scholarly journals The Impact of Tax Substitution on the Price of Pharmaceutical Products in the State of São Paulo

2012 ◽  
Vol 32 (1) ◽  
pp. 97 ◽  
Author(s):  
André Luis Squarize Chagas
2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Marcos Amaku ◽  
Dimas Tadeu Covas ◽  
Francisco Antonio Bezerra Coutinho ◽  
Raymundo Soares Azevedo ◽  
Eduardo Massad

Abstract Background At the moment we have more than 177 million cases and 3.8 million deaths (as of June 2021) around the world and vaccination represents the only hope to control the pandemic. Imperfections in planning vaccine acquisition and difficulties in implementing distribution among the population, however, have hampered the control of the virus so far. Methods We propose a new mathematical model to estimate the impact of vaccination delay against the 2019 coronavirus disease (COVID-19) on the number of cases and deaths due to the disease in Brazil. We apply the model to Brazil as a whole and to the State of Sao Paulo, the most affected by COVID-19 in Brazil. We simulated the model for the populations of the State of Sao Paulo and Brazil as a whole, varying the scenarios related to vaccine efficacy and compliance from the populations. Results The model projects that, in the absence of vaccination, almost 170 thousand deaths and more than 350 thousand deaths will occur by the end of 2021 for Sao Paulo and Brazil, respectively. If in contrast, Sao Paulo and Brazil had enough vaccine supply and so started a vaccination campaign in January with the maximum vaccination rate, compliance and efficacy, they could have averted more than 112 thousand deaths and 127 thousand deaths, respectively. In addition, for each month of delay the number of deaths increases monotonically in a logarithmic fashion, for both the State of Sao Paulo and Brazil as a whole. Conclusions Our model shows that the current delay in the vaccination schedules that is observed in many countries has serious consequences in terms of mortality by the disease and should serve as an alert to health authorities to speed the process up such that the highest number of people to be immunized is reached in the shortest period of time.


PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256092
Author(s):  
Tatiane Fernandes Novaes ◽  
Maisa Camillo Jordão ◽  
Carlos Felipe Bonacina ◽  
André Oswaldo Veronezi ◽  
Carlos Ariel Rodrigues de Araujo ◽  
...  

The state of São Paulo, Brazil, where more than 94.000 dentists are currently registered, has become the epicenter of COVID-19 in Latin America. The aim of this cross-sectional study was to evaluate the impact of COVID-19 pandemic on dentists in this state. A semi-structured questionnaire was sent via e-mail to 93.280 dentists with active registration in the Dental Council of São Paulo (CROSP). The impact of COVID-19 pandemic was assessed through questions related to demographic, socioeconomic, dental practice characteristics and personal protective equipment (PPE) use. Ordinal logistic regression analysis was performed to investigate the association between all the variables (p<0.05). Over 8 days, 2113 responses were received. Only 26.52% of the sample reported a low-income reduction (from 0–10%), while the majority of dentists reported a more negative financial impact, 35.6% with a reduction of more than 50% of their monthly income. Dentists who worked in the private sector and at the capital had a greater financial impact when compared to those of the public sector and countryside of the state (p<0.05). Furthermore, about 83% reported not having received any specific training to control the transmission of coronavirus in the health area. This study provides evidence of the negative impact of the COVID-19 pandemic on the routine of dentists in the state of São Paulo, Brazil. Hopefully, this study will help dental and other health care professionals to better understand the consequences of disease in dental settings and strengthen preparedness throughout the dental health care system.


Author(s):  
Francisco Vidal Luna ◽  
Herbert S. Klein

This chapter examines the basic themes discussed in the book and the major conclusions reached which explain the rise of São Paulo to its important leadership position. We stress the importance of coffee, the role of the state in promoting the economy, the impact of immigration and the infrastructure established which enabled the state to become the leading economy in the second half of the 20th century


Author(s):  
André de Souza Melo ◽  
Ana Iza Gomes da Penha Sobral ◽  
Marcelo Luiz Monteiro Marinho ◽  
Gisleia Benini Duarte ◽  
Amanda Aires Vieira ◽  
...  

Abstract Background To assess the impact of the social isolation index on the number of infections and deaths by COVID-19 in the state of São Paulo (Brazil). Methods Daily isolation data, obtained through geolocation information by mobile phone, were evaluated together with the number of daily infections and deaths by COVID-19 in the state of São Paulo. The study was conducted from February 26 to May 19, 2020. The data were modeled through the vector autoregression (VAR) model. Results The isolation index has an effect of approximately 5% in variation in the number of infections, and 7% in the number of deaths. The impulse response function (IRF) caused a drop of 0.15% in the number of new cases/day, and 0.17% in the number of deaths/day following a shock in the isolation index. For both cases, this effect occurred 1 day after the shock and stabilized after 10 periods. An increase of 1% in the isolation index led to a reduction of 6.91% in new cases and 6.90% in the number of deaths. The 30 cumulative day reduction reached 22.72% in terms of transmission and 35.39% for deaths. Conclusions The social isolation index is related to deaths and infections from SARS-CoV-2. Although distancing measures are accompanied with impacts on the economy and the emergence of other morbidities, the benefits caused by the reduction in the speed of contagion are significant. The adoption of distancing measures has a substantial impact on the number of infected individuals and deaths by COVID-19.


