scholarly journals The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV

2021 ◽  
Vol 15 (11) ◽  
pp. e0009887
Author(s):  
Marília Brasil Xavier ◽  
Carla Andréa Avelar Pires ◽  
Cláudia Maria de Castro Gomes ◽  
Gabriela Fernandes Rodrigues ◽  
Débora Pinheiro Xavier ◽  
...  
Keyword(s):  
Analytical Study ◽  
Life Quality ◽  
Skin Lesions ◽  
Treg Cells ◽  
Tissue Level ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Immunodeficiency Virus ◽  
The Difference

Background Brazil remains endemic for infection by the human immunodeficiency virus (HIV) and leprosy, having a major impact on public health and the life quality of affected patients. Although the relevance of this co-infection is recognized, several aspects, such as the immune response, are not yet fully understood. The objective of this study was to investigate the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics (CD4, CD8, and CV), and the immune reconstitution syndrome in HIV-leprosy co-infection. Methodology/Principal findings An observational, cross-sectional, and analytical study was carried out comparing four groups of patients: those with concomitant diagnosis of leprosy and HIV infection without a leprosy reaction, those with leprosy and HIV co-infection patients with a reverse reaction (RR), those with leprosy without HIV and without reaction, and those with leprosywithout HIV and with RR. The patients were diagnosed at a dermatology outpatient clinic located in Belém, Pará, Brazil, from 2003 to 2017. In the sample studied, there was a positive correlation between FOXP3+ cell density and viral load, negative correlation with blood CD4+ (not statistically significant), significant positive correlation in CD8 count in patients with leprosy reaction, and positive relationship in patients with IRIS. The density of cells expressing FOXP3 was higher in the BL/LL forms in patients without HIV, although the difference was not statistically significant. However, the cell mean was higher in the TT/BT forms in patients co-infected with leprosy and HIV, showing contradictory results. Conclusions/Significance These findings support that higher activity of the HIV may stimulate or result in a higher expression of FOXP3-Tregs and that they may be involved in active immunosuppression observed at the infection site at the tissue level. This supports the need to expand studies on FOXP3+ Treg cells in co-infected patients.

scholarly journals PERBEDAAN KETERAMPILAN PERTOLONGAN PERSALINAN NORMAL ANTARA MEDIA MODEL DAN MEDIA VIDEO PADA MAHASISWA SEMESTER TIGA DI PRODI DIII KEBIDANAN STIKES MUHAMMADIYAH LAMONGAN TAHUN 2016

2018 ◽  
Vol 9 (2) ◽  
pp. 8
Author(s):  
Kustini Kustini
Keyword(s):  
Analytical Study ◽  
Simple Random Sampling ◽  
Learning Objectives ◽  
Cross Sectional ◽  
Normal Delivery ◽  
Knowledge And Skills ◽  
Independent Variable ◽  
The Difference ◽  
Low Performance

Lack of midwives, knowledge and skills leads to low performance and quality of service. The effort can be done is increase the knowledge and skill, reality shows that most learning using only one kind of media and one time demonstration. The issue is using media is minimize exactly on practical helping labor and laboratories learning in STIKES Muhamadiyah Lamongan.The purpose of this study is to determine the difference skill helping normally labor using model and Video in STIKES Muhammadiyah Lamongan 2016. This research is comparative analytical study with cross sectional approach. The population is 100 students and the sample of 80 student, uses simple random sampling. Independent variable is the use of model and video, dependent variable is skill of helping normally labor.The results is more than a majority respondent who use model is able to doing skill helping normally labor, that 29 respondent (72,5%), and more than majority proficient doing skill helping normally labor, that 24 respondent (60%).Analysis using SPP 16.0 with Mann Whitney test α = 0,05, p=0.000 so p < α, concluded that there are difference skill helping normally labor between using model and video media.Seeing these results it is necessary to use a medium that is thought to correspond to the learning objectives that lead to learning motivation so that skills become better destination.Keywords: media, models, videos, normal delivery

scholarly journals Influence of Childhood Scleroderma on Physical Function and Quality of Life

