scholarly journals Neonatal screening of glucose-6-phosphate dehydrogenase deficiency in Yanbu, Saudi Arabia

2005 ◽  
Vol 12 (4) ◽  
pp. 170-171 ◽  
Author(s):  
Mohammed Ahmed Muzaffer
Keyword(s):  
Saudi Arabia ◽  
Cord Blood ◽  
G6pd Deficiency ◽  
Neonatal Screening ◽  
Neonatal Jaundice ◽  
Medical Center ◽  
Royal Commission ◽  
Female Ratio ◽  
Blood Samples ◽  
Glucose 6 Phosphate Dehydrogenase

Objective: To determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the population tested, and to evaluate the prevalence of neonatal jaundice in newborns with G6PD deficiency. Methods: Cord blood of all babies born between October 1996 and October 1998 at the Royal Commission Medical Center in Yanbu, Saudi Arabia, was screened for G6PD deficiency by fluorescent spot test. The results of screening of cord blood samples were reported to the physician in charge, and also placed on the files of the babies and their mothers. These babies were observed for 72 h and discharged if no jaundice developed. Results: During this two-year period, 2505 neonatal cord blood samples from 1278 boys and 1227 girls were screened for G6PD. There were 50 positive results for G6PD deficiency (39 boys and 11 girls), and the prevalence was estimated to be around 2%. The sex-specific prevalence for boys was 3.05%, and for girls 0.9%. Male to female ratio was 3:1. Neonatal jaundice developed in six (12%) babies, five male and one female. All were treated with phototherapy and discharged within one week of birth. Conclusion: The prevalence of G6PD is relatively high in Yanbu. Routine neonatal screening in areas with a high prevalence of G6PD in Saudi Arabia is justifiable.

scholarly journals Population Based Survey of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among People Living in Terai Districts of Nepal

2018 ◽  
Vol 4 ◽  
pp. 73-78
Author(s):  
Niraj Lamichhane ◽  
Nabaraj Adhikari ◽  
Upendra Thapa Shrestha ◽  
Komal Raj Rijal ◽  
Megha Raj Banjara ◽  
...  
Keyword(s):  
G6pd Deficiency ◽  
Population Group ◽  
Population Based ◽  
Female Ratio ◽  
Blood Samples ◽  
Test Kit ◽  
Public Health Office ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Male To Female ◽  
Population Based Survey

Objective: This study was carried out to determine the prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency among population of selected malaria endemic districts in central and eastern terai of Nepal.Methods: Six hundred seventy whole blood samples were collected from the indigenous peoples community, identified based on district public health office records for G6PDd in the past from Jhapa, Morang and Dhanusha districts endemic to malaria, during April to June 2013. Collected blood samples were tested on the sites by using BinaxNow G6PD test kit and CareStartTM G6PD test kits.Results: The G6PD deficiency was found to be in 6.1% and 6.3% in BinaxNow and CareStartTM respectively. In 42 G6PD deficient cases number of male to female ratio was almost equal. Higher proportions of deficient cases were from Rajbanshi and Santhal communities than others. Highest number of deficient cases was in Jhapa followed by Morang and Dhanusha districts respectively.Conclusion: G6PD deficiency in indigenous population group in eastern and central terai are heterogenous. So the testing of G6PD before initiation of radical treatment of Plasmodium vivax infection would be important for reducing the risk of hemolysis following Primaquine (PQ) administration. Rational evidence-based PQ administration may be helpful in contributing towards the elimination of malaria from the country.

scholarly journals From Prejudice to Evidence: The Case of Rhizoma Coptidis in Singapore

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chin Ee Ho ◽  
You Li Goh ◽  
Chang Zhang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Therapeutic Effects ◽  
Evidence Based ◽  
Rhizoma Coptidis ◽  
History Of ◽  
Hepatoprotective Effects ◽  
Glucose 6 Phosphate Dehydrogenase

Rhizoma Coptidis (RC), commonly known ashuanglian, is a herb frequently used in Traditional Chinese Medicine (TCM) prescriptions. Known to have “clearing damp-heat, quenching fire and counteracting poison” properties, it was widely used in the Chinese community in Singapore. Berberine, an alkaloid isolated from RC, is known to have a wide array of therapeutic effects including antimicrobial, antineoplastic, and hepatoprotective effects. In 1978, RC was implicated in causing neonatal jaundice (NNJ) and kernicterus in neonates suffering from glucose-6-phosphate dehydrogenase (G6PD) deficiency, leading to the banning of RC and berberine in Singapore. More than three decades later, accumulating evidence-based studies pointing to the safety of RC for general public and better understanding of G6PD deficiency, the Health Sciences Authority (HSA) in Singapore reviewed and lifted the prohibition on RC and berberine, turning a brand new chapter in the history of TCM in Singapore. This paper aims to review the safety of RC and berberine, using the prohibition of use and subsequent lifting of ban on RC and berberine in Singapore as an illustration to highlight the importance of evidence-based studies in Traditional Chinese Medicine (TCM).

