The Effect Of Eight Weeks Of Endurance Training Of Different Durations On Ghrelin, Insulin, Glucose And Estrogen In Male Rats

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 670
Author(s):  
Rozita Fathi ◽  
Abbass Ghanbari- Niaki ◽  
Sara Nasiri ◽  
Alireza Hossaini-Kakhak
Keyword(s):  
Endurance Training ◽  
Male Rats

Effect of moderate and high-intensity endurance and resistance training on serum concentrations of MSTN and IGF-1 in old male Wistar rats

2019 ◽  
Vol 38 (2) ◽  
Author(s):  
Zohreh Shanazari ◽  
Mohammad Faramarzi ◽  
Ebrahim Banitalebi ◽  
Roohullah Hemmati
Keyword(s):  
Resistance Training ◽  
Endurance Training ◽  
High Intensity ◽  
Intracellular Signaling ◽  
Male Rats ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Control Group ◽  
Significance Level ◽  
Significant Difference

Abstract Background Skeletal muscle is very sensitive to extracellular and intracellular signaling evoked by contractions from endurance and resistance exercise. The aim of this study was to compare the effects of moderate- and high-intensity endurance and resistance training on the serum myostatin (MSTN) and insulin-like growth factor (IGF-1) levels in older rats. Materials and methods Fifty old Wistar male rats (23 months old) were randomly divided into four experimental and one control groups, including moderate-endurance training (MET) (n = 10), high-intensity endurance training (EHT) (n = 10), moderate-intensity resistance training (MRT) (n = 10), high-intensity resistance training (HRT) (n = 10), and control group (C) (n = 10). Seventy-two hours after the last exercise session, euthanasia of the rats were rendered unconscious and direct blood samples were collected. Serum IGF-1 and MSTN concentration were measured using the enzyme-linked immuno sorbent assay (ELISA) method. The statistical analysis was performed using one-way analysis of variance (ANOVA) test with a significance level of p ≤ 0.05. Results There was a significant reduction in MSTN and an increase in IGF-1 concentrations was observed between IGF-I levels in high and moderate resistance and endurance training. However, no significant difference was observed in MSTN levels between groups. Discussion Therefore, it appears that resistance training, especially HRT, is effective to increase growth mediators among older rats.

Effects of curcumin on antioxidant capacity and gastric mucosal injury following strenuous endurance training in rats

2020 ◽  
pp. 1-8
Author(s):  
A. Gorzi ◽  
M. Asadi ◽  
F.A. Voltarelli ◽  
M. Molanouri Shamsi
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Endurance Training ◽  
Serum Levels ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Male Rats ◽  
Antioxidant Defences ◽  
Gastrointestinal Problems ◽  
Male Wistar Rats

Strenuous endurance training (SET) in endurance athletes can cause gastrointestinal problems, such as gastritis. Gastritis is associated with increased oxidative stress and an imbalance between free-radical production and antioxidant defences. The present study investigated the effects of SET and curcumin injection on systemic total antioxidant capacity (TAC), gastric mucosal injury and lipid peroxidation (malondialdehyde – MDA) in male rats. Twenty-six male Wistar rats were randomly divided into four groups including Control, Curcumin, Endurance, and Endurance + curcumin. Incremental endurance training (up to 70 min with 35 m/min), and curcumin injection (30 mg/kg bodyweight, three times per week) was carried out in relevant groups. The pathology of gastritis was measured concerning the restoration factors (the number of neutrophils, the formation of new vessels, and proliferation of fibroblasts), gastric MDA levels and the TAC were measured. SET-induced gastritis symptoms, such as gastric mucosal injury and lipid peroxidation and curcumin decreased systemic TAC. However, curcumin reduced exercise-induced gastric mucosal injury and lipid peroxidation. Also, serum levels of TAC were maintained at normal levels following a combination of SET and curcumin injection. These findings suggest that curcumin injection during SET could be useful for managing gastritis symptoms and improving antioxidant capacity in healthy and eutrophic rats.

The Endurance Training Effects on Apoptosis in the Rat Hippocampus Following Transient Common Carotid Artery Occlusion

2021 ◽  
Author(s):  
Ali Golestani ◽  
Jerome Laurin ◽  
Nicolas Hugues ◽  
Zahra Eslami ◽  
Abdorreza Eghbal Moghanlou ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Endurance Training ◽  
Common Carotid Artery ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Male Rats ◽  
Nissl Staining ◽  
Expression Levels ◽  
Clinical Interest ◽  
Common Carotid Artery Occlusion

Abstract Introduction & Objective: Apoptosis, one of the most important mechanisms explaining stroke-induced functional deficit severity, might be reduced by physical rehabilitation. The purpose of this study is to assess effects of an 8-week endurance training both on apoptosis-related genes and proteins expression levels after a transient common carotid artery occlusion (tCCAO) in rats.Methods: Thirty Wistar male rats were randomly assigned into one of the 3 following groups: Control, tCCAO and tCCAO with endurance training (tCCAO+END). The tCCAO lasted 45 min. The endurance training was performed on treadmill over an 8-week period (5 days per week). BAX and BCL2 genes and proteins expression levels were used by qPCR, immunohistochemistry. Nissl staining was also carried out at the end of the training protocol.Results: The BAX expression increased following tCCAO but decreased when endurance training was performed (p<0.05). The BCL2 expression decreased following tCCAO and increased with training (p<0.05). In parallel, the cell death in the hippocampus was reduced when rats were trained. Conclusion: The endurance training can reduce the pro-apoptotic events after tCCAO suggesting a neuronal survival in the CA1 hippocampus. The link between apoptosis and functional recovery after training seems to be of clinical interest, and thus, should be more investigated.

Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms

2017 ◽  
Vol 131 (8) ◽  
pp. 775-790 ◽  
Author(s):  
Arthur Goron ◽  
Frédéric Lamarche ◽  
Valérie Cunin ◽  
Hervé Dubouchaud ◽  
Christophe Hourdé ◽  
...  
Keyword(s):  
Body Composition ◽  
Protein Synthesis ◽  
Endurance Training ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Synergistic Effects ◽  
Male Rats ◽  
Healthy Male ◽  
Proteomic Approach ◽  
Muscle Protein Metabolism

Background: Exercise and citrulline (CIT) are both regulators of muscle protein metabolism. However, the combination of both has been under-studied yet may have synergistic effects on muscle metabolism and performance. Methods: Three-month-old healthy male rats were randomly assigned to be fed ad libitum for 4 weeks with either a citrulline-enriched diet (1 g·kg−1·day−1) (CIT) or an isonitrogenous standard diet (by addition of nonessential amino acid) (Ctrl) and trained (running on treadmill 5 days·week−1) (ex) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure, mitochondrial metabolism] were explored. Results: Body composition was affected by exercise but not by CIT supplementation. Endurance training was associated with a higher maximal endurance capacity than sedentary groups (P<0.001), and running time was 14% higher in the CITex group than the Ctrlex group (139±4 min versus 122±6 min, P<0.05). Both endurance training and CIT supplementation alone increased muscle protein synthesis (by +27% and +33%, respectively, versus Ctrl, P<0.05) with an additive effect (+48% versus Ctrl, P<0.05). Mitochondrial metabolism was modulated by exercise but not directly by CIT supplementation. However, the proteomic approach demonstrated that CIT supplementation was able to affect energy metabolism, probably due to activation of pathways generating acetyl-CoA. Conclusion: CIT supplementation and endurance training in healthy male rats modulates both muscle protein and energy metabolisms, with synergic effects on an array of parameters, including performance and protein synthesis.

Endurance training in the rat. II. Performance of isolated and intact heart

1981 ◽  
Vol 51 (4) ◽  
pp. 941-947 ◽  
Author(s):  
E. O. Fuller ◽  
D. O. Nutter
Keyword(s):  
Cardiac Function ◽  
Endurance Training ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Treadmill Running ◽  
Cardiac Response ◽  
Male Rats ◽  
Isolated Perfused Heart ◽  
Perfused Heart

The effects of isotonic physical training and detraining on cardiac function were studied in young and adult male rats trained by graded treadmill running and compared with sedentary controls. Absolute left ventricular mass was not increased, and ventricular compliance was not altered by training. Ventricular function curves that plotted peak systolic pressure, maximum rate of rise of left ventricular pressure, cardiac output, coronary flow, or stroke work as a function of atrial filling height in the isolated perfused heart did not demonstrate a training effect in either age group. The cardiac response to hypoxia was also comparable in the trained and sedentary rats. The base-line heart rate of anesthetized rats, in which in situ cardiac function was studied, was lower in the trained rats (321 +/- 14 vs. 377 +/- 8, P less than 0.005). Resting hemodynamics and left ventricular function curves generated from pressure-flow data during volume infusion did not differentiate between the hearts of trained and sedentary rats. In conclusion, a moderate level of endurance training did not enhance cardiac contractility when this was assessed under nonexercise conditions in both the isolated perfused heart and intact in situ heart preparations.

scholarly journals High-Dose Testosterone Propionate Treatment Reverses the Effects of Endurance Training on Myocardial Antioxidant Defenses in Adolescent Male Rats

2011 ◽  
Vol 11 (2) ◽  
pp. 118-127 ◽  
Author(s):  
Ewa Sadowska-Krępa ◽  
Barbara Kłapcińska ◽  
Sławomir Jagsz ◽  
Andrzej Sobczak ◽  
Stanisław J. Chrapusta ◽  
...  
Keyword(s):  
Endurance Training ◽  
Testosterone Propionate ◽  
Male Rats ◽  
Antioxidant Defenses ◽  
Adolescent Male ◽  
High Dose

scholarly journals Effects of different intensities of endurance training on serum fibroblast growth factor level, glucose, and insulin resistance in streptozotocin-diabetic male rats

2019 ◽  
Vol 21 (3) ◽  
pp. 118-124
Author(s):  
Zahra Yadollahi Farsani ◽  
Farzaneh Taghian ◽  
Ebrahim Banitalebi
Keyword(s):  
Insulin Resistance ◽  
Endurance Training ◽  
Training Group ◽  
Diabetic Control ◽  
The Other ◽  
Male Rats ◽  
Moderate Intensity ◽  
Fibroblast Growth ◽  
Blood Samples ◽  
Fgf21 Level

