Targeted Delivery of Immunotoxin by Antibody to Ganglioside GD3: A Novel Drug Delivery Route for Tumor Cells

: The corona virus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel corona virus SARS-CoV2, previously named as 2019-nCoV. COVID-19 has spread across the globe and declared as pandemic by World health organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. Novel drug delivery systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance in COVID-19 has discussed in this paper. It focuses on the currently ongoing research in the implementation of NDDS in COVID-19. Moreover it describes the role of NDDS in vaccine development for COVID-19. This paper also emphasizes how NDDS will help to develop the improved delivery systems (dosage forms) of existing therapeutic agents and also explore the new insights to find out the void spaces for a potential targeted delivery. So in these tough times, NDDS and nanotechnology can be a safeguard to humanity.

Download Full-text

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

Biomeditsinskaya Khimiya ◽

10.18097/pbmc20206606464 ◽

2020 ◽

Vol 66 (6) ◽

pp. 464-468

Author(s):

L.V. Kostryukova ◽

Y.A. Tereshkina ◽

E.I. Korotkevich ◽

V.N. Prozorovsky ◽

T.I. Torkhovskaya ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Cells ◽

Targeted Drug Delivery ◽

Targeted Delivery ◽

Breast Adenocarcinoma ◽

Control Line ◽

Phospholipid Nanoparticles ◽

Significant Difference ◽

Targeted Drug ◽

Cd13 Receptor

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to reduce side effects. One of the promising components as vector molecules (ligands) are NGR-containing peptides that are affinity for the CD13 receptor, which is expressed on the surface of many tumor cells and tumor blood vessels. Previously, a method was developed for preparing a composition of doxorubicin embedded in phospholipid nanoparticles with a targeted fragment in the form of an ultrafine emulsion. The resulting composition was characterized by a small particle size (less than 40 nm) and a high degree of incorporation of doxorubicin (about 93%) into transport nanoparticles. When assessing the penetrating ability and the degree of binding to the surface of fibrosarcoma cells (HT-1080), it was shown that when the composition with the targeted fragment was added to the cells, the level of doxorubicin was almost 2 times higher than that of the liposomal form of doxorubicin, i.e. the drug in the system with the targeted peptide penetrated the cell better. At the same time, on the control line of breast adenocarcinoma cells (MCF-7), which do not express the CD13 receptor on the surface, there was not significant difference in the level of doxorubicin in the cells. The data obtained allow us to draw preliminary conclusions about the prospects of targeted delivery of doxorubicin to tumor cells when using a peptide conjugate containing an NGR motif and the further need for its comprehensive study.

Download Full-text

Development of Novel Drug Delivery Prototypes Devices for Targeted Delivery Drug Therapy at the Molecular Level in Aqueous Media

Current Drug Delivery ◽

10.2174/156720111796642237 ◽

2011 ◽

Vol 8 (5) ◽

pp. 582-585 ◽

Cited By ~ 1

Author(s):

Roy George ◽

Theunis Gerhardus Oberholzer, Victoria Tamara Perchyonok

Keyword(s):

Drug Delivery ◽

Drug Therapy ◽

Targeted Delivery ◽

Molecular Level ◽

Aqueous Media ◽

Novel Drug

Download Full-text

Novel Drug Delivery Systems for Sustained and Targeted Delivery of Anti-Cancer Drugs: Current Status and Future Prospects

Current Drug Delivery ◽

10.2174/156720110791011783 ◽

2010 ◽

Vol 7 (2) ◽

pp. 152-161 ◽

Cited By ~ 28

Author(s):

Puneet Utreja ◽

Subheet Jain ◽

A. K. Tiwary

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Current Status ◽

Cancer Drugs ◽

Future Prospects ◽

Anti Cancer ◽

Novel Drug

Download Full-text

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders

Nanomaterials ◽

10.3390/nano11102632 ◽

2021 ◽

Vol 11 (10) ◽

pp. 2632

Author(s):

