scholarly journals The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256275
Author(s):  
Alleluia Lima Losno Ledesma ◽  
Daniele Leite Rodrigues ◽  
Isabella Monteiro de Castro Silva ◽  
Carlos Augusto Oliveira ◽  
Fayez Bahmad
Keyword(s):  
Otoacoustic Emissions ◽  
Mood State ◽  
Signal To Noise Ratio ◽  
Controlled Clinical Trial ◽  
Caffeine Consumption ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Significant Difference ◽  
Placebo Capsule ◽  
Tinnitus Masking

Objective To test the hypothesis that caffeine can influence tinnitus, we recruited 80 patients with chronic tinnitus and randomly allocated them into two groups (caffeine and placebo) to analyze the self-perception of tinnitus symptoms after caffeine consumption, assuming that this is an adequate sample for generalization. Methods The participants were randomized into two groups: one group was administered a 300-mg capsule of caffeine, and the other group was given a placebo capsule (cornstarch). A diet that restricted caffeine consumption for 24 hours was implemented. The participants answered questionnaires (the Tinnitus Handicap Inventory—THI, the Visual Analog Scale—VAS, the profile of mood state—POMS) and underwent examinations (tonal and high frequency audiometry, acufenometry (frequency measure; intensity measure and the minimum level of tinnitus masking), transient otoacoustic emissions—TEOAE and distortion product otoacoustic emissions—DPOAE assessments) at two timepoints: at baseline and after capsule ingestion. Results There was a significant change in mood (measured by the POMS) after caffeine consumption. The THI and VAS scores were improved at the second timepoint in both groups. The audiometry assessment showed a significant difference in some frequencies between baseline and follow-up measurements in both groups, but these differences were not clinically relevant. Similar findings were observed for the amplitude and signal-to-noise ratio in the TEOAE and DPOAE measurements. Conclusions Caffeine (300 mg) did not significantly alter the psychoacoustic measures, electroacoustic measures or the tinnitus-related degree of discomfort.

scholarly journals Effect of Caffeine on Otoacoustic Emissions

2021 ◽  
Author(s):  
Kumar Sanish Drepath ◽  
Athira Rajan ◽  
Srikanth Nayak ◽  
Arya Vijay ◽  
Sathish Kumar
Keyword(s):  
Otoacoustic Emissions ◽  
Signal To Noise Ratio ◽  
Large Population ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Caffeine Consumption ◽  
Coffee Intake ◽  
Distortion Product ◽  
Study Results ◽  
Before And After

Abstract Introduction Caffeine is consumed everyday in a variety of ways by a large population around the world, including coffee, tea, and soft drinks. Therefore, there is a significant need to explore the effects of caffeine on human auditory system. The present study aimed to investigate the effect of caffeine on cochlea using distortion product otoacoustic emission (DPOAE). Materials and Methods Thirty-three young adults were recruited for the study. The effect of caffeine on cochlea was assessed using DPOAE at frequencies between 1 to 10 kHz before and after caffeine consumption. Results The signal to noise ratio of DPOAE was compared before and after coffee intake, which revealed no significant differences. Conclusion The current study results suggest that caffeine has no effect on cochlear functioning.

scholarly journals Tinnitus in adolescents: the start of the vulnerability of the auditory pathways

CoDAS ◽  
2015 ◽  
Vol 27 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Tanit Ganz Sanchez ◽  
Juliana Casseb Oliveira ◽  
Márcia Akemi Kii ◽  
Katya Freire ◽  
Jaci Cota ◽  
...  
Keyword(s):  
Private School ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Common Symptom ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
High Frequency Audiometry ◽  
Significant Difference ◽  
Hearing Damage

