Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712).

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In VitroActivity of Polymyxin B plus Imipenem, Meropenem, or Tigecycline against KPC-2-Producing Enterobacteriaceae with High MICs for These Antimicrobials

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00365-15 ◽

2015 ◽

Vol 59 (6) ◽

pp. 3596-3597 ◽

Cited By ~ 9

Author(s):

Natália Barth ◽

Vanessa B. Ribeiro ◽

Alexandre P. Zavascki

Keyword(s):

Klebsiella Pneumoniae ◽

Serratia Marcescens ◽

Antimicrobial Agents ◽

Enterobacter Cloacae ◽

Polymyxin B ◽

Synergistic Activity ◽

Content Type ◽

Time Kill ◽

High Mics

ABSTRACTWe evaluated thein vitroactivity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producingEnterobacteriaceaestrains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations forKlebsiella pneumoniaeandEnterobacter cloacaeregardless of the polymyxin B concentration used in the time-kill assay. This combination was also synergistic against twoSerratia marcescensstrains that are intrinsically resistant to polymyxins. Polymyxin B and tigecycline also presented synergistic activity in most experiments.

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Faculty Opinions recommendation of Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1032764.374454 ◽

2006 ◽

Author(s):

Kenneth Thomson

Keyword(s):

Klebsiella Pneumoniae ◽

Molecular Epidemiology ◽

Polymyxin B ◽

Vitro Activity ◽

In Vitro Activity

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Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor

Zeitschrift für Naturforschung C ◽

10.1515/znc-2020-0051 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Nursenem Karaca ◽

Görkem Şener ◽

Betül Demirci ◽

Fatih Demirci

Keyword(s):

Staphylococcus Aureus ◽

Essential Oil ◽

Antibacterial Effect ◽

Synergistic Effects ◽

Pharmaceutical Formulations ◽

Human Pathogens ◽

Broth Microdilution ◽

Antibacterial Effects ◽

Lavandula Latifolia

AbstractCombination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcus aureus and Listeria monocytogenes. Pharmacopoeia quality L. latifolia essential oil and racemic camphor were analyzed and verified by GC-FID and GC/MS, simultaneously. In vitro antibacterial activity of essential oil and camphor (MIC range: 0.16–20 mg/mL) and standard antimicrobial clarithromycin (MIC range: 0.125–16 μg/mL) were carried out by broth microdilution against S. aureus and L. monocytogenes standard strains, respectively. Resulting antibacterial effects were evaluated for their fractional inhibitory concentrations (FICs) as antagonistic, additive and synergistic effects. The analytical results showed that the major component of essential oil was linalool (45.2%) and 1,8-cineole (25.6%). Antibacterial effects of essential oil were determined as MIC 1.25–5 mg/mL. As a result of the experiments, L. latifolia essential oil–camphor combinations were identified as “synergistic (FIC ≤ 0.5), and additive (0.5 < FIC ≤ 1)” in the respective combinations, suggesting further evaluation for formulations for potential antimicrobial applications in food and pharmaceuticals.

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Inter‐strains comparison of the antimicrobial effect and mode of action of a Vietnamese Cinnamomum cassia essential oil from leaves and its principal component against Listeria monocytogenes

Letters in Applied Microbiology ◽

10.1111/lam.13465 ◽

2021 ◽

Author(s):

Emilie Dumas ◽

Pascal Degraeve ◽

Nga‐Thi‐Thanh Trinh ◽

Mai Le Thanh ◽

Nadia Oulahal

Keyword(s):

Listeria Monocytogenes ◽

Essential Oil ◽

Mode Of Action ◽

Principal Component ◽

Antimicrobial Effect ◽

Cinnamomum Cassia

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Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1521 ◽

2020 ◽

Vol 71 (Supplement_4) ◽

pp. S436-S439

Author(s):

Qingyu Shi ◽

Dandan Yin ◽

Renru Han ◽

Yan Guo ◽

Yonggui Zheng ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Infection Control ◽

Polymyxin B ◽

Sequence Type ◽

First Report ◽

Clinical Strains

Abstract This is the first report of ceftazidime–avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem–vaborbactam, cefepime–zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.

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Comparison of Polymyxin B, Tigecycline, Cefepime, and Meropenem MICs for KPC-Producing Klebsiella pneumoniae by Broth Microdilution, Vitek 2, and Etest

Journal of Clinical Microbiology ◽

10.1128/jcm.00760-13 ◽

2013 ◽

Vol 51 (7) ◽

pp. 2472-2472

Author(s):

A. Lat ◽

S. A. Clock ◽

F. Wu ◽

S. Whittier ◽

P. Della-Latta ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Polymyxin B ◽

Broth Microdilution ◽

Vitek 2

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Disease Severity Is an Independent Risk Factor of Mortality and Outcomes in Critically Ill Patients With Carbapenem-resistant Klebsiella Pneumoniae Bloodstream Infections: a 5-year Retrospective Analysis

10.21203/rs.3.rs-658252/v1 ◽

2021 ◽

Author(s):

Yuzhen Qiu ◽

Wen Xu ◽

Yunqi Dai ◽

Ruoming Tan ◽

Jialin Liu ◽

...

Keyword(s):

Risk Factors ◽

Septic Shock ◽

Klebsiella Pneumoniae ◽

Critically Ill Patients ◽

Bloodstream Infections ◽

Polymyxin B ◽

Mortality Rates ◽

Carbapenem Resistant ◽

All Cause Mortality ◽

Independent Risk Factors

Abstract Background: Carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are associated with high morbidity and mortality rates, especially in critically ill patients. Comprehensive mortality risk analyses and therapeutic assessment in real-world practice are beneficial to guide individual treatment.Methods: We retrospectively analyzed 87 patients with CRKP-BSIs (between July 2016 and June 2020) to identify the independent risk factors for 28-day all-cause mortality. The therapeutic efficacies of tigecycline-and polymyxin B-based therapies were analyzed.Results: The 28-day all-cause mortality and in-hospital mortality rates were 52.87% and 67.82%, respectively, arising predominantly from intra-abdominal (56.32%) and respiratory tract infections (21.84%). A multivariate analysis showed that 28-day all-cause mortality was independently associated with the patient’s APACHE II score (p = 0.002) and presence of septic shock at BSI onset (p = 0.006). All-cause mortality was not significantly different between patients receiving tigecycline- or polymyxin B-based therapy (55.81% vs. 53.85%, p = 0.873), and between subgroups mortality rates were also similar. Conclusions: Critical illness indicators (APACHE II scores and presence of septic shock at BSI onset) were independent risk factors for 28-day all-cause mortality. There was no significant difference between tigecycline- and polymyxin B-based therapy outcomes. Prompt and appropriate infection control should be implemented to prevent CRKP infections.

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