scholarly journals Recent trends of glucose-6-phosphate dehydrogenase deficiency among saudi population in Riyadh city

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Fatmah Said Abdullah Al Qahtany
Keyword(s):  
Saudi Arabia ◽  
G6pd Deficiency ◽  
Descriptive Analysis ◽  
Saudi Population ◽  
Cross Sectional ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
King Saud University ◽  
Riyadh City ◽  
Medical City

G6PD deficiency is associated with erythrocyte deficiency in the X-chromosome enzyme. It causes a hematologic syndrome called hemolytic anemia that connects G6PD deficiency with X-linked condition. In the Middle East, including Saudi Arabia, G6PD deficiency is the most dominant genetic blood disorders. It results in higher rates of mortality and morbidity due to its incurable long-lasting nature and prevalence of physical and psychological incapacities. In this study, an attempt was made to evaluate the prevalence of G6PD deficiency among the Saudi population in Riyadh city. A cross-sectional retrospective study was conducted at King Saud University Medical City in Riyadh, Saudi Arabia. The population of the study comprised randomly chosen males and females who visited the hospital from January 2017 to January 2018. Statistical analyses were performed using SPSS, and descriptive analysis was used to find the frequency of G6PD-deficient patients. Out of the 209 patients, 62.2% were males (n=130) and 37.8% were females (n=79). Twenty males and 6 females were found to have G6PD deficiency, with the male to female ratio being 1:3. Out of the total 130 male participants, 20 patients were found to be enzyme deficient and 6 patients of 79 female patients were found to be G6PD deficient. There were 38.4% (n=10) patients with G6PD level <4 units/gram hemoglobin, 26.9% (n=7) patients had G6PD levels of 4.1–7.0 units/gram hemoglobin, and 34.6% (n=9) patients had >7 units/gram hemoglobin. Among the G6PD patients, 23.07% patients were severely anemic, and 5 (19.2%) patients were reported to have high bilirubin. The present study revealed the G6PD prevalence to be 12.4% among the Saudi population; this value is significantly higher than that found in France, Spain, India, and Singapore. In the Saudi population, males are more vulnerable to G6PD-deficient than females. Hence, attention should be paid to G6PD-deficient patients while prescribing antimalarial medication. Such patients may be advised to avoid certain foods to minimize the risk of having hemolytic episodes.

Phototherapy for Neonatal Jaundice in Erythrocyte Glucose-6-Phosphate Dehydrogenase-Deficient Infants

PEDIATRICS ◽  
1977 ◽  
Vol 59 (6) ◽  
pp. 1023-1026
Author(s):  
K. L. Tan
Keyword(s):  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Significant Rise ◽  
Neonatal Hyperbilirubinemia ◽  
Control Group ◽  
Rapid Rise ◽  
Glucose 6 Phosphate Dehydrogenase

The effectiveness of phototherapy in the management of neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient infants was studied. "Prophylactic" phototherapy for six continuous days commencing from the first day of life was effective in preventing a significant rise in bilirubin levels in 12 G6PD-deficient infants in the first three days, during which period a rapid rise was observed in a control group of G6PD-deficient infants. The hemoglobin levels on the first and eighth postnatal days were comparable in both groups. "Therapeutic" phototherapy proved equally effective in reducing bilirubin levels in 24 infants with nonhemolytic hyperbilirubinemia and an equal number of infants with hyperbilirubinemia associated with G6PD deficiency. Phototherapy was efficacious in the prevention or treatment of neonatal hyperbilirubinemia associated with G6PD deficiency; even if its use is prolonged it does not cause hemolysis in such infants.