Background and aims: Fibroblast growth factor 21 (FGF21) is a myokine which is produced and secreted by skeletal muscle. Given the inconsistent results on the relationship between the intensity of training and the improvement of blood indices in diabetic patients, the current research investigated the effect of endurance training at different intensities on serum FGF21 level, glucose, and insulin resistance in streptozotocin (STZ)-diabetic male rats. Methods: To this end, 50 rats (with a mean weight of 23.28±25.05 g) were randomly divided into healthy (non-diabetic) control, diabetic control, as well as low, moderate, and high-intensity endurance training groups. Diabetes was induced in all rats by the injection of STZ. Three days after STZ injection, the blood samples were taken from the cut tip of the tails, and those rats with blood glucose levels above 300 mg/dL were considered diabetic and included in the study. The program included 8-week aerobic training at different intensities. The blood samples (5 cc) were directly collected from the hearts 48 hours after the last training session, followed by measuring the serum FGF21 level, glucose, and insulin. Finally, the analysis of variance and Bonferroni post-hoc test were used for inter-group comparison and the significance level was considered <0.05. Results: Based on the results, the serum glucose level, insulin resistance, and FGF21 reduced after eight weeks of endurance training. The reduction of FGF21 in higher intensity endurance training group was greater compared to the other groups (P<0.05) and the reduction of glucose in moderate intensity group was more significant in comparison to that of the other groups (P<0.001). However, the insulin level increased, which was more pronounced in the moderate intensity training group compared to the other groups (P=0.002). Conclusion: Overall, both moderate and high-intensity endurance training led to a comparatively more effective reduction in blood glucose and insulin resistance. Therefore, these two parameters may have a protective effect on the complications associated with diabetes in the rats.

scholarly journals Changes in gene expression of lactate carriers (MCT1 and CD147) in cardiac muscle of diabetic male rats: the effect of dichloroacetate and endurance training

2020 ◽  
Vol 92 (5) ◽  
pp. 111-119
Author(s):  
H. Rezaeinasab ◽  
◽  
A. Habibi ◽  
M. Nikbakht ◽  
M. Rashno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Muscle ◽  
Endurance Training ◽  
Male Rats

Endurance training and LXR activation increased LXRα and ABCA1 transcripts in Wistar male rats

2018 ◽  
Vol 33 (3) ◽  
pp. 152-157 ◽  
Author(s):  
F. Kazeminasab ◽  
S.M. Marandi ◽  
K. Ghaedi ◽  
F. Esfarjani ◽  
J. Moshtaghian
Keyword(s):  
Endurance Training ◽  
Male Rats ◽  
Wistar Male Rats

scholarly journals Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway

2002 ◽  
pp. 149-157 ◽  
Author(s):  
E Luciano ◽  
EM Carneiro ◽  
CR Carvalho ◽  
JB Carvalheira ◽  
SB Peres ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Endurance Training ◽  
Tolerance Test ◽  
Pi3 Kinase ◽  
Protein Quantification ◽  
Serine Phosphorylation ◽  
Male Rats ◽  
Diabetic Patients ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

BACKGROUND: Endurance training increases insulin-stimulated muscle glucose transport and leads to improved metabolic control in diabetic patients. OBJECTIVE: To analyze the effects of endurance training on the early steps of insulin action in muscle of rats. DESIGN: Male rats submitted to daily swimming for 6 weeks were compared with sedentary controls. At the end of the training period, anesthetized animals received an intravenous (i.v.) injection of insulin and had a fragment of their gastrocnemius muscle excised for the experiments. METHODS: Associations between insulin receptor, insulin receptor substrates (IRS)-1 and -2 and phosphatidylinositol 3-kinase (PI3-kinase) were analyzed by immunoprecipitation and immunoblotting. Akt-1 serine phosphorylation and specific protein quantification were detected by immunoblotting of total extracts, and IRS-1/IRS-2-associated PI3-kinase activity were determined by thin-layer chromatography. RESULTS: Insulin-induced phosphorylation of IRS-1 and IRS-2 increased respectively by 1.8-fold (P<0.05) and 1.5-fold (P<0.05), whereas their association with PI3-kinase increased by 2.3-fold (P<0.05) and 1.9-fold (P<0.05) in trained rats as compared with sedentary controls, respectively. The activity of PI3-kinase associated with IRS-1 and IRS-2 increased by 1.8-fold (P<0.05) and 1.7-fold (P<0.05) respectively, in trained rats as compared with their untrained counterparts. Serine phosphorylation of Akt-1/PKB increased 1.7-fold (P<0.05) in trained rats in response to insulin. These findings were accompanied by increased responsiveness to insulin as demonstrated by a reduced area under the curve for insulin during an i.v. glucose tolerance test, by increased glucose disappearance rate during an insulin tolerance test, and by increased expression of glucose transporter-4. CONCLUSIONS: The increased responsiveness to insulin induced by chronic exercise in rat skeletal muscle may result, at least in part, from the modulation of the insulin signaling pathway at different molecular levels.

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