Oral ulceration and vesiculobullous conditions in the paediatric patient

Deviations from the normal appearance of pale, pink and healthy mucosa require close monitoring or intervention and may be a sign of an underlying systemic disorder. Therefore, it is important that there is timely identification of abnormalities, appropriate management in primary care and onward referral for investigation to specialist services when required. Oral ulceration is the most common soft tissue abnormality in children, with recurrent aphthous stomatitis being the most common type of ulceration. This article discusses the various causes of oral ulceration in addition to vesiculobullous conditions, which may affect the paediatric patient. CPD/Clinical Relevance: It is important that GDPs are aware of the range of causes of ulcers and blisters presenting in children and are aware of when to refer.

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GAMBARAN PENGETAHUAN MASYARAKAT DESA WIAU LAPI TENTANG STOMATITIS AFTOSA REKUREN

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.5.1.2013.2637 ◽

2013 ◽

Vol 5 (1) ◽

Author(s):

Jefrianto Wololy ◽

Billy J. Kepel ◽

Christy N. Mintjelungan

Keyword(s):

Random Sampling ◽

Clinical Symptoms ◽

Simple Random Sampling ◽

Descriptive Study ◽

Common Type ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Cross Sectional ◽

Mucosal Disease ◽

Cross Sectional Design

Abstract: Recurrent aphthous stomatitis (RAS), commonly known among Indonesian people as "sariawan", is an oral mucosal disease which most often affects people. Based on the clinical symptoms, there are three recognized types of RAS, namely: minor RAS as the most common type, major RAS, and herpetiform RAS. Knowledge about RAS is very useful in the prevention and treatment of RAS. This was a descriptive study with a cross-sectional design. Samples were 75 Wiau Lapi villagers who filled in the questionnaires and were selected by using simple random sampling. This study aimed to reveal the knowledge of the villagers of Wiau Lapi about recurrent aphthous stomatitis. The results showed that the knowledge of the villagers of Wiau Lapi about RAS tested with the questionnaire consisting of 11 questions obtained a percentage of 63.8%. Conclusion: Most villagers of Wiau Lapi had good knowledge about recurrent aphthous stomatitis. Keywords: knowledge, recurrent aphtous stomatitis. Abstrak: Stomatitis aftosa rekuren (SAR) atau yang umum dikenal masyarakat Indonesia sebagai “sariawan”, merupakan penyakit mukosa oral yang paling sering diderita manusia. Sampai saat ini terdapat tiga jenis SAR yang dikenal, dengan gejala klinis masing-masing, yaitu: SAR minor sebagai jenis yang paling umum, SAR mayor, dan SAR herpetiformis. Pemahaman yang baik tentang SAR akan sangat bermanfaat ketika penderita berusaha menangani SAR. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan masyarakat Desa Wiau Lapi tentang stomatitis aftosa rekuren. Penelitian ini menggunakan metode deskriptif dengan cross-sectional design yang dilakukan selama satu bulan. Sampel ialah 75 penduduk desa Wiau Lapi yang mengisi kuesioner dan diseleksi dengan menggunakan simple random sampling. Hasil penelitian menunjukkan bahwa pengetahuan masyarakat Desa Wiau Lapi tentang SAR yang diuji dengan kuesioner yang meliputi 11 pertanyaan mencapai persentase sebesar 63,8 %. Simpulan: Pengetahuan masyarakat Desa Wiau Lapi mengenai SAR sudah tergolong baik. Kata kunci: pengetahuan, stomatitis aftosa rekuren.

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Awareness Regarding Oral Aphthous Ulcers and its Risk Factors Among BDS and MBBS Students-A Cross-Sectional Survey

Journal of The Pakistan Dental Association ◽

10.25301/jpda.303.215 ◽

2021 ◽

Vol 30 (03) ◽

pp. 215-218

Author(s):

Marium Azfar ◽

◽

Saima Qureshi ◽

Syeda Noureen Iqbal ◽

Sadia Rizwan ◽

...

Keyword(s):

Risk Factors ◽

Medical Students ◽

Dental Students ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Oral Ulceration ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Adequate Knowledge ◽

Aphthous Ulcers

OBJECTIVE: The objective of this paper was to assess the awareness regarding oral aphthous ulcers and its risk factors among BDS and MBBS students in private institute of Karachi, Pakistan. METHODOLOGY: A cross-sectional survey was conducted at a private institute of Karachi Pakistan for the duration of six months. Medical and dental students of age more than 18 years of either gender were enrolled in the study using non-probability convenience sampling technique. Pre-designed proforma was used to collect data regarding demographics, history of recurrent aphthous stomatitis and knowledge of oral aphthous ulcers and its risk factors. The knowledge score of 4 out of 6 was considered as adequate knowledge. SPSS version 25 was used to analyze data. RESULTS: Of 150 participants, the mean age was reported as 22.94±1.65 years (range: 21-25 years). In those 150 participants 46 were males (30.7%) and 104 were females (69.3%). Overall mean score of knowledge was 4.35±1.29. Wherein 73% had adequate knowledge regarding oral ulceration and its risk factors. The dental students had significantly higher proportion of adequate knowledge regarding oral ulceration than medical students [p=0.024]. CONCLUSION: Overall students had good knowledge of oral ulceration and its risk factors, wherein knowledge of dental students was better than medical students. KEYWORDS: Oral ulcers; Recurrent Aphthous stomatitis; awareness, oral ulceration, risk factors, eating habits