INTRODUCTION: Although tinnitus is an increasingly common symptom, few studies have assessed its prevalence or incidence among adolescents. PURPOSE: To assess whether the presence of tinnitus in adolescents is associated with minimal hearing damage, evaluated through high-frequency audiometry (HFA), otoacoustic emission (OAE), and loudness discomfort level (LDL). METHODS: The sample comprised 168 adolescents of a private school (61.3% boys; mean age 14.1 years old; standard deviation=2). All of them completed a questionnaire about tinnitus and hypersensitivity to sounds (sound intolerance), and then underwent otoscopy, pure-tone audiometry, HFA, LDL, transient and distortion product otoacoustic emissions (TOAE and DPOAE), and tinnitus pitch/loudness matching (the latter only in those with tinnitus). Participants were later divided into three groups: with no tinnitus (n=73, 43.4%), with sporadic tinnitus (n=47, 28%), and with constant tinnitus (n=48, 28.6%). RESULTS: No significant difference was observed between the groups regarding audiometry thresholds in frequencies from 0.25 to 16 kHz, or TOAE and DPOAE. However, the LDL in adolescents with constant tinnitus was significantly lower than that in other groups, suggesting hypersensitivity to sounds. CONCLUSION: There was no evidence of minimal hearing damage in the audiometry and OAE. Nonetheless, the decreased LDL in adolescents with constant tinnitus suggests that their auditory system is more sensitive. Therefore, this may be the first sign of vulnerability to sounds. Future medium- to long-term monitoring of these students may show whether they will begin a process of functional impairment, altering hearing thresholds, and OAE.

Early Changes in Auditory Function As a Result of Platinum Chemotherapy: Use of Extended High-Frequency Audiometry and Evoked Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 25 (10) ◽  
pp. 1190-1195 ◽  
Author(s):  
Kristin R. Knight ◽  
Dale F. Kraemer ◽  
Christiane Winter ◽  
Edward A. Neuwelt
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Function ◽  
Cochlear Function ◽  
Serial Measurement ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Platinum Based Chemotherapy ◽  
Platinum Chemotherapy

Purpose The objective is to describe progressive changes in hearing and cochlear function in children and adolescents treated with platinum-based chemotherapy and to begin preliminary evaluation of the feasibility of extended high-frequency audiometry and distortion product otoacoustic emissions for ototoxicity monitoring in children. Patients and Methods Baseline and serial measurement of conventional pure-tone audiometry (0.5 to 8 kHz) and evoked distortion product otoacoustic emissions (DPOAEs) were conducted for 32 patients age 8 months to 20 years who were treated with cisplatin and/or carboplatin chemotherapy. Seventeen children also had baseline and serial measurement of extended high-frequency (EHF) audiometry (9 to 16 kHz). Audiologic data were analyzed to determine the incidence of ototoxicity using the American Speech-Language-Hearing Association criteria, and the relationships between the different measures of ototoxicity. Results Of the 32 children, 20 (62.5%) acquired bilateral ototoxicity in the conventional frequency range during chemotherapy treatment, and 26 (81.3%) had bilateral decreases in DPOAE amplitudes and dynamic range. Of the 17 children with EHF audiometry results, 16 (94.1%) had bilateral ototoxicity in the EHF range. Pilot data suggest that EHF thresholds and DPOAEs show ototoxic changes before hearing loss is detected by conventional audiometry. Conclusion EHF audiometry and DPOAEs have the potential to reveal earlier changes in auditory function than conventional frequency audiometry during platinum chemotherapy in children.

scholarly journals Hubungan ototoksisitas dan kemoterapi neoadjuvan pada karsinoma nasofaring berdasarkan ASHA, CTCAE, dan DPOAE

2018 ◽  
Vol 47 (2) ◽  
pp. 102
Author(s):  
Meyrna Heryaning Putri ◽  
Pudji Rahaju ◽  
Dyah Indrasworo
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Early Detection ◽  
Adverse Events ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Distortion Product Otoacoustic Emissions ◽  
Hearing Level ◽  
Type Iii ◽  
Distortion Product ◽  
Significant Difference

