Perfecting people: the inexorable rise of prevention science

2017 ◽  
Author(s):  
David Wastell ◽  
Sue White
Keyword(s):  
Economic Modeling ◽  
Prevention Science ◽  
Evidence Based ◽  
Developmental Origins ◽  
Human Flourishing ◽  
Fundamental Limitations ◽  
Policy Interventions ◽  
Early Twenty ◽  
Health And Disease ◽  
Late Twentieth

This chapter reviews the rise of prevention science in the late twentieth and early twenty first centuries. Located within the developmental origins of health and disease paradigm, prevention science promotes intervention to stop damage and ensure optimal human flourishing. Prevention science combines infant determinism, economic modeling and versions of evidence-based practice, with consequences for concepts of normality. Although persuasive, we illustrate the fundamental limitations and flaws of the macro-economical approach, with reference to the influential work of James Heckman. The use of biomarkers to enable more effective targeting of policy interventions is highlighted, although we note that the benefits of such approaches are marginal.

scholarly journals Developmental Origins of Health and Disease: Integrating Environmental Influences

Endocrinology ◽  
2015 ◽  
Vol 156 (10) ◽  
pp. 3416-3421 ◽  
Author(s):  
Jerrold J. Heindel ◽  
John Balbus ◽  
Linda Birnbaum ◽  
Marie Noel Brune-Drisse ◽  
Philippe Grandjean ◽  
...  
Keyword(s):  
Health Program ◽  
Environmental Influences ◽  
Environmental Chemicals ◽  
Noncommunicable Diseases ◽  
Integrative Approach ◽  
Developmental Origins ◽  
Policy Interventions ◽  
Disease Occurrence ◽  
Animal Data ◽  
Health And Disease

Abstract There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned with understanding the pathophysiological basis for how environmental influences acting during early development influence the risk of later noncommunicable diseases. Similarly, there is no global research or public health program built around the DOHaD paradigm that encompasses all aspects of environment. To better inform the global health efforts aimed at addressing the growing epidemic of chronic noncommunicable diseases of environmental origin, we propose a two-pronged approach: first, to make it clear that the current concept of DOHaD comprehensively includes a range of environmental factors and their relevance to disease occurrence not just throughout the life span but potentially across several generations; and second, to initiate the discussion of how adoption of DOHaD can promote a more realistic, accurate, and integrative approach to understanding environmental disruption of developmental programming and better inform clinical and policy interventions. (Endocrinology 156: 3416–3421, 2015)

Exile, Diaspora, and Return

2017 ◽  
Author(s):  
Luis Roniger ◽  
Leonardo Senkman ◽  
Saúl Sosnowski ◽  
Mario Sznajder
Keyword(s):  
Systematic Analysis ◽  
The Arts ◽  
Scientific Disciplines ◽  
Early Twenty ◽  
Transnational Connections ◽  
Late Twentieth ◽  
Institutional Impact ◽  
Global Arena ◽  
Education Science ◽  
The Impact

This book explores how Argentina, Chile, Paraguay, and Uruguay have been affected by postexilic relocations, transnational migrant displacements, and diasporas. It provides a systematic analysis of the formation of exile communities and diaspora politics, the politics of return, and the agenda of democratization in the late twentieth and early twenty-first centuries, focusing on the impact of intellectuals, academics, activists, and public figures who had experienced exile on the reconstitution and transformation of their societies following democratization. Readers are offered a kaleidoscope of intellectual itineraries, debates, and contributions held in the public domain by individuals who confronted and fought authoritarian rule. The book covers their contributions to the restructuring and transformation of scientific disciplines and of the humanities and the arts, as well as their collective institutional impact on higher education, science and technology, and public institutions. Bringing together sociopolitical, cultural, and policy analysis with the testimonies of dozens of intellectuals, academics, political activists, and policymakers, the book addresses the impact of exile on people’s lives and on their fractured experiences, the debates and prospects of return, the challenges of dis-exile and postexilic trends, and, finally, the ways in which those who experienced exile impacted democratized institutions, public culture, and discourse. It also follows some crucial shifts in the frontiers of citizenship, moving analysis to transnational connections and permanent diasporas, including the diasporas of knowledge that increasingly changed the very meaning of being national and transnational, while connecting those countries to the global arena.

