Objective: to conduct a comparative analysis of the structure of somatic pathology in patients with myoma and cancer of the uterine body. Materials and methods: 522 women were examined, including 40 gynecologically healthy (group 1), 314 patients suffering from uterine myoma (group 2), 168 patients with malignant neoplasms of the uterine body (group 3). All patients, in addition to General clinical, histological and instrumental diagnostic methods, were calculated the Charlson comorbidity index, which determines the presence of concomitant diseases and the prognosis of mortality. Results. A comprehensive assessment of concomitant pathology in patients with group 3 showed that the leading positions among all patients in frequency are occupied by arterial hypertension - 72%, coronary heart disease - 28,6%, obesity - 27,9%, endocrinopathy - 25,6%, gastropathy - 23,1%, pathology of the hepatobiliary system - 20,8%. When analyzing somatic pathology in patients with uterine myoma, it was found that arterial hypertension is most common - 23,6% (3,5 times less often than in group 3), anemia - 26,8% (3.8 times more often than in group 3), endocrinopathy - 10,8% (2,4 times less often than in group 3), gastrotopathy - 15% (0,8 times less often than in group 3), pathology of the hepatobiliary system - 15,2% (0,7 times less than with group 3). At the same time, comorbidity has its own characteristics depending on the main pathology and the age of the patients. Thus, the total number of extragenital pathology in women with group 3 was 73% compared to 27,4% in patients with uterine myoma. The Charlson comorbidity index for group 3 was 1,78 overall, and 0,35 for group 2, which is 5 times lower. Conclusion. The range of somatic conditions in patients with benign and malignant uterine tumors is very wide. The age Association is obvious. The leading positions in the two compared groups are occupied by cardiovascular diseases. The total number of extragenital pathology in women with group 3 is 2,7 times higher, and the comorbidity index is 5 times higher, compared to those in patients with uterine myoma.