Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes

Objective Previous reports have indicated that serum bilirubin levels may be associated with diabetic retinopathy. However, the detailed mechanism is not fully understood. In this study, we evaluated the relationship between the severity of diabetic retinopathy and various factors including bilirubin levels and factors influencing bilirubin metabolism. Methods The study participants consisted of 94 consecutive patients with diabetes mellitus admitted to Kyushu University Hospital from April 2011 to July 2012. The patients were classified into three groups: no retinopathy (NDR), simple retinopathy (SDR), and pre-proliferative or proliferative retinopathy (PDR). The relationship between the severity of retinopathy and various factors was evaluated using univariate and logistic regression analyses. In addition, multivariate regression analysis was performed to evaluate the significant determinants for bilirubin levels. Results In univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria. Logistic regression analysis showed that PDR was significantly associated with bilirubin levels, duration of diabetes, and systolic blood pressure (OR 0.737, 95% CI 0.570–0.952, P = 0.012; OR 1.085, 95% CI 1.024–1.149, P = 0.006; OR 1.036, 95% CI 1.011–1.062, P = 0.005, respectively). In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity C-reactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin. Conclusion PDR was negatively associated with bilirubin levels. This negative association may be due to a decreased production of bilirubin rather than its increased consumption considering the positive association between bilirubin and biopyrrin levels.

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Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes

10.1101/2020.11.23.393884 ◽

2020 ◽

Author(s):

Kana Kudo ◽

Tomoaki Inoue ◽

Noriyuki Sonoda ◽

Yoshihiro Ogawa ◽

Toyoshi Inoguchi

Keyword(s):

Blood Pressure ◽

Logistic Regression ◽

Diabetic Retinopathy ◽

Regression Analysis ◽

Systolic Blood Pressure ◽

Multivariate Regression ◽

Serum Bilirubin ◽

Multivariate Regression Analysis ◽

Patients With Diabetes ◽

The Relationship

ABSTRACTAims/IntroductionPrevious reports have indicated that serum bilirubin levels may be associated with diabetic retinopathy. However, the detailed mechanism is not fully understood. In this study, we evaluated the relationship between the severity of diabetic retinopathy and various factors including bilirubin levels and factors influencing bilirubin metabolism.MethodsThe study participants consisted of 94 consecutive patients with diabetes mellitus admitted to Kyushu University Hospital from April 2011 to July 2012. The patients were classified into three groups: no retinopathy (NDR), simple retinopathy (SDR), and pre-proliferative or proliferative retinopathy (PDR). The relationship between the severity of retinopathy and various factors was evaluated using univariate and logistic regression analyses. In addition, multivariate regression analysis was performed to evaluate the significant determinants for bilirubin levels.ResultsIn univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria. Logistic regression analysis showed that PDR was significantly associated with bilirubin levels, duration of diabetes, and systolic blood pressure (OR 0.737, 95% CI 0.570–0.952, P=0.012; OR 1.085, 95% CI 1.024–1.149, P=0.006; OR 1.036, 95% CI 1.011–1.062, P=0.005, respectively). In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity Creactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin.ConclusionsPDR was negatively associated with bilirubin levels. This negative association may be due to a decreased production of bilirubin rather than its increased consumption considering the positive association between bilirubin and biopyrrin levels.

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Epicardial fat thickness as arterial hypertension predictor in normotensive patients with abdominal obesity

