scholarly journals CLINICAL EVALUATION OF TERPENE MEDICAMENT EFFECTIVENESS IN A COMPLEX TREATMENT OF CHRONIC GENERALIZED PARODONTITIS

2018 ◽  
Vol 2 (5) ◽  
pp. 133-136
Author(s):  
Марина Дударь ◽  
Marina Dudar ◽  
Владислав Молоков ◽  
Vladislav Molokov ◽  
Оксана Тирская ◽  
...  

The article presents the comparative analysis of application of terpene-containing medicine Antiran (1:3 solution) and 0.06% chlorhexidine bigluconate solution in a complex therapy of patients with chronic generalized parodontitis. According to the curative effect, these drugs are comparable with antibacterial and antiseptic agents, but they act more gently and, as a rule, do not cause side effects. Currently, as a etiotropic therapy of periodontitis, a wide range of drugs affecting the parodontal pathogenic microflora, irrational use of antibacterial agents has acquired the status of a global problem of modern medicine, since it leads to the emergence of resistant strains of microorganisms that are poorly sensitive or resistant to treatment. The medicaments were used in ultrasonic scaling and for passive ultrasonic irrigation of periodontal pockets during curettage process. The results were evaluated according to the PMA, SBI, PI indexes, an extravazation time formation and periodontal pockets depth. The first total time period of clinical observation established that inflammation process was eliminated earlier when Antiran was used. Thus our study demonstrated and substantiated the successful experience of Antiran application in periodontal practice.

2021 ◽  
Vol 25 (4) ◽  
pp. 192-194
Author(s):  
Marina G. Avdeeva

It is difficult for a modern doctor who relies on a wide range of laboratory diagnostic capabilities to imagine the path of mistakes, insights and delusions traveled by doctors of the past. How exactly through clinical observation the disease was observed. The archival article Half-tree-day fever published in the journal is an example of a clinical and epidemic description of an outbreak of an acute infectious disease, the etiology of which remains unknown. The more interesting are the distinguishing issues of differential diagnostics.


Author(s):  
G.V. Bratko ◽  
◽  
D.D. Dmitriev ◽  
V.I. Bratko ◽  
A.N. Trunov ◽  
...  

Purpose. To study the clinical effectiveness of the administration of complex therapy of drugs to the hemolymphocirculatory organ (pterygopalatine fossa) in edematous exophthalmos in patients with endocrine ophthalmopathy complicated by optical neuropathy. Material and methods. The analysis of the results of treatment of 31 patients (62 eyes) with edematous exophthalmos on the background of endocrine ophthalmopathy complicated by optical neuropathy, who applied for help in the Novosibirsk branch of "MNTC "Eye Microsurgery". All patients were prescribed a 10-day course of intensive complex treatment, consisting of injections into the region of hemolymphocirculation (pterygeal fossa) No. 6 (No. 3 on each side) with an interval of 24 hours of a drug mixture, the formulation of which included Lidocaine 20 mg, Dexazone 4 mg, Hemase 3000 units, Dalargin 1 mg, with additional administration of antioxidants, neuroprotectors, vitamins and keratoprotectors. Results. By the end of treatment, all patients had a pronounced positive trend in the form of a significant (from 0.6 to 1.0) increase in visual acuity, a decrease in exophthalmos (from 2,0 to 3,0 mm), and an increase in color and contrast sensitivity. Conclusions. Due to the violation of venous and lymphatic outflow due to the thickening of extraocular muscles and retrobulbar fiber, injection of drugs with a wide range of decongestant and metabolic effects into the hemolymphocirculation region (pterygeal fossa) is justified and effective. Key words: endocrine ophthalmopathy, optical neuropathy, complex therapy.


2011 ◽  
Vol 18 (4) ◽  
pp. 49-53
Author(s):  
Evgeniy Aleksandrovich Tseymakh ◽  
A A Men'shikov ◽  
A V Bondarenko ◽  
S Yu Kuznetsov ◽  
I N Gontarev ◽  
...  

Results of comparative study of cryoplasmic therapy applied at complex treatment of 168 patients with disseminated intravascular coagulation syndrome were presented. In 56 patients complex therapy included cryosupernatant plasma (CSNP) and 112 patients received fresh frozen plasma (FFP). Study of coagulation and fibrinolysis system showed that restoration of fibrinolysis activity, physiologic anticoagulants and normalization of plasma fibrinogen levels occurred sooner when CSNP was used. Application of CSNP promoted the relaxation of disease severity, prevention of thrombotic complications and decrease of lethality (by 14.2%) to a greater extent as compared to FFP use.


