scholarly journals Early hyaluronidase use in preventing skin necrosis after treatment with dermal fillers: Report of two cases

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 1388
Author(s):  
Francesco Ciancio ◽  
Maria Stella Tarico ◽  
Giuseppe Giudice ◽  
Rosario Emanuele Perrotta
Keyword(s):  
Nitric Oxide ◽  
Hyaluronic Acid ◽  
Skin Necrosis ◽  
Dermal Filler ◽  
Oral Antibiotic ◽  
Safe Procedure ◽  
Dermal Fillers ◽  
Permanent Damage ◽  
Systemic Corticosteroids ◽  
The Face

Injection of dermal fillers, like hyaluronic acid (HA), is a safe procedure, with few and transient side effects such as erythema, bruising and swelling etc. The aim of this report is to provide our protocol for the early treatment of necrotic complications after facial treatment with dermal fillers. We present two cases of skin suffering of the face after dermal infiltration of HA, treated successfully with our early protocol. Our protocol includes the early infiltration of hyaluronidase in the treated areas. We start with infiltration of hyaluronidase distributed over the area to be treated through micro-injections with dosage 40 IU per cm2. Our protocol includes the use of systemic corticosteroids for 4 days, anti-aggregation therapy, oral antibiotic, topical cream with nitric oxide and compresses with gauze and warm water. In the skin complications after dermal filler treatment, marked pain and characteristic reticulated erythema in the skin distribution of the affected vessels is often developed. Due to the implementation of our protocol in these patients, we managed to avoid an irreversible necrotic complication of the face in both cases. In this report, our protocol was compared with results published in the literature and allowed us to avoid complications such as skin necrosis with permanent damage.

scholarly journals Early hyaluronidase use in preventing skin necrosis after treatment with dermal fillers: Report of two cases

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1388 ◽  
Author(s):  
Francesco Ciancio ◽  
Maria Stella Tarico ◽  
Giuseppe Giudice ◽  
Rosario Emanuele Perrotta
Keyword(s):  
Nitric Oxide ◽  
Hyaluronic Acid ◽  
Skin Necrosis ◽  
Dermal Filler ◽  
Oral Antibiotic ◽  
Safe Procedure ◽  
Dermal Fillers ◽  
Permanent Damage ◽  
Systemic Corticosteroids ◽  
The Face

Injection of dermal fillers, like hyaluronic acid (HA), is a safe procedure, with few and transient side effects such as erythema, bruising and swelling etc. The aim of this report is to provide our protocol for the early treatment of necrotic complications after facial treatment with dermal fillers. We present two cases of skin suffering of the face after dermal infiltration of HA, treated successfully with our early protocol. Our protocol includes the early infiltration of hyaluronidase in the treated areas. We start with infiltration of hyaluronidase distributed over the area to be treated through micro-injections with dosage 40 IU per cm2. Our protocol includes the use of systemic corticosteroids for 4 days, anti-aggregation therapy, oral antibiotic, topical cream with nitric oxide and compresses with gauze and warm water. In the skin complications after dermal filler treatment, marked pain and characteristic reticulated erythema in the skin distribution of the affected vessels is often developed. Due to the implementation of our protocol in these patients, we managed to avoid an irreversible necrotic complication of the face in both cases. In this report, our protocol was compared with results published in the literature and allowed us to avoid complications such as skin necrosis with permanent damage.

Superficial Dermal Fillers with Hyaluronic Acid

2019 ◽  
Vol 35 (03) ◽  
pp. 219-223 ◽  
Author(s):  
Jonathan T. Bacos ◽  
Steven H. Dayan
Keyword(s):  
Hyaluronic Acid ◽  
Plastic Surgery ◽  
Dermal Filler ◽  
Intrinsic Properties ◽  
Dermal Fillers ◽  
Facial Plastic Surgery ◽  
Current State ◽  
Facial Plastic ◽  
The Face ◽  
Aesthetic Procedures

AbstractMinimally invasive aesthetic procedures with hyaluronic acid filler have increased drastically since their development in 1989. Patients' desires to avoid surgery and achieve rapid results with minimal recovery led to a transformation in facial plastic surgery, demanding that aesthetic surgeons become proficient in nonsurgical augmentation. Over the years, new hyaluronic acid filler products were developed with different intrinsic properties, allowing clinicians to better treat different deficiencies of the face, reduce postprocedural pain, and optimize outcomes. The purpose of this article is to review the current state of nonsurgical facial plastic surgery with the superficial dermal filler, hyaluronic acid.

scholarly journals Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 948
Author(s):  
Nicola Zerbinati ◽  
Sabrina Sommatis ◽  
Cristina Maccario ◽  
Maria Chiara Capillo ◽  
Giulia Grimaldi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Polyethylene Glycol ◽  
Biological Activities ◽  
Diglycidyl Ether ◽  
Dermal Filler ◽  
Cross Linking ◽  
Matrix Structure ◽  
Dermal Fillers ◽  
Rheological Characterization

