scholarly journals Perfect Timing: Associations Between Dietary Timing, Eating Intervals and Metabolic Health

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A417-A417
Author(s):  
Marriam Ali ◽  
Kristen Knutson ◽  
Sirimon Reutrakul

Abstract Background: Metabolic disorders are on the rise resulting in an increased need for novel interventions to combat this growing concern. One such intervention is time-restricted eating, which consolidates caloric intake to a shortened eating duration, and has consistently demonstrated improvement in metabolic health. Additional interventions could harness circadian clocks, which help regulate daily rhythms of hormone release and maintain metabolic homeostasis. Circadian rhythms are influenced by timing of food intake and therefore meal timing may also impact metabolic health. Objective: To examine whether timing of eating was associated with metabolic health independently of eating duration. Methods: Data are from the National Health and Nutrition Examination Survey (NHANES), a nationally representative U.S. survey and physical exam. We analyzed two non-consecutive dietary recalls, fasting glucose and insulin from 10,575 adults (>18) over four cycles (2005–2012). We calculated eating interval duration as the time between first and last eating occasion (>10kcal) and formulated three groups: <10h, 10-13h, >13h. We then created 6 subgroups based on eating duration start time (before or after 0830 h) to analyze associations of eating interval timing. Linear regression analyses controlling for demographics were computed to determine whether eating interval duration and eating interval timing were associated with fasting glucose and estimated insulin resistance using HOMA-IR. Results: Fasting glucose did not differ significantly among eating interval groups. Adjusted mean HOMA-IR increased with shorter eating interval duration (2.23, 2.20, 1.97 for <10h, 10-13h, >13h; p<0.05). When eating start time occurred before 0830 h compared to start time after 0830 h, mean adjusted HOMA-IR decreased across all eating interval subgroups (1.96 vs 2.28 for <10h, 2.13 vs 2.28 for 10-13h, 1.94 vs 2.13 for >13h; p <0.05). Adjusted mean fasting glucose had a similar pattern (96.3 mg/dL vs 98.7 mg/dL for <10h, 97.3 mg/dL vs 98.4 mg/dL for 10-13h, and 97.3 mg/dL vs 99.3 mg/dL for >13h; p < 0.05). In regression models where eating duration and timing were both entered as continuous variables, only timing was significantly associated with fasting glucose and HOMA-IR. Later time was associated with higher glucose and HOMA values (p<.001) Conclusion: Shorter eating durations, i.e. time-restricted eating, was associated with worse metabolic outcomes, except when paired with an earlier start time. All subgroups with an early eating start time had better metabolic outcomes regardless of eating duration. These findings suggest that timing is more strongly associated with metabolic measures than duration and supports early eating strategies.

Author(s):  
Sang-Dol Kim

(1) Background: Obesity management has become an important issue due to the COVID-19 outbreak; therefore, periodic surveys on the approaches to obesity management of the entire population and target obese population are required. (2) Methods: The study used nationally representative data from the 2018 Korea National Health and Nutrition Examination Survey. Participants reported all approaches they had used to reduce or maintain weight in the past year. Data were analyzed with multiple response methods. (3) Results: The most commonly reported approach was exercise, which included fitness, yoga, biking, and other physical activities (74.7% of respondents), and the second most commonly reported approach was decreased food intake (69.6% of respondents). The use of approaches differed according to respondents’ demographic characteristics. Regarding sex-related differences, in particular, men preferred to exercise, while women were more likely to decrease food intake. Among men, exercise was highest in the 40–49 years age group (48.3%). Among women, decreased food intake was highest in the same age group (16.1%). (4) Conclusions: These findings indicate that it is necessary to introduce individualized weight management approaches and measures according to target groups in obese adults.


