scholarly journals Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

2021 ◽  
Vol 17 (12) ◽  
pp. e1010106
Author(s):  
Olivier Terrier ◽  
Mustapha Si-Tahar ◽  
Mariette Ducatez ◽  
Christophe Chevalier ◽  
Andrés Pizzorno ◽  
...  
Keyword(s):  
Control Strategies ◽  
Influenza Viruses ◽  
Technological Innovations ◽  
The Past ◽  
Research Challenges ◽  
Global Pandemic ◽  
Molecular Determinants ◽  
Viral Emergence ◽  
Pandemic Response ◽  
Review Current

The development of safe and effective vaccines in a record time after the emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a remarkable achievement, partly based on the experience gained from multiple viral outbreaks in the past decades. However, the Coronavirus Disease 2019 (COVID-19) crisis also revealed weaknesses in the global pandemic response and large gaps that remain in our knowledge of the biology of coronaviruses (CoVs) and influenza viruses, the 2 major respiratory viruses with pandemic potential. Here, we review current knowns and unknowns of influenza viruses and CoVs, and we highlight common research challenges they pose in 3 areas: the mechanisms of viral emergence and adaptation to humans, the physiological and molecular determinants of disease severity, and the development of control strategies. We outline multidisciplinary approaches and technological innovations that need to be harnessed in order to improve preparedeness to the next pandemic.

Novel Coronavirus SARS-CoV-2 (COVID-19) and Pregnancy: A hypothetical view

2020 ◽  
Vol 20 ◽  
Author(s):  
Ahmed RG
Keyword(s):  
Immune System ◽  
Cellular Therapy ◽  
Early Stage ◽  
Control Strategies ◽  
Vital Role ◽  
Healthy Life ◽  
Global Pandemic ◽  
Maternal Immune System ◽  
Perinatal Management ◽  
Novel Coronavirus

Background: The complications of the SARS-CoV-2 infection and its COVID-19 disease on mothers and their offspring are less known. Objective: The aim of this review was to determine the transmission, severity, complications of SARS-CoV-2 infection during the pregnancy. This review showed the influence of COVID-19 disease on the neonatal neurogenesis. Owing to no specific vaccines or medicines that were reported for the treatment of COVID-19 disease, this review suggested some control strategies like treatments (medicinal plants, antiviral therapy, cellular therapy, and immunotherapy), nutrition uptake, prevention, and recommendations. Discussion: This overview showed in severely states that SARS-CoV-2 infection during the early stage of pregnancy might increase the risk of stress, panic, and anxiety. This disorder can disturb the maternal immune system, and thus causing a neurodevelopmental disturbance. This hypothesis may be depending on the severity and intensity of the SARS-CoV-2 infection during pregnancy. However, vertical transmission of SARS-CoV-2 from dams to their fetuses is absent until now. Conclusion: During this global pandemic disease, maintaining safety during pregnancy, vaginal delivery, and breastfeeding may play a vital role in a healthy life for the offspring. Thus, international and national corporations should be continuing for perinatal management, particularly during the next pandemic or disaster time.

A Brief outlook on possible available solutions, therapies and suggestions for COVID-19

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Rashmi Saxena Pal ◽  
Yogendra Pal ◽  
Pranay Wal ◽  
Ankita Wal ◽  
Nikita Saraswat
Keyword(s):  
United States ◽  
Plasma Therapy ◽  
Social Distancing ◽  
The Past ◽  
Antiviral Compounds ◽  
Global Pandemic ◽  
Case Count ◽  
Current Scenario ◽  
Hiv Drugs

Background: WHO declared COVID-19 a global pandemic. New cases are being added every day, as the case count in United States are to the maximum. No drugs or biologics are yet found to be effective for the prevention or treatment of COVID-19. Objective: To discuss the possibilities of available treatments available. Materials & Methods: Brief out-look is undertaken over the past issues available over the similar situations occurred with respect to the current scenario and prospectives. Results: There can be various possibilities in form of convalescent plasma therapy. The known drugs as HIV drugs, antimalarial medicines and antiviral compounds can serve as suggestive option. Conclusion: Till a confirm medicine or vaccine is sorted out for Covid-19, we need to take natural immune-boosters, along with precautionary steps, social distancing and other preventions as instructed for the benefit of everyone with an optimistic mind and attitude.

