scholarly journals Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259385
Author(s):  
Mallory R. Taylor ◽  
Michelle M. Garrison ◽  
Abby R. Rosenberg

Background Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer. Methods This was a secondary analysis of baseline data from a randomized trial testing a resilience intervention in AYAs with cancer. Two widely used HRV metrics, the standard deviation of normal to normal beats (SDNN) and root mean square of successive differences (RMSSD), were derived from electrocardiograms. Patient-reported outcome (PRO) survey measures included quality of life, anxiety, depression, distress, and resilience. Linear regression models were used to test associations between HRV and PRO scores. The Wilcoxon rank sum test was used to test differences in median HRV values among participant subgroups. Results Among the n = 76 patients with available electrocardiograms, the mean age was 16 years (SD 3y), 63% were white, and leukemia/lymphoma was the most common diagnosis. Compared to healthy adolescents, AYAs with cancer had lower median HRV (SDNN [Females: 31.9 (12.8–50.7) vs 66.4 (46.0–86.8), p<0.01; Males: 29.9 (11.5–47.9) vs 63.2 (48.4–84.6), p<0.01]; RMSSD [Females: 28.2 (11.1–45.5) vs 69.0 (49.1–99.6), p<0.01; Males: 27.9 (8.6–48.6) vs 58.7 (44.8–88.2), p<0.01]). There was no statistically significant association between PRO measures and SDNN or RMSSD in either an unadjusted or adjusted linear regression models. Conclusion In this secondary analysis, we did not find an association between HRV and psychosocial PROs among AYAs with cancer. HRV measures were lower than for healthy adolescents. Larger prospective studies in AYA biopsychosocial research are needed.

Pain ◽  
2017 ◽  
Vol 158 (8) ◽  
pp. 1509-1516 ◽  
Author(s):  
Lynn S. Walker ◽  
Amanda L. Stone ◽  
Craig A. Smith ◽  
Stephen Bruehl ◽  
Judy Garber ◽  
...  

Author(s):  
Aimée R. Caillet ◽  
Alexandra C. Russell ◽  
Marcus G. Wild ◽  
Sari Acra ◽  
Leonard A. Bradshaw ◽  
...  

2018 ◽  
Vol 16 (3) ◽  
pp. 134-144 ◽  
Author(s):  
Theresa A. Koleck ◽  
Niurka Suero-Tejeda ◽  
Suzanne Bakken

Introduction: Little is known about the Latino symptom experience and how symptoms influence participation in usual activities and satisfaction with participation in social roles. Method: Secondary analysis of survey data collected in community and clinic settings was conducted. Data were collected using Health-Related Quality of Life 30-day items and Patient Reported Outcome Measurement System symptom status scales. Descriptive statistics and univariate linear and multiple linear regression models were computed. Results: Participants ( N = 2,974) were primarily female and Dominican. Most surveys were completed in Spanish and in the community setting; and the clinic sample had more symptoms. In the multiple linear regression for participation in usual activities, as the number of days with symptoms increased, the number of days that poor physical or mental health influenced participation in usual activities increased. In addition, for satisfaction with participation in social roles, as the number of days with pain and levels of depression and anxiety increased, the levels of satisfaction decreased. Spanish survey administration was associated with decreased levels of satisfaction; and recruitment setting was not a significant predictor. Conclusion: The study addressed multiple knowledge gaps about the Latino symptom experience.


2018 ◽  
Vol 6 (12) ◽  
pp. 232596711881236 ◽  
Author(s):  
Jakob Ackermann ◽  
Takahiro Ogura ◽  
Robert A. Duerr ◽  
Alexandre Barbieri Mestriner ◽  
Andreas H. Gomoll

