Proteomic Investigation in Plasma from Women with Fibromyalgia in Response to a 15-Week Resistance Exercise Intervention

AbstractMOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I–III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson’s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282.

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The Impact of Virtual Physical Activity Interventions on Depression and Anxiety among College Students: Randomized Controlled Trial (Preprint)

10.2196/preprints.31839 ◽

2021 ◽

Author(s):

Andy Murray ◽

Michele Marenus ◽

Ana Cahuas ◽

Kathryn Friedman ◽

Haley Ottensoser ◽

...

Keyword(s):

College Students ◽

Resistance Exercise ◽

Interaction Effect ◽

Repeated Measures ◽

Exercise Intervention ◽

Controlled Trial ◽

Depression Symptoms ◽

Depression And Anxiety ◽

Main Effect ◽

The Impact

BACKGROUND Depression and anxiety are growing issues for college students, with both aerobic-resistance training and mindfulness-yoga exercises known to be effective in reducing symptoms and severity. However, no known research is available comparing these two depression and anxiety interventions simultaneously and in a virtual environment. OBJECTIVE This study aimed to determine the effects of a virtual aerobic-resistance exercise intervention (WeActive) and a virtual yoga-mindfulness mindfulness exercise intervention (WeMindful) on depression and anxiety symptoms in college students METHODS The participants were 78 college students who anonymously completed a Qualtrics survey including the Generalized Anxiety Disorder Scale (GAD-7) and the Major Depression Inventory (MDI) at baseline and the post-test. Participants were randomly assigned to either the WeActive or WeMindful group and underwent two 30-minute virtual aerobic-resistance exercise lessons or yoga-mindfulness lessons per week for eight weeks. RESULTS The results of ANCOVA with repeated measures indicated that, while not statistically significant, both groups showed a notable decrease in anxiety with a marginal significant main effect of time (F = 3.485, p = 0.066, η2 = 0.047) but no significant main effect of group and no significant interaction effect of time with group. The two intervention groups experienced a significant decrease in depression with the main effect of time (F = 3.892, p = 0.052, η2 = 0.052). There was no significant main effect of group or interaction effect of time with group for depression. CONCLUSIONS College students in both WeActive and WeMindful groups experienced a significant decrease in depression symptoms and a decrease, though not significant, in anxiety as well. The study suggests that virtual WeActive and WeMindful interventions are effective approaches to managing US college student depression and anxiety during a pandemic.

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Effect of a Resistance Exercise Intervention on Frailty Outcomes in Adults With Diabetes Mellitus

Canadian Journal of Diabetes ◽

10.1016/j.jcjd.2021.09.092 ◽

2021 ◽

Vol 45 (7) ◽

pp. S31

Author(s):

Diana Mager ◽

Chelsea Kamprath ◽

Ashley Wilmott ◽

Maryah Robinson-Jackson ◽

Angela Juby ◽

...

Keyword(s):

Diabetes Mellitus ◽

Resistance Exercise ◽

Exercise Intervention

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Effectiveness of a Diet and Resistance Exercise Intervention on Muscle Health in Older Adults: ProMuscle in Practice

Journal of the American Medical Directors Association ◽

10.1016/j.jamda.2019.11.026 ◽

2020 ◽

Vol 21 (8) ◽

pp. 1065-1072.e3 ◽

Cited By ~ 1

Author(s):

Ellen J.I. van Dongen ◽

Annemien Haveman-Nies ◽

Esmée L. Doets ◽

Berber G. Dorhout ◽

Lisette C.P.G.M. de Groot

Keyword(s):

Older Adults ◽

Resistance Exercise ◽

Exercise Intervention ◽

Muscle Health

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Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

10.21203/rs.3.rs-59386/v2 ◽

2020 ◽

Author(s):

Kyuwan Lee ◽

Nathalie Sami ◽

Debu Tripathy ◽

Wendy Demark-Wahnefried ◽

Mary K. Norris ◽

...