2021 ◽  
Author(s):  
Marcos Amaku ◽  
Dimas Tadeu Covas ◽  
Francisco Antonio Bezerra Coutinho ◽  
Raymundo Soares Azevedo ◽  
Eduardo Massad

AbstractOBJECTIVESWith declining numbers of COVID-19 cases in the State of São Paulo, Brazil, social distancing measures were gradually being lifted. The risk of an increase in the number of cases, however, cannot be overlooked. Even with the adoption of non-pharmaceutical interventions, such as restrictions on mass gatherings, wearing masks, and complete or partial closure of schools, other public health measures may help to control the epidemic. We aimed to evaluate the impact of the contact tracing of symptomatic individuals on the COVID-19 epidemic regardless of the use of diagnostic testing.METHODSWe developed a mathematical model that includes isolation of symptomatic individuals and tracing of contacts to assess the effects of the contact tracing of symptomatic individuals on the COVID-19 epidemic in the State of São Paulo.RESULTSFor a selection efficacy (proportion of isolated contacts who are infected) of 80%, cases and deaths may be reduced by 80% after 60 days when 5000 symptomatic individuals are isolated per day, each of them together with 10 contacts. On the other hand, for a selection efficacy of 20%, the number of cases and deaths may be reduced by approximately 40% and 50%, respectively, compared with the scenario in which no contact tracing strategy is performed.CONCLUSIONContact tracing of symptomatic individuals may be a potential alternative strategy when the number of diagnostic tests available is not sufficient for a massive testing strategy.


2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Gizelton Pereira Alencar ◽  
Zilda Pereira da Silva ◽  
Patrícia Carla Santos ◽  
Priscila Ribeiro Raspantini ◽  
Barbara Laisa Alves Moura ◽  
...  

2021 ◽  
Author(s):  
Eduardo Massad ◽  
Marcos Amaku ◽  
Dimas Tadeu Covas ◽  
Francisco Antonio Bezerra Coutinho ◽  
Raymundo Soares Azevedo

Abstract BackgroundAt the moment we have more than 109 million cases and 2.4 million deaths around the world and vaccination represents the only hope to control the pandemic. Imperfections in planning vaccine acquisition and difficulties in implementing distribution among the population, however, have hampered the control of the virus so far.MethodsWe propose a new mathematical model to estimate the impact of vaccination delay against the 2019 coronavirus induces disease (COVID-19) on the number of cases and deaths by the disease in Brazil. We apply the model to Brazil as a whole and to the State of Sao Paulo, the most affected by COVID-19 in Brazil. We simulated the model for the populations of the State of Sao Paulo and Brazil as a whole, varying the scenarios related to vaccine efficacy and compliance from the populations.ResultsThe model projects that, in the absence of vaccination, almost 170 thousand deaths and more than 350 thousand deaths until the end of 2021 for Sao Paulo and Brazil, respectively. If in contrast, Sao Paulo and Brazil had enough vaccine supply and so started a vaccination campaign in January with the maximum vaccination rate, compliance and efficacy, they could have averted more than 112 thousand deaths and 127 thousand deaths, respectively. In addition, that for each month of delay the number of deaths increases monotonically in a logarithm fashion, for both the State of Sao Paulo and Brazil as a whole.ConclusionsOur model shows that the current delay in the vaccination schedules that is observed in many countries has serious consequences in terms of mortality by the disease and should serve as an alert to health authorities to speed the process up such that the highest number of people to be immunized is reached in the shortest period of time.


2001 ◽  
Vol 09 (04) ◽  
pp. 255-267
Author(s):  
E. MASSAD ◽  
F. A. B. COUTINHO ◽  
M. N. BURATTINI ◽  
L. F. LOPEZ

The devastating figures that recently emerged from a demographic study of the impact of HIV/AIDS in some African countries mark the return to the conditions of the XIXth century, when high birth rates were neutralized by equally high death rates. In the State of São Paulo, Brazil, AIDS is the second cause of death among men aged twenty to forty nine years and the first cause of death of women in the same age class. In this work we propose a mathematical treatment to evaluate the impact of AIDS mortality on the age structure of an affected population, namely, that of the state of São Paulo, Brazil. We propose four indicators for the estimation of the impact of AIDS mortality. The first is the age-dependent differences in ten years survival probabilities attributable to AIDS. The second is the difference in the average age of survivors after 10 years of AIDS. The next is the conventional life expectancy at birth for children born in 1996 and with AIDS prevalence assumed at its maximum value and remaining in steady-state afterwards. Finally, we calculate the differences in the life expectancy of individuals considering the effect of AIDS for only ten years. We found that, in the period between 1987 and 1996 the effects were small but very interesting. However, projecting to the future the conditions of 1996, we calculate that the population of the state of São Paulo would lose 3 years in the average life expectancy at birth.


Author(s):  
Joana Salgueiro ◽  
José Guilherme Moreira Simões Vieira ◽  
Fátima Alves ◽  
Amadeu M. V. M. Soares ◽  
Ulisses Miranda Azeiteiro ◽  
...  

Cananéia is the southernmost city in the state of São Paulo, Brazil. It is a municipality where the tertiary sector is the main contributor to the economy parallel to the maintenance of artisanal fishing activities. The authors perform a study on the impact of tourism in the municipality area (performed through surveys in an attempt to determine how the different population segments [residents, promoters, users] see the activity and its impacts on nature and on the local economy). The majority of tourists surveyed come from the state of São Paulo (83.3%) and the rest of Santa Catarina and Paraná, with ages from 19-25 (36.7%) (70% having higher education). 43.3% of the inquired stated that tourism is not correctly managed (however without relevant environmental impacts). 93.3% of the boaters and 66.7% of the interviewed referred lack of information about the sites ecology and the drivers of change of biodiversity, ecosystem services, and climate change. Questionnaires results clearly demonstrated the need for visitor information and interpretation envisaging sustainable tourism implementation.


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