2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Lydia Q. Ong ◽  
John Bellettiere ◽  
Citlali Alvarado ◽  
Paul Chavez ◽  
Vincent Berardi

Abstract Background Prior research examining the relationship between cannabis use, sedentary behavior, and physical activity has generated conflicting findings, potentially due to biases in the self-reported measures used to assess physical activity. This study aimed to more precisely explore the relationship between cannabis use and sedentary behavior/physical activity using objective measures. Methods Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey. A total of 2,092 participants (ages 20–59; 48.8% female) had accelerometer-measured sedentary behavior, light physical activity, and moderate-to-vigorous physical activity. Participants were classified as light, moderate, frequent, or non-current cannabis users depending on how often they used cannabis in the previous 30 days. Multivariable linear regression estimated minutes in sedentary behavior/physical activity by cannabis use status. Logistic regression modeled self-reported moderate-to-vigorous physical activity in relation to current cannabis use. Results Fully adjusted regression models indicated that current cannabis users’ accelerometer-measured sedentary behavior did not significantly differ from non-current users. Frequent cannabis users engaged in more physical activity than non-current users. Light cannabis users had greater odds of self-reporting physical activity compared to non-current users. Conclusions This study is the first to evaluate the relationship between cannabis use and accelerometer-measured sedentary behavior and physical activity. Such objective measures should be used in other cohorts to replicate our findings that cannabis use is associated with greater physical activity and not associated with sedentary behavior in order to fully assess the potential public health impact of increases in cannabis use.


2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Charumathi Sabanayagam ◽  
Srinivas Teppala ◽  
Anoop Shankar

We examined gender and ethnic differences in the association between sleep disordered breathing (SDB) and diabetes among 6,522 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2005–08. SDB severity was defined based on an additive summary score including sleep duration, snoring, snorting, and daytime sleepiness. We found that the summary SDB score was significantly associated with diabetes after adjusting for potential confounders in the whole population. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of diabetes among those with ≥3 sleep disturbances was 2.04 (1.46–2.87). In sex-specific analyses, this association was significant only in women (OR (95% CI) = 3.68 (2.01–6.72)) but not in men (1.10 (0.59–2.04)),P-interaction=0.01. However, there were no ethnic differences in this association,P-interaction=0.7. In a nationally representative sample of US adults, SDB was independently associated with diabetes only in women, but not in men.


2014 ◽  
Vol 112 (10) ◽  
pp. 1662-1673 ◽  
Author(s):  
Earl S. Ford ◽  
Chaoyang Li ◽  
Timothy J. Cunningham ◽  
Janet B. Croft

Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and α-tocopherol and all-cause mortality among US adults with obstructive lung function. Data collected from 1492 adults aged 20–79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988–94) were used. Through 2006, 629 deaths were identified during a median follow-up period of 14 years. After adjustment for demographic variables, the concentrations of the following antioxidants modelled as continuous variables were found to be inversely associated with all-cause mortality among adults with obstructive lung function: α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001); vitamin C (P< 0·001). In maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality. No effect modification by sex was detected, but the association between lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status (Pinteraction= 0·048). The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function.


PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17584 ◽  
Author(s):  
Yiyi Zhang ◽  
Wendy S. Post ◽  
Darshan Dalal ◽  
Elena Blasco-Colmenares ◽  
Gordon F. Tomaselli ◽  
...  

Author(s):  
Ramanjit Kaur ◽  
Abhishek Mewada ◽  
Vikas Veeranna ◽  
Sandip Zalawadiya ◽  
Krithi Ramesh ◽  
...  

Background Diabetes mellitus (DM) is a major cause of overall mortality even with optimal control. We sought to explore the association of novel biomarkers with mortality in a nationally representative cohort of adults based on DM status and control. Methods Adults (aged >20 years) in the National Health and Nutrition Examination Survey ( NHANES ) 1999-2008 we subdivided into four groups: no DM, Controlled DM, Uncontrolled DM and Evidence of DM but no formal diagnosis. Cox-proportional hazard analysis was performed to determine the association between novel biomarkers and mortality across the subgroups. Results Red cell distribution width (RDW) and homocysteine remained significant predictors of mortality beyond traditional risk factors (for age, sex, race, body mass index, hypertension, dyslipidemia, smoking and additionally for hemoglobin, mean corpuscular volume and nutritional factor deficiencies) across all the DM subgroups in comparison to the other biomarkers. (Table 1). Conclusion RDW and homocysteine predict mortality irrespective of the diabetes status. These may be the potential targets for future research to ascertain the exact pathophysiologic mechanism.