Financial Crises and the Public Discourse on Financial Elites

2018 ◽  
Author(s):  
Youssef Cassis ◽  
Giuseppe Telesca
Keyword(s):  
Great Depression ◽  
Great Recession ◽  
Public Discourse ◽  
Codes Of Conduct ◽  
The Public ◽  
The Great Recession ◽  
The Great Depression ◽  
Early Twenty ◽  
Before And After ◽  
Late Twentieth

Why were elite bankers and financiers demoted from ‘masters’ to ‘servants’ of society after the Great Depression, a crisis to which they contributed only marginally? Why do they seem to have got away with the recent crisis, in spite of their palpable responsibilities in triggering the Great Recession? This chapter provides an analysis of the differences between the bankers of the Great Depression and their colleagues of the late twentieth/early twenty-first century—regarding their position within, and attitude towards the firm, work culture, mental models, and codes of conduct—complemented with a scrutiny of the public discourse on bankers and financiers before and after the two crises. The authors argue that the (relative) mildness of the Great Recession, compared to the Great Depression, has contributed to preserve elite bankers’ and financiers’ status, income, wealth, and influence. Yet, the long-term consequences of their loss of reputational capital are difficult to assess.

Continuing Visions

2018 ◽  
Author(s):  
Linda Freedman
Keyword(s):  
Social Activism ◽  
William Blake ◽  
First Century ◽  
Ridley Scott ◽  
American Novel ◽  
Early Twenty ◽  
Protest Group ◽  
Late Twentieth ◽  
Twenty First Century ◽  
Dead Man

The questions that drove Blake’s American reception, from its earliest moments in the nineteenth century through to the explosion of Blakeanism in the mid-twentieth century, did not disappear. Visions of America continued to be part of Blake’s late twentieth- and early twenty-first century American legacy. This chapter begins with the 1982 film Blade Runner, which was directed by the British Ridley Scott but had an American-authored screenplay and was based on a 1968 American novel, Do Androids Dream of Electric Sheep? It moves to Jim Jarmusch’s 1995 film, Dead Man and Paul Chan’s twenty-first century social activism as part of a protest group called The Friends of William Blake, exploring common themes of democracy, freedom, limit, nationhood, and poetic shape.

American Obscurantism

2018 ◽  
Author(s):  
Peter Lurie
Keyword(s):  
American Literature ◽  
William Faulkner ◽  
Herman Melville ◽  
Edgar Allan Poe ◽  
Hart Crane ◽  
Stanley Kubrick ◽  
Early Twenty ◽  
Racial History ◽  
Late Twentieth ◽  
Ongoing Development

American Obscurantism argues for a salutary indirection in U.S. culture. From its earliest canonical literary works through films of the late twentieth and early twenty-first centuries, the most compelling manifestations of America’s troubled history have articulated this content through a unique formal and tonal obscurity. Envisioning the formidable darkness attending racial history at nearly every stage of the republic’s founding and ongoing development, writers such as William Faulkner and Hart Crane, and directors like the Coen brothers and Stanley Kubrick, present a powerful critique of American conquest, southern plantation culture, and western frontier ideology. American Obscurantism engages the basis of these explorations in Edgar Allan Poe and Herman Melville, each of whom present notable occlusions in their characters’ racial understanding, an obtuseness or naivety that is expressed by a corresponding formal opacity. Such oblique historicity as the book describes allows a method at odds with—and implicitly critical of—the historicizing trend that marked literary studies in the wake of the theoretical turn. The book thus restores an emphasis on aesthetic and medium-specific features to argue for a formalist historicity. Working through challenges to an implicitly white, bourgeois, heteronormative polity, American Obscurantism posits an insistent, vital racial otherness at the heart of American literature and cinema. It examines this pattern across a canon that shows more self-doubt than assuredness, arguing for the value of openness and questioning in place of epistemological or critical certainty.