2010 ◽  
Vol 38 (1) ◽  
pp. 167-173 ◽  
Author(s):  
EILEEN M. BAILDAM ◽  
HOLLY ENNIS ◽  
HELEN E. FOSTER ◽  
LINDSAY SHAW ◽  
ALICE S.E. CHIENG ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Child Health ◽  
Physical Function ◽  
Demographic Data ◽  
Life Quality ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Life Questionnaire ◽  
Cross Sectional

Objective.There have been few studies of quality of life in childhood scleroderma and these focused predominantly on self-perception and the influence of skin lesions. Our cross-sectional study aimed to describe the influence of childhood scleroderma on physical function and quality of life in relation to clinical and demographic measures.Methods.Children with either localized scleroderma or systemic sclerosis (SSc) attending pediatric rheumatology clinics, together with their parents or guardians, were asked to complete a set of 4 validated measures. Clinical and demographic data were provided by consultant pediatric rheumatologists.Results.In total, 28 children and their parents/guardians participated in the study (68% female, median age 13 yrs; 86% localized scleroderma, 14% SSc). The median Child Health Assessment Questionnaire (CHAQ) score was 0.1 (range 0–3, 0 indicating no impairment), the median Child Dermatology Life Quality Index (CDLQI) score was 5 (range 0–30, 0 indicating no impairment), and the median Child Quality of Life Questionnaire (CQOL) function score was 26 (range 0–105, 0 indicating no impairment). Family activity, measured by the Child Health Questionnaire (CHQ-PF50), was also moderately impaired by scleroderma, with a median score of 83 (0–100, 100 indicating no impairment).Conclusion.Scleroderma had only a moderate effect on quality of life and physical function as measured by the 4 validated instruments. Although a small number of children reported greater impairment, this is an encouraging finding, given its potential disfiguring and debilitating effects.

Health related quality of life of rosacea patients in China assessed by DLQI and willingness to pay: Cross-Sectional Questionnaire Study (Preprint)

2020 ◽  
Author(s):  
Yaqun Huang ◽  
Sha Yan ◽  
Hongfu Xie ◽  
Ben Wang ◽  
Zhixiang Zhao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Willingness To Pay ◽  
Disease Duration ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

BACKGROUND Rosacea is a chronic inflammatory dermatosis with facial skin involved, leading to physical and emotional problems, which greatly affected quality of life (QoL) of patients. Dermatology Life Quality Index (DLQI) and willingness to pay (WTP) are well-established instruments assessing the health-related quality of life (HRQoL), while very few studies have been focused on this topic about rosacea in China. OBJECTIVE To investigate HRQoL in Chinese rosacea patients assessed by DLQI and WTP and investigate potential predictors for patients with HRQoL severely affected. METHODS This cross-sectional study was conducted on 973 patients with rosacea. Sociodemographic data, clinical features and DLQI were collected, and WTP was assessed by three standardized items. Multivariable logistic analysis was performed to investigate independent factors influencing QoL. RESULTS 921 questionnaires were accomplished by participants. The mean DLQI score was 11.6 (median 11). Patients were willing to pay an average of $1050.2 or € 896.2 (median $431.4 or € 368.1) for complete cure. 33.3% would like to pay more than 20% of their monthly income to achieve sustainable control. There were positive correlations between WTP with DLQI (P < .05). DLQI could be independently impacted by age (21-30 and 31-40, OR = 3.242 and 3.617, respectively), the occupational requirement of appearance (high, OR = 4.410), disease duration (< 2 years, OR = 1.582), oedema (OR = 1.844) and severity of flushing, burning, stinging and pruritus (severe, OR = 2.003, 1.981, 2.491, 2.249, respectively). There were no significant associations between WTP and most of the clinical factors. CONCLUSIONS The QoL was negatively affected and should not be ignored among rosacea patients in China. Patients aged 21-40y, having occupational requirement of appearance, with the disease duration less than 2 years, and suffering severe flushing and related symptoms were more likely to have severe or very severe limitation of QoL.

