Prevalence and Clinical Profile of Chronic Kidney Diseases among Pediatric Patients Attending Al-Thawrah General Hospital in Sana’a City, Yemen

2016 ◽  
Vol 33 (3-4) ◽  
pp. 227-248
Author(s):  
Hala A. Al-Kherbash ◽  
Abdulrahman Al-Hadi
Keyword(s):  
General Hospital ◽  
Pediatric Patients ◽  
Kidney Diseases ◽  
Clinical Profile ◽  
Chronic Kidney Diseases

Characteristics of nocardiosis patients with different immune status from a Chinese tertiary general hospital during 8-year period

2019 ◽  
Author(s):  
Lei Huang ◽  
Liying Sun ◽  
Yan Yan
Keyword(s):  
Soft Tissue ◽  
General Hospital ◽  
Species Identification ◽  
Clinical Data ◽  
Antibiotic Susceptibility ◽  
Clinical Characteristics ◽  
Kidney Diseases ◽  
Test Method ◽  
Chronic Kidney Diseases ◽  
Nocardia Species

Abstract Background: Nocardia is an opportunistic pathogen from environment, which is generally thought to infect immunosuppressed patients (ISPs), but recent studies showed it could also cause infections in immunocompetent patients (ICPs). Objective: To compare the clinical characteristics, patients’ outcome, Nocardia species identification and antibiotic susceptibility profiles of nocardiosis between ICPs and ISPs. Methods: The detailed clinical data were collected from all the non-repetitive nocardiosis patients during 2011 and 2018, from a tertiary general hospital in Beijing, China. Then each Nocardia isolate was identified to species level by DNA sequencing. The antibiotic susceptibility testing was performed by E-test method, and interpreted following CLSI M24 document. The clinical and microbiological characteristics between ICPs and ISPs were compared statistically. Results: A total of 23 non-repetitive nocardiosis patients with detailed clinical data were enrolled in this study. Among them, 9 were ICPs and 14 were ISPs. All the skin and soft tissue infections occurred in ICPs (33.3% versus 0%, P<0.05). Bronchiectasis occurred more frequently in ICPs (44.4% versus 21.4%), while chronic kidney diseases and co-infection with aspergillosis occurred more frequently in ISPs (35.7% versus 0%, 35.7% versus 0%, respectively), although they did not reach the statistical significance. There were no significant difference in other clinical characteristics, Nocardia species identification, and antibiotic susceptibility between ISPs and ICPs (P>0.05). Conclusion: Nocardiosis could occur in both ISPs and ICPs. Skin and soft tissue infection and bronchiectasis occurred more frequently in ICPs. Chronic kidney diseases and co-infection with aspergillosis occurred more frequently in ISPs. These characteristics should be noticed by physicians in diagnosis of nocardiosis.

#95: Clinical Profile and Outcome of Pediatric Acute Lymphoblastic Leukemia Patients with Tuberculosis at the Philippine General Hospital

2021 ◽  
Vol 10 (Supplement_1) ◽  
pp. S17-S17
Author(s):  
Maika Kamille Mortel ◽  
Ana Patricia Alcasabas ◽  
Anna Lisa Ong-Lim
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
General Hospital ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Demographic Data ◽  
The Philippines ◽  
Clinical Profile ◽  
Drug Resistant ◽  
Resistant Tuberculosis ◽  
Latent Tb Infection

