Δείκτες παρακολούθησης και πρόγνωσης στην ιδιοπαθή πνευμονική ίνωση

2013 ◽  
Author(s):  
Χριστίνα Τριανταφυλλίδου
Keyword(s):  
Survival Analysis ◽  
Gas Exchange ◽  
Regression Models ◽  
Research Council ◽  
Medical Research Council ◽  
Cox Regression ◽  
Exertional Dyspnea ◽  
Functional Parameters ◽  
Relationship Of ◽  
The Relationship

Background: In Idiopathic Pulmonary Fibrosis (IPF) irreversibly progressive fibrosingparenchymal damage, leads to defects in mechanics and gas exchange, manifesting withdisabling exertional dyspnea. Previous studies have shown a relationship betweenfibroblast foci (FF) profusion and disease severity and survival. We hypothesized arelationship between Medical Research Council (MRC) dyspnea scale with FF, and arelationship between FF and functional parameters and survival.Methods: We retrospectively reviewed 24 histologically documented IPF patients.Profusion of FF was semiquantitatively evaluated by two scores, Brompton andMichigan. Survival analysis was performed by fitting Cox regression models toexamine the relationship of the two scores with survival and the non-parametricSpearman correlation coefficient was calculated to describe the relationships of FFscores with dyspnea scores and functional parameters.Results: No statistically significant correlation between FF scores and the MRC scoreswas observed (p = 0.96 and p = 0.508 respectively). No significant correlation betweenFF scores and survival (p = 0.438 and p = 0.861 respectively) or any functionalparameter was observed.Conclusions: The lack of relationship between the MRC dyspnea scale and the FFmight relate to the fact that dyspnea in IPF better reflects the overall of lung damageand its related consequences on mechanics and gas exchange whereas FF, one of itshistological hallmarks, may not reflect its entire histology derangement also constrainedby the geographically limited sampled tissue. This might be also valid for the observedlack of association between FF and survival or functional parameters.

Lacunes, Microinfarcts, and Vascular Dysfunction in Cerebral Amyloid Angiopathy

Neurology ◽  
2021 ◽  
Vol 96 (12) ◽  
pp. e1646-e1654
Author(s):  
Elif Gokcal ◽  
Mitchell J. Horn ◽  
Susanne J. van Veluw ◽  
Aina Frau-Pascual ◽  
Alvin S. Das ◽  
...  
Keyword(s):  
Cerebral Amyloid Angiopathy ◽  
Regression Models ◽  
Cox Regression ◽  
Vascular Dysfunction ◽  
Blood Oxygen Level Dependent ◽  
White Matter Hyperintensity ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid ◽  
Relationship Of ◽  
The Relationship

ObjectiveTo analyze the relationship of lacunes with cortical cerebral microinfarcts (CMIs), to assess their association with vascular dysfunction, and to evaluate their effect on the risk of incident intracerebral hemorrhage (ICH) in cerebral amyloid angiopathy (CAA).MethodsThe count and topography of lacunes (deep/lobar), CMIs, and white matter hyperintensity (WMH) volume were retrospectively analyzed in a prospectively enrolled CAA cohort that underwent high-resolution research MRIs. The relationship of lacunes with CMIs and other CAA-related markers including time to peak (TTP) of blood oxygen level–dependent signal, an established measure of vascular dysfunction, was evaluated in multivariate models. Adjusted Cox regression models were used to investigate the relationship between lacunes and incident ICH.ResultsThe cohort consisted of 122 patients with probable CAA without dementia (mean age, 69.4 ± 7.6 years). Lacunes were present in 31 patients (25.4%); all but one were located in lobar regions. Cortical CMIs were more common in patients with lacunes compared to patients without lacunes (51.6% vs 20.9%, p = 0.002). TTP was not associated with either lacunes or CMIs (both p > 0.2) but longer TTP response independently correlated with higher WMH volume (p = 0.001). Lacunes were associated with increased ICH risk in univariate and multivariate Cox regression models (p = 0.048 and p = 0.026, respectively).ConclusionsOur findings show a high prevalence of lobar lacunes, frequently coexisting with CMIs in CAA, suggesting that these 2 lesion types may be part of a common spectrum of CAA-related infarcts. Lacunes were not related to vascular dysfunction but predicted incident ICH, favoring severe focal vessel involvement rather than global ischemia as their mechanism.

scholarly journals Haemolytic streptococci in the dust of hospital wards, and their relationship to infection: A report to the Medical Research Council

1944 ◽  
Vol 43 (4) ◽  
pp. 256-265 ◽  
Author(s):  
Derrick G. ff. Edward
Keyword(s):  
Research Council ◽  
Medical Research Council ◽  
Streptococcal Infection ◽  
Cross Infection ◽  
Group A Streptococci ◽  
Group A ◽  
Relationship Of ◽  
Hospital Wards ◽  
The Relationship ◽  
Nose And Throat