European Heart Journal ◽

10.1093/ehjci/ehaa946.2730 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

T Kuznetsova ◽

M Druzhilov

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Blood Glucose ◽

Waist Circumference ◽

Arterial Hypertension ◽

Multivariate Regression ◽

Fasting Blood Glucose ◽

Multivariate Regression Analysis ◽

Epicardial Fat Thickness ◽

Fat Thickness

Abstract Objective Arterial hypertension (HTN) is one of the most common diseases associated with obesity. Visceral obesity (VO) with dysfunctional visceral adipose tissue plays the main role in obesity induced HTN. Direct criteria of VO including echocardiographic epicardial fat thickness (EFT) may become an additional predictor of HTN. Purpose The aim was to assess the role of echocardiographic EFT (EEFT) as a predictor of HTN in normotensive patients with abdominal obesity (AO). Methods 526 normotensive men (according to ambulatory blood pressure monitoring (ABPM) without therapy) with AO (waist circumference (WC) >94 cm) and SCORE <5%, without cardiovascular diseases and diabetes mellitus were examined (age 45.1±5.0 years). The lipid and glucose profiles, creatinine, uric acid and C-reactive protein blood levels, albuminuria evaluation, echocardiography, carotid ultrasound, bifunctional ABPM were performed. The values of EEFT ≥75 percentile for persons 35–45 years and 46–55 years were 4.8 mm and 5.8 mm respectively. These values used as epicardial VO criteria. Patients with subclinical carotid atherosclerosis due to the lipid-lowering therapy administration (n=98) were excluded from the follow-up. Re-examination with ABPM was conducted on average through 46.3±5.1 months. Data were summarized as mean ± standard error, statistical analysis conducted with paired two-tailed t-tests, Pearson χ2 criterion and multivariate regression analysis. Results Data of 406 persons were available for analysis. HTN as average daily blood pressure ≥130/80 mm Hg was detected in 157 (38.7%) patients. These patients were characterized by initially higher values of age (45.9±4.6 years vs 44.3±4.9 years, p<0.001), waist circumference (106.9±7.3 cm vs 104.2±7.3 cm, p<0.001), body mass index (BMI) (32.0±3.3 kg/m2 vs 30.9±3.2 kg/m2, p<0.001), average daily systolic and diastolic blood pressure (120.7/74.5±4.6/3.4 mm Hg vs 118.2/73.2±5.5/3.9 mm Hg, p<0.001), EEFT (5.2±0.7 mm vs 4.4±1.0 mm, p<0.001). The epicardial VO was initially detected in 95 (23.3%) patients. In patients with HTN the initial prevalence of epicardial VO was greater (58.0% vs 23.3%, p<0.001). As predictors for the multivariate regression analysis the clinical and laboratory examinations data and EEFT were evaluated. According to the results a mathematical model for estimating the probability HTN was obtained: 0.696*fasting blood glucose + 0.198*systolic BP + 2.844*EFT – 40.166 (constant). Among these predictors EEFT was characterized by the highest standardized regression coefficient (0.302, p<0.001) (0.295, p<0.01 for fasting blood glucose, 0.035, p<0.001 for systolic BP). The Hosmer-Lemeshow test value was 0.863, the total percentage of correct classifications was 86%, the area under the ROC-curve was 0.913. Conclusions EEFT (4.8 mm for persons 35–45 years and 5.8 mm for persons 46–55 years) may be an additional predictor of HTN in normotensive patients with AO. Funding Acknowledgement Type of funding source: None

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Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽

10.1161/hyp.62.suppl_1.a412 ◽

2013 ◽

Vol 62 (suppl_1) ◽

Author(s):

Mohan Thanikachalam ◽

Shasha Bai ◽

Vijayakumar Harivanzan ◽

Ragavendra R Baliga ◽

William T Abraham ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Arterial Stiffness ◽

Multivariate Regression ◽

Independent Predictor ◽

Density Lipoprotein ◽

Multivariate Regression Analysis ◽

Population Based ◽

Cross Sectional Survey ◽

Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

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Investigating the effect of social capital on delinquency of 15-to-19-year-old juveniles in shiraz

Global Journal of Guidance and Counseling in Schools Current Perspectives ◽

10.18844/gjgc.v5i1.130 ◽

2015 ◽

Vol 5 (1) ◽

Author(s):

Zinab Adelmand ◽

Fatemeh Adelmand ◽

Tahmineh Adelmand ◽

Maryam Zarnaghash

Keyword(s):