Latar belakang: Kemoterapi neoadjuvan adalah induksi kemoterapi sebelum radioterapi dengan regimen cisplatin dan 5-Fluorouracil. Kemoterapi cisplatin bersifat ototoksik pada pendengaran sensorineural bilateral progresif dan bersifat irreversible. Kriteria dari American Speech-Language Hearing Association (ASHA) dan Common Terminology Criteria for Adverse Events (CTCAE) merupakan kriteria untuk mengidentifikasi ototoksisitas dengan menggunakan audiometri, selain pemeriksaan Distortion Product Otoacoustic Emissions (DPOAE). Tujuan: Mengidentifikasi hubungan ototoksisitas dengan kemoterapi neoadjuvan pada penderita karsinoma nasofaring (KNF) WHO tipe III menggunakan ASHA, CTCAE, serta DPOAE. Metode: Studi ini adalah penelitian observasional dengan desain cohort. Kriteria inklusi penelitian yaitu penderita baru KNF WHO tipe III, yang mendapatkan kemoterapi regimen standar dan berusia <60 tahun. Kriteria pemeriksaan DPOAE adalah penderita dengan ambang dengar ≤40 dB. Percontoh dilakukan pemeriksaan timpanometri, audiometri, dan DPOAE. Hasil: Terdapat 9 sampel percontoh penelitian. Uji repeated-ANOVA menunjukkan tidak ditemukan perbedaan bermakna pada tiga hasil pengukuran audiometri antara pascakemoterapi pertama, kedua, dan ketiga (p>0,05). Deteksi awal ototoksisitas menggunakan kriteria ASHA menunjukkan sensitivitas sebesar 67% dan dan CTCAE 44%, dibandingkan baku emas menggunakan DPOAE. Kesimpulan: Ototoksisitas cisplatin ditemukan sejak kemoterapi pertama dengan menggunakan pemeriksaan DPOAE walaupun tidak bermakna secara statistik. Kemampuan DPOAE untuk mendeteksi awal ototoksisitas lebih baik dibandingkan kriteria ASHA dan CTCAE yang menggunakan audiometri nada murni.Kata kunci: Karsinoma nasofaring, ototoksisitas sisplatin, DPOAE, CTCAE, ASHA ABSTRACT Introduction: Neoadjuvant chemotherapy is induction chemotherapy before radiotherapy with cisplatin and 5-Fluorouracyl regiment. Chemotherapy cisplatin is ototoxic, leads to frequently progresive and irreversible bilateral sensorineural hearing loss. American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE) are the criteria to determine ototoxicity with audiometry, beside Distortion Product Otoacoustic Emissions (DPOAE). Purpose: To identify the relationship between ototoxicity with neoadjuvant chemotherapy in patients NPC WHO type III using ASHA, CTCAE, and DPOAE. Method: This observational study approach with cohort design. Inclusion criteria: new patients NPC WHO type III who consented to undergo standard regiment chemotherapy, and age <60 year-old. For DPOAE examination: hearing level ≤40 dB. Exclucion criteria: NPC WHO type III patients who underwent chemotherapy with unconventional standard regiment. Examinations for hearing function conducted with tympanometry, pure tone audiometry, and Distortion Product Otoacoustic Emissions (DPOAE). Result: There were 9 sample in this study. The result of Repeated-ANOVA test showed no significant difference in three audiometry measurements among three series of chemotherapies. Early detection of ototoxicity using ASHA and CTCAE criterias showed sensitivity of 67% and 44% (compared with DPOAE as a gold standard). Conclusion: Cisplatin ototoxicity had occured since the first chemotherapy and detected with DPOAE, but statistically was not significantly related. Early detection of cisplatin ototoxicity with DPOAE was much better than with criteria American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE), which used pure tone audiometry.Keywords: Nasopharyngeal carcinoma, cisplatin ototoxicity, DPOAE, CTCAE, ASHA

scholarly journals Is the Level of Noise in a School Environment be Harmful to the Hearing of Teachers?

2020 ◽  
Vol 24 (04) ◽  
pp. e503-e507
Author(s):  
Gabriela Guenther Ribeiro Novanta ◽  
Sergio Luiz Garavelli ◽  
Andre Luiz Lopes Sampaio
Keyword(s):  
Classroom Environment ◽  
School Environment ◽  
Otoacoustic Emissions ◽  
Signal To Noise Ratio ◽  
Signal Amplitude ◽  
Daily Basis ◽  
Outer Hair Cells ◽  
Distortion Product ◽  
Teachers And Students ◽  
The Difference

Abstract Introduction The excessive noise observed in the school environment can cause damages or losses to the learning process as well as risks to the health of teachers and students, such as physical, mental and social impairments, including, among them, hearing loss. Objective To assess otoacoustic emissions in teachers and determine whether classroom noise reduces distortion-product otoacoustic emissions (DPOAEs) amplitude and signal-to-noise ratio (SNR). Method Sixty-seven teachers were evaluated using otoacoustic emissions testing in two situations: after hearing rest and after the working day. Results Signal amplitude (p = 0.044 [2 kHz]; p = 0.01 [4 kHz]) and SNR for frequencies of 2 kHz (p = 0.008) and 4 kHz (p = 0.001) decreased significantly between time points. Mean classroom noise was associated with the magnitude of the difference in signal amplitude at 2 kHz (p = 0.017) and 4 kHz (p = 0.015), and SNR at 4 kHz (p = 0.023). Conclusions There was a decrease in the amplitude and in the SNR after exposure to the noise in the classroom environment. The high levels of sound pressure that teachers are exposed to on a daily basis can cause a temporary change in the outer hair cells of the Corti organ, and these changes may become permanent over time.

