Hierarchical transfer of stereochemical information in synthetic macromolecules

2002 ◽  
Vol 74 (11) ◽  
pp. 2021-2030 ◽  
Author(s):  
J. J. L. M. Cornelissen
Keyword(s):  
Recent Literature ◽  
Structural Information ◽  
Building Blocks ◽  
Information Storage ◽  
Self Organization ◽  
Protein Polymer ◽  
Polymer Hybrid ◽  
Recent Developments ◽  
Quaternary Structures ◽  
Synthetic Macromolecules

In Nature, a wide variety of complex tasks (e.g., catalysis, transport, and information storage) is performed by biomacromolecules with precise composition, dimensions, and architecture. To achieve the precise organization required for efficient function, structural information is built into the smallest building blocks of biomacromolecules (i.e., amino and nucleic acids) and subsequently transferred in a hierarchical fashion to form larger quaternary structures. These construction principles have been an inspiration for synthetic and supramolecular chemists alike, and a number of synthetic biomimetic helical macromolecules have been reported in the recent literature. Here, some recent developments in the field of helical polyisocyanides will be reviewed in combination with new prospects on the self-organization of protein/polymer hybrid architectures.

scholarly journals Hierarchical structures via self-assembling protein-polymer hybrid building blocks

Polymer ◽  
2012 ◽  
Vol 53 (26) ◽  
pp. 6045-6052 ◽  
Author(s):  
Patrick van Rijn ◽  
Nathalie C. Mougin ◽  
Alexander Böker
Keyword(s):  
Hierarchical Structures ◽  
Building Blocks ◽  
Protein Polymer ◽  
Self Assembling ◽  
Polymer Hybrid

Materials for Electron Beam Information Storage

1969 ◽  
Vol 27 ◽  
pp. 152-153 ◽  
Author(s):  
D. E. Speliotis
Keyword(s):  
Magnetic Field ◽  
Electron Beam ◽  
Recent Literature ◽  
Electron Beams ◽  
Information Storage ◽  
The Subject ◽  
The Magnetic Field

The interaction of electron beams with a large variety of materials for information storage has been the subject of numerous proposals and studies in the recent literature. The materials range from photographic to thermoplastic and magnetic, and the interactions with the electron beam for writing and reading the information utilize the energy, or the current, or even the magnetic field associated with the electron beam.

Combinatorial Peptide Libraries for Selecting Inorganic-Binding Proteins: A Step in Molecular Biomimetics

2003 ◽  
Vol 773 ◽  
Author(s):  
C. Tamerler ◽  
S. Dinçer ◽  
D. Heidel ◽  
N. Karagûler ◽  
M. Sarikaya
Keyword(s):  
Binding Proteins ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Inorganic Materials ◽  
Combinatorial Peptide Libraries ◽  
Self Assembling ◽  
Complex Functions ◽  
Recent Developments ◽  
Specific Proteins ◽  
Molecular Biomimetics

AbstractProteins, one of the building blocks in organisms, not only control the assembly in biological systems but also provide most of their complex functions. It may be possible to assemble materials for practical technological applications utilizing the unique advantages provided by proteins. Here we discuss molecular biomimetic pathways in the quest for imitating biology at the molecular scale via protein engineering. We use combinatorial biology protocols to select short polypeptides that have affinity to inorganic materials and use them in assembling novel hybrid materials. We give an overview of some of the recent developments of molecular engineering towards this goal. Inorganic surface specific proteins were identified by using cell surface and phage display technologies. Examples of metal and metal oxide specific polypeptides were represented with an emphasis on certain level of specificities. The recognition and self assembling characteristics of these inorganic-binding proteins would be employed in develeopment of hybrid multifunctional materials for novel bio- and nano-technological applications.

scholarly journals Geometric Effect for Biological Reactors and Biological Fluids

2018 ◽  
Vol 5 (4) ◽  
pp. 110 ◽  
Author(s):  
Kazusa Beppu ◽  
Ziane Izri ◽  
Yusuke Maeda ◽  
Ryota Sakamoto
Keyword(s):  
Biological Fluids ◽  
Biological Systems ◽  
Self Organization ◽  
Active Matter ◽  
Confined Space ◽  
Self Organized ◽  
Motile Cells ◽  
Recent Developments ◽  
A Cell