2018 ◽  
Vol 76 (3) ◽  
pp. 181-188 ◽  
Author(s):  
Mary R Rooney ◽  
Pamela L Lutsey ◽  
Parveen Bhatti ◽  
Anna Prizment

ObjectiveTo test cross-sectional associations between urinary concentrations of 2,5-dichlorophenol (2,5-DCP) and 2,4-dichlorophenol (2,4-DCP) with the prevalence of cardiovascular disease (CVD), cancer, lung disease, thyroid problems and liver conditions.MethodsLogistic regression was used to evaluate associations of urinary concentrations of 2,5-DCP and 2,4-DCP with prevalence of various medical conditions among 3617 National Health and Nutrition Examination Survey participants from 2007–2008 and 2009–2010. ORs and 95% CIs for each disease were estimated. All regression models were adjusted for urinary creatinine.ResultsWe observed a monotonically increasing association between quartiles of 2,5-DCP and prevalence of CVD. After adjustment for sociodemographic and lifestyle characteristics, participants with the highest versus lowest quartile of urinary 2,5-DCP had an OR=1.84 (95% CI 1.26 to 2.70) (p linear trend=0.006). The association was similar with further adjustment for established clinical CVD risk factors. Higher 2,5-DCP was also associated with prevalence of all cancers combined (ORQ4 vs Q1=1.50 (95% CI 1.00 to 2.26); p trend=0.05) and, in exploratory analyses, with gynaecological cancers (ORQ4 vs Q1=4.15 (95% CI 1.51 to 11.40; p trend=0.01)). No associations were detected between 2,5-DCP and lung diseases, thyroid problems or liver conditions, nor between 2,4-DCP and prevalent disease.ConclusionIn this nationally representative study, higher urinary 2,5-DCP concentrations were associated with greater prevalence of CVD and all cancers combined. Further examination may be warranted to assess whether chronic exposure to 2,5-DCP is associated with incidence of adverse health outcomes.


Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Catrine Tudor-Locke ◽  
John M Schuna ◽  
Tiago V Barreira ◽  
Emily F Mire ◽  
Stephanie T Broyles ◽  
...  

Introduction: Reference values used to interpret objectively monitored ambulatory activity (steps/day) represent summarized data collected with different instruments and protocols and aggregated across typically small, select, and disparate samples (e.g., sex composition and age groupings). A full distribution of nationally representative normative data presented by sex-age year collected using a single instrument and a standardized protocol is preferred. The purpose of this analysis of the 2005-2006 National Health and Nutrition Examination Survey (NHANES) accelerometer data is to provide smoothed (i.e., using LMS curve analyses) sex-age rankings from 6-85 years of age. Hypothesis: We hypothesized that, across the lifespan, accelerometer-determined steps/day would be 1) higher in males than females; and 2) lower with higher ages. Methods: Objectively monitored steps/day were measured using the ActiGraph accelerometer (model 7164) worn for 7 consecutive days. The analysis sample was comprised of 6,354 (51.8% female) individuals with valid accelerometer data (≤1 days with ≤10 monitored hours). Percentile values (25 th , 50 th , 75 th , 95 th ) were computed for each single-year age by sex using the LMS method (LMS Chartmaker Pro Version 2.3). To avoid artificially creating sex/age differences through modeling procedures, the L, M and S parameters were chosen using the entire sample then applied to males and females separately to create the curves. Apparent differences by sex and age were noted. Results: LMS curves for steps/day percentile values are presented in the Figure. Steps/day were higher for males than females at every age. A distinct pattern of incrementally reduced steps/day was apparent with higher age across the lifespan. Conclusions: Sex and age are apparent modifiers of steps/day. These normative accelerometer-determined steps/day values can be used for multiple purposes including screening, program development and evaluation, comparison between populations, and tracking change.


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