Dewey and Pragmatist Feminist Philosophy

2017 ◽  
pp. 270-290
Author(s):  
Lisa Heldke
Keyword(s):  
Political Philosophy ◽  
Philosophy Of Education ◽  
Family Members ◽  
Value Theory ◽  
Feminist Epistemology ◽  
First Century ◽  
Feminist Philosophy ◽  
Small Field ◽  
Early Twenty ◽  
Late Twentieth

John Dewey’s record as a feminist and an advocate of women is mixed. He valued women intellectual associates whose influences he acknowledged, but did not develop theoretical articulations of the reasons for women’s subordination and marginalization. Given his mixed record, this chapter asks, how useful is Dewey’s work as a resource for feminist philosophy? It begins with a survey of the intellectual influences that connect Dewey with a set of women family members, colleagues, and students. It then discusses Dewey’s influence on the work of late twentieth- and early twenty-first-century pragmatist feminist philosophers. Dewey’s influence has been strongest in the fields of feminist epistemology, philosophy of education, and social and political philosophy. Although pragmatist feminist philosophy remains a small field within feminist philosophy, this chapter argues that its conceptual resources could be put to further good use, particularly in feminist metaphysics, epistemology, and value theory.

History, the Hindu Right, and Subversion of Brahmanical-Hindu Political Thought

2019 ◽  
pp. 239-260
Author(s):  
Stuart Gray
Keyword(s):  
Political Theory ◽  
Political Thought ◽  
Positive Answer ◽  
Source Material ◽  
Caste System ◽  
Hindu Tradition ◽  
Early Twenty ◽  
Indian Nationalism ◽  
Late Twentieth ◽  
Locus Classicus

How can scholars critically engage premodern Indic traditions without falling prey to Hindu conservatism or Brahmanical-Hindu apologism? This question is pressing for Indic political theory and contemporary Indian democracy because of ethnically exclusivist, Hindu nationalist movements that have emerged in the late twentieth and early twenty-first centuries. This chapter argues that a positive answer to the question must begin by taking seriously the tremendous pluralism in India’s political and philosophical history, which requires systematically engaging with premodern source material and uncovering the internal pluralism within a longer and larger Brahmanical-Hindu tradition of political thought. The author explains how it is both possible and politically necessary to internally subvert Brahmanical-Hindu political thought, which can help diffuse essentialist and exclusivist arguments coming from the Hindu right. Locating such plurality and engaging in internal subversion can help challenge historical justifications for Indian nationalism and contribute to decolonization, thus contesting the Hindu right on its own conceptual and genealogical turf. To advance this argument, the author provides a critical reinterpretation of the infamous “Puruṣa Sūkta,” which is often viewed as the locus classicus of the modern caste system, providing a novel interpretation that challenges caste hierarchy and supplies new resources for democratic thought and practice in India.

scholarly journals Targeting the Renin–Angiotensin–Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins

2021 ◽  
Vol 22 (5) ◽  
pp. 2298
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Kidney Disease ◽  
Current Knowledge ◽  
Current Evidence ◽  
Developmental Origins ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Health And Disease ◽  
Nitric Oxide Deficiency ◽  
Developing Kidney ◽  
Prevention Of Hypertension

The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney disease. The developing kidney can be programmed by various early-life insults by so-called renal programming, resulting in hypertension and kidney disease in adulthood. This theory is known as developmental origins of health and disease (DOHaD). Conversely, early RAAS-based interventions could reverse program processes to prevent a disease from occurring by so-called reprogramming. In the current review, we mainly summarize (1) the current knowledge on the RAAS implicated in renal programming; (2) current evidence supporting the connections between the aberrant RAAS and other mechanisms behind renal programming, such as oxidative stress, nitric oxide deficiency, epigenetic regulation, and gut microbiota dysbiosis; and (3) an overview of how RAAS-based reprogramming interventions may prevent hypertension and kidney disease of developmental origins. To accelerate the transition of RAAS-based interventions for prevention of hypertension and kidney disease, an extended comprehension of the RAAS implicated in renal programming is needed, as well as a greater focus on further clinical translation.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

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