Quality of life in Hungarian polio survivors

2021 ◽  
Author(s):  
Erika Viktória Miszory ◽  
Melinda Járomi ◽  
Annamária Pakai
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Sample Selection ◽  
Cross Sectional Study ◽  
Two Dimensions ◽  
Cross Sectional ◽  
Emotional Role ◽  
The Difference ◽  
Polio Survivors

Abstract Aim The number of Hungarian polio patients can be estimated at approximately 3000. Polio infection is currently affecting people 56–65 years of age. The aim of the study was to reveal the quality of life of patients living with polio virus in Hungary. Subject and methods The quantitative cross-sectional study was conducted in January–April 2017 among polyomyelitis patients living in Hungary. In the non-random, targeted, expert sample selection, the target group was composed of patients infected with poliovirus (N = 268). We have excluded those who refused to sign the consent statement. Our data collection method was an SF-36 questionnaire. Using the IBM SPSS Statistics Version 22 program, descriptive and mathematical statistics (χ2-test) were calculated (p < 0.05). Results The mean age of the members of the examined population is 63.5 years; 68.1% were women and 31.90% were men. The majority of the respondents were infected by the polyovirus in 1956 (11.9%), 1957 (24.3%), and 1959 (19.5%). Polio patients, with the exception of two dimensions (mental health, social operation), on the scale of 100 do not reach the “average” quality of life (physical functioning 23 points, functional role 36 points, emotional role 47 points, body pain 48 points, general health 42 points, vitality 50 points, health change 31 points). Conclusion The quality of life of polio patients is far below the dimensions of physical function, while the difference in mental health compared to healthy people is minimal. It would be important to educate health professionals about the existing disease, to develop an effective rehabilitation method.

scholarly journals Quality of Life Prior and in the Course of the COVID-19 Pandemic: A Nationwide Cross-Sectional Study with Brazilian Dietitians

2021 ◽  
Vol 18 (5) ◽  
pp. 2712
Author(s):  
Raquel Adjafre da Costa Matos ◽  
Rita de Cassia Coelho de Almeida Akutsu ◽  
Renata Puppin Zandonadi ◽  
Raquel Braz Assunção Botelho
Keyword(s):  
Quality Of Life ◽  
Psychological Health ◽  
Social Relationship ◽  
Healthcare Professionals ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chi Squared

Dietitians as healthcare professionals could decrease their quality of life during the SARS-COV-2 pandemic period; therefore, this study aimed to compare Brazilian dietitians’ perceptions of quality of life before and during the pandemic. This nationwide cross-sectional research aimed to evaluate Brazilian dietitians’ quality of life before and in the course of the COVID-19 pandemic, using a previously validated self-administered instrument WHO-QOL-BREF in Brazilian-Portuguese. The questionnaire was composed of 26 items (four domains) to evaluate life quality (physical, psychological, social relationship, and environment). The questionnaire also presented some sociodemographic variables and three questions about the COVID-19 pandemic. It was applied using GoogleForms® platform (Google LLC, Mountain View, CA, USA). For the statistical analysis of data, Paired T-test, Chi-squared test, and Analysis of Variance were used. A total of 1290 Brazilian dietitians replied to the instrument. Comparing quality of life (QoL) before SARS-COV-2 (3.83 ± 0.59) and during the pandemic (3.36 ± 0.66), data was statistically different. Comparing prior and in the course of the COVID-19 pandemic, all variables and domains presented statistical differences (better before the pandemic period). Among Brazilian dietitians, the psychological health domain was the most affected. The Sars-Cov-2 pandemic negatively impacted the QoL of Brazilian dietitians since health professionals face changes in their lives because of work.

scholarly journals Qualidade de vida de estudantes de graduação

2019 ◽  
Vol 13 ◽  
Author(s):  
Rafael Lemes de Aquino ◽  
Douglas Ataniel Alves Xavier ◽  
Meirielen Danubia Marra ◽  
Nubia Fernandes Fernandes Teixeira ◽  
Lorena Silva Vargas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Undergraduate Students ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Academic Life ◽  
Cross Sectional ◽  
Calidad De Vida ◽  
Student’S T ◽  
The University

