Effect of Ringer-Lactate and isotonic saline solutions on mucociliary clearance of tracheal epithelium: an experimental study in rats

2002 ◽  
Vol 116 (7) ◽  
pp. 536-538 ◽  
Author(s):  
Murat Ünal ◽  
Hakki Oktay Seymen
Keyword(s):  
Experimental Study ◽  
Mucociliary Clearance ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Tracheal Epithelium ◽  
Ringer Lactate ◽  
Carbon Particles ◽  
Septal Surgery ◽  
Tracheal Lavage ◽  
Saline Solutions

Isotonic saline solution is frequently used in nasal and tracheal lavage. In a previous clinical study, it was found that Ringer-Lactate solution, as a nasal lavage, was better for mucociliary clearance function than isotonic saline solution after nasal septal surgery. In this experimental study, the effects of Ringer-Lactate and isotonic saline solutions on mucociliary clearance of healthy rat tracheal epithelium were investigated by measuring the transport of carbon particles. We found that tracheal segments that were irrigated with Ringer-Lactate had better mucociliary transport than those irrigated with isotonic saline (p = 0.035).

Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study

2021 ◽  
pp. 1-4
Author(s):  
E Ocak ◽  
S Mulazimoglu ◽  
D Kocaoz ◽  
E Mirici ◽  
E Dagli ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mucociliary Clearance ◽  
Isotonic Saline ◽  
Sodium Hyaluronate ◽  
Controlled Study ◽  
Control Group ◽  
Clearance Time ◽  
Nasal Irrigation ◽  
Persistent Allergic Rhinitis ◽  
Randomised Controlled

Abstract Objective To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis. Methods A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared. Results Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03). Conclusion Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.

scholarly journals Effects of Saline Solutions on the Desiccation Cracking and Shrinkage Behavior of Gaomiaozi Bentonite

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Long Tan ◽  
Penglin Zheng ◽  
Qingbing Liu
Keyword(s):  
Water Content ◽  
Saline Solution ◽  
Shrinkage Strain ◽  
Sample Surface ◽  
Water Evaporation ◽  
Gmz Bentonite ◽  
Residual Water ◽  
High Concentration ◽  
Desiccation Cracking ◽  
Saline Solutions

Bentonite, when used as buffer/backfill material in the deep disposal of high-level radioactive waste (HLW), could undergo desiccation shrinkage or even cracking due to the heat released from HLW, impairing the efficiency of the barrier system. Furthermore, in-service buffer materials are inevitably in contact with the groundwater, which sometimes contain high salt concentrations. The groundwater salinity may modify the properties of bentonite and hence affect the process of desiccation and its performance. To investigate this effect, in this study, a series of temperature-controlled desiccation tests was conducted on compacted specimens of Gaomiaozi (GMZ) bentonite preliminarily saturated with two different saline solutions (NaCl and CaCl2) at the concentration varying from 0.5 to 2.0 mol/L. The experimental results indicated that, as the concentration of saline solution increases, the initial saturated water content of bentonite decreases, whereas the residual water content at the completion of the desiccation test increases. The water evaporation rate is reduced for the specimens saturated with a high-concentration saline solution, and CaCl2 has a more significant influence on water evaporation than NaCl. The evolution of cracks on the sample surface during the desiccation process can be divided into four stages: crack growth, maintenance, closure, and stabilization; an increase in the salt concentration effectively inhibits crack development. It was shown that the infiltration of saline solutions alters the microstructure of bentonite by changing the arrangement of clay particles from a dispersed pattern to more aggregate state, which results in a decrease in shrinkage strain and shrinkage anisotropy.

scholarly journals The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug

2006 ◽  
Vol 43 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Afonso Luiz Villa ◽  
Ceneviva Reginaldo ◽  
Fernanda Viaro ◽  
Fernando Ramalho ◽  
Antonio Dorival Campos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Isosorbide Dinitrate ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Nitric Oxide Donor ◽  
Group Iii ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Gastric Mucous ◽  
Lesion Index

BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AIM: To define a possible cytoprotective effect of a nitric oxide donor, isosorbide dinitrate, on the gastric mucous of rats submitted to non-steroidal anti-inflammatory drugs ketoprofen treatment. METHODS: Adult male Wistar rats, previously submitted to starvation for 24 hours and divided in three groups: group I (standard): animals that received isotonic saline solution intragastric by gavage and intravenous. Group II (control-ketoprofen): animals that received isotonic saline solution intragastric by gavage and ketoprofen intravenous. Group III (nitrate/ketoprofen): animals that received 2mM solution of isosorbide dinitrate intragastric by gavage and ketoprofen intravenous. Later on, these animals were sacrificed and had their stomach removed and submitted to macroscopical, microscopical and biochemical studies. The evaluated parameters were: a) gastric lesion index; b) gastric mucous layer thickness; c) gastric tissue nitrate/nitrite (NOx) concentration and d) gastric tissue malondialdehyde concentration. RESULTS: a) Gastric lesion index evaluation showed a smaller statistically significant incidence on the animals of group III; b) group III showed a thicker mucous layer, which also was statistically significant, when compared to group II; c) the variation on tissue nitrate/nitrite concentration was similar in all three groups, without statistical significance when compared to each other. CONCLUSION: Isosorbide dinitrate has a cytoprotective activity on the gastric mucosa of rats submitted to ketoprofen action.

Effects of isotonic saline solution resuscitation on blood coagulation in uncontrolled hemorrhage

Surgery ◽  
1996 ◽  
Vol 119 (5) ◽  
pp. 528-533 ◽  
Author(s):  
Jeffrey B. Selby ◽  
James E. Mathis ◽  
Carrie F. Berry ◽  
Frederick N. Hagedorn ◽  
Hana P. Illner ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Uncontrolled Hemorrhage

Hyperosmolarity alters micturition: a comparison of urinary bladder motor activity in hyperosmolar and cyclophosphamide-induced models of overactive bladder

2010 ◽  
Vol 88 (9) ◽  
pp. 899-906 ◽  
Author(s):  
Kajetan Juszczak ◽  
Agata Ziomber ◽  
Marek Wyczółkowski ◽  
Piotr J. Thor
Keyword(s):  
Motor Activity ◽  
Isotonic Saline ◽  
Bladder Capacity ◽  
Physiological Model ◽  
Female Rats ◽  
Hypertonic Solution ◽  
Motility Index ◽  
Pressure Threshold ◽  
Experimental Tool ◽  
Saline Solutions

Hyperosmolar factors induce the neurogenic inflammatory response, leading to bladder overactivity (OAB). The aim of the study was to compare the bladder motor activity in a hyperosmolar and acute cyclophosphamide (CYP)-induced model of OAB. Furthermore, we set our sights on defining the most physiological model of OAB in experimental practice. Forty-two female rats were divided randomly into 5 groups. All animals underwent cystometry with the usage of isotonic saline or saline of increasing concentration. Acute chemical cystitis was induced by CYP to elicit OAB. The following cystometric parameters were analyzed: basal pressure, threshold pressure, micturition voiding pressure, intercontraction interval, compliance, functional bladder capacity, motility index, and detrusor overactivity index. CYP and hypertonic saline solutions induced OAB. Having been compared with CYP OAB, none of the rats infused with hypertonic solution exhibited macroscopic signs of bladder inflammation. The comparison of CYP and hyperosmolar models of OAB revealed that the greatest similarity existed between the 2080 mOsm/L OAB model and the acute CYP-induced model. We postulate that the 2080 mOsm/L model of OAB can be established as being a less invasive and more physiological model when compared with the CYP-induced OAB model. Additionally, it may also be a more reliable experimental tool for evaluating novel therapeutics for OAB as compared with CYP-induced models.

Fluid Movement Across the Wall of the Small Intestine in Vitro

1956 ◽  
Vol 187 (2) ◽  
pp. 244-246 ◽  
Author(s):  
T. Hastings Wilson
Keyword(s):  
Small Intestine ◽  
Sodium Chloride ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Bicarbonate Secretion ◽  
Serosal Side ◽  
Fluid Movement ◽  
Mucosal Side

Small sacs of everted jejunum of the hamster were incubated in sugar free bicarbonate-saline solution in vitro. Both fluid and sodium chloride moved across the wall of the intestine from mucosal to serosal side. This movement of isotonic saline solution across the intestine was inhibited anaerobically. A small bicarbonate secretion was noted in the direction of serosal to mucosal side.

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