scholarly journals Breaking the Skin Barrier: Current Advancement in Drug Delivery via Skin

2014 ◽  
Vol 2 (5A) ◽  
pp. 0-0
Author(s):  
Yasser Shahzad ◽  
Madeeha Malik
Keyword(s):  
Drug Delivery ◽  
Skin Barrier

Elegant flexible vesicular nanocarriers for the efficient skin delivery of topically applied drugs-

2021 ◽  
Vol 18 ◽  
Author(s):  
Waleed Albalawi ◽  
Surur Alharbi ◽  
Fahad Alanazi ◽  
Hameed Alahmadi ◽  
Mothib Alghamdi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Skin Barrier ◽  
Therapeutic Outcome ◽  
Health Concern ◽  
Inflammatory Skin Diseases ◽  
Skin Delivery ◽  
Pubmed Database ◽  
Vesicular Carriers

Background: Skin diseases represent a major health concern worldwide and negatively impact patients’ quality of life. Despite the availability of various efficacious drugs, their therapeutic outcome is often limited due to shortcomings related to the formidable skin barrier and unfavorable physicochemical properties of drugs. Flexible nano-vesicles have shown tremendous potential to overcome these hurdles and improve the local therapeutic effect of these drugs. Objective: This review article is aimed to shed light on flexible nano-vesicular carriers as a means to combat skin diseases. Methods: The literature was reviewed using PubMed database using various keywords such as liposomes, flexible (deformable liposomes) (transferosomes), ethosomes, transethosomes, niosomes, and spanlastics. Results: Liposomes and niosomes were found effective for the loading and release of both hydrophilic and lipophilic drugs. However, their limited skin penetration led to drug delivery to the outermost layers of skin only. This necessitates the search for innovative vesicular carriers, including liposomes, flexible (deformable liposomes), ethosomes, transethosomes, and spanlastics. These flexible nano-vesicular carriers showed enhanced drug delivery and deposition across various skin layers, which was better than their corresponding conventional vesicles. This resulted in superior drug efficacy against various skin diseases such as skin cancer, inflammatory skin diseases, superficial fungal infections, etc. Conclusion: Flexible nano-vesicular carriers have proven themselves as efficient drug delivery systems that are able to deliver their cargo into the deep skin layers and thus, improve the therapeutic outcome of various skin diseases. However, there remain some challenges that need to be addressed before these nanocarriers can be translated from the lab to clinics.

Nanocapsules for drug delivery through the skin barrier by tissue-tolerable plasma

2013 ◽  
Vol 10 (8) ◽  
pp. 083001 ◽  
Author(s):  
J Lademann ◽  
A Patzelt ◽  
H Richter ◽  
O Lademann ◽  
G Baier ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Barrier

scholarly journals Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 684 ◽  
Author(s):  
Christian Gorzelanny ◽  
Christian Mess ◽  
Stefan W. Schneider ◽  
Volker Huck ◽  
Johanna M. Brandner
Keyword(s):  
Drug Delivery ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Multiphoton Microscopy ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Transepidermal Water Loss ◽  
Hair Follicles

Although, drugs are required in the various skin compartments such as viable epidermis, dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the skin is still challenging. An improved understanding of skin barrier physiology is mandatory to optimize drug penetration and permeation. The various barriers of the skin have to be known in detail, which means methods are needed to measure their functionality and outside-in or inside-out passage of molecules through the various barriers. In this review, we summarize our current knowledge about mechanical barriers, i.e., stratum corneum and tight junctions, in interfollicular epidermis, hair follicles and glands. Furthermore, we discuss the barrier properties of the basement membrane and dermal blood vessels. Barrier alterations found in skin of patients with atopic dermatitis are described. Finally, we critically compare the up-to-date applicability of several physical, biochemical and microscopic methods such as transepidermal water loss, impedance spectroscopy, Raman spectroscopy, immunohistochemical stainings, optical coherence microscopy and multiphoton microscopy to distinctly address the different barriers and to measure permeation through these barriers in vitro and in vivo.

scholarly journals Cationic Supramolecular Hydrogels for Overcoming the Skin Barrier in Drug Delivery

ChemistryOpen ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 585-598 ◽  
Author(s):  
David Limón ◽  
Claire Jiménez-Newman ◽  
Mafalda Rodrigues ◽  
Arántzazu González-Campo ◽  
David B. Amabilino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Barrier

scholarly journals Microneedle Array Patches: Characterization and in -vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 66-75
Author(s):  
Zainab A. Sadeq
Keyword(s):  
Drug Delivery ◽  
Blood Vessel ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Solid Polymer ◽  
Microneedle Array ◽  
Microneedle Patch ◽  
Novel Drug

 Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle.  Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

scholarly journals Monitoring the Effect of Transdermal Drug Delivery Patches on the Skin Using Terahertz Sensing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2052
Author(s):  
Hannah Lindley-Hatcher ◽  
Jiarui Wang ◽  
Arturo I. Hernandez-Serrano ◽  
Joseph Hardwicke ◽  
Gabit Nurumbetov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Content ◽  
Biomedical Applications ◽  
Skin Barrier ◽  
High Sensitivity ◽  
Thz Spectroscopy ◽  
Transdermal Patches ◽  
Patch Removal ◽  
Terahertz Sensing