scholarly journals Phylogenetic Complexity of Morphologically Identified Anopheles squamosus in Southern Zambia

Insects ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 146
Author(s):  
Jordan Hoffman ◽  
Ilinca Ciubotariu ◽  
Limonty Simubali ◽  
Twig Mudenda ◽  
William Moss ◽  
...  
Keyword(s):  
Phylogenetic Relationships ◽  
Catchment Area ◽  
Control Strategies ◽  
Light Trap ◽  
Current Control ◽  
Control Measures ◽  
Morphological Identification ◽  
The Past ◽  
Blood Meal Source ◽  
Residual Malaria Transmission

Despite dramatic reductions in malaria cases in the catchment area of Macha Hospital, Choma District, Southern Province in Zambia, prevalence has remained near 1–2% by RDT for the past several years. To investigate residual malaria transmission in the area, this study focuses on the relative abundance, foraging behavior, and phylogenetic relationships of Anopheles squamosus specimens. In 2011, higher than expected rates of anthropophily were observed among “zoophilic” An. squamosus, a species that had sporadically been found to contain Plasmodium falciparum sporozoites. The importance of An. squamosus in the region was reaffirmed in 2016 when P. falciparum sporozoites were detected in numerous An. squamosus specimens. This study analyzed Centers for Disease Control (CDC) light trap collections of adult mosquitoes from two collection schemes: one performed as part of a reactive-test-and-treat program and the second performed along a geographical transect. Morphological identification, molecular verification of anopheline species, and blood meal source were determined on individual samples. Data from these collections supported earlier studies demonstrating An. squamosus to be primarily exophagic and zoophilic, allowing them to evade current control measures. The phylogenetic relationships generated from the specimens in this study illustrate the existence of well supported clade structure among An. squamosus specimens, which further emphasizes the importance of molecular identification of vectors. The primarily exophagic behavior of An. squamosus in these collections also highlights that indoor vector control strategies will not be sufficient for elimination of malaria in southern Zambia.

scholarly journals 666 Innovations in ENT Surgery During The COVID-19 Pandemic

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
M Aziz ◽  
M Benamer ◽  
S Hany ◽  
Y Sahib
Keyword(s):  
Healthcare Workers ◽  
Sinus Surgery ◽  
Healthcare Team ◽  
Ear Surgery ◽  
The Past ◽  
Ent Surgery ◽  
Global Pandemic ◽  
Theatre Staff ◽  
Reduce Risk ◽  
Nose And Throat

Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is responsible for the coronavirus disease 2019 (COVID – 19) global pandemic. Similar coronavirus epidemics over the past years affected healthcare workers significantly. Aerosol generating procedures (AGPs) presented a unique risk to ear, nose and throat (ENT) Surgeons. We introduce various methods of reducing risk in ENT AGPs. Recommendations During trachesostomies we advocate the adoption of a specialist checklist based on ENT UK guidelines. We also advise the use of a clear drape to create a clear barrier between the patient and staff. For ear surgery we advise suturing 2 microscope pieces together end-to-end so that a clear drape can sperate the patient from surgeon. During nasal and sinus surgery, we advise attaching a clear drape to the sterile camera drape used in rigid nasal endoscopy to create a barrier between patient and surgeon. Discussion Our recommendations will create an extra barrier between the patient and the rest of healthcare team. This should reduce the risks to theatre staff from AGPs. Conclusions COVID 19 is a serious health issue affecting healthcare workers, especially during AGPs in ENT surgery. We recommend several techniques to reduce risk. These can also be used during future epidemics.

