men, whose low T typically results from hypothalamic-pituitary dysfunction and is associated with metabolic derangements.

Abstract 3595: Inverse Association of Adiponectin with Insulin Resistance is Attenuated with the Escalation of Insulin Resistance: a Possible Finding of Adiponectin Resistance

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Kunihiro Matsushita ◽  
Hiroshi Yatsuya ◽  
Koji Tamakoshi ◽  
Takashi Muramatsu ◽  
Hirotsugu Mitsuhashi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Resistance Index ◽  
Multiple Linear Regression Analysis ◽  
Inverse Association ◽  
Insulin Resistant ◽  
Glucose And Lipid Metabolism ◽  
Adiponectin Resistance

Introduction: Adiponectin has been known to play an important role in the glucose and lipid metabolism, and thereby may be considered as a potential treatment target for diabetes mellitus or atherosclerotic diseases. Recently, some basic studies showed that adiponectin might not function in an insulin-resistant condition, a concept called “adiponectin resistance.” However, this concept has not been confirmed in human. Therefore, we assessed the hypothesis that the well-known inverse association between adiponectin and insulin resistance is weakened in the insulin-resistant state. Methods: We studied 2,316 middle-aged Japanese men without a medical history of cancer, cardiovascular disease, diabetes, hypertension, or dyslipidemia to determine whether or not the association between serum adiponectin levels and the insulin resistance index (HOMA-IR) differed according to insulin resistant states. Results: Mean age and body mass index of study subjects were 48±7 and 23±3, respectively. A multiple linear regression analysis revealed that log-adiponectin was inversely associated with log-HOMA-IR independently of covariates (β= − 0.235, P <0.001). Subsequently, we re-analyzed after dividing study subjects according to the tertile of HOMA-IR. As shown in the Table , the inverse association between adiponectin and HOMA-IR was considerably weakened with the escalation of insulin resistance. Specifically, adiponectin was almost positively associated with HOMA-IR in insulin-resistant subjects (β= 0.114, P =0.059). Interestingly, statistically significant associations of adiponectin with triglyceride and HDL-C were uniformly observed in all tertiles. Conclusion: The inverse association of adiponectin with insulin resistance weakened with the escalation of insulin resistance, suggesting the existence of “adiponectin resistance” in insulin-resistant individuals. This adiponectin resistance may be restricted in glucose metabolism. Table. Coefficients of adiponectin in multiple linear regression analyses with independent variables

Mediterranean diet and mental distress: “10,001 Dalmatians” study

2019 ◽  
Vol 121 (6) ◽  
pp. 1314-1326 ◽  
Author(s):  
Fiorella Pia Salvatore ◽  
Ajka Relja ◽  
Ivona Šimunović Filipčić ◽  
Ozren Polašek ◽  
Ivana Kolčić
Keyword(s):  
Mental Health ◽  
Mediterranean Diet ◽  
Mental Distress ◽  
Linear Regression Analysis ◽  
Community Dwelling ◽  
Multivariate Linear Regression Analysis ◽  
Inverse Association ◽  
Content Type ◽  
The Mediterranean ◽  
The Impact

PurposeThe impact of eating habits on mental health is gaining more attention recently. The purpose of this paper is to investigate the association between mental distress and the Mediterranean diet (MD) in a community-dwelling adult population of Dalmatia, Croatia.Design/methodology/approachParticipants from the “10,001 Dalmatians” study from the Island of Korcula and the City of Split were included (n=3,392). Lifestyle habits were investigated using a self-administered questionnaire, while mental distress was evaluated using the General Health Questionnaire-30 (GHQ-30) in a cross-sectional design. MD compliance was assessed using the Mediterranean Diet Serving Score. Multivariate linear regression analysis was used in the analysis.FindingsMD compliance was associated with lesser mental distress (ß=−1.96, 95% CI −2.75, −1.17;p<0.001). Inverse association was found between mental distress and higher intake of fruits (ß=−0.64; 95% CI −0.89, −0.39;p<0.001), vegetables (ß=−0.39; 95% CI −0.65, −0.13;p=0.003), olive oil (ß=−0.30; 95% CI −0.56, −0.04;p=0.022) and legumes (ß=−0.83; 95% CI −1.66, 0.00;p=0.049). Mental distress was more intense in women, older participants, those with worse material status, subjects with previously diagnosed chronic diseases and in current smokers.Originality/valueThis study suggests beneficial association of MD and overall mental health, offering important implications for public health provisions. Since the literature search did not reveal any previous study on the association between the MD and GHQ-based mental distress in the general population, this study delivers interesting results and fills this knowledge gap.

