scholarly journals Insights from mathematical modelling and quantitative analysis on the proposed WHO 2030 targets for visceral leishmaniasis on the Indian subcontinent

2019 ◽  
Vol 3 ◽  
pp. 1651
Author(s):  
Keyword(s):  
Public Health ◽  
Visceral Leishmaniasis ◽  
Health Problem ◽  
Indian Subcontinent ◽  
Public Health Problem ◽  
District Level ◽  
World Health ◽  
Kala Azar ◽  
Health Organization ◽  
The Impact

Visceral leishmaniasis (VL) is a neglected tropical disease (NTD) caused by Leishmania protozoa that are transmitted by female sand flies. On the Indian subcontinent (ISC), VL is targeted by the World Health Organization (WHO) for elimination as a public health problem by 2020, which is defined as <1 VL case (new and relapse) per 10,000 population at district level in Nepal and sub-district level in Bangladesh and India. WHO is currently in the process of formulating 2030 targets, asking whether to maintain the 2020 target or to modify it, while adding a target of zero mortality among detected cases. The NTD Modelling Consortium has developed various mathematical VL transmission models to gain insight into the transmission dynamics of VL, identify the main knowledge gaps, and predict the feasibility of achieving and sustaining the targets by simulating the impact of varying intervention strategies. According to the models, the current target is feasible at the appropriate district/sub-district level in settings with medium VL endemicities (up to 5 reported VL cases per 10,000 population per year) prior to the start of the interventions. However, in settings with higher pre-control endemicities, additional efforts may be required. We also highlight the risk that those with post-kala-azar dermal leishmaniasis (PKDL) may pose to reaching and sustaining the VL targets, and therefore advocate adding control of PKDL cases to the new 2030 targets. Spatial analyses revealed that local hotspots with high VL incidence remain. We warn that the current target provides a perverse incentive to not detect/report cases as the target is approached, posing a risk for truly achieving elimination as a public health problem although this is taken into consideration by the WHO procedures for validation. Ongoing modelling work focuses on the risk of recrudescence when interventions are relaxed after the elimination target has been achieved.

scholarly journals Morocco succeeds to eliminate trachoma as a public health problem: World Health Organization

2017 ◽  
Vol 22 (1) ◽  
pp. 46
Author(s):  
SaurabhRamBihariLal Shrivastava ◽  
PrateekSaurabh Shrivastava ◽  
Jegadeesh Ramasamy
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Health Problem ◽  
Public Health Problem ◽  
World Health ◽  
Health Organization

scholarly journals Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152

2021 ◽  
Author(s):  
Pragya D Yadav ◽  
Gajanan Sapkal ◽  
Raches Ella ◽  
Rima R Sahay ◽  
Dimpal A Nyayanit ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
The Other ◽  
World Health ◽  
Neutralization Titer ◽  
Protective Response ◽  
Neutralization Potential ◽  
Recent Emergence ◽  
Health Organization

Recently, multiple SARS-CoV-2 variants have been detected across the globe.The recent emergence of B.1.617 lineage has created serious public health problem in India. The high transmissibility was observed with this lineage which has led to daily increase in the number of SARS-CoV-2 infections. Apparently, the sub-lineage B.1.617.2 has slowly dominated the other variants including B1617.1, B.617.3 and B.1.1.7. With this, World Health Organization has described B.1.617.2 as variant of concern. Besides this, variant of concern B.1.351 has been also reported from India, known to showreducedefficacyfor many approved vaccines. With the increasing threat of the SARS-CoV-2 variants, it is imperative to assess the efficacy of the currently available vaccines against these variants. Here, we have evaluated the neutralization potential of sera collected from COVID-19 recovered cases (n=20) and vaccinees with two doses of BBV152 (n=17) against B.1.351 and B.1.617.2 compared to the prototype B.1 (D614G) variant.The finding of the study demonstrated a reduction in neutralization titers with sera of COVID-19 recovered cases(3.3-fold and 4.6-fold) and BBV152 vaccinees (3. 0 and 2.7 fold) against B.1.351 and B.1.617.2 respectively. Although, there is reduction in neutralization titer, the whole-virion inactivated SARS-CoV-2 vaccine (BBV152) demonstrates protective response against VOC B.1351 and B.1.617.2.

scholarly journals Food behaviors and youth obesity in Pakistan - doi: 10.4025/actascihealthsci.v35i2.11885

2013 ◽  
Vol 35 (2) ◽  
pp. 223 ◽  
Author(s):  
Anjum Hashmi ◽  
Jamil Ahmed Soomro ◽  
Khalid Saleem
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Health Problem ◽  
Significant Proportion ◽  
Public Health Problem ◽  
World Health ◽  
Major Public Health Problem ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Health Organization

