scholarly journals Novel antifungal agents in clinical trials

F1000Research ◽  
2022 ◽  
Vol 10 ◽  
pp. 507
Author(s):  
Samantha E. Jacobs ◽  
Panagiotis Zagaliotis ◽  
Thomas J. Walsh
Keyword(s):  
Public Health ◽  
Antifungal Agents ◽  
Laboratory Diagnostics ◽  
Significant Morbidity ◽  
New Agents ◽  
Invasive Fungal Diseases ◽  
Public Health Threat ◽  
Phases Of Development ◽  
Yeasts And Molds ◽  
Growing Population

Invasive fungal diseases due to resistant yeasts and molds are an important and increasing public health threat, likely due to a growing population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics.  The significant morbidity and mortality associated with these pathogens bespeaks the urgent need for novel safe and effective therapeutics.  This review highlights promising investigational antifungal agents in clinical phases of development: fosmanogepix, ibrexafungerp, rezafungin, encochleated amphotericin B, oteseconazole (VT-1161), VT-1598, PC945, and olorofim.  We discuss three first-in-class members of three novel antifungal classes, as well as new agents within existing antifungal classes with improved safety and tolerability profiles due to enhanced pharmacokinetic and pharmacodynamic properties.

scholarly journals Novel antifungal agents in clinical trials

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 507
Author(s):  
Samantha E. Jacobs ◽  
Panagiotis Zagaliotis ◽  
Thomas J. Walsh
Keyword(s):  
Public Health ◽  
Antifungal Agents ◽  
Laboratory Diagnostics ◽  
Significant Morbidity ◽  
New Agents ◽  
Invasive Fungal Diseases ◽  
Public Health Threat ◽  
Phases Of Development ◽  
Yeasts And Molds ◽  
Growing Population

Invasive fungal diseases due to resistant yeasts and molds are an important and increasing public health threat, likely due to a growing population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics.  The significant morbidity and mortality associated with these pathogens bespeaks the urgent need for novel safe and effective therapeutics.  This review highlights promising investigational antifungal agents in clinical phases of development: fosmanogepix, ibrexafungerp, rezafungin, encochleated amphotericin B, oteseconazole (VT-1161), VT-1598, PC945, and olorofim.  We examine three first-in-class members of three novel antifungal classes, as well as new agents within existing antifungal classes with improved safety and tolerability profiles due to enhanced pharmacokinetic and pharmacodynamic properties.

scholarly journals Current pharmacologic treatments for smoking cessation and new agents undergoing clinical trials

2019 ◽  
Vol 13 ◽  
pp. 175346661987592 ◽  
Author(s):  
Tatsuya Nagano ◽  
Masahiro Katsurada ◽  
Yuichiro Yasuda ◽  
Kazuyuki Kobayashi ◽  
Yoshihiro Nishimura
Keyword(s):  
Public Health ◽  
Clinical Trials ◽  
Smoking Cessation ◽  
Literature Review ◽  
First Line ◽  
New Agents ◽  
Cochrane Database ◽  
Public Health Threat ◽  
Supplementary Material ◽  
Pharmacologic Treatments

Smoking causes various diseases and is a major public health threat worldwide. Therefore, promoting smoking cessation is the most important intervention contributing to maintaining the health of smokers and nonsmokers and saving enormous financial expense. We reviewed existing and emerging smoking-cessation pharmacotherapies from the Cochrane Database of Systemic Reviews, PubMed, Ovid, and ClinicalTrials.gov databases. A literature review revealed that bupropion may be appropriate for patients interested in reducing smoking who dislike, or who have failed, nicotine-replacement therapy (NRT). Additionally, varenicline and NRT are efficacious first-line smoking cessation treatments and should be given to all individuals unless contraindicated. The reviews of this paper are available via the supplementary material section.

Natural Products, for Fungal Diseases Management and Prevention

2021 ◽  
Vol 11 ◽  
Author(s):  
Nahid Akhtar ◽  
Rabia Ayoubi ◽  
Vinaypreet Kour ◽  
Umesh Goutam ◽  
M. Amin-ul Mannan
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Antifungal Agents ◽  
Fungal Species ◽  
Antifungal Drugs ◽  
Fungal Diseases ◽  
Naturally Occurring ◽  
Invasive Fungal Diseases ◽  
Emergence Of Resistance