2020 ◽  
Vol 30 (3) ◽  
pp. 489-504
Author(s):  
SIMON WOLFGANG FUCHS

AbstractThis article draws on a wide range of Shiʽi periodicals and monographs from the 1950s until the present day to investigate debates on the status of Sayyids in Pakistan. I argue that the discussion by reformist and traditionalist Shiʽi scholars (ʽulama) and popular preachers has remained remarkably stable over this time period. Both ‘camps’ have avoided talking about any theological or miracle-working role of the Prophet's kin. This phenomenon is remarkable, given the fact that Sayyids share their pedigree with the Shiʽi Imams, who are credited with superhuman qualities. Instead, Shiʽi reformists and traditionalists have discussed Sayyids predominantly as a specific legal category. They are merely entitled to a distinct treatment as far as their claims to charity, patterns of marriage, and deference in daily life is concerned. I hold that this reductionist and largely legalising reading of Sayyids has to do with the intense competition over religious authority in post-Partition Pakistan. For both traditionalist and reformist Shiʽi authors, ʽulama, and preachers, there was no room to acknowledge Sayyids as potential further competitors in their efforts to convince the Shiʽi public about the proper ‘orthodoxy’ of their specific views.


2020 ◽  
pp. 82-94 ◽  
Author(s):  
V. O. Belash ◽  
L. R. Urazgalieva ◽  
R. I. Fayzullina ◽  
L. G. Agasarov

Introduction. Degenerative-dystrophic changes in the spine are the most common chronic human diseases. Pronounced clinical manifestations of vertebrogenic diseases are observed during active labor activity and represent one of the most frequent causes of temporary disability. It is also known that any pain syndromes are accompanied by the development of psychovegetative disorders, which reduces the effectiveness of treatment. In recent years, there has been a reasonable increase in the interest of the medical community to the non-drug treatment methods. It is caused by the polypharmacotherapy side effects, an increased numbers of allergic reactions, problems with polypragmasia, and a low level of compliance. At the same time, the question of the possibility of various non-drug treatment methods combining is quite acute.The goal of research is to substantiate the clinical effectiveness of the combined application of osteopathic correction and reflexotherapy in the complex treatment of patients with dorsopathy at the cervical-thoracic level.Materials and methods. A prospective controlled randomized study was conducted on the basis of the medical clinics of LLC «Family Health» (Kazan) and ANO «Center for SEB assistance» (Kazan) from April 2018 to May 2019. The study involved 52 people with dorsopathy at the cervical-thoracic level, aged from 25 to 45 years. In accordance with the exclusion criteria, 7 people dropped out of the study. The remaining patients (45 people), depending on the used treatment method, were divided by a simple randomization method using a random number generator into three groups of 15 people. The first group (main group) received osteopathic correction and reflexotherapyon the background of standard drug therapy; the second and the third groups (control groups) received only osteopathic correction orreflexotherapy, respectively, on the background of standard drug therapy. The osteopathic examination was performed for all patients regardless of the group, before and after the course of therapy, with the formation of an osteopathic conclusion.Also there was the estimation of the degree of pain syndrome severity,the asthenia, and the degree of accumulated emotional and energy charge that does not get out in a person.Results. It was found in the course of the study that the inclusion of osteopathic correction and reflexotherapy in the complex therapy of patients with dorsopathy at the cervical-thoracic level is clinically more effective than the isolated use of these methods. Such complex therapy allows to achieve a more significant reduction in the severity of the pain syndrome by VAS (p<0,05), relief of internal emotional tension (p<0,05), and increase the effectiveness of correction of dominant somatic dysfunction. Based on the obtained data, it could be assumed that reflexotherapy potentiates the effects of osteopathic correction.Conclusion. Based on the study, it can be concluded that the combination of osteopathic correction and reflexotherapy in the treatment of patients with dorsopathy at the cervical-thoracic level increases the clinical effectiveness of the standard drug therapy. At the same time, it is worth noting the potentiating effect of the combined use of two non-medicinal methods. The question of combining of various non-drug treatment methods is quite acute today, so this study will be continued. 


2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.