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous “spiderweb-like” matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible.

scholarly journals Cetuximab associated dermal filler reaction

2019 ◽  
Vol 12 (8) ◽  
pp. e228882 ◽  
Author(s):  
Shivanshan Pathmanathan ◽  
Marcin Dzienis
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Radiation Therapy ◽  
Hyaluronic Acid ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Epidermal Growth ◽  
Receptor Inhibitor

A 52-year-old male patient with hyaluronic acid-based dermal fillers injected in his cheeks was diagnosed with glossotonsillary malignancy, and managed with concurrent cetuximab (epidermal growth factor receptor inhibitor) and radiation therapy. He developed significant inflammation around the dermal filler sites after first cycle of cetuximab which improved with dissolution of the dermal fillers with hyaluronidase. This suggests that cetuximab can lead to inflammation around the dermal filler sites, which can be treated with dissolution of the filler.

Dermal filler migration complications following lip augmentation procedures

2020 ◽  
Vol 9 (7) ◽  
pp. 276-281
Author(s):  
Danielle Davy
Keyword(s):  
Hyaluronic Acid ◽  
Rare Complication ◽  
Post Treatment ◽  
The Body ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Short Term ◽  
Lip Augmentation ◽  
Permanent Fillers

Filler migration is a rare complication of dermal filler treatment. Although most research has found that more permanent fillers, such as silicone, are more likely to migrate due to their long-term presence in the body, there have also been reported cases of filler migration from short-term hyaluronic acid-based dermal fillers. As lip augmentation procedures are fast becoming one of the most frequently requested treatments in medical aesthetics, this article looks at the longevity of hyaluronic acid lip dermal fillers, while also aiming to assess the cause of dermal filler post-treatment migration and evaluating how to minimise its risk.

scholarly journals Dermal Filler types, Effect on soft tissue and Life Style correlation

2020 ◽  
Vol 3 ◽  
pp. 1
Author(s):  
Dalia A Mohamed
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Life Style ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Bovine Collagen ◽  
The World ◽  
History Of ◽  
Facial Contours ◽  
Common Manifestation

One of the most common manifestation in our time, especially among girls, is those procedures on the skin or maintaining or to modify some of the changes in the skin, such as those that come due to aging or any other cosmetic reasons. Fillers and Botox are two of the most popular procedures. Dermal fillers are effective treatments used to soften and reduce wrinkles and deep lines, fill out the cheeks and smooth facial contours. There are four main types of injectable dermal fillers, including fat, collagen, hyaluronic acid, and microsphere-containing carriers of another material such as polymethyl methacrylate (PMMA). So that to understand any type of injection, it is important to look at its history for valuable lessons and for successful progress. Honestly, it is very interesting to see what and where the world gets in the last 40 years of injectable. Today, we will be examining the brief history of dermal fillers from their bovine collagen roots, to the advanced fillers that are available today. In this review, we aimed to show some types of dermal fillers including a variety of its complication in soft tissue. Also, we try to correlate the factor of lifestyle  with its variant effects.

scholarly journals Comparative Physicochemical Analysis among 1,4-Butanediol Diglycidyl Ether Cross-Linked Hyaluronic Acid Dermal Fillers

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 139
Author(s):  
Nicola Zerbinati ◽  
Sabrina Sommatis ◽  
Cristina Maccario ◽  
Maria Chiara Capillo ◽  
Giulia Grimaldi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Medical Devices ◽  
Physicochemical Analysis ◽  
Diglycidyl Ether ◽  
Dermal Filler ◽  
Cross Linking ◽  
Matrix Structure ◽  
Dermal Fillers ◽  
Aesthetic Medicine

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used in several chirurgical practices and in aesthetic medicine. HA filler stability can be enhanced through different cross-linking technologies; one of the most frequently cross-linker used is 1,4-butanediol diglycidyl ether (BDDE), also present in the HA-BDDE dermal filler family of the company Matex Lab S.p.A. (Brindisi, Italy). Our overview is focused on their characterization, drawing a correlation between matrix structure, rheological and physicochemical properties related to their cross-linking technologies. (2) Methods: Four different injectable HA hydrogels were characterized through optical microscopic examination and rheological behavior investigation. (3) Results: The cross-linked HA dermal fillers showed a fibrous “spiderweb-like” matrix structure and an elastic and solid-like profile. (4) Conclusions: The comparative analysis represents a preliminary characterization of these injectable medical devices in order to identify their best field of application.

scholarly journals HYALURONIC ACID FILLER INJECTION FOR COSMETIC PURPOSE: SKIN NECROSIS COMPLICATION AND TREATMENT - CASES REPORTS