scholarly journals The Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats

2017 ◽  
Vol 96 (6) ◽  
pp. E12-E17 ◽  
Author(s):  
Aylin Göl ◽  
Engin Şengül ◽  
Beyhan Yılmaz ◽  
Fazıl Emre Özkurt ◽  
Mehmet Akdağ ◽  
...  
Keyword(s):  
Experimental Study ◽  
Hair Cells ◽  
Otoacoustic Emissions ◽  
Albino Rats ◽  
Protective Effects ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Dexamethasone Group ◽  
Significant Difference ◽  
Intratympanic Dexamethasone

The purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended. On the 45th day, after the final DPOAE tests, animals of all groups were sacrificed under general anesthesia. The differences between the amplitudes of DPOAE results were determined, and hearing results were statistically analyzed. Also, the cochleas of each rat were histopathologically evaluated under a light microscope with hematoxylin and eosin staining. In the intratympanic dexamethasone group it was observed that cochlear hair cells were mostly protected. No significant difference was seen between the DPOAE results before and after treatment (p > 0.05). On the other hand, loss was observed in the hearing functions and hair cells of the rats that received streptomycin and streptomycin plus intratympanic saline (p < 0.05). In the streptomycin plus intratympanic dexamethasone group, the cochlear hair cells were partially protected. A significant difference was observed when the DPOAE results (DP-grams) of the streptomycin plus intratypmanic dexamethasone group were compared to those of the streptomycin plus intratympanic saline group (p < 0.05). After the experimental study, ototoxic effects of the administration of streptomycin and intratympanic dexamethasone were observed on the rats’ cochlear hair cells. We conclude that intratympanic dexamethasone has protective effects against this cochlear damage in rats.

scholarly journals Does Vincristine affect Cochlear function in children with acute lymphoblastic leukaemia?

2016 ◽  
Vol 27 (1) ◽  
pp. 3-7
Author(s):  
Suchetha Rao ◽  
Ranjith Kumar ◽  
Jayashree Bhat ◽  
Nutan Kamath
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Lymphoblastic Leukemia ◽  
Statistical Significance ◽  
Pure Tone Audiometry ◽  
Cochlear Function ◽  
Hearing Sensitivity ◽  
Distortion Product ◽  
High Frequency Audiometry

Context: Vincristine chemotherapy has dose dependent ototoxicity. Early detection of ototoxicity is better with otoacoustic emissions and high frequency audiometry than conventional pure tone audiometry. The study was done to see if vincristine treatment interferes with hearing sensitivity in children.Methods and Material: A prospective study was conducted on twenty-three children with acute lymphoblastic leukemia (ALL) on Multi Center Protocol (MCP 841).These were subjected to conventional audiometry, high frequency audiometry and distortion product otoacoustic emissions (DPOAEs) before starting chemotherapy. The follow up audiological evaluation after early intensive phase chemotherapy (approximately 6 months) was conducted in thirteen children, who received 12 doses of vincristine (1.4 mg/m2), cranial irradiation of 1800cGy (>3 years) as per protocol and antibiotics as per clinical demands.Results: Baseline audiological evaluation was normal. Follow-up evaluation DPOAEs showed a declining tendency, however changes did not reach statistical significance. Differences in median hearing thresholds prior and post treatment in higher frequency audiometry were also minimal which was not statistically significant. Conventional audiometric thresholds were not altered.Conclusions: The reduction in the signal noise ratio of DPOAE, and reduced hearing sensitivity in high frequencies in post chemotherapy in comparison with baseline measures cannot be ignored though it has failed to reach the level of statistical significance. children on vincristine should have a pre chemotherapy and follow up audiological evaluation with DPOAE The results of the present study needs to be strengthened by including larger sample and long term follow up.Bangladesh J Medicine Jan 2016; 27(1) : 3-7

