scholarly journals Comparison between different methods of calculating Kt/V as the marker of adequacy of dialysis

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Fazl e Mateen ◽  
Sajad Ahmad ◽  
Irfan Elahi ◽  
Muhammad Anees

Objectives: To compare different methods of calculating adequacy of hemodialysis in terms of Kt/V. Methods: This was an observational, quantitative study undertaken after the approval of Internal Review Board at the Hemodialysis Unit of Nephrology department, Mayo Hospital, Lahore from 1st December 2018 to 30th June 2019. Sixty hemodynamically stable patients of end stage renal disease undergoing hemodialysis for more than three months with age 18 to 70 years were included in the study by convenience non probability sampling. Critically ill patients with multiple co-morbidities like sepsis (i.e. total leukocyte count >11000 or <4000 x 109/L), ischemic heart disease, pace- makers, malignancies, cirrhosis etc were excluded. Patients who were not adherent to dialysis prescription or hemodynamically unstable were also excluded. One way ANOVA and Pearson’s correlation were used to find correlation between three methods of measuring Kt/V. Results: Mean ultrafiltration was 2.1+ 0.76 liter/session. Pre dialysis weight was 64.7 +14.7 kgs, mean post dialysis weight was 62.5 + 14.7 kgs. For every patient blood flow rate was 300 ml/m and dialysis flow rate was 500 ml/min. The mean values of Kt/V measured by Daugirdas formula was 1.35 ± 0.33, mean online clearance monitoring (OCM) value was 1.17 ± 0.29 and by normogram was 1.36 ± 0.33. There was positive significant correlation between values of Daugirdas formula, Normogram and online clearance monitoring (OCM) i.e. r = 0.897 (p-value < 0.001) measured by Pearson’s correlation and one way-ANOVA. Conclusion: Online clearance monitoring can be used for measuring adequacy of hemodialysis, but OCM slightly underestimates Kt/V as compared to Daugirdas formula and Normogram. doi: https://doi.org/10.12669/pjms.38.1.4281 How to cite this:Fazl-e-Mateen, Ahmad S, Elahi I, Anees M. Comparison between different methods of calculating Kt/V as the marker of adequacy of dialysis. Pak J Med Sci. 2022;38(1):167-171. doi: https://doi.org/10.12669/pjms.38.1.4281 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

2015 ◽  
Vol 16 (5) ◽  
pp. 366-371 ◽  
Author(s):  
Matt T Lam ◽  
So Ran Kwon ◽  
Fang Qian ◽  
Gerald E Denehy

ABSTRACT Aim The E4D Compare software is an innovative tool that provides immediate feedback to students’ projects and competencies. It should provide consistent scores even when different scanners are used which may have inherent subtle differences in calibration. This study aimed to evaluate potential discrepancies in evaluation using the E4D Compare software based on four different NEVO scanners in dental anatomy projects. Additionally, correlation between digital and visual scores was evaluated. Materials and methods Thirty-five projects of maxillary left central incisors were evaluated. Among these, thirty wax-ups were performed by four operators and five consisted of standard dentoform teeth. Five scores were obtained for each project: one from an instructor that visually graded the project and from four different NEVO scanners. A faculty involved in teaching the dental anatomy course blindly scored the 35 projects. One operator scanned all projects to four NEVO scanners (D4D Technologies, Richardson, TX, USA). The images were aligned to the gold standard, and tolerance set at 0.3 mm to generate a score. The score reflected percentage match between the project and the gold standard. One-way ANOVA with repeated measures was used to determine whether there was a significant difference in scores among the four NEVO scanners. Paired-sample t-test was used to detect any difference between visual scores and the average scores of the four NEVO scanners. Pearson's correlation test was used to assess the relationship between visual and average scores of NEVO scanners. Results There was no significant difference in mean scores among four different NEVO scanners [F(3, 102) = 2.27, p = 0.0852 one-way ANOVA with repeated measures]. Moreover, the data provided strong evidence that a significant difference existed between visual and digital scores (p = 0.0217; a pairedsample t-test). Mean visual scores were significantly lower than digital scores (72.4 vs 75.1). Pearson's correlation coefficient of 0.85 indicated a strong correlation between visual and digital scores (p < 0.0001). Conclusion The E4D Compare software provides consistent scores even when different scanners are used and correlates well with visual scores. Clinical significance The use of innovative digital assessment tools in dental education is promising with the E4D Compare software correlating well with visual scores and providing consistent scores even when different scanners are used. How to cite this article Lam MT, Kwon SR, Qian F, Denehy GE. Evaluation of an Innovative Digital Assessment Tool in Dental Anatomy. J Contemp Dent Pract 2015;16(5):366-371.