scholarly journals The association between intake of dietary lycopene and other carotenoids and gestational diabetes mellitus risk during mid-trimester: a cross-sectional study

2019 ◽  
Vol 121 (12) ◽  
pp. 1405-1412 ◽  
Author(s):  
Qin Gao ◽  
Chunrong Zhong ◽  
Xuezhen Zhou ◽  
Renjuan Chen ◽  
Ting Xiong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Interaction Analysis ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Oral Glucose ◽  
Inverse Association ◽  
Cross Sectional

AbstractThis study aimed to determine whether increased carotenoids intake was associated with reduced risk of gestational diabetes mellitus (GDM). We performed a cross-sectional analysis using data from Tongji Maternal and Child Health Cohort study. The dietary carotenoids intake of 1978 pregnant women was assessed using a researcher-administered FFQ before undertaking an oral glucose tolerance test at 24–28 weeks. Multivariate logistic and linear regression analyses were used to obtain the effect estimates. Participants in the highest quartile of lycopene intake showed a lower risk of GDM (OR 0·50; 95 % CI 0·29, 0·86; Pfor trend = 0·007) compared with those in the lowest quartile; each 1 mg increase in lycopene consumption was associated with a 5 % (95 % CI 0·91, 0·99; Pfor trend = 0·020) decrease in GDM risk. No significant association was found between α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin intake and GDM risk. Multiple linear regression analysis suggested an inverse association between lycopene intake and fasting blood glucose (FBG) (Pfor trend < 0·001); each 1 mg increase in lycopene intake was associated with 0·005 (95 % CI 0·002, 0·007; Pfor trend < 0·001) mmol/l decrease in FBG. Interaction analysis indicated consistent effect on each age or pre-BMI subgroup; however, a stronger protective effect of lycopene intake against GDM was observed among primigravid women (OR 0·20; 95 % CI 0·07, 0·55 in the highest v. the lowest quartile of intake; Pfor interaction = 0·036). In conclusion, dietary lycopene intake was mainly assumed via reducing FBG to decrease GDM risk, and the protection was relatively increased among primigravid women.

scholarly journals Successful Aging Among a Sample of Iranian Older Adults

2020 ◽  
Vol 13 (1) ◽  
pp. 67-73
Author(s):  
Nasibeh Zanjari ◽  
Yadollah A. Momtaz
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Successful Aging ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Community Dwelling ◽  
Stepwise Multiple Linear Regression ◽  
Validated Questionnaire ◽  
The Mean

Background: Successful Aging (SA), as one of the most important indicators of elderly people's health, has received substantial attention in the gerontological literature. Objective: The present study aimed to identify the successful aging status and its associated factors. Methods: A cross-sectional study was conducted using the stratified multistage sampling method. In 2015, a total of 600 community-dwelling participants aged 60 years or older in Tehran participated in this study. The SA was measured by a validated questionnaire consisting of seven dimensions. A Stepwise multiple linear regression analysis was done using SPSS to identify the most important predictors of SA. Results: The mean age of the participants was 69.7 (SD=7.5), and around 46% of them were retired. The mean score of the composite index of the SA was 65.6 (SD=10.8; expected range 0-100). The results of the study showed that 11.2% of the participants were aging successfully. The results of the stepwise multiple linear regression analysis revealed that childhood health status, socioeconomic status in childhood, level of education, marital status, income, and the number of diseases are significantly contributed to successful aging. Conclusion: The results of the present study showing only a few of the participants are aging successfully, imply that social and health policymakers must pay more attention to the aging population, particularly those with low social status and chronic medical status.

STUDY OF SERUM IRISIN AND ITS ASSOCIATION WITH INSULIN RESISTANCE IN POLY CYSTIC OVARY SYNDROME

2021 ◽  
pp. 212-215
Author(s):  
G.G. Kaushik ◽  
Poonam Chaudhary ◽  
Ankita Sharma
Keyword(s):  
Insulin Resistance ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Mean Value ◽  
Metabolic Parameters ◽  
Control Group ◽  
Endocrine Disorders ◽  
Ovary Syndrome ◽  
Cystic Ovary