Abstract: Fungal diseases cause more deaths as compared to combined deaths due to malaria and tuberculosis. There are around 3.8 million fungal species, but only about 300 of them are pathogenic to humans. Invasive fungal diseases are majorly caused by Aspergillus, Candida, Cryptococcus, Histoplasma, Mucorales, and Pneumocystis. It has been estimated that around 1.5 million people die because of these infections across the globe. The emergence of resistance against the major classes of antifungal drugs poses a serious threat to public health. Moreover, the commonly used antifungal drugs are loaded with side effects. Some of them are nephrotoxic, hepatotoxic, cause cardiomyopathy, and in acute cases, cytotoxicity. Hence, it is important to seek novel molecules that can be safe and effective antifungal drugs. Naturally occurring molecules in plants and various microorganisms can be a safe and effective alternative to the existing antifungal drugs. In this review, the role of various phytochemicals such as alkaloids, flavonoids, saponins, and phenols as potential antifungal agents has been discussed. Similarly, naturally occurring molecules in other microorganisms like algae, bacteria, and various other fungi have been summarized. The information discussed in this review can be useful in the identification of novel antifungals.

LGBTQ Intimate Partner Violence

2017 ◽  
Author(s):  
Adam M. Messinger
Keyword(s):  
Public Health ◽  
Intimate Partner Violence ◽  
Partner Violence ◽  
Intimate Partner ◽  
Sexual Relationships ◽  
Evidence Based ◽  
Policy Practice ◽  
The Past ◽  
Victim Services ◽  
Public Health Threat

Many nations today recognize intimate partner violence (IPV) in romantic-sexual relationships as a major public health threat, yet not all victims are treated equally. Contrary to myths, lesbian, gay, bisexual, trans*, and queer (LGBTQ) people are more likely to experience IPV than heterosexual-cisgender people. Unfortunately, LGBTQ victims face major barriers to reaching safety in a world that too often stigmatizes their identities and overlooks their relationships when forming victim services and policies. Offering a roadmap forward, LGBTQ Intimate Partner Violence: Lessons for Policy, Practice, and Research is the first book to synthesize nearly all existing research from the past forty years on this pressing issue. At once highly organized and engaging, it provides evidence-based tips for academic and nonacademic audiences alike.

scholarly journals Descriptive Epidemiology of Rescue-Related Fatal Drowning in Turkey

2021 ◽  
Vol 18 (12) ◽  
pp. 6613
Author(s):  
Ali Işın ◽  
Adnan Turgut ◽  
Amy E. Peden
Keyword(s):  
Public Health ◽  
Retrospective Study ◽  
Relative Risk ◽  
Confidence Interval ◽  
Descriptive Epidemiology ◽  
Death Registry ◽  
Public Health Threat ◽  
Reduction Strategies ◽  
Media Reports ◽  
Risk Reduction Strategies

Drowning is a public-health threat and a leading cause of injury-related death. In Turkey, drowning results in 900 fatalities annually, and the rate is rising. As data on rescue-related drowning are scarce, this retrospective study explores the epidemiology of fatal drowning among rescuers in Turkey. As there are no routinely collected death registry data on drowning in Turkey, data were sourced from media reports of incidents between 2015 and 2019. Rescuer fatalities were analysed by age, sex, activity prior to rescue, location, incident day of week and season, and place of death. Statistical analyses comprised X2 tests of significance (p < 0.05) and calculation of relative risk (95% confidence interval) using fatality rates. In total, 237 bystander rescuers drowned (90% male; 35% 15–24 years). In 33% of cases, the primary drowning victim (PDV) was successfully rescued, while in 46% of cases the rescue resulted in multiple drowning fatalities (mean = 2.29; range 1–5 rescuers). Rescues were more likely to be successful in saving the PDV if undertaken at the beach/sea (X2 = 29.147; p < 0.001), while swimming (X2 = 12.504; p = 0.001), or during summer (X2 = 8.223; p = 0.029). Risk of bystander rescue-related fatal drowning was twice as high on weekdays compared to on weekends (RR = 2.04; 95%CI: 1.56–2.67). While bystanders play an important role in reducing drowning, undertaking a rescue is not without risk and can lead to multiple drowning incidents. Training in rescue and resuscitation skills (especially the prioritization of non-contact rescues) coupled with increasing awareness of drowning risk, are risk-reduction strategies which should be explored in Turkey.

scholarly journals A road-map for addressing antimicrobial resistance in low- and middle-income countries: lessons learnt from the public private participation and co-designed antimicrobial stewardship programme in the State of Kerala, India

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Sanjeev Singh ◽  
Esmita Charani ◽  
Sarada Devi ◽  
Anuj Sharma ◽  
Fabia Edathadathil ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Antimicrobial Stewardship ◽  
Infection Prevention ◽  
The State ◽  
Action Plans ◽  
Public And Private ◽  
Middle Income ◽  
Middle Income Countries ◽  
Public Health Threat