scholarly journals Glucose-6-phosphate Dehydrogenase Deficiency: A Case Report

2017 ◽  
Vol 12 (1) ◽  
pp. 47-49
Author(s):  
Md Kamrul Hassan ◽  
Aloke Kumar Saha ◽  
Lakshman Chandra Kundu ◽  
Poly Begum ◽  
Abu Yousuf
Keyword(s):  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Dehydrogenase Deficiency ◽  
Cultural Factors ◽  
Enzyme Defect ◽  
Asian Populations ◽  
Hemolytic Crisis ◽  
Life Threatening ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme disorder and more than 200 million people have a deficiency in this enzyme. G6PD deficiency is an X-linked enzyme defect, and one of its main signs is the presence of hemolytic anemia. It is a worldwide important cause of neonatal jaundice and causes life threatening hemolytic crisis in childhood. At later ages, certain drugs such as anti-malarial drugs and fava beans cause hemolysis among G6PD deficiency patients. The frequency and severity is influenced by genetic and cultural factors. It is common in Mediterranean, African and some East Asian populations but rare in Bangladeshi peoples. Genetic counseling may be of benefit for patients and their families. Other treatment is symptomatic and supportive.Faridpur Med. Coll. J. Jan 2017;12(1): 47-49

scholarly journals Incidence of G6PD Deficiency in a Tertiary Care Hospital in South India

2016 ◽  
Vol 36 (2) ◽  
pp. 141-142
Author(s):  
Chenna Chandrashekhar ◽  
Kasi Bandaru
Keyword(s):  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Cell Metabolism ◽  
Tertiary Care ◽  
Test Method ◽  
Care Hospital ◽  
Red Cell ◽  
Drug Induced ◽  
Normal Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy affecting red cell metabolism. Its presentation can vary from drug induced haemolysis to neonatal jaundice with a prevalence ranging from 0-27% in India. The objective of this study was to find out the incidence of G6PD deficiency in babies delivered in our hospital and to assess its contribution in causing neonatal jaundice. 500 babies were screened for G6PD deficiency by Fluorescent spot test method. All the babies were found to have normal enzyme activity. Hence we concluded the burden of G6PD deficiency causing neonatal jaundice is less in our setup.J Nepal Paediatr Soc 2016;36(2):141-142.

scholarly journals FREQUENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY IN NEONATAL JAUNDICE IN DISTRICT SWAT, PAKISTAN

1969 ◽  
Vol 3 (1) ◽  
pp. 242-247
Author(s):  
AMREEK LAL ◽  
S.M.NAEEM ◽  
SHAHJEHAN ◽  
ASHFAQ AHMAD ◽  
ISRARUL HAQ
Keyword(s):  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Dehydrogenase Deficiency ◽  
Reduction Method ◽  
Serum Bilirubin ◽  
Newborn Infants ◽  
Dye Reduction ◽  
Complete Blood Counts ◽  
Deficiency Screening ◽  
Glucose 6 Phosphate Dehydrogenase

Background: Hyperbilirubinemia is the most common cause of neonatal jaundice. Severe neonatalhyperbilirubinemia and kemicterus continue to be reported worldwide in otherwise healthy term infants.We conducted this study to estimate the incidence of severe neonatal hyperbilirubinemia and to determineunderlying causes, improved knowledge of which would be valuable to help identify strategies for riskreduction.Methods: 100 infants of both sexes, of the age between 1-28 days, with no infection and Rh incompatibilitywere included in the study. The activity of G6PD was determined by a dye-reduction method screening testdevised by Sigma Diagnostics USA. Complete blood counts (CBC) with reticulocyte count, serum bilirubin(total and indirect) were performed and the results were recorded for further analyses.Results: Out of the total 100 subjects, classified in two groups on the basis of presence of jaundice, 14 (14%)were G6PD deficient. The frequency of G6PD deficiency was markedly prominent, in neonates withjaundice.Discussion: G6PD deficiency is one of the major causes of jaundice in neonates. The study area also have aconsiderable number of G6PD deficient individuals. This indicates a need for a more thorough assessmentof newborn infants and consideration of strategies to identify at-risk newborns, such as pre-dischargemeasurement of serum bilirubin levels and G6PD deficiency screening.

scholarly journals Glucose-6-phosphate dehydrogenase deficiency; the single most important cause of neonatal hyperbilirubinaemia in Kano, Nigeria

1970 ◽  
Vol 44 (2) ◽  
pp. 44-49
Author(s):  
ZL Farouk ◽  
M Ibrahim ◽  
WN Ogala
Keyword(s):  
Risk Factor ◽  
Neonatal Jaundice ◽  
Dehydrogenase Deficiency ◽  
Cross Sectional Study ◽  
Important Risk Factor ◽  
Mortality Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Male To Female