RESUMO Objetivos: avaliar a qualidade de vida de acadêmicos regularmente ativos em uma universidade; verificar se existe associação entre qualidade de vida e sintomas depressivos. Método: trata-se de estudo quantitativo, tipo transversal, aplicar-se-ão três questionários estruturados, autoaplicáveis para mensurar o nível da qualidade de vida e índice de depressão entre acadêmicos. Far-se-á a análise estatística descritiva, empregar-se-á o teste Liliefors e usar-se-ão o teste t de Student. Apresentar-se-ão os resultados em forma de figuras. Resultados esperados: realizar-se-á a correlação entre a qualidade de vida dos estudantes dos cursos de graduação da universidade e a incidência de fatores depressivos com o início da vida acadêmica. Descritores: Depressão; Vida Acadêmica; Qualidade de Vida; Universidade; Estudantes; Educação Superior.ABSTRACT Objectives: to evaluate the quality of life of academically active students in a university; to verify if there is an association between quality of life and depressive symptoms. Method: this is a quantitative cross-sectional study. Three structured, self-administered questionnaires will be applied to measure the level of quality of life and depression index among academics. The descriptive statistical analysis will be done, the Liliefors test will be used and the Student's t-test will be used. The results will be presented in the form of figures. Expected results: the correlation between the quality of life of undergraduate students of the university and the incidence of depressive factors with the beginning of academic life will be realized. Descriptors: Depression; Academic life; Quality of Life; Universities; Students; Education, Higher.RESUMEN Objetivos: evaluar la calidad de vida de los académicos regularmente activos en una universidad; comprobar si existe asociación entre calidad de vida y síntomas depresivos. Método: se trata de estudio cuantitativo, tipo transversal, se aplicarán tres cuestionarios estructurados, autoaplicables para medir el nivel de la calidad de vida e índice de depresión entre académicos. Se hará el análisis estadístico descriptivo, se empleará la prueba Liliefors y se utilizarán la prueba t de Student. Se presentarán los resultados en forma de figuras. Resultados esperados: se realizará la correlación entre la calidad de vida de los estudiantes de los cursos de grado de la universidad y la incidencia de factores depresivos con el inicio de la vida académica. Descriptores: Depresión; Vida académica; Calidad de Vida; Universidades; Estudiantes; Educación Superior.

scholarly journals Perbedaan kadar hemoglobin pada remaja gizi baik yang tinggal di pegunungan dengan yang tinggal di tepi pantai

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Marianne C. Jacobus ◽  
Max F.J Mantik ◽  
Adrian . Umboh
Keyword(s):  
Analytical Study ◽  
Nutrition Status ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Good Nutrition ◽  
The Difference ◽  
Cross Sectional Design ◽  
And Gender ◽  
Main Component

Abstract: Haemoglobin is the main component of red blood cells that serves as a transporter of oxygen and carbon dioxide in the blood. The normal range of haemoglobin values can be used to determine the degree of anemia according to age and gender. Geographical condition such as altitude influences the haemoglobin value. This study aimed to obtain the difference of haemoglobin levels between teenagers with good nutrition status who live at the highland and those at the seaside. This was an observational analytical study with a cross sectional design. Samples were students with good nutrition status of SMPN 3 Tomohon (living at the highland) and those of SMP Kristen Nazaret Tuminting (living at the seaside). There were 60 students who met the inclusion criteria as follows: adolescent, good nutrition status, healthy, aged 13-15 years, lived at the highland or at the seaside ≥ 6 month, and willing to be performed blood examinations, and had been approved by their parents. The Mann-Whitney test for the difference between haemoglobin levels of the two groups showed a p value < 0,001. Conclusion: There was a very significant difference between haemoglobin levels of good nutrition teenagers who lived at the highland and at the seaside. Keywords: haemoglobin levels, good nutrition, teenagers, highland, seaside  Abstrak: Hemoglobin merupakan komponen utama sel darah merah dan berfungsi sebagai transporter oksigen dan karbon dioksida dalam darah. Batas normal nilai hemoglobin dapat digunakan untuk menetapkan derajat anemia, dengan distribusi usia dan jenis kelamin spesifik didasarkan pada sampel referensi sehat. Kondisi geografis, seperti ketinggian tempat dari permukaan laut menjadi faktor pertimbangan dalam distribusi nilai normal hemoglobin. Penelitian ini bertujuan untuk mendapatkan perbedaan kadar hemoglobin antara remaja gizi baik yang tinggal di pegunungan dengan yang tinggal di tepi pantai. Jenis penelitian ini analitik-observasional dengan desain potong lintang. Sampel penelitian yaitu remaja gizi baik yang tinggal di pegunungan yaitu siswa SMPN 3 Tomohon dan yang di tepi pantai yaitu siswa SMP Kristen Nazaret Tuminting. Subjek penelitian berjumlah 60 remaja yang memenuhi kriteria inklusi yaitu gizi baik, sehat, berumur 13-15 tahun, berdomisili di pegunungan atau tepi pantai ≥6 bulan, bersedia dilakukan pemeriksaan darah, dan telah disetujui oleh orang tua. Data yang diperoleh dianalisis menggunakan uji Mann-Whitney dengan bantuan program SPSS. Hasil uji Mann-Whitney mengenai perbedaan kadar hemoglobin antara kedua kelompok menunjukkan nila p <0,001. Simpulan: Terdapat perbedaan yang sangat bermakna kadar hemoglobin remaja gizi baik yang tinggal di pegunungan dengan di tepi pantai.Kata kunci: kadar hemoglobin, remaja gizi baik, pegunungan, tepi pantai

