scholarly journals Extra-immunological role of complement activation in diabetic nephropathy

OA Nephrology ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
T Fujita
Keyword(s):  
Diabetic Nephropathy ◽  
Complement Activation

The lectin-like domain of thrombomodulin interferes with complement activation and protects against diabetic nephropathy

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
H Wang ◽  
V Ilya ◽  
Q Zhou ◽  
T He ◽  
M Thati ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Complement Activation

scholarly journals Role of endocannabinoid CB1 receptors in Streptozotocin-induced uninephrectomised Wistar rats in diabetic nephropathy

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jayarami Reddy Medapati ◽  
Deepthi Rapaka ◽  
Veera Raghavulu Bitra ◽  
Santhosh Kumar Ranajit ◽  
Girija Sankar Guntuku ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Morphological Changes ◽  
Serum Levels ◽  
Cb1 Receptors ◽  
Protective Effects ◽  
Renal Hypertrophy ◽  
Necrosis Factor Alpha

Abstract Background The endocannabinoid CB1 receptor is known to have protective effects in kidney disease. The aim of the present study is to evaluate the potential agonistic and antagonistic actions and to determine the renoprotective potential of CB1 receptors in diabetic nephropathy. The present work investigates the possible role of CB1 receptors in the pathogenesis of diabetes-induced nephropathy. Streptozotocin (STZ) (55 mg/kg, i.p., once) is administered to uninephrectomised rats for induction of experimental diabetes mellitus. The CB1 agonist (oleamide) and CB1 antagonist (AM6545) treatment were initiated in diabetic rats after 1 week of STZ administration and were given for 24 weeks. Results The progress in diabetic nephropathy is estimated biochemically by measuring serum creatinine (1.28±0.03) (p < 0.005), blood urea nitrogen (67.6± 2.10) (p < 0.001), urinary microprotein (74.62± 3.47) (p < 0.005) and urinary albuminuria (28.31±1.17) (p < 0.0001). Renal inflammation was assessed by estimating serum levels of tumor necrosis factor alpha (75.69±1.51) (p < 0.001) and transforming growth factor beta (8.73±0.31) (p < 0.001). Renal morphological changes were assessed by estimating renal hypertrophy (7.38± 0.26) (p < 0.005) and renal collagen content (10.42± 0.48) (p < 0.001). Conclusions From the above findings, it can be said that diabetes-induced nephropathy may be associated with overexpression of CB1 receptors and blockade of CB1 receptors might be beneficial in ameliorating the diabetes-induced nephropathy. Graphical abstract

Gender bias in the genetic vulnerability towards type 2 diabetes and diabetic nephropathy: Role of forkhead box Protein3 transcription factor gene variants

Gene ◽  
2021 ◽  
Vol 774 ◽  
pp. 145426
Author(s):  
Swetha Chikoti ◽  
Umme Najiya Mahwish ◽  
Sree Bhushan Raju ◽  
Sumanlatha Gaddam ◽  
Parveen Jahan
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Diabetic Nephropathy ◽  
Gender Bias ◽  
Gene Variants ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Forkhead Box
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