Background: Patient-reported outcome (PRO) measures are progressively utilized as evaluation tools in preoperative and postoperative assessments in orthopaedic practice. Identifying the potential utility of psychosocial factors to predict patient-reported pain and functional outcomes is of increasing interest to determine which patients will derive the greatest benefit from surgical treatment. Purpose/Hypothesis: The purpose of this study was to determine potential predictive associations between the preoperative 12-Item Short Form Health Survey Mental Component Summary (SF-12 MCS) score, patient characteristics or osteochondral allograft (OCA) morphology, and PROs in patients who underwent OCA transplantation. We hypothesized that poor preoperative mental health is associated with diminished PROs at final follow-up. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 67 patients with a mean follow-up of 2.7 ± 1.0 years (range, 2-6 years) with complete preoperative and at least 24-month postoperative SF-12 MCS, Knee injury and Osteoarthritis Outcome Score (KOOS), Tegner, Lysholm, and International Knee Documentation Committee (IKDC) scores were included in this study. Pearson correlation coefficients and linear regression models were used to distinguish associations between age, sex, smoking status, body mass index, workers’ compensation, previous surgery, concomitant surgery, number of grafts, defect location, total graft size, SF-12 MCS score, and postoperative PRO scores as well as their improvement from baseline (delta). Results: The SF-12 MCS showed significant correlation with the KOOS Activities of Daily Living subscale ( P = .015), KOOS Sport/Recreation subscale ( P = .024), and IKDC ( P = .039). In the multivariable linear regression models, the SF-12 MCS had no predictive association with any PRO measure. Patient sex contributed significantly to the final regression models of the KOOS Sport/Recreation ( P = .042), Tegner score ( P = .024), and Lysholm score ( P = .031). The SF-12 MCS showed no bivariate correlation with changes in any PRO score (delta) ( P > .05). Conclusion: Preoperative mental health status did not predict perceived functional outcomes as assessed by PRO measures at final follow-up. Female sex was negatively correlated with KOOS Sport/Recreation, Tegner, and Lysholm scores.


2018 ◽  
Vol 48 (5) ◽  
pp. 386-396 ◽  
Author(s):  
Jessica L. Bourdon ◽  
Ashlee A. Moore ◽  
Meridith Eastman ◽  
Jeanne E. Savage ◽  
Laura Hazlett ◽  
...  

Author(s):  
Mario Estévez-Báez ◽  
Claudia Carricarte-Naranjo ◽  
Javier Denis Jas-García ◽  
Evelyn Rodríguez-Ríos ◽  
Calixto Machado ◽  
...  

2020 ◽  
Vol 6 (2) ◽  
pp. 118-135
Author(s):  
Abigail T. Evans ◽  
Jess Wilhelm ◽  
Haneen Abudayyeh ◽  
Lexie Perreras ◽  
Amy M. Cohn

Objectives: In this study, we measured the effects of cigarillo packaging colors and flavor descriptors on appeal and perceived risk among young adults. Methods: United States-based young adults (ages 18-24) recruited via Amazon Mechanical Turk were randomized to view one of 7 images of cigarillo packages that varied in color (Black and White [B&W], brown, red) and flavor descriptor (none, tobacco, apple). Respondents rated the product's appeal, risk, and addictiveness. Differences in ratings by study condition were assessed using linear regression models with bootstrapped standard errors. Results: There were 2818 participants, and 26.5% reported having ever used a little cigar or cigarillo. Brown and red packaging were rated as more appealing (vs B&W) across 4 dimensions (all ps < .05). Compared to no flavor descriptor, tobacco flavor was rated as more "Attention-Grabbing" (b = 0.21, p = .010) and apple flavor was rated higher on all 8 measures of appeal (all ps < .05) and perceived as less addictive (b = -0.13, p = .024). Conclusions: Colors and flavor descriptors on cigarillo packaging increased appeal and decreased perceived addictiveness. Restricting color and flavor descriptors on packaging may reduce their appeal.


2018 ◽  
Vol 23 (1) ◽  
pp. 60-71
Author(s):  
Wigiyanti Masodah

Offering credit is the main activity of a Bank. There are some considerations when a bank offers credit, that includes Interest Rates, Inflation, and NPL. This study aims to find out the impact of Variable Interest Rates, Inflation variables and NPL variables on credit disbursed. The object in this study is state-owned banks. The method of analysis in this study uses multiple linear regression models. The results of the study have shown that Interest Rates and NPL gave some negative impacts on the given credit. Meanwhile, Inflation variable does not have a significant effect on credit given. Keywords: Interest Rate, Inflation, NPL, offered Credit.


Author(s):  
Nykolas Mayko Maia Barbosa ◽  
João Paulo Pordeus Gomes ◽  
César Lincoln Cavalcante Mattos ◽  
Diêgo Farias Oliveira

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