Water content of the skin is an important parameter for controlling the penetration rate of chemicals through the skin barrier; therefore, for transdermal patches designed for drug delivery to be successful, the effects of the patches on the water content of the skin must be understood. Terahertz (THz) spectroscopy is a technique which is being increasingly investigated for biomedical applications due to its high sensitivity to water content and non-ionizing nature. In this study, we used THz measurements of the skin (in vivo) to observe the effect of partially and fully occlusive skin patches on the THz response of the skin after the patches had been applied for 24 h. We were able to observe an increase in the water content of the skin following the application of the patches and to identify that the skin remained hyper-hydrated for four hours after the removal of the fully occlusive patches. Herein, we show that THz spectroscopy has potential for increasing the understanding of how transdermal patches affect the skin, how long the skin takes to recover following patch removal, and what implications these factors might have for how transdermal drug patches are designed and used.

scholarly journals THE THE MICROEMULSION AS A KEY PLAYER IN CONQUERING THE SKIN BARRIER FOR THE AIM OF TRANSDERMAL DELIVERY OF DRUGS: REVIEWING A SUCCESSFUL DECADE

2019 ◽  
pp. 34-48
Author(s):  
RANIA YEHIA ◽  
DALIA A ATTIA
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Barrier ◽  
The Other ◽  
Penetration Enhancers ◽  
The Past ◽  
Transdermal Drug Delivery Systems ◽  
The One

Microemulsion (ME) systems are now considered of the most successful transdermal drug delivery systems. This is due to their nanodroplets size in the one hand and to their composition that enables the use of several mechanistically penetration enhancers in the same formulation on the other hand. This work summarizes the types, properties, and the merits of the use of MEs for transdermal delivery and reviews the successful studies that were performed to deliver several drugs through this important route during the past 10–12 years.

Limitations and Opportunities in Topical Drug Delivery: Interaction Between Silica Nanoparticles and Skin Barrier

2019 ◽  
Vol 25 (4) ◽  
pp. 455-466 ◽  
Author(s):  
Francisco Arriagada ◽  
Javier Morales
Keyword(s):  
Drug Delivery ◽  
Adverse Effects ◽  
Silica Nanoparticles ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Bioactive Compound ◽  
Penetration Enhancers ◽  
Topical Drug Delivery ◽  
Skin Delivery ◽  
The Stability

The first limiting barrier for the transport in the skin is the stratum corneum; different strategies have been developed to overcome this barrier, including chemical enhancers. However, these penetration enhancers have limitations, including toxic adverse effects. In this context, research into nanomaterials has provided new tools to increase the residence time of drugs by generating a reservoir, increasing the specificity of drugs and reducing their adverse effects, and improving the penetration of drugs that are difficult to formulate. Silica nanoparticles have been proposed as suitable nanocarriers for skin delivery. Unfortunately, the mechanisms involved in the interaction, transport and fate of silica nanoparticles in the skin have not been fully investigated. This paper reviews significant findings about the interaction between silica-based nanocarriers and the skin. First, this review focuses on the properties and functions of the skin, the skin penetration properties of silica nanoparticles, their synthesis strategies and their toxicity. Finally, advances and evidence on the application of silica nanocarriers in skin drug delivery are provided, in which the use of nanoparticles increases the stability and solubility of the bioactive compound, enhancing its performance, act as penetrator enhancer and improving controlled release. Thus, improving the treatment of some skin disorders.

Current updates in transdermal therapeutic systems and their role in neurological disorders

2020 ◽  
Vol 21 ◽  
Author(s):  
Neelu Yadav ◽  
Ashu Mittal ◽  
Javed Ali ◽  
Jagannath Sahoo
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Neurological Disorders ◽  
Active Agent ◽  
Skin Barrier ◽  
Extended Period ◽  
The Elderly ◽  
Global Functioning ◽  
Metered Dose ◽  
Bioactive Agents

Abstract:: The transdermal therapeutic system presents an important role in the treatment of neuropathic pain. Transdermal drug delivery is considered an ideal therapeutic approach for the management of chronic neurological disorders in the elderly population, It is a simple to use, non-invasive and painless drug delivery system, which provides sustained therapeutic plasma levels of drug for an extended period. Moreover, it bypasses the first-pass metabolism of the active agent, improves bioavailability and reduces undesired adverse effects, which in turn improves patient compliance. Several transdermal delivery systems are currently under investigation for the treatment of Parkinson’s syndrome, Alzheimer’s disorders, and Neurological pain. Drug delivery via the transdermal route is proposed as an alternative remedy to overcome the drawbacks associated with the conventional dosage forms for chronic neurological disorders. The management of Alzheimer’s disease via transdermal drug administration exhibits the greatest therapeutic improvements in the treatment of cognition and global functioning among neuropathic patients. Technological breakthroughs in transdermal drug administration such as microreservior system, microneedles, metered-dose transdermal spray (MDTS), needle-free injections, ultrasound-based transdermal therapeutic systems have been successfully used to treat neurological disorders. For example microneedle (MN) is a highly efficient and versatile device due to its distinctive properties. Ultrasounds have been very popular for the delivery of bioactive agents across the skin barrier. This review focuses on the recent advances of various technologies employed in the transdermal therapeutic systems and its applications towards neurological disorders for achieving patient therapeutic outcomes.

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