OBJECTIVE: Poly cystic ovary syndrome (PCOS) is clinically heterogeneous endocrine disorders. Insulin resistance-related proteins play a role in the etiopathogenesis of PCOS. Irisin is a newly identied myokine which act like adipokines. Irisin has been shown to be associated with insulin-resistance and metabolic syndrome. The purpose of this study was to determine the serum levels of irisin in PCOS patients and evaluate its association with insulin resistance. PATIENTS AND METHODS: Eighty ve PCOS patients and eighty ve matched healthy controls were enrolled to study .Serum irisin levels , anthropometric and metabolic parameters including HOMA-IR were measured. Linear regression analysis was employed to study the relationship between irisin and metabolic parameters. RESULTS: Serum irisin level in PCOS patients ( mean value ; 0.50+0.07 ng/ml) was signicantly elevated when compared to control group ( mean value; 0.203+0.043ng/ml)(p value <0.001).Linear regression analysis showed that serum irisin was positively associated with body mass index , fasting insulin and lipid prole in PCOS patients. CONCLUSIONS: Serum irisin level of PCOS patients was high compared to that of healthy control subjects . In patients with PCOS , this situation may be due to insulin resistance .

PENGARUH FAKTOR-FAKTOR INTERNAL PERBANKAN TERHADAP NON PERFORMING FINANCING PADA BANK UMUM SYARIAH

2019 ◽  
Vol 6 (2) ◽  
pp. 115-130
Author(s):  
Eka Ambara Harci Putranta ◽  
Lilik Ambarwati
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Capital Adequacy ◽  
Annual Reports ◽  
Regression Methods ◽  
Capital Adequacy Ratio ◽  
Negative Effect ◽  
Independent Variable

The study aims to analyze the influence of internal banking factors in the form of: Capital Adequency Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing at Sharia Banks. This research method used multiple linear regression analysis with the help of SPSS 16.00 software which is used to see the influence between the independent variables in the form of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing. The sample of this study was 3 Islamic Commercial Banks, so there were 36 annual reports obtained through purposive sampling, then analyzed using multiple linear regression methods. The results showed that based on the F Test, the independent variable had an effect on the NPF, indicated by the F value of 17,016 and significance of 0,000, overall the independent variable was able to explain the effect of 69.60%. While based on the partial t test, showed that CAR has a significant negative effect, Total assets have a significant positive effect with a significance value below 0.05 (5%). Meanwhile FDR does not affect NPF.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

Struktur Organisasi, Desain Kerja, Budaya Organisasi Dan Pengaruhnya Terhadap Produktivitas Karyawan Studi Kasus Pada PT. XX Di Jakarta

Liquidity ◽  
2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Yanti Budiasih
Keyword(s):  
Organizational Culture ◽  
Regression Analysis ◽  
Linear Regression ◽  
Organizational Structure ◽  
Research Method ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Job Design ◽  
Employee Productivity ◽  
Dominant Influence

The objectives of this study are to analyze changes in organizational structure, job design, organizational culture and its influence on employee productivity at PT. XX in Jakarta and to identify variables that have a dominant influence on the productivity of employees. The research method used is using multiple linear regression analysis. The results show that the all variables simultaneously and partially change the organizational structure, job design, and organizational culture has a significant impact on employee productivity at PT. XXin Jakarta.

The Contribution of Sexual Identity Towards the Students’ Perception of Lesbian, Gay, Bisexual, and Transgender

10.32698/0642 ◽  
2019 ◽  
Vol 2 (2) ◽  
pp. 120
Author(s):  
Wiwi Delfita ◽  
Neviyarni S. ◽  
Riska Ahmad
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Sexual Identity ◽  
Student Perceptions ◽  
Undergraduate Students ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Simple Linear Regression ◽  
Simple Linear Regression Analysis ◽  
Bisexual And Transgender

Some students perceive lesbian, gay, bisexual, and transgender (LGBT) positively, even though LGBT is a sexual deviation that is not appropriate with values and norms. There are several factors that influence an individual's perception of LGBT, including sexual identity. This study aims at looking at the contribution of sexual identity to student perceptions about LGBT. This research used a quantitative approach with a descriptive method and a simple linear regression analysis. The sample of this research was 385 taken from 15.752 undergraduate students of Universitas Negeri Padang which the sample was drawn by using the Slovin formula and continued with a Proportional Random Sampling technique. The instrument used was the Guttman model's sexual identity scale and the scale of students' perceptions of the LGBT Likert model. After analyzing the data with the descriptive technique and the simple linear regression analysis, the results showed that sexual identity significantly contributed to the students' perceptions of LGBT. This research has implications as a basis for counselors to help students avoid sexual identity mismatches and prevent the emergence of positive perceptions of LGBT.

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