scholarly journals The study of life quality parameters in children and adolescents with HIV associated tuberculosis

2020 ◽  
Vol 98 (9) ◽  
pp. 14-17
Author(s):  
D. N. Аdzhablaeva
Keyword(s):  
Hiv Infection ◽  
Children And Adolescents ◽  
Life Quality ◽  
Quality Parameters ◽  
Hiv Status ◽  
Cross Sectional ◽  
Quality Of Life Inventory ◽  
Life Inventory ◽  
Hiv Negative

The objective of the study: to perform comparative assessment of life quality (LQ) associated with health of children and adolescents suffering from tuberculosis, both HIV negative and HIV positive.Subjects and methods. In 2017-2019, the cross-sectional epidemiological study was conducted in Pediatric Department of Samarkand Regional TB Dispensary, the study was aimed to assess life quality associated with health in 70 children and adolescents at the age from 5 to 18 years old. 35 of them had tuberculosis and HIV infection (TB/HIV Group), 35 had tuberculosis and negative HIV status. Pediatric Quality of Life Inventory – PedsQL was used to assess the life quality.Conclusion. The combination of HIV infection and tuberculosis has a more pronounced effect on the physical and mental functioning of patients and worsens the life quality of children and adolescents to a greater extent than tuberculosis. 

scholarly journals The Prevalence of Disability and Its Relationship With the Demographic Characteristics of the Elderly in Gonabad City, Iran, in 2019

2021 ◽  
Vol 27 (1) ◽  
pp. 34-47
Author(s):  
Saleh Baghery Kakhki ◽  
◽  
Mehdi Basiri Moghadam ◽  
Leila Sadeghmoghadam ◽  
◽  
...  
Keyword(s):  
Analytical Study ◽  
Early Death ◽  
The Elderly ◽  
Demographic Characteristics ◽  
Cross Sectional ◽  
Background History ◽  
Literacy Level ◽  
Spss Software ◽  
Elderly Disability

Aims: Disability reduces the independence and quality of life in the elderlies and it increases their independence and causes increased need of support, more admittance in nursing homes and early death. The aim of this study was to examine the prevalence of disability and its relationship with the demographic characteristics. Methods & Materials: This cross-sectional (descriptive-analytical) study was performed on 470 elderly people aged 60 and over living in Gonabad by random stratified sampling. Data collection tools included a demographic profile questionnaire and a standardized questionnaire from the WHO to assess disability in the elderly. The data collected were analyzed using SPSS software version 14.5 and the Kai Scoyer test and ranked logistic regression. Significant levels of less than 0.05 were considered Findings: 35.6% of the elderly had very low disability, 40.6% had low disability, 15.2% had moderate disability and 8.6% had severe disability. Age (P<0.001), sex (P=0.03), literacy level (P<0.001), and background history (P<0.001) were significant predictors of elderly disability Conclusion: There is a relationship between disability and its level with aging. According to the growth in elderly’s population, paying attention to health and reducing disability and promoting their life’s quality is necessary.

Sign in / Sign up

Export Citation Format

Share Document