Keyword(s):

Breast Cancer ◽

Cardiovascular Disease ◽

Resistance Exercise ◽

Cancer Survivors ◽

Usual Care ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

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Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer

JAMA Oncology ◽

10.1001/jamaoncol.2019.0038 ◽

2019 ◽

Vol 5 (5) ◽

pp. 710 ◽

Cited By ~ 8

Author(s):

Kyuwan Lee ◽

Debu Tripathy ◽

Wendy Demark-Wahnefried ◽

Kerry S. Courneya ◽

Nathalie Sami ◽

...

Keyword(s):

Breast Cancer ◽

Cardiovascular Disease ◽

Resistance Exercise ◽

Exercise Intervention ◽

Disease Risk ◽

Early Stage ◽

Cardiovascular Disease Risk ◽

Early Stage Breast Cancer

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Resistance Exercise Regulates Hepatic Lipolytic Factors as Effective as Aerobic Exercise in Obese Mice

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17228307 ◽

2020 ◽

Vol 17 (22) ◽

pp. 8307

Author(s):

Ju Yong Bae

Keyword(s):

Resistance Training ◽

Resistance Exercise ◽

Aerobic Exercise ◽

Exercise Intervention ◽

Cannabinoid Receptor ◽

Regulatory Element ◽

Obese Mice ◽

Alcoholic Fatty Liver ◽

Protein Levels ◽

Type Of Exercise

Non-alcoholic fatty liver disease (NAFLD) is associated with obesity. The effect of resistance exercise without dietary restriction on the regulation of hepatic lipolytic factors is unclear. This study aimed to analyze the effects of aerobic and resistance exercise on hepatic lipolytic factors of obese mice. High-fat diet (HFD)-induced obese mice were divided into HFD + sedentary (HF), HFD + aerobic exercise, and HFD + resistance exercise groups. Exercise group mice were subjected to treadmill or ladder climbing exercise for 8 weeks. Fat mass and liver triglycerides were significantly decreased in both aerobic and resistance training groups. In the results of protein levels related to hepatic steatosis, HFD significantly increased liver cannabinoid receptor 1 and sterol-regulatory element binding protein 1 (SREBP-1). Both aerobic and resistance training significantly (p < 0.05) increased liver carnitine palmitoyltransferase-1, phosphor-AMP-activated protein kinase (p-AMPK), and p-AMPK/AMPK and decreased liver SREBP-1. However, the type of exercise did not exert any significant effects on these protein levels. Thus, resistance exercise, similarly to aerobic exercise, effectively regulated hepatic lipolytic factors of obese mice. Therefore, a sustainable type of exercise selected based on the fitness level, disease type, musculoskeletal disorder status, and preference of the patients is the best exercise intervention for alleviating NAFLD.

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Resistance exercise versus aerobic exercise combined with metformin therapy in the treatment of type 2 diabetes: a 12-week comparative clinical study

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320999200918143227 ◽

2020 ◽

Vol 20 ◽

Author(s):

Walid Kamal Abdelbasset

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

Resistance Exercise ◽

Aerobic Exercise ◽

Exercise Intervention ◽

Fasting Blood Glucose ◽

Exercise Program ◽

Model Assessment ◽

Study Program

Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM) while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Objectives: This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients Methods: Fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups, each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted trice weekly for executive twelve weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMAIR), and maximal oxygen uptake (VO2max) were evaluated before and after study intervention. Results: Significant differences were reported after the 12-week intervention inter-groups in the outcome variables (p˂0.05). FBG, HbA1c, HOMA-IR, and VO2max improved significantly in REP group (p˂0.001) and also in the AEP group (p=0.016, p=0.036, p=0.024, and p=0.019 respectively) while the Met group showed only significant reduction in FBG (p=0.049), and non-significant changes in HbA1c, HOMA-IR, and VO2max (p˃0.05). REP group achieved greater improvements than AEP group (FBG, p=0.034; HbA1c%, p=0.002; HOMA-IR, p˂0.001; and VO2max, p=0.024). Conclusions: Both resistance and aerobic exercise programs combined with metformin are effective in controlling T2DM. Resistance exercise combined with metformin is more effective than aerobic exercise combined with metformin in the treatment of T2DM.

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