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Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol32no3.23664 ◽

2020 ◽

Vol 32 (3) ◽

pp. 237

Author(s):

Dewi Zakiawati ◽

Nanan Nur'aeny ◽

Riani Setiadhi

Keyword(s):

Oral Mucosa ◽

Descriptive Study ◽

Medical Data ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Herpes Labialis ◽

Oral Medicine ◽

Oral Ulceration ◽

Outpatient Unit ◽

Dental Hospital

Introduction: Oral ulceration defines as discontinuity of the oral mucosa caused by the damage of both epithelium and lamina propria. Among other types of lesions, ulceration is the most commonly found lesion in the oral mucosa, especially in the outpatient unit. Oral Medicine Integrated Installation (OMII) Department in Universitas Padjadjaran Dental Hospital serves as the centre of oral health and education services, particularly in handling outpatient oral medicine cases. This research was the first study done in the Department which aimed to observe the distribution of oral ulceration in OMII Department university Dental Hospital. The data is essential in studying the epidemiology of the diseases. Methods: The research was a descriptive study using the patient’s medical data between 2010 and 2012. The data were recorded with Microsoft® Excel, then analysed and presented in the table and diagram using GraphPad Prism® Results: During the study, the distribution of oral ulceration cases found in OMII Department was 664 which comprises of traumatic ulcers, recurrent aphthous stomatitis, angular cheilitis, herpes simplex, herpes labialis, and herpes zoster. Additionally, more than 50% of the total case was recurrent aphthous stomatitis, with a precise number of 364. Conclusion: It can be concluded that the OMII Department in university Dental Hospital had been managing various oral ulceration cases, with the most abundant cases being recurrent aphthous stomatitis.

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Oral Ulceration: An Overview of Diagnosis and Management

Primary Dental Journal ◽

10.1177/205016841600500102 ◽

2016 ◽

Vol 5 (1) ◽

pp. 30-33

Author(s):

Priya Thakrar ◽

Shahid I Chaudhry

Keyword(s):

Clinical Decision Making ◽

Systemic Disease ◽

Clinical Decision ◽

Recurrent Aphthous Stomatitis ◽

Healthy Individuals ◽

Oral Ulceration ◽

Diagnosis And Management ◽

Common Complaint ◽

Dental Practitioners ◽

Primary Care Practitioners

Mouth ulcers are a common complaint by patients, with individuals regularly presenting to primary care practitioners for diagnosis and treatment. The aetiology and pathogenesis of oral ulceration is, however, both varied and complex. This article highlights the importance of differentiating recurrent aphthous stomatitis (RAS) in otherwise healthy individuals from recurrent oral ulceration (ROU) secondary to known or unknown systemic disease. An overview of the diagnosis and management of such patients is provided as a framework to guide general dental practitioners’ with clinical decision making on whether to treat or refer to secondary care.

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4CPS-153 Case report: paediatric patient with recurrent aphthous stomatitis treated with thalidomide

10.1136/ejhpharm-2018-eahpconf.244 ◽

2018 ◽

Cited By ~ 1

Author(s):

MA González González ◽

N Ferreras ◽

L Ortega ◽

MA Rodriguez ◽

GM Flores ◽

...

Keyword(s):

Case Report ◽

Paediatric Patient ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis

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Plester sariawan efektif dalam mempercepat penyembuhan stomatitis aftosa rekuren dan ulkus traumatikus

Majalah Kedokteran Gigi Indonesia ◽

10.22146/majkedgiind.22097 ◽

2017 ◽

Vol 3 (2) ◽

pp. 69

Author(s):

Rahmi Amtha ◽

M Marcia ◽

Anggia Irma Aninda

Keyword(s):

Triamcinolone Acetonide ◽

Positive Control ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Oral Diseases ◽