The epidemic of obesity took off from about 1980 and in almost all countries has been rising inexorably ever since. Only in 1997 did world health organization accept that this was a major public health problem. It is also becoming an important public health problem among Pakistani children due to changes in life style and other factors. The increasing prevalence of childhood obesity and its concomitant health risks justify widespread efforts toward prevention. A Cross-sectional study was conducted to elaborate the various types of foods and change in eating behavior leading to abnormal weight gain among the youth. A total of 504 male and female students of class six to ten were selected through simple random sampling. Anthropometric measurements were done with calibrated instruments using the age and sex specific BMI cut off points according to World Health Organization growth reference. Results showed significant proportion of girls (86%) and boys (85%) had abnormal waist to hip ratio. The determinants of the obesity lie within the rapid changes in food intake behavior and lifestyle patterns which had a clear and significant impact on the prevalence of obesity in youth of Pakistan.

scholarly journals Trachoma Prevalence After Discontinuation of Mass Azithromycin Distribution

2020 ◽  
Vol 221 (Supplement_5) ◽  
pp. S519-S524
Author(s):  
William Godwin ◽  
Joaquin M Prada ◽  
Paul Emerson ◽  
P J Hooper ◽  
Ana Bakhtiari ◽  
...  
Keyword(s):  
Public Health ◽  
Diagnostic Tests ◽  
Public Health Problem ◽  
World Health ◽  
Simulation Based ◽  
The World ◽  
Health Organization ◽  
Program Cycle ◽  
The Impact ◽  
Oral Azithromycin

Abstract Background As the World Health Organization seeks to eliminate trachoma by 2020, countries are beginning to control the transmission of trachomatous inflammation–follicular (TF) and discontinue mass drug administration (MDA) with oral azithromycin. We evaluated the effect of MDA discontinuation on TF1–9 prevalence at the district level. Methods We extracted from the available data districts with an impact survey at the end of their program cycle that initiated discontinuation of MDA (TF1–9 prevalence &lt;5%), followed by a surveillance survey conducted to determine whether TF1–9 prevalence remained below the 5% threshold, warranting discontinuation of MDA. Two independent analyses were performed, 1 regression based and 1 simulation based, that assessed the change in TF1–9 from the impact survey to the surveillance survey. Results Of the 220 districts included, TF1–9 prevalence increased to &gt;5% from impact to surveillance survey in 9% of districts. Regression analysis indicated that impact survey TF1–9 prevalence was a significant predictor of surveillance survey TF1–9 prevalence. The proportion of simulations with &gt;5% TF1–9 prevalence in the surveillance survey was 2%, assuming the survey was conducted 4 years after MDA. Conclusion An increase in TF1–9 prevalence may represent disease resurgence but could also be due to measurement error. Improved diagnostic tests are crucial to elimination of TF1–9 as a public health problem.

scholarly journals Lipid Metabolism as a Targetable Metabolic Vulnerability in Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 301
Author(s):  
Yekaterina Zaytseva
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Lipid Metabolism ◽  
World Health Organization ◽  
Health Problem ◽  
Public Health Problem ◽  
World Health ◽  
The World ◽  
Health Organization

Colorectal cancer (CRC), the second leading cause of cancer-related deaths according to the World Health Organization, remains a substantial public health problem worldwide [...]

scholarly journals Insights from mathematical modelling and quantitative analysis on the proposed 2030 goals for trachoma

2021 ◽  
Vol 3 ◽  
pp. 1721
Author(s):  
Keyword(s):  
Public Health ◽  
Quantitative Analysis ◽  
Health Problem ◽  
Statistical Models ◽  
Public Health Problem ◽  
World Health ◽  
Neglected Tropical Disease ◽  
Monitoring Tools ◽  
Health Organization ◽  
Trachomatous Trichiasis

Trachoma is a neglected tropical disease and the leading infectious cause of blindness worldwide. The current World Health Organization goal for trachoma is elimination as a public health problem, defined as reaching a prevalence of trachomatous inflammation-follicular below 5% in children (1-9 years) and a prevalence of trachomatous trichiasis in adults below 0.2%. Current targets to achieve elimination were set to 2020 but are being extended to 2030. Mathematical and statistical models suggest that 2030 is a realistic timeline for elimination as a public health problem in most trachoma endemic areas. Although the goal can be achieved, it is important to develop appropriate monitoring tools for surveillance after having achieved the elimination target to check for the possibility of resurgence. For this purpose, a standardized serological approach or the use of multiple diagnostics in complement would likely be required.

scholarly journals Suicide, A Public Health Problem in Brazil

2021 ◽  
Author(s):  
Maria Cecília de Souza Minayo ◽  
Camila Alves Bahia
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Mortality Rate ◽  
Health Problem ◽  
Age Groups ◽  
Public Health Problem ◽  
Incidence Rates ◽  
World Health ◽  
History Of ◽  
Health Organization