Abstract Background The global concern over antimicrobial resistance (AMR) is gathering pace. Low- and middle-income countries (LMICs) are at the epicentre of this growing public health threat and governmental and healthcare organizations are at different stages of implementing action plans to tackle AMR. The South Indian state of Kerala was one of the first in India to implement strategies and prioritize activities to address this public health threat. Strategies Through a committed and collaborative effort from all healthcare related disciplines and its professional societies from both public and private sector, the Kerala Public Private Partnership (PPP) has been able to deliver a state-wide strategy to tackle AMR A multilevel strategic leadership model and a multilevel implementation approach that included developing state-wide antibiotic clinical guidelines, a revision of post-graduate and undergraduate medical curriculum, and a training program covering all general practitioners within the state the PPP proved to be a successful model for ensuring state-wide implementation of an AMR action plan. Collaborative work of multi-professional groups ensured co-design and development of disease based clinical treatment guidelines and state-wide infection prevention policy. Knowledge exchange though international and national platforms in the form of workshops for sharing of best practices is critical to success. Capacity building at both public and private institutions included addressing practical and local solutions to the barriers e.g. good antibiotic prescription practices from primary to tertiary care facility and infection prevention at all levels. Conclusion Through 7 years of stakeholder engagement, lobbying with government, and driving change through co-development and implementation, the PPP successfully delivered an antimicrobial stewardship plan across the state. The roadmap for the implementation of the Kerala PPP strategic AMR plan can provide learning for other states and countries aiming to implement action plans for AMR.

scholarly journals COVID-19 public health measures: a reduction in hospital admissions for COPD exacerbations

Thorax ◽  
2020 ◽  
pp. thoraxjnl-2020-216083
Author(s):  
Jing Yuan Tan ◽  
Edwin Philip Conceicao ◽  
Liang En Wee ◽  
Xiang Ying Jean Sim ◽  
Indumathi Venkatachalam
Keyword(s):  
Public Health ◽  
Clinical Outcomes ◽  
Hospital Admissions ◽  
Viral Infections ◽  
Significant Morbidity ◽  
Common Cause ◽  
Copd Exacerbations ◽  
Health Measures ◽  
Acute Exacerbations ◽  
Respiratory Viral Infections

Hospitalisations for acute exacerbations of COPD (AECOPD) carry significant morbidity and mortality. Respiratory viral infections (RVIs) are the most common cause of AECOPD and are associated with worse clinical outcomes. During the COVID-19 pandemic, public health measures, such as social distancing and universal masking, were originally implemented to reduce transmission of SARS-CoV-2; these public health measures were subsequently also observed to reduce transmission of other common circulating RVIs. In this study, we report a significant and sustained decrease in hospital admissions for all AECOPD as well as RVI-associated AECOPD, which coincided with the introduction of public health measures during the COVID-19 pandemic.

scholarly journals Fatal SARS-CoV-2 and Mycobacterium tuberculosis coinfection in an infant: insights from Botswana

2021 ◽  
Vol 14 (4) ◽  
pp. e239701
Author(s):  
Unami Koolebogile Mulale ◽  
Thanolo Kashamba ◽  
Jonathan Strysko ◽  
Lynnette Tumwine Kyokunda
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Immune Reconstitution ◽  
Fatal Case ◽  
Failure To Thrive ◽  
Supplemental Oxygen ◽  
Sub Saharan Africa ◽  
Public Health Threat ◽  
Pandemic Response ◽  
Sub Saharan

We report a fatal case of SARS-CoV-2 and Mycobacterium tuberculosis coinfection in an infant, Botswana’s first paediatric COVID-19-associated fatality. The patient, a 3-month-old HIV-unexposed boy, presented with fever and respiratory distress in the setting of failure to thrive. Both the patient and his mother tested positive for rifampin-sensitive M. tuberculosis (Xpert MTB/Rif) and SARS-CoV-2 (real time-PCR). Initially stable on supplemental oxygen and antitubercular therapy, the patient experienced precipitous clinical decline 5 days after presentation and subsequently died. Autopsy identified evidence of disseminated tuberculosis (TB) as well as histopathological findings similar to those described in recent reports of SARS-CoV-2 infections, including diffuse microthrombosis. TB remains a serious public health threat in hyperendemic regions like sub-Saharan Africa, and is often diagnosed late in infants. In addition to raising the question of additive/synergistic pathophysiology and/or immune reconstitution, this case of coinfection also highlights the importance of leveraging the COVID-19 pandemic response to strengthen efforts for TB prevention, screening and detection.

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