Short-term effects of aflatoxin B1 on serum lipids in subhuman primates

1979 ◽  
Vol 13 (2) ◽  
pp. 67-68 ◽  
Author(s):  
O. Bassir ◽  
T. C. Alozie
Keyword(s):  
Serum Cholesterol ◽  
Aflatoxin B1 ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Cercopithecus Aethiops ◽  
Total Lipids ◽  
Lipid Levels ◽  
Short Term ◽  
Erythrocebus Patas ◽  
Aflatoxin B

Summary Aflatoxin B1 significantly depressed serum lipid levels in specimens of Cercopithecus aethiops, Cercopithecus mona, Erythrocebus patas and Papio enubis. Serum cholesterol, total phospholipids and total lipids were not affected to the same extent.

scholarly journals Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4637 ◽  
Author(s):  
Xingchen Zhou ◽  
Wu Zhu ◽  
Minxue Shen ◽  
Yijing He ◽  
Cong Peng ◽  
...  
Keyword(s):  
Serum Level ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

scholarly journals Low cholesterol levels in children predict impulsivity in young adulthood

2019 ◽  
Vol 32 (4) ◽  
pp. 196-205
Author(s):  
Katrin Tomson-Johanson ◽  
Tanel Kaart ◽  
Raul-Allan Kiivet ◽  
Toomas Veidebaum ◽  
Jaanus Harro
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Young Adulthood ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Low Levels

AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

scholarly journals The relationship between measures of obesity and atherogenic lipids among Nigerians with hypertension

2019 ◽  
Vol 31 (3) ◽  
pp. 193-197
Author(s):  
Olamoyegun A Michael
Keyword(s):  
Serum Lipid ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Advanced Age ◽  
Newly Diagnosed ◽  
Lipid Levels ◽  
Anthropometric Indices ◽  
Study Population ◽  
The Relationship

AimThis study aimed to determine the relationship between measures of obesity and serum lipid levels among hypertensive patients.MethodsThis was a cross-sectional study in which participants newly diagnosed with hypertension formed the study population. A range of demographic and anthropometric data was obtained, including weight, height, and waist and hip circumference. Fasting serum lipids were also measured, including total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Low density lipoprotein cholesterol (LDL-C) was calculated using Friedewald formula. Statistical analysis was then carried out to determine the relationship between anthropometric indices and lipid profile levels. ResultsThe study population consisted of 124 male and 290 female subjects with a mean age of 66±16.95 years (range, 30–100 years).The female subjects were older than the male subjects (p=0.020). Our analysis showed that 85%, 58.5% and 30.7% of the study population had abnormal waist circumference (WC), abnormal waist-hip ratio (WHR) and a body mass index (BMI) >25 kg/m2, respectively. Decreased HDL-C (70.1%) was the commonest lipid abnormality detected, followed by elevated LDL (6.0%). None of the anthropometric indices were independent predictors of abnormal lipid levels. However, advanced age and female sex were independent predictors for at least one serum lipid abnormality.ConclusionNone of the measures of obesity could independently predict abnormal lipid levels in individuals newly diagnosed with hypertension. However, female sex, advanced age and systolic blood pressure were independently associated with abnormal serum lipids. Encouraging regular exercise, and the possible addition of statins, may be beneficial in addressing both obesity and dyslipidaemia.

scholarly journals Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia

2014 ◽  
Vol 15 (3) ◽  
pp. 294-299 ◽  
Author(s):  
BS Ganavi ◽  
Shankargouda Patil
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Cholesterol ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Control Group ◽  
Matched Healthy Control ◽  
Healthy Control ◽  
Lipids And Lipoproteins