Social Capital ◽

Regression Analysis ◽

Life Style ◽

Multivariate Regression ◽

Religious Life ◽

Multivariate Regression Analysis ◽

Modern Life ◽

Family Control ◽

New Variables ◽

The Relationship

The aim of this study was to investigate the effect of social capital on 15-to-19-year-old juveniles’ delinquency. Regarding this objective, Yang internet addiction questionnaire (1996) was used to collect the data. This questionnaire contains 20questions classified in some groups. Results of Multivariate Regression Analysis for explaining delinquency indicate that among the variables selected in the analytical model of this study, 5 factors(religious life style, modern life style (friends network), family control, communications (the relationship between social capital and the groups), the respondents’ fathers’ income) have had a significant effect on delinquency and have remained in the equation. After entering these five variables, the entry of new variables have been stopped. In fact, these five variables totally explain 36/1% changes of the dependent variable (delinquency. Keywords: delinquency, Social Capital

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Impact of Firm Specific Factors on Credit Risk: A Case of Karachi Stock Exchange

International Letters of Social and Humanistic Sciences ◽

10.18052/www.scipress.com/ilshs.54.140 ◽

2015 ◽

Vol 54 ◽

pp. 140-143

Author(s):

Sajid Iqbal ◽

Saima Nasir Chaudry ◽

Nadeem Iqbal

Keyword(s):

Regression Analysis ◽

Credit Risk ◽

Significant Relationship ◽

Multivariate Regression ◽

Stock Exchange ◽

Manufacturing Sector ◽

Multivariate Regression Analysis ◽

Specific Factors ◽

Relationship Of ◽

The Relationship

The current study aims to explore the relationship of firm’s specific factors i-e profitability, ROA, leverage and bank size on credit risk. The population of the study consists of manufacturing sector of Pakistan. The sample of study is cement sector of Pakistan. The sample units are 22 and listed at Karachi stocks exchange. The multivariate regression analysis is used to test the data of sample. The study revealed negative significant relationship of all firm specific factors with credit risk in Pakistan. Thus, the study supported historic investigations regarding credit risk.

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Interaction analysis of systolic blood pressure and glycosylated hemoglobin in diabetic retinopathy: A Chinese sample

Traditional Medicine and Modern Medicine ◽

10.1142/s2575900019500101 ◽

2019 ◽

Vol 02 (03) ◽

pp. 119-125

Author(s):

Xiangying Meng ◽

Yuanhao Zhang ◽

Qing Kong ◽

Yubao Lv ◽

Hailin Hu ◽

...

Keyword(s):

Blood Pressure ◽

Logistic Regression ◽

Diabetic Retinopathy ◽

Systolic Blood Pressure ◽

Interaction Analysis ◽

Demographic Data ◽

Glycosylated Hemoglobin ◽

Fundus Photography ◽

Chinese Sample ◽

Glucose Profiles

Background: The objective of this study was to evaluate (1) the association of blood pressure (BP) profiles and glucose profiles with diabetic retinopathy (DR) and (2) the interaction between BP profiles and glucose profiles in DR in a Chinese sample. Methods: This was a cross-sectional study of 984 DR patients. Demographic data, BP profiles, glucose profiles, renal function parameters, and medical histories were recorded. All the participants underwent testing for DR with digital nonmydriatic fundus photography and image analysis, using a standardized protocol. A multiple variable logistic regression (MLR) was employed to detect the associations and interactions of BP profiles and glucose profiles with DR. Results: Systolic blood pressure (SBP) and glycated hemoglobin (HbA1c) were significantly correlated with DR ([Formula: see text] for SBP, [Formula: see text]; [Formula: see text] for HbA1c, [Formula: see text]). An interaction between SBP and HbA1c was detected in a multiple logistic regression (MLR) model after adjustment for relevant potential confounders ([Formula: see text], [Formula: see text]). Conclusion: The present study suggested that SBP and HbA1c were independently and significantly associated with DR and that SBP interacted with HbA1c to impact on DR.

