scholarly journals Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Cuiping Xiang ◽  
Xuegui Zhou ◽  
Xiaoxia Zheng
Keyword(s):  
Blood Pressure ◽  
Magnesium Sulfate ◽  
Blood Viscosity ◽  
Protein S ◽  
Control Group ◽  
Observation Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
The Difference ◽  
Better Than

Objective: To investigate the effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome (PIHS). Methods: Total 118 pregnant women with PIHS who were admitted to our hospital from April 2017 to June 2018 were randomly divided into control group (59 cases) and observation group (59 cases). The observation group was treated by magnesium sulfate in combination with nifedipine, while the control group was treated by magnesium sulfate. The therapeutic effect, serum leukaemia inhibitory factor (LIF), Apelin level, blood pressure, blood viscosity, urinary protein, S/D and Umbilical Artery Resistance Index (UARI) were compared between the two groups. Results: The effective rate of the observation group was 94.9%, higher than 83.1% of the control group, and the difference was statistically significant (P<0.05). The decrease level of systolic and diastolic blood pressure in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). The decrease of blood viscosity, urinary protein, S/D and UARI in the observation group was greater than that in the control group, and the difference was statistically significant (P<0.05). The improvement of serum LIF and Apelin levels in the observation group was better than that in the control group (P<0.05), and the difference was statistically significant (P<0.05). Conclusion: Magnesium sulfate combined with nifedipine in the treatment of PIHS has a significant effect, which can effectively control edema, blood pressure, proteinuria and protect kidney. It is worth clinical promotion. doi: https://doi.org/10.12669/pjms.36.2.706 How to cite this:Xiang C, Zhou X, Zheng X. Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension. Pak J Med Sci. 2020;36(2):21-25. doi: https://doi.org/10.12669/pjms.36.2.706 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension

2019 ◽  
Vol 36 (1) ◽  
Author(s):  
Cuiping Xiang ◽  
Xuegui Zhou ◽  
Xiaoxia Zheng
Keyword(s):  
Blood Pressure ◽  
Magnesium Sulfate ◽  
Blood Viscosity ◽  
Protein S ◽  
Control Group ◽  
Observation Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
The Difference ◽  
Better Than

Objective: To investigate the effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome (PIHS). Methods: Total 118 pregnant women with PIHS who were admitted to our hospital from April 2017 to June 2018 were randomly divided into control group (59 cases) and observation group (59 cases). The observation group was treated by magnesium sulfate in combination with nifedipine, while the control group was treated by magnesium sulfate. The therapeutic effect, serum leukaemia inhibitory factor (LIF), Apelin level, blood pressure, blood viscosity, urinary protein, S/D and Umbilical Artery Resistance Index (UARI) were compared between the two groups. Results: The effective rate of the observation group was 94.9%, higher than 83.1% of the control group, and the difference was statistically significant (P<0.05). The decrease level of systolic and diastolic blood pressure in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). The decrease of blood viscosity, urinary protein, S/D and UARI in the observation group was greater than that in the control group, and the difference was statistically significant (P<0.05). The improvement of serum LIF and Apelin levels in the observation group was better than that in the control group (P<0.05), and the difference was statistically significant (P<0.05). Conclusion: Magnesium sulfate combined with nifedipine in the treatment of PIHS has a significant effect, which can effectively control edema, blood pressure, proteinuria and protect kidney. It is worth clinical promotion. doi: https://doi.org/10.12669/pjms.36.1.706How to cite this:Xiang C, Zhou X, Zheng X. Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension. Pak J Med Sci. 2020;36(1):---------. doi: https://doi.org/10.12669/pjms.36.1.706 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Arthroscopic Debridement Combined with Rehabilitation Training in the Treatment of Knee Osteoarthritis

2021 ◽  
Vol 7 (5) ◽  
pp. 3384-3388
Author(s):  
Wei Sun ◽  
Wenjie Yu ◽  
Yanhua Wang ◽  
Guangliang Hu
Keyword(s):  
Knee Osteoarthritis ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Arthroscopic Debridement ◽  
Rehabilitation Training ◽  
The Difference ◽  
Score Result ◽  
Better Than

Objective: The clinical effect of arthroscopic debridement combined with rehabilitation training in the treatment of knee arthritis was studied and analyzed. Methods: A total of 90 patients with knee osteoarthritis treated in our hospital from August 2017 to August 2018 were selected as the research objects. All patients were divided into the observation group and the control group by using the random number method. The control group was treated by arthroscopic cleaning operation, and the observation group was treated by combined rehabilitation training on the basis of the treatment in the control group. The total effective rate and simple McGill pain of the two groups were compared Score and lyshoim score. Result: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the difference was statistically significant; after treatment, the simple McGill pain score of the observation group was significantly lower than that of the control group (P < 0.05), the difference was statistically significant, the lyshoim score of the observation group was significantly better than that of the control group (P < 0.05), the difference was statistically significant. Conclusion: In the treatment of knee osteoarthritis, arthroscopic debridement combined with rehabilitation training has a significant effect, which can significantly reduce the pain and improve the prognosis of patients. It is worth popularizing in clinical treatment.