ABSTRACT Background Oral cancer is the 8th most common cancer worldwide. Squamous cell carcinomas constitute 94% of all oral malignancies and are often preceded by leukoplakia. Despite many adjunctive techniques to monitor transformation of leukoplakia to oral squamous cell carcinoma (OSCC), the mortality rate is on the rise. Incidentally, patients diagnosed with oral potentially malignant disorders (OPMDs) and oral cancers manifest with low choles-terol levels. Given a thought, hypolipidemia may be a useful adjunctive tool as it reflects the initial changes within the neo-plastic cells, thus giving a red alert in malignant transformation of leukoplakia at the earlier stage. Aim To evaluate the feasibility of serum lipid profile as an adjunct early marker for malignant transformation of leukoplakia to OSCC. Objectives To estimate the serum cholesterol, triglycerides and lipoprotein (HDL, LDL, VLDL) levels in patients with leukoplakia, OSCC and age matched healthy control group. To compare the serum cholesterol, triglycerides and lipoprotein levels between patients of leukoplakia, OSCC and age matched healthy control group. Materials and methods The study group comprised of selected 30 individuals which included 10 each of histopathologically confirmed OSCC, leukoplakia and healthy controls. A written consent was taken from all of them, and a thorough case history was recorded and then venous blood was collected 12 hours post fasting and centrifuged. The serum cholesterol, triglycerides and HDL were estimated by enzymatic and colorimetric methods using commercially available kits — Roche/ Hitachi cobas systems. Chemistry assay QC procured from Bio-Rad was used as control. VLDL and LDL were derived from these values. Results were statistically analyzed using ANOVA and post hoc Tukey Test. Results Oral squamous cell carcinoma patients demonstrated significantly lower mean serum cholesterol level (151.60 mg/dl) than the control group (183.70 mg/dl). The mean cholesterol level in leukoplakia patients (173.90 mg/dl) was lower than that of control group (183.70 mg/dl) but higher than that of the OSCC group (151.60 mg/dl) with no statistical significance. Conclusion Convenience, universal availability, patient compatibility and simplicity being the merits of serum lipid profile make it a feasible adjunctive prognosticator in leukoplakic patients. How to cite this article Ganavi BS, Patil S, Rao RS. Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia. J Contemp Dent Pract 2014;15(3):294-299.

Effect of Short-Term Beta Blockade on Serum Lipid Levels and on the Interaction of LDL with Human Arterial Proteoglycans

1990 ◽  
Vol 30 (S2) ◽  
pp. S124-S131 ◽  
Author(s):  
Tomas Lindén ◽  
Germán Camejo ◽  
Olov Wiklund ◽  
Ingrid Warnold ◽  
Sven-Olof Olofsson ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Beta Blockade ◽  
Lipid Levels ◽  
Short Term ◽  
Serum Lipid Levels

scholarly journals Serum Lipids are Novel Predictors for Thyroid Autoimmunity in the General Population with Normal TSH Levels From A Cross-Sectional Study

2021 ◽  
Author(s):  
Jiarong Li ◽  
Zixiao Wang ◽  
He Liu ◽  
Jinrong Fu ◽  
Fengye Qin ◽  
...  
Keyword(s):  
General Population ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Thyroid Autoimmunity ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Thyroid Autoantibody ◽  
Serum Lipid Levels ◽  
Tsh Levels

Abstract Objective Serum lipids have been shown to regulate inflammatory and immune processes, but little is known about their association with thyroid autoimmunity. This study aimed to investigate the association of serum lipids with thyroid autoantibody positivity in the general population with normal thyroid-stimulating hormone (TSH) levels. Methods Data regarding the 7,688 subjects’ baseline characteristics were retrospectively collected. All subjects were categorized into four groups according to thyroid autoantibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) positivity and serum lipid levels were compared. Binary logistic regression models were used to evaluate the risk of TgAb or TPOAb positivity with increasing serum lipid levels. Results In 6,456 included subjects, after adjusting for confounders, the risk of TgAb positivity was positively associated with increasing low-density lipoprotein cholesterol (LDL-C) levels (OR 1.10, 95%CI 1.02–1.19, P = 0.014) and negatively correlated with the increasing high-density lipoprotein cholesterol (HDL-C) levels (OR 0.80, 95%CI 0.67–0.96, P = 0.014). In female subjects, the association between increasing LDL-C (OR 1.15, 95%CI 1.05–1.26, P = 0.004) or HDL-C levels (OR 0.74, 95%CI 0.60–0.91, P = 0.005) and TgAb positivity become more pronounced. Moreover, there was a positive correlation between LDL-C levels and TPOAb positivity (OR 1.14, 95%CI 1.02–1.26, P = 0.016). Conclusion We have shown the associations of HDL-C and LDL-C with thyroid autoantibody positivity in the general population with normal TSH levels in a gender-dependent manner. This study highlights that serum lipids may be new predictors of thyroid autoimmunity even when TSH is within the reference range.