Author(s):  
Godson Emeka Anyanwu ◽  
Salome Nwaelom Ezeofor ◽  
Emmanuel Nebuwa Obikili ◽  
Ekene Valentine Ugbor

Background: Radiological identification is important in clinical, surgical and forensic medicine particularly in the absence of comparative deoxyribonucleic Acid (DNA) samples and fingerprints. Aim is to establish the morphometry of frontal sinus (FS), maxillary sinus (MS) and bizygomatic distance (BZD) and their relationship with age and gender in Igbos and Ogonis of Nigeria using computed tomography (CT). Methods: Head CT scans of 625 subjects (477 Igbos and 148 Ogonis) between 18 and 85 years, showing normal FS, MS and BZD, were measured using DICOM viewer software. The Igbos and Ogonis were 247 males and 230 females; 84 males and 64 females respectively. The height, width and depth of the sinuses, intermaxillary sinus distances (IMD) and BZD were measured in centimeters (cm). The data were analyzed using SPSS version 20 and difference between groups was obtained using one way ANOVA. P-value less than 0.05 was considered as statistically significant. Results: Mean values for the right and left MS volume for the Igbos are 13.79 ±10.91 and 13.81±11.03 and for the Ogonis 20.84±5.83 and 20.19±5.59 cm respectively. All FS dimensions are higher in the Igbos (P<0.001) except right FS depth. Mean IMD are 3.64±0.50 and 3.39±0.45 cm in the Igbos and Ogonis respectively (P<0.001). Ogonis have higher BZD (P>0.05). In both groups, males had larger values in both FS depth, MS dimensions and BZD (P<0.001). Age correlated positively with left FS height and IMD. Prevalence of unilateral FS aplasia was 3.35% on the right and 1.47% on the left among the Igbos while the Ogonis have 2.03% on the right and 2.70% on the left. Bilateral FS aplasia was 2.94% among the Igbos but not observed among the Ogonis. Conclusion: Normative values is established. Ethnic differences exists with Igbos significantly having higher values of FS and IMD while in the Ogonis, the MS dimensions are higher. These findings would act as a guide for facial reconstructive surgeries, forensic experts and classification of fossil remains in anthropology.


Author(s):  
Tayyab Mumtaz Khan ◽  
Sana Mansoor ◽  
Munazzah Kaleem ◽  
Muhammad Shahid Zafar ◽  
Anisa Shoail ◽  
...  

Happiness is a collection of various kinds of emotions including positive and negative because of satisfaction in life. Happiness affects almost every aspect of life, however, among students, its most important impact is on their academic performance. Academic performance is positively affected by happiness and subsequently their performance as a physician. Therefore, our current study is set to assess the impact of happiness on academic performance among final-year medical students of Rawalpindi Medical University Pakistan. This may provide us a new way to bring improvement in academic performance of medical students. This descriptive cross-sectional study was carried out among final-year medical students of Rawalpindi Medical University in January 2020. Collection of data was accomplished with the help of two questionnaires including Oxford Happiness Questionnaire for happiness assessment and self-structured questionnaire which was developed to obtain required data about demographic details and marks in last professional examination. Students who had diagnosed any physical and mental illness were excluded. From total of 223 students who were enrolled at the beginning of study, only 186 returned correctly filled questionnaires so final sample size became 186. Data analysis was completed through SPSS v.25.0. Different statistical tests including Independent sample t-test, Chi-square test, Pearson’s correlation, and linear regression were used to assess the study variables. Statistically significant and strong positive association was noted between happiness and academic performance of students (p = 0.000). To evaluate the direction and strength of association between happiness and academic performance, Pearson’s correlation coefficient was calculated, and it was 0.809 with p-value 0.000). Difference in happiness score between male students and female students (p=0.015) and between boarder students and non-boarder students (p=0.000) was statistically significant. Likewise, the difference in academic performance that was assessed through marks in last professional examination was also statistically significant between male student and female students (p=0.001) and between boarder students and non-boarder students (p=0.000) was also statistically significant. With p-value of 0.000 for F test, simple linear regression model was valid. Value of unstandardized regression Coefficient (B) was 61.40. R² was 0.655 (65.5%). Our study overall shows higher happiness score and better academic performance among female and non-boarder students relative to male and boarder students. This current study also indicates statistically significant and strong positive association between happiness and academic performance, which means that increase in happiness increases the academic performance of students and vice versa. So, with the implementation of appropriate measures for the increase in happiness we can bring enhancement in academic performance of medical students.