1. A weekly examination for haemolytic streptococci was made of the dust of two hospital wards; observations lasted in each ward for about six months. The wards chosen were a combined ear, nose and throat and eye ward used for adult patients, and a children's ward.2. It was found that on an average for the whole period the dust of the former ward contained 300,000 haemolytic streptococci per gram and the dust of the latter 250,000 per gram.3. Representative colonies of haemolytic streptococci grown from each sample of dust were examined serologically to determine their group. About 33% of those isolated from the E.N.T. Eye ward were group A and about 80% of those from the children's ward.4. In order to determine the relationship of the streptococci in the dust to streptococcal infection among patients and staff, throat swabs and swabs from septic lesions were regularly examined.5. In the children's ward 27·8% of 270 patients were found to be infected with haemolytic streptococci either on admission or at some time during their stay in hospital. The incidence of infection acquired in hospital was more than 12·2%. About two-thirds of these infections were latent.6. Group A streptococci isolated from the dust and swabs were identified serologically according to type. It was noted that the occurrence of a particular type in the dust often resulted from the presence of one or more infected persons in the ward.7. It was, however, frequently noted that a particular type made its first appearance in the dust when it could not be cultured from any of the swabs. It is possible that these strains were introduced to the ward by visitors, such as patients' relatives and friends or patients from other wards coming for septic dressings.8. No conclusive example of a hospital cross-infection conveyed by dust was noted.I wish to thank Dr T. J. Hennelly and Dr D. G. Morgan, Medical Superintendents of the two hospitals, for giving me the facilities to carry out the investigation; also Dr S. T. Crowther and Dr Duncan Davies, and the sisters and nursing staff for their assistance and co-operation. I am especially indebted to Dr V. D. Allison for his helpful advice and criticism.

scholarly journals Laboratory studies on a strain of Asian influenza virus used as a living vaccine. (A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines)

1967 ◽  
Vol 65 (2) ◽  
pp. 255-262 ◽  
Author(s):  
D. Hobson ◽  
E. A. Gould ◽  
Hilary I. Flockton
Keyword(s):  
Clinical Trials ◽  
Blood Cells ◽  
Research Council ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Influenza Viruses ◽  
Laboratory Studies ◽  
Elution Rate ◽  
Relationship Of ◽  
The Relationship

Two pools of living influenza vaccine derived from the Russian A 2 strain Iksha had given discrepant results in clinical trials. The less effective pool showed an increased thermostability of haemagglutinin, an increased elution rate from red blood cells and a reduced ability to grow in chorioallantoic membranes at temperatures above 40° C. The relationship of these findings to the virulence of influenza viruses is discussed.

scholarly journals The effects of ambient temperature and heatwaves on dailyCampylobactercases in Adelaide, Australia, 1990–2012

2017 ◽  
Vol 145 (12) ◽  
pp. 2603-2610 ◽  
Author(s):  
A. MILAZZO ◽  
L. C. GILES ◽  
Y. ZHANG ◽  
A. P. KOEHLER ◽  
J. E. HILLER ◽  
...  
Keyword(s):  
Regression Models ◽  
South Australia ◽  
Maximum Temperature ◽  
Daily Maximum Temperature ◽  
Daily Maximum ◽  
Infectious Gastroenteritis ◽  
Food Borne ◽  
Relationship Of ◽  
The Relationship

SUMMARYCampylobacterspp. is a commonly reported food-borne disease with major consequences for morbidity. In conjunction with predicted increases in temperature, proliferation in the survival of microorganisms in hotter environments is expected. This is likely to lead, in turn, to an increase in contamination of food and water and a rise in numbers of cases of infectious gastroenteritis. This study assessed the relationship ofCampylobacterspp. with temperature and heatwaves, in Adelaide, South Australia.We estimated the effect of (i) maximum temperature and (ii) heatwaves on dailyCampylobactercases during the warm seasons (1 October to 31 March) from 1990 to 2012 using Poisson regression models.There was no evidence of a substantive effect of maximum temperature per 1 °C rise (incidence rate ratio (IRR) 0·995, 95% confidence interval (95% CI) 0·993–0·997) nor heatwaves (IRR 0·906, 95% CI 0·800–1·026) onCampylobactercases. In relation to heatwave intensity, which is the daily maximum temperature during a heatwave, notifications decreased by 19% within a temperature range of 39–40·9 °C (IRR 0·811, 95% CI 0·692–0·952). We found little evidence of an increase in risk and lack of association betweenCampylobactercases and temperature or heatwaves in the warm seasons. Heatwave intensity may play a role in that notifications decreased with higher temperatures. Further examination of the role of behavioural and environmental factors in an effort to reduce the risk of increasedCampylobactercases is warranted.