Practising piety in a (post-) pandemic time: A spatial reading of piety in Psalm 66 from the perspectives of memory and bodily imagery

2021 ◽  
Vol 77 (4) ◽  
Author(s):  
Lodewyk Sutton
Keyword(s):  
Old Testament ◽  
Social Anthropology ◽  
The Past ◽  
Body Imagery ◽  
Research Article ◽  
Global Pandemic ◽  
Practical Theological ◽  
The Individual ◽  
Exodus Narrative ◽  
The Church

Situated in the larger collection of Psalms 51–72, also known as the second Davidic Psalter, the smaller group of Psalms 65–68 is found. This smaller collection of psalms can be classified mostly as psalms of praise and thanksgiving. The relation and compositional work in this cluster of psalms become apparent on many points in the pious expressions between groups and persons at prayer, especially in the universal praise of God, and in the imagery referring to the exodus, the Jerusalem cult and blessing. Such piety becomes most discernible in the imagery and expressions in Psalm 66. The psalm’s two main sections may be described as praise, with verses 1–12 being praise by the group or the ‘we’, and verses 13–20 being praise by the individual or the ‘I’. Personal or individual piety and private piety are expressed by the desire of the ‘we’ and the ‘I’, and the experienced immediacy to God by transposing the past into the present through the memory of the exodus narrative, the Jerusalem cultic imagery and the use of body imagery. In this research article, an understanding of piety in Psalm 66 in terms of the memory of past events and body imagery is discussed from a perspective of space and appropriated for a time of (post-) pandemic where normal or traditional ecclesiological formal practices cannot take place.Contribution: This article makes an interdisciplinary contribution based on knowledge from the Psalms in the Old Testament, social anthropology, literary spatial theories and practical theological perspectives on the church in order to contribute to the relevance and practice of theology today, during a time of turmoil and a global pandemic.

Equine and canine influenza: a review of current events

2010 ◽  
Vol 11 (1) ◽  
pp. 43-51 ◽  
Author(s):  
E. Paul J. Gibbs ◽  
Tara C. Anderson
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Influenza A ◽  
One Health ◽  
Control Strategies ◽  
Close Association ◽  
Companion Animals ◽  
Emerging Diseases ◽  
Influenza Viruses ◽  
Canine Influenza

AbstractIn the past decade, the pandemics of highly pathogenic avian influenza H5N1 and the novel H1N1 influenza have both illustrated the potential of influenza viruses to rapidly emerge and spread widely in animals and people. Since both of these viruses are zoonotic, these pandemics have been the driving force behind a renewed commitment by the medical and veterinary professions to practice One World, One Health for the control of infectious diseases. The discovery in 2004 that an equine origin H3N8 influenza virus was the cause of an extensive epidemic of respiratory disease in dogs in the USA came as a surprise; at that time dogs were thought to be refractory to infection with influenza viruses. In 2007, a second emerging canine influenza was confirmed in Korea, but this time the causal virus was an H3N2 avian influenza virus. This review focuses on recent events associated with equine and canine influenza viruses. While these viruses do not appear to be zoonotic, the close association between humans and dogs, and to a lesser extent horses, demands that we develop better surveillance and control strategies for emerging diseases in companion animals within the context of One World, One Health.

scholarly journals How alkaline compounds control atmospheric aerosol particle acidity

2021 ◽  
Vol 21 (19) ◽  
pp. 14983-15001
Author(s):  
Vlassis A. Karydis ◽  
Alexandra P. Tsimpidi ◽  
Andrea Pozzer ◽  
Jos Lelieveld
Keyword(s):  
Public Health ◽  
Aerosol Particle ◽  
Atmospheric Chemistry ◽  
Climate Model ◽  
Control Strategies ◽  
Atmospheric Particulate Matter ◽  
Cloud Formation ◽  
Mass Composition ◽  
The Past ◽  
Aerosol Hygroscopicity