Analysis of Nursing Cooperation in Microscopic Pituitary Tumor Resection via Transsphenoidal Approach

2021 ◽  
Vol 7 (6) ◽  
pp. 6445-6452
Author(s):  
Haijuan Hu ◽  
Yishu Zhao ◽  
Jianhua Ma
Keyword(s):  
Statistical Significance ◽  
Tumor Resection ◽  
Nursing Intervention ◽  
Transsphenoidal Approach ◽  
Control Group ◽  
Mechanical Equipment ◽  
Study Group ◽  
Observation Group ◽  
The Difference ◽  
Better Than

To analyze the clinical effect of nursing cooperation in transsphenoidal approach microscopic hypophysectomy. From January 2017 to January 2020, 80 patients who underwent transsphenoidal microscopic hypophysectomy in our hospital were selected to participate in the analysis and study. They were divided into two groups according to the randomized allocation, namely the observation group and the control group. Among them, 40 patients in the observation group and 40 patients in the control group were given routine nursing care for the patients in the control group, and comprehensive nursing intervention was adopted for the patients in the observation group, and the overall nursing effect of the two groups of patients was compared. After taking different nursing methods, the condition of patients in both groups was effectively controlled, and the effective rate of patients in the observation group with comprehensive nursing intervention was significantly better than that of patients in the control group with conventional nursing methods, and the difference had certain statistical significance (P < 0.05); The satisfaction degree of patients in the study group was significantly better than that of patients in the control group, and the difference was statistically significant (P < 0.05). The degree of negative emotions of patients in the study group was significantly better than that of patients in the control group after receiving comprehensive nursing intervention, and the difference was statistically significant (P < 0.05), and the difference in the incidence of adverse events between the two groups was not statistically significant (P > 0.05); The scores of each index of SF-36 questionnaire of patients in both groups were higher than those before nursing, and the scores of each index of patients in observation group were higher than those of patients in control group, and the difference was statistically significant (P > 0.05). With adequate preoperative preparation and mastery of the use of mechanical equipment, comprehensive nursing intervention can effectively improve the treatment effect of patients, make patients more satisfied with the nursing work, and can soothe patients’ negative psychological mood, eliminate panic, improve patients' life confidence, enhance intraoperative cooperation, and ensure that the operation can be completed smoothly.

scholarly journals Safety of Different Anesthesia Methods Combined with Intravenous Fast Channel Anesthesia in Lower Extremity Orthopedic Surgery of the Elderly

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Peng Chen ◽  
Jia Yang ◽  
Dandan Hu ◽  
Xu Jing ◽  
Dajin Liu
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Lower Extremity ◽  
Epidural Anesthesia ◽  
Orthopedic Surgery ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
Fascial Space ◽  
Spinal Epidural

Objective. To compare the safety of different anesthesia methods combined with intravenous fast channel anesthesia in elderly lower extremity surgery and the effect on postoperative outcome. Methods. A total of 106 elderly patients who underwent lower extremity orthopedic surgery in our hospital from February 2018 to February 2021 were selected and randomly divided into the control group (n = 53) and the observation group (n = 53) according to random number table. All patients received intravenous fast-track anesthesia. On this basis, the control group received spinal-epidural anesthesia, and the observation group received iliac fascial space block on the affected side combined with sciatic nerve block. The operation conditions, blood pressure and heart rate changes, awakening time, postoperative ICU admission rate, and complications were compared between the two groups. Results. There was no statistical difference in the success rate of one-time operation between the two groups ( P > 0.05 ). The times of using analgesics and vasoactive drugs and the dosage of propofol in the observation group during the operation were lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). At T2, T3, and T4, the levels of HR, DBP, and SBP in the observation group were lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). After operation, the time of awakening, spontaneous breathing recovery, and extubation in the observation group were lower than those in the control group, and the difference were statistically significant ( P < 0.05 ). The incidence of complications in the observation group was lower than that in the control group, the cognitive impairment was the most significant one in the incidence of single complication, and the difference was statistically significant ( P < 0.05 ). Conclusion. Based on the combined intravenous fast channel anesthesia, the operation difficulty of the affected side iliac fascial space block combined with sciatic nerve block is the same as that of spinal-epidural anesthesia. It has a higher success rate of one operation, better analgesic and anesthetic effects during the operation, and little effect on blood flow of patients. It can maintain relatively stable heart rate and blood pressure and does not easily cause postoperative complications. Its safety is higher than that of spinal-epidural anesthesia.