Mark J. Lynch ◽

Oliviero L. Gobbo

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Rational Design ◽

In Vitro Models ◽

Clinical Translation ◽

Clinical Testing ◽

Cns Disorders ◽

Novel Drug

Nanotheranostics constitute a novel drug delivery system approach to improving systemic, brain-targeted delivery of diagnostic imaging agents and pharmacological moieties in one rational carrier platform. While there have been notable successes in this field, currently, the clinical translation of such delivery systems for the treatment of neurological disorders has been limited by the inadequacy of correlating in vitro and in vivo data on blood–brain barrier (BBB) permeation and biocompatibility of nanomaterials. This review aims to identify the most contemporary non-invasive approaches for BBB crossing using nanotheranostics as a novel drug delivery strategy and current non-animal-based models for assessing the safety and efficiency of such formulations. This review will also address current and future directions of select in vitro models for reducing the cumbersome and laborious mandate for testing exclusively in animals. It is hoped these non-animal-based modelling approaches will facilitate researchers in optimising promising multifunctional nanocarriers with a view to accelerating clinical testing and authorisation applications. By rational design and appropriate selection of characterised and validated models, ranging from monolayer cell cultures to organ-on-chip microfluidics, promising nanotheranostic particles with modular and rational design can be screened in high-throughput models with robust predictive power. Thus, this article serves to highlight abbreviated research and development possibilities with clinical translational relevance for developing novel nanomaterial-based neuropharmaceuticals for therapy in CNS disorders. By generating predictive data for prospective nanomedicines using validated in vitro models for supporting clinical applications in lieu of requiring extensive use of in vivo animal models that have notable limitations, it is hoped that there will be a burgeoning in the nanotherapy of CNS disorders by virtue of accelerated lead identification through screening, optimisation through rational design for brain-targeted delivery across the BBB and clinical testing and approval using fewer animals. Additionally, by using models with tissue of human origin, reproducible therapeutically relevant nanomedicine delivery and individualised therapy can be realised.

Download Full-text

Suitable Polymers in Floating Gastro-Retentive Drug Delivery

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst207269 ◽

2020 ◽

pp. 371-382

Author(s):

Kaustubh Gavali ◽

Preeti Karade

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Delivery ◽

Floating Drug Delivery ◽

Effect Of Food ◽

Multiple Unit ◽

Novel Drug ◽

Absorption Window ◽

Gastro Retentive

Gastro-retentive drug delivery is novel drug delivery system which is emerged for controlled and targeted delivery of drug especially when target site lies in or near the stomach. The drug with absorption window in stomach, locally acting drug in stomach, etc. are the best suitable candidate for this drug delivery system. It can be formulated in various types like floating, expandable & unfoldable, Raft forming, swelling system Bio adhesive, High density system etc. The gastro-retentive form can be used in various dosage forms like tablet, capsule, microsphere, granules, powders, pills and laminated films according to the need. It can be also formulated as single unit and multiple unit dosage form but sometime this gastro-retention is unpredictable due to effect of pH, gastric mobility, effect of food etc. This review mainly focuses on the floating drug delivery its types, polymer used in floating drug delivery and application.

Download Full-text

Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Potential Drug Delivery Route for Tumor Cells

PLoS ONE ◽

10.1371/journal.pone.0003597 ◽

2008 ◽

Vol 3 (10) ◽

pp. e3597 ◽

Cited By ~ 13

Author(s):

Liliana D. Kojic ◽

Sam M. Wiseman ◽

Fariba Ghaidi ◽

Bharat Joshi ◽

Hinyu Nedev ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Cells ◽

Phosphoglucose Isomerase ◽

Potential Drug ◽

Autocrine Motility Factor ◽

Motility Factor ◽

Delivery Route

Download Full-text

Tumor Microenvironment Responsive Pepper Mild Mottle Virus-Based Nanotubes for Targeted Delivery and Controlled Release of Paclitaxel

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2021.763661 ◽

2021 ◽

Vol 9 ◽

Author(s):

Jiejun Peng ◽

Yueyan Yin ◽

Hongze Liang ◽

Yuwen Lu ◽

Hongying Zheng ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Cells ◽

Targeted Delivery ◽

Plant Virus ◽

Drug Carriers ◽

Cell Uptake ◽

Mottle Virus ◽

Ph Responsive ◽

Pepper Mild Mottle Virus ◽

Strong Candidate

Plant virus nanoparticles (PVNPs) have been widely used for drug delivery, antibody development and medical imaging because of their good biodegradation and biocompatibility. Particles of pepper mild mottle virus (PMMoV) are elongated and may be useful as drug carriers because their shape favours long circulation, preferential distribution and increased cellular uptake. Moreover, its effective degradation in an acidic microenvironment enables a pH-responsive release of the encapsulated drug. In this study, genetic engineering techniques were used to form rod-shaped structures of nanoparticles (PMMoV) and folated-modified PMMoV nanotubes were prepared by polyethylene glycol (PEG) to provide targeted delivery of paclitaxel (PTX). FA@PMMoV@PTX nanotubes were designed to selectively target tumor cells and to release the encapsulated PTX in response to pH. Efficient cell uptake of FA@PMMoV@PTX nanotubes was observed when incubated with tumor cells, and FA@PMMoV@PTX nanotubes had superior cytotoxicity to free PTX, as reflected by cell survival and apoptosis. This system is a strong candidate for use in developing improved strategies for targeted treatment of tumors.

Download Full-text