Introduction: Glucose- 6-phosphate dehydrogenase deficiency is the most common enzymatic disorder of the red cell and an important risk factor for neonatal jaundice.Methodology: The aim of the study was to determine the incidence of G-6-PD deficiency among jaundiced neonates, and describe the associated morbidity and mortality pattern in them. A prospective cross sectional study was conducted and we studied one hundred consecutive jaundiced neonates (55 males, 45 females) presenting at Aminu Kano Teaching Hospital from between 2004 and August 2005. G-6-PD activity was assayed by Quantitative spectrophotometric method of Kornberg; serum bilirubin and haemoglobin levels were estimated by standard techniques. Exposure to possible Icterogenic agents, clinical features of kernicterus and the outcome were noted.Results: The incidence of G-6-PD deficiency was found to be 46% with male to female ratio of 3:1 (Χ2 = 15, p = 0.001). A higher proportion (60.6%) of the inborn neonates had G-6-PD deficiency (X2 = 5.5, p = 0.06). Jaundice was noticed significantly earlier in the G-6-PD deficient neonates (mean = 2.0, SD = 1 days) compared to (mean = 2.7, SD = 1.6 days) in the sufficient neonates (t = 2.3, p = 0.02). Sixteen (16%) neonates developed kernicterus, of these 10 (63%) were G-6-PD deficient. The mortality rate among G-6-PD deficient neonates was 15% (7 of 46) twice as much as in the sufficient neonates 7% (4 of 54). Only six neonates 0.6% ware exposed to naphthalene of whom three were G -6PD deficient. Five babies were given traditional medicine two of which were G6-PD deficient.Conclusion: G-6-PD deficiency is an important risk factor for neonatal jaundice. Jaundice appeared early in the deficient neonates. There is high incidence of kernicterus and mortality among them. Low admission weight significantly contributed to the mortality.Key Words: G-6-PD deficiency; Neonatal Jaundice; Kernicterus

scholarly journals Pattern of diseases among Bangladeshi Hajj Pilgrimsin Mecca, Saudi Arabia

2021 ◽  
Vol 10 (1-2) ◽  
pp. 96-101
Author(s):  
Md Nurul Amin ◽  
Md Rafiqul Islam ◽  
Md Rafiqul Islam
Keyword(s):  
Saudi Arabia ◽  
Heart Diseases ◽  
Medical Center ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Respiratory Illness ◽  
Cross Sectional ◽  
Female Ratio ◽  
Ulcer Disease ◽  
Mass Migration

Background & objective: Each year millions of Muslims embark on a religious pilgrimage called the “Hajj” to Mecca in Saudi Arabia. The mass migration during the Hajj is unparalleled in scale, and pilgrims face numerous health hazards. Performing the tasks of pilgrimage is stressful and laborious and as such requires immense mental and physical fitness on the part of the pilgrims. But a substantial proportion of the pilgrims lack it. Besides, the hot and dry environment and untold overcrowding predispose them to the risk of many communicable diseases. The present study, was therefore, intended to find the pattern of diseases among Bangladeshi Hajj pilgrims at Mecca, Saudi Arabia. Methods: This descriptive cross-sectional study was carried out on Bangladeshi Hazz pilgrims in Mecca Saudi Arabia over a period of 1 month from mid-September to mid-October, 2015. A total of 710 pilgrims (18 or > 18 years) attending at Bangladeshi Hazz Medical Center (BHMC) in Mecca, Saudi Arabia during the period were consecutively included in the study after having voluntary verbal consent obtained from them. Diseases were diagnosed mainly on the basis of clinical signs and symptoms with provision of only random and fasting blood sugar estimation and ECG. The diagnosed diseases were grouped into major and minor problems or conditions and were treated as out-patient basis. Result: In the present study upper middle-aged (50 – 60 years) and elderly (≥ 60 years) pilgrims together formed nearly 73% of the patients with mean age of the patients being 56 years. Males were a bit higher than the females with male-female ratio being roughly 11:9. The study demonstrated that the commonest cause of out-patient visit was respiratory illness (41.2%) followed by diabetes (17.2%), peptic ulcer disease (PUD) (11.7%) and cardiovascular diseases (10.7%)(which included hypertension, new onset ischemia or exacerbation of preexisting ischemic heart diseases). A few (3.2%) of the patients presented with diarrhoeal diseases (loose motion or dysentery). Other minor ailments were allergy or dermatitis, insomnia, paronychia, anxiety, UTI, hemorrhoids, epistaxis, glossitis, oral ulcer, earache, conjunctivitis, worm infestation, spot bleeding etc., accounting for 4.8% of the patients. Conclusion: The study concluded that respiratory illness is the most common health problems among pilgrims visiting to Mecca, Saudi Arabia followed by diabetes, PUD and cardio-vascular diseases. The pilgrims should be educated in their home country before starting for pilgrimage as how to maintain their health in their new and challenging environment and Bangladesh Hazz Mission in Mecca should ensure enough medical support to them. Ibrahim Card Med J 2020; 10 (1&2): 96-101

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