scholarly journals Frequency of dyslipidemia in young overweight and obese students (age 10-16 years) in private schools of swat

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Rubina Nazli ◽  
Sadia Fatima ◽  
Nazish Farooq ◽  
Ihsan Ullah ◽  
Jamila Haider ◽  
...  
Keyword(s):  
Private Schools ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Strong Association ◽  
Cross Sectional Study ◽  
Lipid Levels ◽  
Cross Sectional ◽  
Serum Lipid Levels ◽  
Logistic Regression Method ◽  
Student’S T

Objectives: The objective of the current study was to estimate the frequency of pediatric dyslipidemia in overweight and obese students of private schools in Swat. Study Design: Questionnaire based cross-sectional study. Setting: Three private schools of district Swat. Period: 6 months. Method: Study analysis was done in Research laboratories of Biochemistry Department, Institute of Basic medical Sciences (IBMS), Khyber Medical University Peshawar. Well-designed questionnaires were used for screening of 99 out of 1374 students, including both girls and boys. Anthropometric measurements were taken. Blood samples were collected for the analysis of serum lipids using an Automated Cobas Analyzer. SPSS version 20, Student’s t test and Logistic regression method was used for statistical analysis. Results: The prevalence of dyslipidemia was measured to be 42.4%. A significantly direct association was found between the rate of dyslipidemia and BMI. Highly significant P values were found for serum lipids in obese children as compared to overweight children thus showing strong association between the biochemical Parameters and BMI. Even though rate of dyslipidemia was measured to be a little higher in boys as compared to girls, no statistically significant gender differences were found in serum lipid levels. Conclusion: Reduce long-term complications in adulthood is possible through controlling the serum lipid levels of children and adolescents.

scholarly journals Significance of Levothyroxine Treatment on Serum Lipid in Pregnant Women With Subclinical Hypothyroidism

2022 ◽  
Author(s):  
Yuxi Yang ◽  
Huabing Yuan ◽  
Xueran Wang ◽  
Zheng Zhang ◽  
Ruixia Liu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Reference Range ◽  
Intervention Group ◽  
First Trimester ◽  
Reference Ranges ◽  
Lipid Levels

Abstract BackgroundThere is no consensus reference range for serum lipid levels during pregnancy. The benefit of levothyroxine (L-T4) on serum lipid levels are unclear among pregnant women with subclinical hypothyroidism (SCH).ObjectiveTo determine the recommended reference ranges for serum lipid concentrations during pregnancy and effects of L-T4 treatment on serum lipids in pregnant women with SCH. Designcohort study.MethodsA analysis of 20365 women in the first trimester was conducted at Beijing Obstetrics and Gynecology Hospital, Capital Medical University during 2018–2020. After excluding women with adverse pregnancy outcomes, we determined the reference range of serum lipid in the first and third trimesters of pregnancy by using median and quartile to determine appropriate percentiles. Next, we divided into three groups as follows: SCH L-T4 treatment group (n=319), SCH non-intervention group (n=103) and the control group(n=9598).ResultsThe recommended reference range for serum lipids in the first trimester of pregnancy should be: TC < 5.33 mmol/L, TG < 1.73 mmol/L, LDL-C < 3.12 mmol/L and HDL-C> 1.1 mmol/L, and in third trimester of pregnancy should be: TC < 8.47 mmol/L, TG < 4.86 mmol/L, LDL-C < 5.3 mmol/L and HDL-C >1.34 mmol/L.There are significant differences in TC and LDL-C levels between SCH treatment group and SCH non-intervention Group (P=0.043, P=0.046; respectively).ConclusionsWe determine the recommended reference ranges for serum lipid concentrations during pregnancy. TC and LDL-C levels in pregnant women with SCH could improve after L-T4 treatment.

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