Oral Ulceration ◽

Lesion Diameter ◽

Mouth Ulcer ◽

Specific Medication ◽

Quasi Experimental

Mouth ulcer plaster is effective in accelerating the healing of recurrent aphthous stomatitis and traumatic ulcers. Recurrent aphthous stomatitis (RAS) is one of the most commonly occurring oral diseases. The prevalence of oral ulceration worldwide is 4%, with RAS having the largest proportion (25%). Recurrent aphthous stomatitis is oral ulceration which has a self-limiting disease, but the specific medication to reduce pain caused by lesion is still less varied nowadays. This study aimed to examine the differences in the effectiveness between topical application of hyaluronic acid (HA), mouth ulcer plaster (MUP) and 0.1% triamcinolone acetonide (TA) as a positive control in the healing of RAS and traumatic ulcers (TU). This was a quasi-experimental study by measuring the lesion diameter as well as visual analogue scale (VAS) pre- and post-administration of three types of medication. Kruskal-walis test results show that there are differences in effectiveness (p=0.000) of the three types of medication to cure RAS and TU. There are signicant differences in the reduction of RAS and TU lesion diameter (p = 0.015) and VAS (p = 0.038) with the use of HA and MUP on the 4th day. There is no signicant difference in effectiveness (diameter and VAS) of MUP and TA medication on the fourth day (p = 0.880 and p = 1.000 respectively). There is no signicant difference among HA, MUP and TA on the healing of the lesions on the seventh day (p>0.05). It can be concluded that the effectiveness of MUP is similar to that of topical medications containing corticosteroids in the healing of RAS and traumatic ulcers.ABSTRAKStomatitis aftosa rekuren (SAR) merupakan salah satu penyakit mulut yang paling umum terjadi. Prevalensi ulserasi mulut di seluruh dunia adalah 4%, dengan SAR menempati urutan terbesar yaitu 25%. Stomatitis aftosa rekuren merupakan ulserasi mulut yang memiliki self-limiting disease, namun sediaan obat yang spesifik untuk mengurangi rasa sakit yang ditimbulkan lesi sampai saat ini masih kurang bervariasi. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas antara aplikasi topikal asam hialuronat (AH), plester sariawan (PS) serta triamcinolone acetonide 0,1% (TA) sebagai kontrol positif dalam menyembuhkan SAR dan ulkus traumatikus (UT). Jenis penelitian eksperimental klinis kuasi dengan mengukur diameter lesi serta skala visual analog (VAS) pra dan paska pemberian tiga jenis obat. Hasil uji Kruskal-walis menunjukkan bahwa terdapat perbedaan efektivitas (p=0,000) ketiga jenis obat terhadap penyembuhan SA dan UT. Terdapat perbedaan bermakna penurunan diameter lesi (p = 0,015) dan VAS (p = 0,038) SAR dan UT dengan penggunaan AH dan PS pada hari ke-4. Tidak ada perbedaan bermakna efektivitas (diameter dan VAS) obat PS dan TA pada hari ke-4 (p = 0,880 dan p = 1,000 secara berurutan). Tidak ada perbedaan bermakna antara masing-masing obat AH, PS dan TA terhadap penyembuhan lesi pada hari ke-7 (p >0,05). Kesimpulan efektivitas PS sama dengan obat topikal yang mengandung kortikosteroid dalam menyembuhkan stomatitis aftosa dan ulkus traumatikus.

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Erythrophagocytosis in the Liver in Hemolytic Anemias

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100664 ◽

1968 ◽

Vol 26 ◽

pp. 184-185

Author(s):

O. T. Minick ◽

E. Orfei ◽

F. Volini ◽

G. Kent

Keyword(s):

Acid Phosphatase ◽

Oxidative Damage ◽

Phosphatase Activity ◽

Kupffer Cells ◽

Acid Phosphatase Activity ◽

Common Type ◽

Red Cell ◽

Cell Fragments ◽

Reticulo Endothelial System ◽

Important Site

Hemolytic anemias were produced in rats by administering phenylhydrazine or anti-erythrocytic (rooster) serum, the latter having agglutinin and hemolysin titers exceeding 1:1000.Following administration of phenylhydrazine, the erythrocytes undergo oxidative damage and are removed from the circulation by the cells of the reticulo-endothelial system, predominantly by the spleen. With increasing dosage or if animals are splenectomized, the Kupffer cells become an important site of sequestration and are greatly hypertrophied. Whole red cells are the most common type engulfed; they are broken down in digestive vacuoles, as shown by the presence of acid phosphatase activity (Fig. 1). Heinz body material and membranes persist longer than native hemoglobin. With larger doses of phenylhydrazine, erythrocytes undergo intravascular fragmentation, and the particles phagocytized are now mainly red cell fragments of varying sizes (Fig. 2).

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Ultrastructural diagnosis of peritoneal malignant mesothelioma

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100168906 ◽

1994 ◽

Vol 52 ◽

pp. 234-235

Author(s):

S. Siew

Keyword(s):

Malignant Mesothelioma ◽

Common Type ◽

Abdominal Discomfort ◽

The Body ◽

Metastatic Adenocarcinoma ◽

Common Site ◽

Primary Malignancy ◽

Peritoneal Implant ◽

Morphological Diagnosis ◽

Malignant Neoplasia

Mesothelial cells constitute the lining of the three serous sacs of the body i.e. the pleura, pericardium and peritoneum. The more common type of malignant neoplasia of the serous sacs is seeding by metastatic tumors and primary malignancy of the mesothelium is unusual. Of the three sacs, the pleura is the most common site of malignant mesothelioma. Involvement of the peritoneum is extremely rare.We report 3 cases of malignant mesothelioma of the peritoneum. All of them were female. Their ages were 57, 67 and 72 years, respectively. The patients presented with abdominal discomfort and/or ascites. The extent of the tumors ranged from a peritoneal implant to widespread infiltration of the peritoneum and omentum. Histologic examination in Case 1 showed the presence of a diffusely infiltrating papillary mesothelioma without a sarcomatoid component. A mesodermal element was present in the other two cases. In order to establish a morphological diagnosis of malignant mesothelioma, the possibility has to be excluded of a metastatic adenocarcinoma.

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