2019 ◽  
Vol 15 (1) ◽  
pp. 5-9
Author(s):  
Sanam Tauheed ◽  
Attiya Shaikh ◽  
Mubassar Fida

Background: The present study was conducted in order to determine cervical posture in different skeletal sagittal malocclusions as well as to assess whether a correlation existed between cervical posture and skeletal relationships. Methods: Cervical curvature and inclination of 63 subjects was assessed using their lateral cephalometric radiographs. Cervical inclination was assessed using the cervicohorizontal postural variables namely OPT/HOR and CVT/HOR whereas cervical curvature was determined by measuring the angle OPT/CVT. Sagittally, the subjects were also categorized into skeletal Class I, II and III based on the angle ANB. One way ANOVA was used for the comparison of cervical posture in different skeletal sagittal malocclusions. Pearson’s correlation was used to evaluate the correlation of cervical posture with different skeletal sagittal jaw relations. Statistical significance level was set at p≤0.05. Results: Statistically significant differences were found between the different skeletal malocclusions for the cervical curvature angle OPT/CVT (p=0.025). A weak correlation of cervical curvature angle OPT/CVT (r=0.305, p=0.016) with sagittal malocclusion was found.  Conclusions: Skeletal sagittal malocclusions differ in their cervical postures, especially  cervical curvature. Skeletal Class III subjects have significantly straighter cervical columns than skeletal Class I subjects. Cervical curvature is correlated with sagittal jaw relations.  Keywords: cervical curvature; cervical posture; skeletal sagittal malocclusions .  


2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Jilly J. G. Masihor ◽  
Max F. J. Mantik ◽  
Maya Memah ◽  
Arthur E. Mongan

Abstract: Dengue hemorrhagic fever (DHF) is an acute fever disease with high mortality and morbidity in many regions of the world. Leucopenia and thrombocytopenia are two of several laboratory findings that could be found in the course of DHF. This was an analytical retrospective study with a cross sectional design. Samples were patients diagnosed with DHF in Prof. Dr. R.D Kandou General Hospital Manado during the period of 2012. The inclusion criteria were patients <15 years, were diagnosed as DHF according to WHO 1997 criteria, and were examined for platelet and white blood cell count. This study used the medical record data which were analyzed statistically by using the Pearson's correlation test. There were 137 children with DHF during the period of 2012. Samples were 56 children that fulfiled the inclusion criteria. The Pearson correlation test showed a P value 0.801 and correlation coefficient r = -0.034 that indicated that there was a negative correlation which was not significant. Conclusion: There was no significant correlation between the number of thrombocytes and leukocytes in children with dengue hemorrhagic fever.Keywords: dengue hemorrhagic fever, leukocyte, thrombocyteAbstrak: Demam berdarah dengue (DBD) merupakan penyakit demam akut dengan morbiditas dan mortalitas yang tinggi di banyak daerah di dunia. Leukopenia dan trombositopenia merupakan dua temuan laboratorik yang sering ditemukan pada DBD. Penelitian ini bersifat analitik retrospektif dengan pendekatan potong lintang. Sampel penelitian ialah pasien anak yang terdiagnosis DBD di RSUP Prof. Dr. R.D. Kandou Manado selama periode tahun 2012. Pasien yang masuk dalam kriteria inklusi ialah pasien < 15 tahun, telah terdiagnosis menurut kriteria WHO 1997, serta melakukan pemeriksaan laboratorium trombosit dan leukosit. Penelitian ini menggunakan catatan rekam medik, dan untuk analisis statistik digunakan Pearson’s correlation test. Terdapat 137 anak dengan demam berdarah dengue pada periode 2012 dan 56 anak menjadi sampel dalam penelitian ini. Hasil penelitian melalui uji korelasi Pearson mendapatkan nilai P = 0,801 dan koefisien korelasi r = -0,034 yang berarti bahwa korelasi tidak bermakna, dengan kekuatan korelasi lemah dan arah korelasi negatif. Simpulan: Tidak terdapat hubungan yang bermakna antara jumlah trombosit dan leukosit pada pasien anak demam berdarah dengue.Kata kunci: demam berdarah dengue, leukosit, trombosit


Author(s):  
Roberton Gautam ◽  
Vasundhara Kulshreshtha ◽  
Pradeep Singh ◽  
Anshu Gupta