The Effects of Body Position on Distortion-Product Otoacoustic Emission Testing

2004 ◽  
Vol 15 (08) ◽  
pp. 566-573 ◽  
Author(s):  
Carlie Driscoll ◽  
Joseph Kei ◽  
Jenny Shyu ◽  
Natasha Fukai
Keyword(s):  
Otoacoustic Emissions ◽  
Signal To Noise Ratio ◽  
Body Position ◽  
Otoacoustic Emission ◽  
Clinical Results ◽  
Distortion Product Otoacoustic Emission ◽  
Position Effects ◽  
Distortion Product ◽  
Emission Testing ◽  
Common Clinical Practice

Otoacoustic emissions are frequently acquired from patients in a variety of body positions aside from the standard, seated orientation. Yet little knowledge is available regarding whether these deviations will produce nonpathological changes to the clinical results obtained. The present study aimed to describe the effects of body position on the distortion-product otoacoustic emissions of 60 normal-hearing adults. With particular attention given to common clinical practice, the Otodynamics ILO292, and the measurement parameters of amplitude, signal-to-noise ratio, and noise were utilized. Significant position-related effects and interactions were revealed for all parameters. Specifically, stronger emissions in the mid frequencies and higher noise levels at the extreme low and high frequencies were produced by testing subjects while lying on their side compared with the seated position. Further analysis of body position effects on emissions is warranted, in order to determine the need for clinical application of position-dependent normative data.

Detection of Hearing Loss Using 2f2-f1 and 2f1-f2 Distortion-Product Otoacoustic Emissions

2005 ◽  
Vol 48 (5) ◽  
pp. 1165-1186 ◽  
Author(s):  
Tracy S. Fitzgerald ◽  
Beth A. Prieve
Keyword(s):  
Otoacoustic Emissions ◽  
Signal To Noise Ratio ◽  
Normal Hearing ◽  
Hearing Impaired ◽  
Distortion Product Otoacoustic Emissions ◽  
Signal To Noise ◽  
Primary Level ◽  
Distortion Product ◽  
Hearing Status ◽  
Stimulus Parameters

Although many distortion-product otoacoustic emissions (DPOAEs) may be measured in the ear canal in response to 2 pure tone stimuli, the majority of clinical studies have focused exclusively on the DPOAE at the frequency 2f1-f2. This study investigated another DPOAE, 2f2-f1, in an attempt to determine the following: (a) the optimal stimulus parameters for its clinical measurement and (b) its utility in differentiating between normal-hearing and hearing-impaired ears at low-to-mid frequencies (≤2000 Hz) when measured either alone or in conjunction with the 2f1-f2 DPOAE. Two experiments were conducted. In Experiment 1, the effects of primary level, level separation, and frequency separation (f2/f1) on 2f2-f1 DPOAE level were evaluated in normal-hearing ears for low-to-mid f2 frequencies (700–2000 Hz). Moderately high-level primaries (60–70 dB SPL) presented at equal levels or with f2 slightly higher than f1 produced the highest 2f2-f1 DPOAE levels. When the f2/f1 ratio that produced the highest 2f2-f1 DPOAE levels was examined across participants, the mean optimal f2/f1 ratio across f2 frequencies and primary level separations was 1.08. In Experiment 2, the accuracy with which DPOAE level or signal-to-noise ratio identified hearing status at the f2 frequency as normal or impaired was evaluated using clinical decision analysis. The 2f2-f1 and 2f1-f2 DPOAEs were measured from both normal-hearing and hearing-impaired ears using 2 sets of stimulus parameters: (a) the traditional parameters for measuring the 2f1-f2 DPOAE (f2/f1 = 1.22; L1, L2 = 65, 55 dB SPL) and (b) the new parameters that were deemed optimal for the 2f2-f1 DPOAE in Experiment 1 (f2/f1 = 1.073, L1 and L2 = 65 dB SPL). Identification of hearing status using 2f2-f1 DPOAE level and signal-to-noise ratio was more accurate when the new stimulus parameters were used compared with the results achieved when the 2f2-f1 DPOAE was recorded using the traditional parameters. However, identification of hearing status was less accurate for the 2f2-f1 DPOAE measured using the new parameters than for the 2f1-f2 DPOAE measured using the traditional parameters. No statistically significant improvements in test performance were achieved when the information from the 2 DPOAEs was combined, either by summing the DPOAE levels or by using logistic regression analysis.

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