As expressed “God made the bulk; the surface was invented by the devil” by W. Pauli, the surface has remarkable properties because broken symmetry in surface alters the material properties. In biological systems, the smallest functional and structural unit, which has a functional bulk space enclosed by a thin interface, is a cell. Cells contain inner cytosolic soup in which genetic information stored in DNA can be expressed through transcription (TX) and translation (TL). The exploration of cell-sized confinement has been recently investigated by using micron-scale droplets and microfluidic devices. In the first part of this review article, we describe recent developments of cell-free bioreactors where bacterial TX-TL machinery and DNA are encapsulated in these cell-sized compartments. Since synthetic biology and microfluidics meet toward the bottom-up assembly of cell-free bioreactors, the interplay between cellular geometry and TX-TL advances better control of biological structure and dynamics in vitro system. Furthermore, biological systems that show self-organization in confined space are not limited to a single cell, but are also involved in the collective behavior of motile cells, named active matter. In the second part, we describe recent studies where collectively ordered patterns of active matter, from bacterial suspensions to active cytoskeleton, are self-organized. Since geometry and topology are vital concepts to understand the ordered phase of active matter, a microfluidic device with designed compartments allows one to explore geometric principles behind self-organization across the molecular scale to cellular scale. Finally, we discuss the future perspectives of a microfluidic approach to explore the further understanding of biological systems from geometric and topological aspects.

Droplet-microfluidics towards the assembly of advanced building blocks in cell mimicry

Nanoscale ◽  
2016 ◽  
Vol 8 (47) ◽  
pp. 19510-19522 ◽  
Author(s):  
Adam Armada-Moreira ◽  
Essi Taipaleenmäki ◽  
Fabian Itel ◽  
Yan Zhang ◽  
Brigitte Städler
Keyword(s):  
Building Blocks ◽  
Droplet Microfluidics ◽  
Spherical Particles ◽  
Recent Developments

This minireview outlines recent developments in droplet microfluidics regarding the assembly of nanoparticles, Janus-shaped and other non-spherical particles, and cargo-loaded particles which could potentially be employed as building blocks in cell mimicry.

scholarly journals Emergence and Self-Organisation of Complex Systems: the role of energy flows and information a philosophical approach

2018 ◽  
Vol 2 (1) ◽  
pp. 31 ◽  
Author(s):  
Norbert Fenzl
Keyword(s):  
Complex Systems ◽  
Driving Forces ◽  
Open Systems ◽  
Structural Information ◽  
Self Organization ◽  
Specific Information ◽  
Philosophical Approach ◽  
Energy Flows ◽  
Energy And Material Flows

How order emerges from noise? How higher complexity arises from lower complexity? For what reason a certain number of open systems start interacting in a coherent way, producing new structures, building up cohesion and new structural boundaries? To answer these questions we need to precise the concepts we use to describe open and complex systems and the basic driving forces of self-organization.   We assume that self-organization processes are related to the flow and throughput of Energy and Matter and the production of system-specific Information. These two processes are intimately linked together: Energy and Material flows are the fundamental carriers of signs, which are processed by the internal structure of the system to produce system-specific structural Information (Is). So far, the present theoretical reflections are focused on the emergence of open systems and on the role of Energy Flows and Information in a self-organizing process. Based on the assumption that Energy, Mass and Information are intrinsically linked together and are fundamental aspects of the Universe, we discuss how they might be related to each other and how they are able to produce the emergence of new structures and systems. 

scholarly journals WATER STRUCTURES IN MECHANICAL FIELDS

2015 ◽  
pp. 126-133
Author(s):  
V. D. Shantarin ◽  
M. Yu. Zemenkova
Keyword(s):  
Electric Conductivity ◽  
Structural Information ◽  
Pure Water ◽  
Weak Field ◽  
Fractal Model ◽  
Hexagonal Structure ◽  
Self Organization ◽  
Equilibrium System ◽  
Concentration Of Ions ◽  
Free Molecules

This article is devoted to studying the properties of water and its model. It is shown that the existing models are not able to explain the entire set of properties of water, considering water as a non-equilibrium system and possessing the properties of self-organization and sensitive to weak field effects. The results of the authors’ research confirm a cluster-fractal model which considers water as a mixture of free molecules and fragments with the ordered hexagonal structure. It is shown that pure water electric conductivity depends on concentration of ions and the water capability of a relay way of transfer of these ions, which depends on its structural- information state.