This text focuses on the situation of suicide in Brazil, defines and quantifies information, and presents a description of the main risk factors, as well as a reflection on the phenomenon and the possibilities for prevention. Fatal suicide is a serious public health problem. In 2012, 172 member states of the World Health Organization registered 804,000 self-inflicted deaths, representing an annual rate of 11.4/100,000, of which 15/100,000 men and 8.0/100,000 women. Consummate suicide rates are unevenly distributed globally, within countries, according to sex and according to age groups. The mortality rate is highest in Asia (17.7/100 thousand inhabitants), followed in Europe (12/100 thousand inhabitants). The Americas have a mortality rate of 7.3/100 thousand inhabitants (WHO, 2014). In Brazil, with an unevenly distributions between the regions, gender and ages, the total rate is 4.5/100,000. In the country and everywhere, risk factors are classified as medical, psychiatric and psychological, micro social, social and environmental. The history of the occurrence of suicides shows that it is possible to prevent them and to reduce the incidence rates. This requires investment in local diagnostics and multidisciplinary action. Given the delicacy of the problem and the taboos that surround it, the protection network for people at risk for suicide needs to be constantly in the process of training and taking action. As national and international surveys show, at least two-thirds of the individuals who tried or committed suicide had somehow communicated to friends, family, acquaintances or health professionals their intention to kill themselves.

scholarly journals Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India

2020 ◽  
Author(s):  
Epke A Le Rutte ◽  
Luc E Coffeng ◽  
Johanna Muñoz ◽  
Sake J de Vlas
Keyword(s):  
Public Health ◽  
Visceral Leishmaniasis ◽  
Health Problem ◽  
Public Health Problem ◽  
Mitigation Strategy ◽  
Mitigation Strategies ◽  
Transmission Model ◽  
Potential Impact ◽  
Age Structured ◽  
The Impact

AbstractBackgroundIn March 2020, India declared a nationwide lockdown to control the spread of COVID-19. As a result, control efforts against visceral leishmaniasis (VL) were interrupted.MethodsUsing an established age-structured deterministic VL transmission model, we predicted the impact of a 6 to 24-month programme interruption on the timeline towards achieving the VL elimination target, as well as on the increase of VL cases. We also explored the potential impact of a mitigation strategy after the interruption.ResultsDelays towards the elimination target are estimated to range between 0 to 9 years. Highly endemic settings where control efforts have been ongoing for 5-8 years are most affected by an interruption, for which we identified a mitigation strategy to be most relevant. However, more importantly, all settings can expect an increase in the number of VL cases. This increase is substantial even for settings with a limited expected delay in achieving the elimination target.ConclusionBesides implementing mitigation strategies, it is of great importance to try and keep the duration of the interruption as short as possible, to prevent new individuals from becoming infected with VL, and continue the efforts towards VL elimination as a public health problem in India.

scholarly journals Achieving Elimination as a Public Health Problem for Schistosoma mansoni and S. haematobium: When Is Community-Wide Treatment Required?

2019 ◽  
Vol 221 (Supplement_5) ◽  
pp. S525-S530 ◽  
Author(s):  
Jaspreet Toor ◽  
David Rollinson ◽  
Hugo C Turner ◽  
Anouk Gouvras ◽  
Charles H King ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Treatment Guidelines ◽  
Treatment Strategies ◽  
Public Health Problem ◽  
World Health ◽  
School Enrolment ◽  
School Based ◽  
Good School ◽  
Health Organization

Abstract The World Health Organization (WHO) has set elimination as a public health problem (EPHP) as a goal for schistosomiasis. As the WHO treatment guidelines for schistosomiasis are currently under revision, we investigate whether school-based or community-wide treatment strategies are required for achieving the EPHP goal. In low- to moderate-transmission settings with good school enrolment, we find that school-based treatment is sufficient for achieving EPHP. However, community-wide treatment is projected to be necessary in certain high-transmission settings as well as settings with low school enrolment. Hence, the optimal treatment strategy depends on setting-specific factors such as the species present, prevalence prior to treatment, and the age profile of infection.

scholarly journals Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India

2021 ◽  
Author(s):  
Epke A Le Rutte ◽  
Luc E Coffeng ◽  
Johanna Muñoz ◽  
Sake J de Vlas
Keyword(s):  
Public Health ◽  
Visceral Leishmaniasis ◽  
Health Problem ◽  
Public Health Problem ◽  
Mitigation Strategy ◽  
Mitigation Strategies ◽  
Transmission Model ◽  
Potential Impact ◽  
Age Structured ◽  
The Impact

Abstract Background In March 2020, India declared a nationwide lockdown to control the spread of coronavirus disease 2019. As a result, control efforts against visceral leishmaniasis (VL) were interrupted. Methods Using an established age-structured deterministic VL transmission model, we predicted the impact of a 6- to 24-month programme interruption on the timeline towards achieving the VL elimination target as well as on the increase of VL cases. We also explored the potential impact of a mitigation strategy after the interruption. Results Delays towards the elimination target are estimated to range between 0 and 9 y. Highly endemic settings where control efforts have been ongoing for 5–8 y are most affected by an interruption, for which we identified a mitigation strategy to be most relevant. However, more importantly, all settings can expect an increase in the number of VL cases. This increase is substantial even for settings with a limited expected delay in achieving the elimination target. Conclusions Besides implementing mitigation strategies, it is of great importance to try and keep the duration of the interruption as short as possible to prevent new individuals from becoming infected with VL and continue the efforts towards VL elimination as a public health problem in India.

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