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31P nuclear magnetic resonance measurement of free erythrocyte magnesium concentration in man and its relation to blood pressure

Clinical Science ◽

10.1042/cs0740513 ◽

1988 ◽

Vol 74 (5) ◽

pp. 513-517 ◽

Cited By ~ 14

Author(s):

K. L. Woods ◽

D. Walmsley ◽

A. M. Heagerty ◽

D. L. Turner ◽

Lu-Yun Lian

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Multivariate Regression ◽

Oral Contraceptive Pill ◽

Positive Association ◽

Multivariate Regression Analysis ◽

Magnesium Concentration ◽

History Of ◽

Free Magnesium ◽

Age And Sex

1. 31P n.m.r. spectroscopy was used to measure the dissociation constant of MgATP under simulated intracellular conditions and to measure erythrocyte free magnesium concentration. 2. In a group of 40 subjects, the relationship between erythrocyte free magnesium and blood pressure, age and sex was examined by univariate and multivariate regression analysis. 3. A weak positive association was found between erythrocyte free magnesium and mean blood pressure. This association was lost in a multivariate regression analysis including both age and sex. 4. No significant relationship was found between erythrocyte free magnesium and age, sex, family history of hypertension or use of the combined oral contraceptive pill in the sample studied.

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The association between Chiari malformation Type I, spinal syrinx, and scoliosis

Journal of Neurosurgery Pediatrics ◽

10.3171/2014.11.peds14135 ◽

2015 ◽

Vol 15 (6) ◽

pp. 607-611 ◽

Cited By ~ 31

Author(s):

Jennifer Strahle ◽

Brandon W. Smith ◽

Melaine Martinez ◽

J. Rajiv Bapuraj ◽

Karin M. Muraszko ◽

...

Keyword(s):

Regression Analysis ◽

Chiari Malformation ◽

Multivariate Regression ◽

Univariate Analysis ◽

Multivariate Regression Analysis ◽

Older Age ◽

Type I ◽

Chiari Malformation Type I ◽

Female Sex ◽

The Relationship

OBJECT Chiari malformation Type I (CM-I) is often found in patients with scoliosis. Most previous reports of CM-I and scoliosis have focused on patients with CM-I and a spinal syrinx. The relationship between CM-I and scoliosis in the absence of a syrinx has never been defined clearly. The authors sought to determine if there is an independent association between CM-I and scoliosis when controlling for syrinx status. METHODS The medical records of 14,118 consecutive patients aged ≤ 18 years who underwent brain or cervical spine MRI at a single institution in an 11-year span were reviewed to identify patients with CM-I, scoliosis, and/or syrinx. The relationship between CM-I and scoliosis was analyzed by using multivariate regression analysis and controlling for age, sex, CM-I status, and syrinx status. RESULTS In this cohort, 509 patients had CM-I, 1740 patients had scoliosis, and 243 patients had a spinal syrinx. The presence of CM-I, the presence of syrinx, older age, and female sex were each significantly associated with scoliosis in the univariate analysis. In the multivariate regression analysis, older age (OR 1.02 [95% CI 1.01–1.03]; p < 0.0001), female sex (OR 1.71 [95% CI 1.54–1.90]; p < 0.0001), and syrinx (OR 9.08 [95% CI 6.82–12.10]; p < 0.0001) were each independently associated with scoliosis. CM-I was not independently associated with scoliosis when controlling for these other variables (OR 0.99 [95% CI 0.79–1.29]; p = 0.9). CONCLUSIONS A syrinx was independently associated with scoliosis in a large pediatric population undergoing MRI. CM-I was not independently associated with scoliosis when controlling for age, sex, and syrinx status. Because CM-I is not independently associated with scoliosis, scoliosis should not necessarily be considered a symptom of low cerebellar tonsil position in patients without a syrinx.