Introduction: Age, sex and stature are primary characteristics for identification of an individual. Stature has a definite and proportional biological relationship with each and every part of human body i.e. head, neck, trunk and extremities. Material & Methods: The present study comprised of 300 medical students belonging to North India of age group between 18 yrs. to 25 yrs. of S.N. Medical College, Agra. The two anthropometric parameters, arm span and stature were used to calculate mean, standard deviation and Pearson’s correlation coefficient. Results: The Pearson’s correlation coefficient was found to be 0.9171 and p value was calculated to be <0.00001 thus, showing a significant positive correlation between the stature and arm span for the North Indian population. Conclusion: The correlation between arm span and the stature in adult males and females, was found to be an accurate predictor of stature. Thus it becomes an important anthropologic tool for the scientists in limb reconstruction surgeries. In mass disasters like train accidents, earthquakes, etc. and where the subject is in highly decomposed, fragmentary and mutilated form, it can be helpful in determining the identity of an individual.


Author(s):  
Ajay Sharawat ◽  
Kamal Kumar Sen ◽  
Sangram Panda ◽  
Sudhansu Sekhar Mohanty ◽  
Darsana Bhuyan ◽  
...  

Introduction: Novel Coronavirus-2019 (nCoV-2019) is capable of human-to-human transmission and can lead to acute respiratory distress syndrome similar to Middle East Respiratory Syndrome (MERS) due to lung parenchyma destruction. Some patients with COVID-19 consistently demonstrated no hypoxaemia, however, some patients develop sense of difficulty in breathing due to increased airway resistance. Aim: To assess the potential of High Resolution Computed Tomography (HRCT) thorax as an early predictor of hypoxaemia in COVID-19 patients. Materials and Methods: A prospective longitudinal cohort study of 1000 Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 and HRCT thorax positive patients, who were monitored simultaneously for SpO2 levels, were undertaken. HRCT findings were graded into Computerised Tomography Severity Index (CTSI) and correlated with patient’s SpO2 levels, at the time of scan on admission. Patients, who had normal SpO2 levels (≥95%) at the time of initial scan, were monitored upto five days. Pearson’s correlation test was used to find correlation between CTSI and SpO2 levels. Results: In present study group there was male predominance (4:1). Fever was the most common clinical presentation followed by cough. HRCT thorax features were categorised as Typical 769 (76.9%), Indeterminate 176 (17.6%) and atypical 55 (5.5%). 371 (82.8%) patients with SpO2 >95% were having CTSI between 0-7, similarly 189 (54.4%) patients with SpO290-94% were having CTSI between 8-15 and 133 (64.8%) patients with SpO2 <90% were having CTSI between 16-25. So, the present study categorised the patients into three groups- Category 1 (CTSI 0-7), Category 2 (CTSI 8-15) and Category 3 (CTSI 16-25) for better and prompt identification of clinical severity and their management. Majority of patients in CTSI category 1, 2 and 3 were having SpO2 levels ≥95%, 90-94% and <90%, respectively. Statistical correlation between CTSI and SpO2 levels at the time of initial scan was significant (Pearson’s correlation coefficient (r)=-0.261 and p-value <0.01). Number of patients who developed hypoxaemia (SpO2 <95%) on follow-up in CTSI Category 1, 2 and 3 were 42 (11.32%), 10 15.87%) and 2 (14.28%), respectively. The association between CTSI and development of hypoxaemia based on follow-up SpO2 levels was statistically found to be insignificant (chi-square value=1.21, degree of freedom (d.f.) 2 and p-value=0.570). Conclusion: In present study group, a negative correlation was established between CTSI and SpO2 levels. The association between CTSI and development of hypoxaemia on follow-up SpO2 monitoring was found to be non-significant statistically. So, HRCT thorax cannot be relied upon as an early predictor of hypoxaemia in COVID-19 patients.


2020 ◽  
Vol 11 (1) ◽  
pp. 511-518
Author(s):  
Aman Gupta ◽  
Abhishek Kumar Singh ◽  
Ramesh Deka C