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Vu Ngoc Lam ◽  
Nguyen Quang Duc ◽  
Le Diep Linh ◽  
Le Thi Thu Hai
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Skin Necrosis ◽  
Early Recognition ◽  
Complete Healing ◽  
Soft Tissue Augmentation ◽  
Filler Materials ◽  
Dermal Fillers ◽  
Filler Injection ◽  
Specific Protocol

Background: Hyaluronic acid (HA) fillers for aesthetic are generally considered safe and the use of dermal fillers for soft tissue augmentation has become a very popular technique in aesthetic practices. Dermal fillers temporarily remove the appearance of rhytids and reduce the depth of skin folds. This is one of the most effective method for facial improvement used in Viet Nam nowadays.  However, complications such as skin necrosis, blind... may happen and hence any filler injection practitioner need to be aware of such side effects, contraindications and precaution to be adopted while using fillers. Even with the most experienced of injectors, adverse effects can and do occur ranging from mild bruising to severe injection necrosis. Aims: HA filler injectors should be able to prevent and treat the severe complication of skin necrosis and detect impending necrosis after injection of a augmentation filler. Materials and Methods: Cases report of 3 patients who were HA filler injection for nose augmentation and had suffered from skin necrosis. These patients were followed for 3-6 months from time of injection of hyaluronic acid filler to complete healing of wound. Results: Complete wound healing were achieved with early recognition and institution of treatment, surgical procedures applied in some severe cases. The functional of the noses are remained but  most of the patients have bad scar on the nose. Discussion: We review cases report of injection necrosis and methods used to prevent and treat this complication. Conclusion: Early recognition of vascular necrosis with specific protocol for treatment after injection necrosis with hyaluronic acid fillers improves the outcome of wound healing.

Using cannulas for dermal filler placement: why, when and how?

2019 ◽  
Vol 8 (5) ◽  
pp. 230-233
Author(s):  
Marina Landau
Keyword(s):  
Patient Experience ◽  
Dermal Filler ◽  
Hypodermic Needle ◽  
Dermal Fillers ◽  
The Past ◽  
The Face ◽  
The Aesthetic ◽  
Improve Patient

Traditionally, dermal fillers have been administered to the face using a hypodermic needle. However, injecting using cannulas has become increasingly popular over the past decade, due to the changing goals of treatment, aims to improve patient experience and attemting to prevent complications. Many dermal filler products are now sold packaged with both a needle and a cannula in order to give the practitioner the choice of injection tool. It is therefore essential that the aesthetic practitioner is well educated on the topic of how to select the best injection tool for a procedure. This article aims to asses why we have seen an increase in the use of cannulas in administering this procedure, with the hope of helping the aesthetic practitioner to make the best decision regarding injection tools.

scholarly journals The use of high-frequency ultrasonography for the diagnosis of palpable nodules after the administration of dermal fillers

2020 ◽  
Vol 20 (83) ◽  
pp. 248-253
Author(s):  
Robert Krzysztof Mlosek ◽  
◽  
Bartosz Migda ◽  
Ewa Skrzypek ◽  
Katarzyna Słoboda ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
High Frequency ◽  
Diagnostic Methods ◽  
Dermal Filler ◽  
Ultrasound Images ◽  
High Frequency Ultrasound ◽  
Dermal Fillers ◽  
Hyaluronic Acid Injection ◽  
Acid Injection ◽  
Frequency Ultrasound

Introduction: Esthetic medicine is a buoyant field of medicine. As the number of performed procedures – mainly injections of botulin toxin and dermal fillers – is increasing, the number of complications is rising as well. The most popular dermal filler is hyaluronic acid. Injection of hyaluronic acid dermal fillers is considered a minimally invasive procedure, but complications in the form of skin nodules and lumps are being encountered more and frequently. Esthetic medicine does not currently offer its own diagnostic methods that would allow one to diagnose complications. In these circumstances, the implementation of objective diagnostic methods from other fields of medicine becomes significant. High-frequency ultrasound is one of such methods. Aim of the study: The aim of this study was to implement high-frequency ultrasound for the diagnosis of palpable nodules after the administration of dermal fillers. Material and method: The study group included 15 women who developed palpable nodules in the region of hyaluronic acid injection. The study includes both early and late complications. An EPIQ 5 (Philips, Bothell, USA) ultrasound machine and a L5–18 transducer were used to examine the nodules. Ultrasound images were evaluated qualitatively by 2 independent investigators. Results: Ultrasound enabled the diagnosis of hyaluronic acid deposition in 9 women, granulomas in 3 women, fibrosis in 2 women and a deposition with inflammation in 1 case. Each of the diagnosed structures presented a typical ultrasound appearance. Conclusions: High-frequency ultrasound is a useful diagnostic method that has a chance to become a widespread tool to diagnose and treat complications. Because of a low number of study reports in this area, continued research is warranted.

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