scholarly journals The Effect of Pomegranate Juice Extract on Hormonal Changes of Female Wistar Rats Caused by Polycystic Ovarian Syndrome

2015 ◽  
Vol 8 (2) ◽  
pp. 971-977 ◽  
Author(s):  
KARGAR HOSSEIN ◽  
KARGAR LEILA ◽  
TAVAKOL EBRAHIM ◽  
SHAFIEI NAZANIN ◽  
POORGHOLAMI FARZAD ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Polycystic Ovarian Syndrome ◽  
Pomegranate Juice ◽  
Hormonal Changes ◽  
Female Wistar Rats ◽  
Ovarian Syndrome

scholarly journals Biochemical and Toxicological Evaluations of Aqueous Extract of Parquetina nigrescens (Afzel.) leaves on Mifepristone-induced Polycystic Ovarian Syndrome in Rats

2020 ◽  
Vol 10 (2-s) ◽  
pp. 94-101
Author(s):  
Fehintoluwa Joy Femi-olabisi ◽  
Opeyemi Faokunla ◽  
Anthonia Oluyemi Agboola ◽  
Imoleayo Moses Olorunyolemi
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Polycystic Ovarian Syndrome ◽  
Serum Alkaline Phosphatase ◽  
Female Rats ◽  
Distilled Water ◽  
Reference Drug ◽  
Female Wistar Rats ◽  
Ovarian Syndrome

The biochemical and toxicological effects of aqueous extract of Parquetina nigrescens leaves (AEPNL) at the doses of 50, 100, and 200 mg/kg body weight on mifepristone-induced in Polycystic Ovarian Syndrome (PCOS) was investigated in female Wistar rats. Sixty female Wistar rats (190.00 ± 13.00 g) were assigned into 6 groups (A - F) of ten each: animals in group A received 0.5 ml of distilled water orally on daily basis for 30 days while the mifepristonized rats in groups B, C, D and E also received orally 0.5 ml of distilled water, 7.14mg/kg of metformin (reference drug) and same volume of the extract corresponding to 50, 100, and 200 mg/kg body weight of AEPNL respectively after which levels of some biochemical and toxicological indices were determined. AEPNL aggravated mifepristone-treatment related increases in albumin, total protein and liver aspartate aminotransferase activity and mitigated the increases in globulin, total bilirubin, urea, creatinine, liver and serum alkaline phosphatase and alanine aminotransferase activities, and no treatment-related histoarchitectural changes occurred in the liver, kidney and uterus of the female rats. Therefore, the aqueous extract of Parquetina nigrescens leaves attenuated and also aggravated some biochemical parameters in the serum, liver and kidney but with no histological changes in the liver, kidney and uterus of the mifepristonized female Wistar rats. Keywords: Mifepristone, toxicology, Parquetina nigrescens, Polycystic Ovarian Syndrome, histology

scholarly journals Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

2013 ◽  
Vol 169 (4) ◽  
pp. 503-510 ◽  
Author(s):  
M L Hendriks ◽  
T König ◽  
R S Soleman ◽  
T Korsen ◽  
R Schats ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Transvaginal Ultrasound ◽  
Ovarian Hormones ◽  
Pulse Interval ◽  
Hormonal Changes ◽  
Before And After ◽  
Mechanical Manipulation ◽  
Lh Secretion ◽  
Late Follicular Phase ◽  
Ovarian Syndrome

ObjectiveLittle is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. DesignProspective case–control study (2008–2010).MethodsTen PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation.ResultsAll PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P<0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (P=0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, P=0.67). None of the ovarian hormones (estradiol, progesterone, anti-Müllerian hormone, inhibin B, androstenedione and testosterone) changed in either group.ConclusionsOvarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic–pituitary system is the most reasonable explanation.

scholarly journals Effect of bee venom on IL-6, COX-2 and VEGF levels in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

2013 ◽  
Vol 19 (1) ◽  
pp. 32 ◽  
Author(s):  
Latifeh Karimzadeh ◽  
Mohammad Nabiuni ◽  
Homa Kouchesfehani ◽  
Hamed Adham ◽  
Amir Bagheri ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Polycystic Ovarian Syndrome ◽  
Bee Venom ◽  
Estradiol Valerate ◽  
Cox 2 ◽  
Ovarian Syndrome

scholarly journals Valproate, bipolar disorder and polycystic ovarian syndrome

2016 ◽  
Vol 69 (3-4) ◽  
pp. 121-126 ◽  
Author(s):  
Milana Okanovic ◽  
Olga Zivanovic
Keyword(s):  
Bipolar Disorder ◽  
Polycystic Ovarian Syndrome ◽  
Treatment Guidelines ◽  
Polycystic Ovary ◽  
The United States ◽  
Reproductive Age ◽  
Hormonal Changes ◽  
Polycystic Ovaries ◽  
Increased Risk ◽  
Ovarian Syndrome

Introduction. Polycystic ovarian syndrome is a syndrome of ovarian dysfunction with the principal features of hyperandrogenism and polycystic ovary morphology. A large number of studies conducted on this topic have suggested a possible role of anticonvulsants, particularly valproate, in the pathogenesis or risk factors associated with polycystic ovarian syndrome. Bipolar treatment guidelines from Canada and the United States of America recommend valproate as the first line strategy in the acute treatment of bipolar disorder. Discussion. Most persons with bipolar disorder require maintenance treatment. Long-term administration of valproate in women with bipolar disorder or epilepsy is believed to result in the increased risk of hyperandro?genism, menstrual abnormalities and polycystic ovaries. Valproate may also increase the risk of infertility and other associated symptoms of polycystic ovarian syndrome. Therefore, particular caution is indicated in the use of valproate in women of reproductive age. Conclusion. The treatment of the female patients with bipolar disorder presents various challenges for the clinician. Every woman of reproductive age needs to know the risk and benefits of her pharmacologic treatment options. Bipolar disorder should be considered chronic disorder, whose development is largely affected by hormonal changes and reproductive cycle in women. These issues should be researched more thoroughly in order to opt for the most appropriate treatment in women with bipolar disorder.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

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