To determine the risk associated with combined therapy of oral hypoglycemic agents and insulin in the development of cognitive decline secondary to hypoglycemia. The study comprised of two arms, in arm 1 (n=30) diabetic patients on OHA and insulin combined therapy were observed for cognitive derangement based on Mini Cog score (Pearson’s correlation r was calculated between the two)and the patients were also ruled out for hypoglycemia episodes. Similarly, in arm 2(n=30), only OHA therapy patients were evaluated on the same parameters using Pearson’s correlation. Mean Mini Cog scores were found to be 1.79  in patients on combinational therapy of OHA and insulin. In the case of patients only on OHA for diabetes control mean Mini Cog, the score was 2.0. Pearson’s coefficient r 1 between OHA plus insulin duration of therapy in years with Mini Cog score was  -0.5831 at a statistically significant p value of 0.0007. While on the other hand, patients only on OHA therapy (in years)were not significantly correlated with Mini Cog scores.(r 2= - 0.0149 ; p value =0.93771).In the arm 1 (OHA + Insulin(n=30)), the average number of hypoglycemia episodes were found to be 2.633 as compared to the OHA only group in which mean hypoglycemia episodes were 0.866. There was a significant difference in the hypoglycemia episodes, as confirmed by the student t-test (4.06368) at a p value = 0.000147. Based on the study findings, combined Treatment with Oral Hypoglycemic agents and insulin in longer run may lead to cognitive derangement secondary to hypoglycemia.*Significance level <0.01, Negative correlations are indicative of lower the values of battery scores higher would be cognitive derangement.


2020 ◽  
Vol 4 (6) ◽  
pp. 154-157
Author(s):  
Naveen Verma ◽  
John Karthik ◽  
Sameer Jain

INTRODUCTION: The use of contraceptives has been practiced since thousand of years and if used correctly can lead to birth control. AIM: To assess the knowledge, attitude and practices of contraceptive of reproductive females aged 18 years and above.MATERIALS AND METHOD: The present study was cross-sectional in nature and included married females above 18 years of age were asked to fill up an online questionnaire, divided into 4 sections and containing 17 questions. After application of descriptive statistics, the multivariate logistic regression and Pearson’s correlation was applied. p value was significant when it was ≤0.05RESULTS: Most respondents has poor knowledge (54.5%) of contraceptives with the most preferred method of contraception being OCP (36.3%) closely followed by condoms (36.1%). Awareness regarding emergency use on contraceptives was mostly seen to be poor (43.9%). The most common method used for contraception was condoms (49.7%%), followed by IUDs (15.6%),Injectables (14.3%) and OCPs(12.7%). Only a few (5.3%) did not practice any method for contraception and 2.4% underwent sterilization. the multivariate logistic regression revealed a significant relation (p=0.03) while and Pearson’s correlation (p=0.76) revealed a strong association. CONCLUSION: There is a need to educate females more about the various methods of contraception to promote their reproductive health


2021 ◽  
Vol 1 (1) ◽  
pp. 1-11
Author(s):  
Andi Sesarina Tenri Ola Sapada ◽  
Suliati P. Amir ◽  
Zulfahmidah Zulfahmidah ◽  
Ratih Natasha Maharani ◽  
Andi Tenri Sanna Arifuddin

Rendahnya intensitas pencahayaan pada panti asuhan di Kota Makassar, yang penghuninya didominasi usia sekolah, dapat mempengaruhi ketajaman penglihatan penghuninya. Hal ini dapat menjadi masalah, karena dapat mengganggu fungsi penglihatan yang dibutuhkan dalam perkembangan anak usia sekolah. Penelitian ini bertujuan untuk mengetahui hubungan antara intensitas cahaya pada panti asuhan dengan ketajaman penglihatan, faktor yang terlibat di dalamnya, serta kondisi penerangan dan ketajaman penglihatan penghuni panti asuhan. Metode penelitian menggunakan analitik observasional dengan desain cross sectional. Intensitas cahaya masing-masing sampel diukur menggunakan lux meter, sedangkan ketajaman penglihatan diukur dengan snellen chart. Analisis data menggunakan Pearson’s correlation coefficient test. Jumlah sampel 47 orang yang berasal dari 7 panti asuhan di Kecamatan Manggala Kota Makassar. Hasil analisis data menunjukkan bahwa hubungan intensitas cahaya dengan visus terbaik tidak signifikan (p value 0,240) sedangkan hubungan intensitas cahaya dengan visus terburuk signifikan dengan korelasi positif (p value 0,046). Faktor yang turut mempengaruhi adalah lama paparan harian (p value 0,019) serta jarak antara mata dan bacaan (p value 0,047). Intensitas cahaya panti asuhan masih belum memenuhi standar (kurang dari 200-300 lux) dan sebagian besar penghuninya memiliki ketajaman penglihatan menurun (kurang dari 6/6). Berdasarkan data objektif dan hasil analisis, ditemukan hubungan yang signifikan antara intensitas cahaya panti asuhan dengan ketajaman penglihatan.


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