scholarly journals Effects of Natural Convalescent Factors Combined with Motor Intelligence Management on Patients’ Blood Pressure

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Shasha Li ◽  
Zhuoming Hu ◽  
Jianping Zhang
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Physical Function ◽  
Statistical Significance ◽  
Blood Pressure Level ◽  
Control Group ◽  
Observation Group ◽  
Research Subjects ◽  
The Difference

To explore the application of natural convalescent factors combined with exercise intelligence management in blood pressure control of patients with hypertension, 102 patients with hypertension who were admitted from January 2017 to August 2019 were selected as the research subjects. According to the odd-even number method, they were divided into two groups with 51 cases in each group. The control group was treated with natural convalescent factor therapy alone, and the observation group was treated with natural convalescent factor combined with motor intelligence management. The application effects of the two groups were compared. Before sports intelligence management, the levels of systolic blood pressure (SBP) in control group and observation group were (145.45 ± 8.44) mmHg (1 mmHg = 0.133 kPa) and (146.55 ± 8.37) mmHg, respectively; the diastolic blood pressure (DBP) levels of the control group and the observation group were (98.47 ± 3.48) mmHg and (98.94 ± 3.48) mmHg, respectively, with no statistical significance ( P > 0.05 ). After the exercise intelligence management, the SBP levels of the control group and the observation group were (132.76 ± 4.48) mmHg and (130.06 ± 2.48) mmHg, respectively. The DBP levels of the control group and the observation group were (85.48 ± 5.38) mmHg and (83.47 ± 3.35) mmHg, respectively. The difference was statistically significant ( P < 0.05 ). The scores of each index of quality of life in the observation group were higher than those in the control group, and the differences of physical function and psychological/mental scores were significant. The scores of physical function in the two groups before administration were (48.36 ± 1.69) and (48.74 ± 1.62), and the differences were not statistically significant ( P > 0.05 ). After management, the physiological function scores of the two groups were (40.32 ± 1.33) and (32.15 ± 1.54) and the difference was statistically significant ( P < 0.05 ). There were no significant differences in the psychological (30.75 ± 1.26)/mental scores (30.26 ± 1.48) between the two groups before management ( P > 0.05 ), but there were significant differences in the psychological (25.30 ± 1.02)/mental scores (18.76 ± 1.36) between the two groups after management ( P < 0.05 ). The combination of natural convalescent factors and intelligent exercise management can effectively control the blood pressure level and improve the quality of life of patients with hypertension, and the clinical application effect is good.

scholarly journals Doppler Ultrasound Imaging Combined with Fetal Heart Detection in Predicting Fetal Distress in Pregnancy-Induced Hypertension under the Guidance of Artificial Intelligence Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Su Liu ◽  
Yue Sun ◽  
Na Luo
Keyword(s):  
Umbilical Artery ◽  
Fetal Heart ◽  
Fetal Distress ◽  
Current Status ◽  
Control Group ◽  
Observation Group ◽  
Pregnancy Induced Hypertension ◽  
Heart Monitoring ◽  
Induced Hypertension ◽  
D Values