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Remifentanil Reduces Blood Loss During Orthognathic Surgery

Anesthesia Progress ◽

10.2344/anpr-63-03-04 ◽

2017 ◽

Vol 64 (1) ◽

pp. 3-7 ◽

Cited By ~ 5

Author(s):

Nobuyuki Matsuura ◽

Taiki Okamura ◽

Satoko Ide ◽

Tatsuya Ichinohe

Keyword(s):

Blood Pressure ◽

Logistic Regression ◽

Regression Analysis ◽

Blood Loss ◽

Systolic Blood Pressure ◽

Odds Ratio ◽

Orthognathic Surgery ◽

Total Blood ◽

Independent Variables ◽

Duration Of Surgery

Remifentanil is reported to reduce oral tissue blood flow. We performed a retrospective investigation using logistic regression analysis of anesthesia records to investigate whether the use of remifentanil infusion in a balanced anesthesia technique was useful as a primary technique to reduce blood loss during orthognathic surgery. Subjects were 80 patients who underwent Le Fort I osteotomy and sagittal split ramus osteotomy of the mandible. The variables included gender, age, weight, type of maintenance anesthetic, type and dose or infusion rate of opioid, mean systolic blood pressure (SBP-mean), coefficient of variation of systolic blood pressure (CVSBP) during surgery, mean heart rate (HR-mean), duration of surgery, total blood loss, volume of infusion used, amount of local anesthetic used, body temperature, and urine output. Gender, type of maintenance anesthetic, type of opioid, SBP-mean, CVSBP, HR-mean, and duration of surgery were used as candidates for independent variables. Logistic regression analysis was performed for the selected independent variables with the total blood loss as the dependent variable. The factors associated with the reduction of blood loss were the use of remifentanil (odds ratio, 3.112; 95% CI, 1.166–8.307; P = .023) and smaller CVSBP (odds ratio, 2.747; 95% CI, 1.07–7.053; P = .036). Use of remifentanil and smaller CVSBP were associated with a reduction of blood loss during orthognathic surgery.

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Association between blood pressure and the risk of biopsy-induced endobronchial hemorrhage during bronchoscopy

BMC Pulmonary Medicine ◽

10.1186/s12890-022-01822-5 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Saibin Wang ◽

Qian Ye

Keyword(s):

Lung Cancer ◽

Blood Pressure ◽

Regression Analysis ◽

Multivariate Regression ◽

Diastolic Pressure ◽

Tertiary Care ◽

Systolic Pressure ◽

Multivariate Regression Analysis ◽

Care Hospital ◽

Hemorrhage Risk

Abstract Background Hemorrhage is one of the most common complications of bronchoscopy. Although several hemorrhage risk factors have been proposed, it remains unclear whether blood pressure affects the onset of biopsy-induced endobronchial hemorrhage. Methods We conducted a retrospective cohort study of 643 consecutive adults with lung cancer over an approximately 4-year period (from January 2014 to February 2018) at a large tertiary care hospital. Patients were divided into the hemorrhage group and the non-hemorrhage group based on endobronchial biopsy (EBB) findings. The association between systolic pressure (SP), diastolic pressure (DP), mean arterial pressure (MAP), pulse pressure (PP), PP to DP ratio (PP/DP) and the risk of EBB-induced hemorrhage was evaluated using multivariate regression analysis and smooth curve fitting adjusted for potential confounding factors. Results The EBB-induced bleeding incidence was 37.8% (243/643) in our cohort. An independent association was found between PP/PD and the EBB-induced hemorrhage risk (per 1 SD, adjusted odds ratio, 0.788; 95% confidence interval, 0.653-0.951). The multivariate regression analysis performed using quartiles of PP/DP revealed that lower level of PP/DP ratio was related to a higher risk of EBB-induced hemorrhage (P for trend <0.05) after adjustment for potential confounders. However, no association was observed between SP, DP, MAP, PP and EBB-induced hemorrhage. Conclusions Low PP/DP was the independent risk factor for biopsy-induced endobronchial hemorrhage during bronchoscopy in patients with lung cancer.

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