Abstract Background The Philippines remains one of the countries on the WHO list of high-burden countries for tuberculosis (TB), and malignancy has long been recognized as a risk factor for this disease. This report describes the clinical profile and outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) diagnosed with tuberculosis. Methods Medical records of pediatric patients with ALL consulting at the University of the Philippines – Philippines General Hospital diagnosed from January 2015 to December 2017 (excluding those with concomitant HIV infection) were reviewed. Those diagnosed with tuberculosis infection were further analyzed, obtaining demographic data, results of diagnostics, and treatment. Results Out of 102 patients, 5 were found to have tuberculosis, all of them being male, with an average age of 7.2 years old. All cases were pulmonary, with one patient having multi-drug-resistant TB. PPD was positive in 4 cases, with indurations measuring &gt;10mm, while chest radiographs showed nonspecific findings for 3 patients. Of 3 patients who underwent sputum AFB testing, one had a positive result. While 1 patient was diagnosed with TB and ALL concurrently, majority of patients were diagnosed after entering remission. Three patients completed 6 months of TB treatment, while 1 patient is still on medication for multi-drug-resistant tuberculosis. One patient abandoned treatment. Conclusion In this group of ALL patients, malnutrition and corticosteroid use were not found to be independent risk factors for TB. As TB disease may be due to reactivation of latent TB infection (LTBI) during immunosuppression, screening for LTBI may be a worthwhile strategy to decrease morbidity. Transmission precautions are emphasized to reduce acquired TB infection in immunocompromised populations.

scholarly journals Nephrotoxicity of Herbal Products in Europe—A Review of an Underestimated Problem of Nephrotoxicity of Herbal Products

2021 ◽  
Vol 22 (8) ◽  
pp. 4132
Author(s):  
Katarzyna Kiliś-Pstrusińska ◽  
Anna Wiela-Hojeńska
Keyword(s):  
Kidney Diseases ◽  
Herbal Medicines ◽  
Kidney Injury ◽  
Herbal Products ◽  
Chronic Kidney Diseases ◽  
European Origin ◽  
Synthetic Drugs ◽  
The Many ◽  
Pharmacologically Active ◽  
Traditional Chinese Herbal Medicines

Currently in Europe, despite the many advances in production technology of synthetic drugs, the interest in natural herbal medicines continues to increase. One of the reasons for their popular use is the assumption that natural equals safe. However, herbal medicines contain pharmacologically active ingredients, some of which have been associated with adverse effects. Kidneys are particularly susceptible to injury induced by toxins, including poisonous constituents from medicinal plants. The most recognized herb-induced kidney injury is aristolochic acid nephropathy connected with misuse of certain Traditional Chinese herbal medicines. Data concerning nephrotoxicity of plant species of European origin are scarce. Here, we critically review significant data of the nephrotoxicity of several plants used in European phytotherapy, including Artemisia herba-alba, Glycyrrhiza glabra, Euphorbia paralias, and Aloe). Causative mechanisms and factors predisposing to intoxications from the use of herbs are discussed. The basic intention of this review is to improve pharmacovigilance of herbal medicine, especially in patients with chronic kidney diseases.

scholarly journals Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities

2021 ◽  
Author(s):  
Melissa C. Stein ◽  
Fabian Braun ◽  
Christian F. Krebs ◽  
Madeleine J. Bunders
Keyword(s):  
Kidney Diseases ◽  
Three Dimensional ◽  
Renal Tissue ◽  
Chronic Kidney Diseases ◽  
Immune Mediated ◽  
Primary Epithelial Cell ◽  
Challenges And Opportunities ◽  
Underlying Mechanisms ◽  
Global Population

AbstractAcute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At present, targeted approaches for many kidney diseases are still lacking, as the underlying mechanisms remain insufficiently understood. With the recent development of organoids—a three-dimensional, multicellular culture system, which recapitulates important aspects of human tissues—new opportunities to investigate interactions between renal cells and immune cells in the pathogenesis of kidney diseases arise. To date, kidney organoid systems, which reflect the structure and closer resemble critical aspects of the organ, have been established. Here, we highlight the recent advances in the development of kidney organoid models, including pluripotent stem cell-derived kidney organoids and primary epithelial cell-based tubuloids. The employment and further required advances of current organoid models are discussed to investigate the role of the immune system in renal tissue development, regeneration, and inflammation to identify targets for the development of novel therapeutic approaches of immune-mediated kidney diseases.

scholarly journals Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185476 ◽  
Author(s):  
Yoko Kubo ◽  
Takahiro Imaizumi ◽  
Masahiko Ando ◽  
Masahiro Nakatochi ◽  
Yoshinari Yasuda ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Kidney Function ◽  
Kidney Diseases ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chronic Kidney Diseases ◽  
Japanese Male ◽  
Male Workers
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