2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>


Author(s):  
Г. Кульбаева

Аннотация. В статье рассматривается вопрос о функционировании русского языка в образовательном пространстве КГМА. Большое место в работе занимает роль русского языка в учебной деятельности студентов-медиков. Мотивацией к изучению именно, русского языка являются следующие факторы: статус официального языка; возможность привлечь внимание широкого круга специалистов к своим исследованиям; понимание престижности русского языка. В статье нашли отражение различные формы работы по расширению сферы использования русского языка в медицинской академии. В работе уделено внимание и профильным учебным пособиям, разработанным автором статьи. Анализ некоторых заданий позволяет констатировать тот факт, что содержание пособии определено через компетенции, одной из которых является языковая. Ключевые слова:язык обучения, фундаментальные науки, соматические ФЕ, компетентностная основа, профессиональная направленность, жаргонная лексика. Аннотация. Макалада КММАнын билим берүү мейкиндеги орус тилин өздөштүү маселеси каралат. Орус тили студент-медиктердин окуу ишмердигинде чоң роль ойнойт. Расмий тил статусу, өз изилдөөлөрүнө көпчүлүк адистердин көңүлүн буруу мүмкүнчүлүгү, орус тилинин баркын түшүнүү, өзгөчөлөп билүүгө далил болуп эсептелет. Макалада медициналык академияда орус тили колдонуу чөйрөсүн кеңейтүү боюнча иштөөнү ар кандай формалары көрсөтүлгөн. Эмгекте макаланын автору иштеп чыккан адистик окуу колдонмолорго да көңул бурулган. Кээ бир тапшырмалардын анализи колдонмонун мазмуну компетенция, анын бирөөсү тил аркылуу аныкталганын факт катары көрсөтүүгө мүмкүндүк түзөт. Түйүндүү сөздөр: фундаменталдык илимдер, соматикалык фразеологизмдер, компетенттик негиз, профессионалдык багытталыш, жаргондук лексика. Summary. The article discusses the Russian language functioning in the of the KSMA’s educational space. Russian language plays a big role in the educational activity of the medical students. The main motivation of learning the Russian language has the following points: the status of the official language; the opportunity to attract the attention of a wide range of specialists to their research; understanding of the prestige of the Russian language. The article reflected various forms of work to expand the scope of the use of the Russian language at the medical academy. The work focuses on specialized textbooks developed by the author of the article. An analysis of some tasks allows us to state the fact that the content of the manual is determined through competencies, one of which is the language. Key words: teaching language, fundamental sciences, somatic phraseological unit, slang vocabulary.


2020 ◽  
Vol 65 (5-6) ◽  
pp. 30-34
Author(s):  
L. L. Logvina ◽  
D. N. Bayram ◽  
Z. A. Kambachokova ◽  
F. V. Shavaeva ◽  
Z. S. Krymshokalova ◽  
...  

Evaluation of the effectiveness of aminophthalhydroside in the complex treatment of patients with recurrent genital herpes was carried out. The efficacy of the drug was assessed by clinical, biochemical, and immunological criteria. The inclusion of aminophthalhydrazide in the complex therapy of patients with recurrent herpesvirus infection led to an earlier relief of clinical manifestations of the disease, an increase in the relapse period, a decrease in lipid peroxidation products in the blood plasma, an increase in the content of antioxidant defense components, and correction of immunological disorders.


2019 ◽  
Vol 26 (23) ◽  
pp. 4323-4354 ◽  
Author(s):  
Ana Cristina Lima Leite ◽  
José Wanderlan Pontes Espíndola ◽  
Marcos Veríssimo de Oliveira Cardoso ◽  
Gevanio Bezerra de Oliveira Filho

Background: Privileged motifs are recurring in a wide range of biologically active compounds that reach different pharmaceutical targets and pathways and could represent a suitable start point to access potential candidates in the neglected diseases field. The current therapies to treat these diseases are based in drugs that lack of the desired effectiveness, affordable methods of synthesis and allow a way to emergence of resistant strains. Due the lack of financial return, only few pharmaceutical companies have been investing in research for new therapeutics for neglected diseases (ND). Methods: Based on the literature search from 2002 to 2016, we discuss how six privileged motifs, focusing phthalimide, isatin, indole, thiosemicarbazone, thiazole, and thiazolidinone are particularly recurrent in compounds active against some of neglected diseases. Results: It was observed that attention was paid particularly for Chagas disease, malaria, tuberculosis, schistosomiasis, leishmaniasis, dengue, African sleeping sickness (Human African Trypanosomiasis - HAT) and toxoplasmosis. It was possible to verify that, among the ND, antitrypanosomal and antiplasmodial activities were between the most searched. Besides, thiosemicarbazone moiety seems to be the most versatile and frequently explored scaffold. As well, phthalimide, isatin, thiazole, and thiazolidone nucleus have been also explored in the ND field. Conclusion: Some described compounds, appear to be promising drug candidates, while others could represent a valuable inspiration in the research for new lead compounds.


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