This study was to improve the feasibility and economic benefits of intelligent medical system Doppler ultrasound (DUS) imaging technology combined with fetal heart detection to predict the fetal distress in pregnancy-induced hypertension (PIH), so as to reduce the risk of deterioration of the patient’s condition. The characteristics of DUS images were analyzed, and a diffusion filter reducing the specificity was adopted to improve the smooth speckle noise of DUS images. 120 pregnant women in hospital were the subjects of the study, all of whom received ultrasound cord blood flow testing and fetal heart monitoring. 88 PIH patients with fetal distress were diagnosed and included in the observation group, and 32 healthy pregnant women tested during the same period were identified as the control group. Clinical data were reviewed and analyzed. The diagnostic rates of fetal distress by simple fetal heart monitoring and DUS detection combined with fetal heart monitoring were compared. The results showed that 26.7% of fetal distress were diagnosed by fetal heart monitoring alone, and 73.3% of fetal distress were diagnosed by combined testing, so the diagnostic accuracy of the combined detection method was greatly higher than the single fetal heart detection ( P < 0.05 ). The Pulsatility index (PI), resistance index (RI), and S/D values detected by the umbilical artery in the observation group were 1.48, 0.85, and 4.31, respectively. The PI, RI, and S/D values detected by the umbilical artery in the control group were 0.96, 0.64, and 3.59, respectively. The results of arterial detection were significantly higher than those of the control group, and the difference was of significant scientific significance ( P < 0.05 ). In summary, the PI and RI values of the middle cerebral artery (MCA) detected by DUS diagnosis can effectively reflect the current status of the fetus in the uterus and reduce the mortality of the fetus. The images guided by DUS imaging technology can clearly show the current status of the fetus in the uterus, effectively improve the medical diagnostic efficiency, and have important reference value for the development of intelligent medical equipment.

scholarly journals Short-Term Efficacy and Quality of Life of Gastric Cancer Patients Undergoing Radical Gastrectomy Assisted by External Vision

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jian Zheng ◽  
Yingwei Xue ◽  
Chunfeng Li
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Control Group ◽  
Observation Group ◽  
Radical Gastrectomy ◽  
The Difference ◽  
Gastric Cancer Patients ◽  
Better Than

Objective. To evaluate the clinical effects and survival prognosis of radical gastrectomy assisted by external vision in gastric cancer. Methods. A total of 60 hospitalized gastric cancer patients from June 2016 to December 2018 were selected and divided into the observation group and control group according to different surgical procedures. The control group was treated with traditional open radical gastrectomy, while the observation group was treated with radical gastrectomy assisted by an external vision microscope. Relevant surgical indicators, visual analogue scale (VAS), postoperative complications, and life quality assessment were analyzed and compared between the two groups. Results. The incision length and intraoperative blood loss in the observation group were smaller than those in the control group, and the difference was statistically significant ( P < 0.05 ); compared with the control group, the observation group had significantly shorter hospital stay, earlier postoperative first exhaust time, and lower gastric fluid volume at the 3rd day after surgery ( P < 0.05 ). The pain scores of the observation group at 1, 4, and 12 weeks after surgery were lower than those of the control group ( P < 0.05 ), and the difference was significant. The quality of life scores at the 1st week and 12th week after surgery showed that the dysphagia symptom scores of the observation group and the control group were significantly reduced but the two groups had significant differences in fatigue, physical function, pain score, postoperative pain, and overall quality of life. The observation group was significantly better than the control group ( P < 0.05 ). Follow-up studies showed no significant difference between mortality and cancer recurrence ( P > 0.05 ); the patients recovered well at postoperation, and the diet of the observation group was better than that of the control group ( P < 0.05 ); gastric reflux and knife pain were less than those of the control group ( P < 0.05 ). Conclusion. Radical gastrectomy assisted by external vision for gastric cancer yields clinical benefits for gastric cancer patients, which not only dramatically shortened the length of hospital stay but also effectively ameliorated the quality of life of patients, all indicating that external vision-assisted surgery was significantly better than traditional gastrectomy in improving the postoperative quality of life of gastric cancer patients in the absence of increasing the risk of adverse events.

scholarly journals Intervention Effect of Sequential Blood Purification on Early Morning Hypertension in Hemodialysis Patients

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Jibo Li ◽  
Peiqin Jiang ◽  
Gang Wang
Keyword(s):  
Blood Pressure ◽  
Early Morning ◽  
Hemodialysis Patients ◽  
Blood Purification ◽  
Control Group ◽  
Observation Group ◽  
Significant Difference ◽  
Morning Blood Pressure ◽  
The Difference ◽  
Morning Hypertension

Objective: To investigate the effect of sequential blood purification on early morning hypertension in hemodialysis patients. Methods: A total of 76 hemodialysis patients who were admitted in the University of Chinese Academy of Sciences Shenzhen Hospital from June 2017 to August 2019 were selected and recruited in the present study. These patients were randomly divided into two groups, namely the control group and observation group. Each group consisted of 38 patients. The patients in the control group were treated with hemodialysis, while the patients in the observation group were treated with sequential blood purification. Early morning blood pressure was compared between the control group and observation group after 12 weeks of treatment. Results: There was no significant difference in blood pressure between the two groups of patients before treatment (P > 0.05), whereas the blood pressure in the observation group was lower than that in the control group after the treatment, and the difference was statistically significant (P < 0.05). Conclusion: The use of sequential blood purification treatment for hemodialysis patients can significantly reduce the blood pressure in the morning and is worthy of clinical use.