Abstract. The acidity of atmospheric particulate matter regulates its mass, composition, and toxicity and has important consequences for public health, ecosystems and climate. Despite these broad impacts, the global distribution and evolution of aerosol particle acidity are unknown. We used the comprehensive atmospheric multiphase chemistry–climate model EMAC (ECHAM5/MESSy Atmospheric Chemistry) to investigate the main factors that control aerosol particle acidity and uncovered remarkable variability and unexpected trends during the past 50 years in different parts of the world. Aerosol particle acidity decreased strongly over Europe and North America during the past decades while at the same time it increased over Asia. Our simulations revealed that these particle acidity trends are strongly related to changes in the phase partitioning of nitric acid, production of sulfate in aqueous aerosols, and the aerosol hygroscopicity. It is remarkable that the aerosol hygroscopicity (κ) has increased in many regions following the particle pH. Overall, we find that alkaline compounds, notably ammonium and to a lesser extent crustal cations, regulate the particle pH on a global scale. Given the importance of aerosol particles for the atmospheric energy budget, cloud formation, pollutant deposition, and public health, alkaline species hold the key to control strategies for air quality and climate change.

scholarly journals Deciphering Molecular Determinants Underlying Penicillium digitatum’s Response to Biological and Chemical Antifungal Agents by Tandem Mass Tag (TMT)-Based High-Resolution LC-MS/MS

2022 ◽  
Vol 23 (2) ◽  
pp. 680
Author(s):  
Lucía Citores ◽  
Mariangela Valletta ◽  
Vikram Pratap Singh ◽  
Paolo Vincenzo Pedone ◽  
Rosario Iglesias ◽  
...  
Keyword(s):  
Fungal Pathogens ◽  
Control Strategies ◽  
Chemical Compounds ◽  
Postharvest Disease ◽  
Tandem Mass ◽  
Cell Wall Degrading Enzymes ◽  
Inhibitory Mechanisms ◽  
Proteomic Approach ◽  
Molecular Determinants ◽  
Protein Toxins

Penicillium digitatum is a widespread pathogen responsible for the postharvest decay of citrus, one of the most economically important crops worldwide. Currently, chemical fungicides are still the main strategy to control the green mould disease caused by the fungus. However, the increasing selection and proliferation of fungicide-resistant strains require more efforts to explore new alternatives acting via new or unexplored mechanisms for postharvest disease management. To date, several non-chemical compounds have been investigated for the control of fungal pathogens. In this scenario, understanding the molecular determinants underlying P. digitatum’s response to biological and chemical antifungals may help in the development of safer and more effective non-chemical control methods. In this work, a proteomic approach based on isobaric labelling and a nanoLC tandem mass spectrometry approach was used to investigate molecular changes associated with P. digitatum’s response to treatments with α-sarcin and beetin 27 (BE27), two proteins endowed with antifungal activity. The outcomes of treatments with these biological agents were then compared with those triggered by the commonly used chemical fungicide thiabendazole (TBZ). Our results showed that differentially expressed proteins mainly include cell wall-degrading enzymes, proteins involved in stress response, antioxidant and detoxification mechanisms and metabolic processes such as thiamine biosynthesis. Interestingly, specific modulations in response to protein toxins treatments were observed for a subset of proteins. Deciphering the inhibitory mechanisms of biofungicides and chemical compounds, together with understanding their effects on the fungal physiology, will provide a new direction for improving the efficacy of novel antifungal formulations and developing new control strategies.

scholarly journals Planetarium commute accessibility in the United States of America

2021 ◽  
Author(s):  
Alexander A. Kaurov ◽  
Vyacheslav Bazhenov ◽  
Mark SubbaRao
Keyword(s):  
United States ◽  
United States Of America ◽  
Science Communication ◽  
The United States ◽  
Census Bureau ◽  
Global Pandemic ◽  
Commute Time ◽  
Pandemic Response ◽  
Zip Code ◽  
The U.S

The COVID-19 global pandemic unprecedently disturbed the education system in the United States and lead to the closure of all planetariums that were providing immersive science communication. This situation motivates us to examine how accessible the planetarium facilities were before the pandemic. We investigate the most important socioeconomic and geographical factors that affect the planetarium accessibility using the U.S. Census Bureau data and the commute time to the nearest planetarium for each ZIP Code Tabulated Area. We show the magnitude of the effect of permanent closure of a fraction of planetariums. Our study can be informative for strategizing the pandemic response.

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