scholarly journals Relation between swine weight and morphometric measurements

2020 ◽  
Vol 9 (9) ◽  
pp. e891998013
Author(s):  
Mônica Calixto Ribeiro de Holanda ◽  
Marco Aurélio Carneiro de Holanda ◽  
Leandro Ricardo Rodrigues de Lucena
Keyword(s):  
Mathematical Model ◽  
Body Weight ◽  
Regression Models ◽  
Hip Circumference ◽  
Morphometric Measurements ◽  
Large White ◽  
Male And Female ◽  
Lactation Phase ◽  
Relationship Of ◽  
The Relationship

Objective was to define a mathematical model that better explain the relationship of the animals weight depending not only on the animals age but also on the animals morphometric measurements. 40 piglets, half Duroc-Large White blood, were used, 20 males and 20 females, from 3 to 35 days of age (lactation phase) initially weighing 1.518 ± 0.121 kg and from 36 to 66 days of age (calving phase) with a body weight of 7.010 ± 0.704 kg. The animals were weighed weekly on a digital balance. The relationship of animal weight, age and morphometric measurements of male and female piglets were performed using regression models: existing, linear and power. The models were evaluated according to nine criterialinear model was the most adequate to explain the weight of male pigs, while for female pigs was the power. The age of the pig, the shank and palette length, as well as the circumference of the shank jointly explain the weight of the male piglets. The weight of females is explained jointly by age, body length, thorax and hip circumference.

scholarly journals The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit

2020 ◽  
Vol 19 ◽  
pp. 153303382097754
Author(s):  
Rongchang Zhao ◽  
Dan Ding ◽  
Wenyan Yu ◽  
Chunrong Zhu ◽  
Yan Ding
Keyword(s):  
Lung Adenocarcinoma ◽  
Cox Regression ◽  
Clinicopathological Characteristics ◽  
Survival Prognosis ◽  
Kaplan Meier ◽  
Relationship Of ◽  
Immune Score ◽  
The Relationship ◽  
Kaplan Meier Plotter ◽  
Tumor Topography

Background: As a common pathological type of lung cancer, lung adenocarcinoma (LUAD) is mainly treated by surgery, chemotherapy, targeted therapy and radiotherapy. Although a relatively mature treatment system has been established, there are few studies on the microenvironment of LUAD. Material and Methods: The immune and stromal scores of patients from the LUAD cohort in the TCGA database were obtained by using ESTIMATE. The relationship of immune and stromal scores with the clinicopathological characteristics and overall survival of LUAD patients was assessed by R. GO, KEGG and Cox regression analyses were employed to analyze intersecting genes and to identify reliable prognostic markers. The identified genes were also analyzed in the GEPIA database to assess their correlations with survival, and these relationships were verified with the Kaplan-Meier Plotter database. Results: The immune score was related to the survival time and tumor topography of LUAD patients. There was a significant correlation between stromal score and tumor metastasis. Through multivariate analysis, stage (HR = 1.640, 95% CI = 1.019-2.642, P = 0.042) and risk score (HR = 1.036, 95% CI = 1.026-1.046, P < 0.001). The genes (ARHGAP15, BTLA, CASS4, CLECL1, FAM129C, STAP1, TESPA1, and S100P) showed credible prognostic value in LUAD patients in TCGA through GEPIA database online analysis and verification in the Kaplan-Meier plotter database. Conclusions: In the microenvironment of lung adenocarcinoma, the differentially expressed genes screened by immune score and stromal score have certain value in evaluating the survival/prognosis of patients, as well as the invasion and progression of tumors.

scholarly journals Temporal-Spatial Analysis of Traffic Congestion Based on Modified CTM

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Chenglong Chu ◽  
Na Xie ◽  
Xiqun Chen ◽  
Yuxin Wu ◽  
Xiaoxiao Sun
Keyword(s):  
Traffic Congestion ◽  
Regression Models ◽  
Piecewise Linear ◽  
Transmission Model ◽  
Spatial Evolution ◽  
Cell Transmission Model ◽  
Linear Regression Models ◽  
Piecewise Linear Regression ◽  
Relationship Of ◽  
The Relationship

A modified cell transmission model (CTM) is proposed to depict the temporal-spatial evolution of traffic congestion on urban freeways. Specifically, drivers’ adaptive behaviors and the corresponding influence on traffic flows are emphasized. Two piecewise linear regression models are proposed to describe the relationship of flow and density (occupancy). Several types of cellular connections are designed to depict urban rapid roads with on/off-ramps and junctions. Based on the data collected on freeway of Queen Elizabeth, Ontario, Canada, we show that the new model provides a relatively higher accuracy of temporal-spatial evolution of traffic congestions.

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