scholarly journals Therapeutic Effect of Long-Term Epidural Block in Rats with Pregnancy Induced Hypertension

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Nianjiao Han ◽  
Yang Li ◽  
Youjing Dong
Keyword(s):  
Blood Pressure ◽  
Therapeutic Effect ◽  
Normal Saline ◽  
Epidural Block ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Serum Concentrations ◽  
Sprague Dawley ◽  
Induced Hypertension

Background. Pregnancy induced hypertension (PIH) causes a variety of systemic disorders that negatively affect the maternal placenta and fetal growth. Epidural sympathetic block elicits symptoms of decreased blood pressure. This study was designed to determine the therapeutic effect of long-term epidural block in rats with PIH. Methods. Forty healthy pregnant Sprague Dawley rats were randomized into four groups with each group consisting of 10 rats. On gestation day (GD) 14, rats in control group underwent a sham procedure; rats in RUPP group were operated on to obtain reduced uterine perfusion pressure (RUPP); rats in RUPP plus normal saline (NS) group were also subjected to the RUPP procedure and underwent epidural block with 25 μl normal saline twice daily until delivery; rats in RUPP plus epidural block (EB) group were treated as those in RUPP plus NS group except that an epidural block with 25 μl of 0.125% bupivacaine was administered two times per day until delivery. On GD 20, blood pressure was measured in all groups before delivery, and blood samples were collected in order to quantify the serum concentrations of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1). Results. The mean arterial pressure (MAP) of rats in RUPP group (147.6±6.0 mmHg) was markedly increased when compared with control group (80.8±4.6 mmHg) (p<0.05). The MAP of rats in RUPP plus EB group (114.4±7.2 mmHg) was clearly decreased in contrast with RUPP group but was still higher than in control group (p<0.05). The variation of fetal weight in all groups followed a similar trend to that of MAP. However, there were no significant differences between control group and RUPP plus EB group with respect to placental weight (p=0.186). Variation in MAP was positively correlated with the expression of sFlt-1 in each group but was negatively correlated with VEGF. Conclusion. This study demonstrates that long-term epidural block decreases blood pressure in PIH rats and improves the serum concentrations of VEGF and sFlt-1. Taken together, long-term epidural block may have a potential role in PIH treatment.

scholarly journals Efficacy of normodyne-magnesium sulfate combination treatment on pregnancy-induced hypertension, and its effect on VEGF and Flt-1 levels

2021 ◽  
Vol 20 (10) ◽  
pp. 2155-2161
Author(s):  
Xiaoyan Diao ◽  
Kun Ding ◽  
Xuemei Ma
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Magnesium Sulfate ◽  
Pregnancy Outcomes ◽  
Group Treatment ◽  
Adverse Pregnancy Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Adverse Pregnancy ◽  
Group B

Purpose: To investigate the efficacy of the combined use of normodyne and magnesium sulfate in the treatment of pregnancy-induced hypertension, and its effect on vascular endothelial growth factor (VEGF) and factor receptor-1 (Flt-1) levels in serum.Methods: A total of 100 patients with pregnancy-induced hypertension attending Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China, were categorized as Group A, and then further subdivided into control sub-group (who were treated with magnesium sulfate only) and study sub-group (treated with magnesium sulfate plus normodyne). Furthermore, 100 healthy pregnantwomen attending the hospital for prenatal examination during the same period were categorized as Group B. Serum expressions of VEGF and Flt-1 in all patients were determined and compared. The therapeutic effect, adverse reactions, adverse pregnancy outcomes, blood pressure before and after treatment, 24 h proteinuria, and serum expression levels of VEGF and Flt-1 in the study and control groups were determined and compared.Results: Serum VEGF levels in patients with pregnancy-mediated hypertension were significantly lower than those of healthy pregnant women, and Flt-1 was raised in healthy pregnant women (p < 0.05). In the study group, treatment was markedly more effective, and the degree of amelioration of blood pressure, 24 h proteinuria, serum VEGF, and Flt-1 were significantly higher than for control sub-group. There were lower adverse pregnancy outcomes in study sub-group than in control (p < 0.05).Conclusion: The combination of magnesium sulfate and normodyne produces greater clinical efficacy in the treatment of patients with pregnancy-induced hypertension than magnesium sulfate alone, and also shows a high safety profile.

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