Nano-Sized and Nanocrystalline Calcium Orhophosphates in Biomedical Engineering

2009 ◽  
Vol 3 ◽  
pp. 59-92 ◽  
Author(s):  
Sergey V. Dorozhkin
Keyword(s):  
Bone Repair ◽  
Dental Enamel ◽  
Building Blocks ◽  
Research Area ◽  
Future Research ◽  
Biological Origin ◽  
Current State ◽  
Calcium Orthophosphates ◽  
Recent Developments ◽  
Hard Tissue Engineering

There has been much recent activity in the research area of nanoparticles and nanocrystalline materials, in many fields of science and technology. This is due to their outstanding and unique physical, mechanical, chemical and biological characteristics. Recent developments in biomineralization have demonstrated that nano-sized particles play an important role in the formation of the hard tissues of animals. It is well established that the basic inorganic building blocks of bones and teeth of mammals are nano-sized and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds of nanocrystals of biological apatite are found to combine into self-assembled structures under the control of bio-organic matrixes. It was also confirmed experimentally that the structure of both dental enamel and bones could be mimicked by an oriented aggregation of nano-sized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nano-sized and nanocrystalline calcium orthophosphates for clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various cells were detected on smaller crystals of calcium orthophosphates. Furthermore, studies revealed that the differentiation of various cells was promoted by nano-sized calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have the potential to revolutionize the field of hard tissue engineering, in areas ranging from bone repair and augmentation to controlled drug delivery devices. This paper reviews the current state of knowledge and recent developments of various nano-sized and nanocrystalline calcium orthophosphates, covering topics from the synthesis and characterization to biomedical and clinical applications. This review also provides possible directions of future research and development.

Cybersecurity in Israel

2021 ◽  
pp. 630-648
Author(s):  
Lior Tabansky
Keyword(s):  
Soft Power ◽  
Intelligent Systems ◽  
Critical Infrastructure ◽  
Building Blocks ◽  
Strategic Choices ◽  
Innovation Ecosystem ◽  
Policy Goals ◽  
Recent Developments ◽  
Innovation Capacity ◽  
Economic Boom

The long-standing pillars in the grand strategy of Israel—namely, the qualitative edge principle and self-reliance in defence—enabled considerable cybersecurity achievements. Israel, the sole developed nation facing existential threats, has carried out audacious cyberspace operations yet never suffered material damage from cyberattacks. ‘Made in Israel’ inventions have long been embedded in building blocks of the global digital technologies, and drive much of the economic boom. As high-technology innovation flourishes, strategic choices taken over many decades created the foundations of Israel’s vibrant innovation ecosystem. Power, the currency of international relations, undergoes technology-driven change. Innovation capacity grows in importance in periods of profound change. Cyber power must be smart, integrating hard and soft power. The official Israel now shares sensitive cybersecurity expertise with foreign stakeholders, aiming to advance a range of foreign policy goals from counterterrorism to sustainable development. The milestones in Israel’s national cybersecurity evolution include the 2002 state-guided Critical Infrastructure Protection (CIP); the 2011 official national cybersecurity strategy with ambitious goals and comprehensive scope; and the most recent developments in the Israel National Cyber Directorate (INCD) and the Israel Defence Forces (IDF). However, Israel’s cybersecurity journey is far from complete. Harnessing digital transformation, in particular narrow artificial intelligence and intelligent systems, requires further profound innovation in national security. This chapter outlines four guiding principles and forces shaping Israel’s cybersecurity, and sketches three long-term policy challenges for Israel. As long as a coherent strategy guides innovation, Israel as well as other small nations can gain and utilize ample cyber power.

Towards Macro-Economic Convergence in SACU: The Position of Botswana

2020 ◽  
Vol 41 (2) ◽  
Author(s):  
Mabutho Shangase
Keyword(s):  
Economic Policy ◽  
Regional Integration ◽  
Secondary Data ◽  
Free Trade Area ◽  
Building Blocks ◽  
Customs Union ◽  
Economic Convergence ◽  
Trade Area ◽  
Recent Developments

In light of recent developments such as the African Continental African Free Trade Area agreement (AfCFTA), incrementalist approaches to regional inte gration that focus on sub-regions seems to have been pushed to the backburner as more focus puts the entire African continent at the centre of integration processes. With all its potential, gradual macro-economic convergence has accordingly been neglected. Discussions on macro-economic convergence have on the other hand been cast over the broader sub-region such as the Southern African Development Community (SADC) where a number of indicators and targets have been identified and pursued closely. Whilst looking at Botswana as a point of departure, this paper argues that incremental macro-economic convergence is pivotal to broader regional integration and the Southern African Customs Union (SACU) provides an ideal stepping-stone. An incrementalist approach to macro-economic convergence as well as broader regional integration should begin with identifying key formal institutions that serve as custodians of macro-economic policy such as the central banks and departments of finance or treasuries. Using secondary data sources, with Botswana as a case study, this paper foregrounds macro-economic convergence, macro-economic policy making institutions, and SACU as critical building blocks for broader regional integration.

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