scholarly journals Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

2008 ◽  
Vol 54 (9) ◽  
pp. 1489-1496 ◽  
Author(s):  
Arve Ulvik ◽  
Stein Emil Vollset ◽  
Geir Hoff ◽  
Per Magne Ueland
Keyword(s):  
Pyridoxal Phosphate ◽  
Smoking Status ◽  
Plasma Concentrations ◽  
Coffee Consumption ◽  
Progressive Increase ◽  
B Vitamins ◽  
Middle Aged ◽  
Coffee Intake ◽  
Men And Women ◽  
B Vitamin

Abstract Background: Coffee consumption has been associated with several risk factors for coronary heart disease, including increased cholesterol, increased blood pressure, and increased plasma total homocysteine (tHcy). tHcy is determined by several B-vitamins. However, reports about the association between coffee intake and B-vitamin status are few. Methods: We measured plasma B-vitamins and tHcy in a cohort of 10 601 healthy, middle-aged Norwegian men and women. Information about lifestyle factors, including coffee consumption, smoking, alcohol use, height, and weight, was obtained by interview. Results: Coffee consumption was dose-dependently associated with reduced plasma B-vitamin concentrations. Compared with coffee abstainers, individuals drinking ≥4 cups/day had 11.7% (P < 0.001), 14.1% (P < 0.001), and 5.5% (P = 0.01) lower plasma concentrations of folate, pyridoxal phosphate, and riboflavin, respectively, and the mean tHcy concentration was 6.8% (P < 0.001) higher. Quantile regression analysis showed essentially no difference in B-vitamin concentrations between coffee consumption categories at low vitamin concentrations but a progressive increase in the difference at higher concentrations. This pattern of differences (effect profile) was found independently of smoking status, alcohol intake, and sex. The decrease in folate explained approximately half of the increase in tHcy. Conclusions: Coffee consumption was associated with reduced circulating B-vitamin concentrations. The observed effect profiles indicated that coffee consumption preferentially affected the upper, but not the lower, part of the B-vitamin concentration distributions. We hypothesize that coffee consumption may increase the loss of surplus B-vitamins by excretion in urine.

scholarly journals The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Ngoc Minh Pham ◽  
Daigo Yoshida ◽  
Makiko Morita ◽  
Guang Yin ◽  
Kengo Toyomura ◽  
...  
Keyword(s):  
Uric Acid ◽  
Coffee Consumption ◽  
Baseline Survey ◽  
Inverse Association ◽  
Coffee Intake ◽  
Japanese Men ◽  
Men And Women ◽  
Statistical Adjustment ◽  
Diuretic Drugs ◽  
Lifestyle Related Diseases

Objective. Few studies have suggested an inverse relation between coffee intake and serum concentrations of uric acid (UA), but none has addressed the relation in men and women separately. We examined the relation between coffee intake and serum UA levels in free-living middle-aged and elderly men and women in Fukuoka, Japan.Methods. Study subjects were derived from the baseline survey of a cohort study on lifestyle-related diseases, and included 11.662 men and women aged 49–76 years; excluded were those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease. Statistical adjustment was made for body mass index, alcohol use, hypertension, diabetes mellitus, and other factors.Results. There were inverse associations of coffee consumption with serum UA concentrations and hyperuricemia in men regardless of adjustment for covariates. Women showed a statistically significant, but weaker, inverse association between coffee and serum UA levels after allowance for the confounding factors.Conclusion. The findings add to evidence for a protective association between coffee intake and hyperuricemia.

scholarly journals Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins

2010 ◽  
Vol 56 (5) ◽  
pp. 755-763 ◽  
Author(s):  
Arve Ulvik ◽  
Marta Ebbing ◽  
Steinar Hustad ◽  
Øivind Midttun ◽  
Ottar Nygård ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Smoking Status ◽  
High Plasma ◽  
B Vitamins ◽  
Functional Marker ◽  
Gas Liquid Chromatography ◽  
Short Term ◽  
Intervention Trials ◽  
B Vitamin ◽  
Short Term Effects

Abstract Background: Smoking is associated with decreased concentrations of several antioxidant vitamins. We sought to determine the relation between circulating concentrations of selected B vitamins and smoking status, with particular attention to longitudinal associations. Methods: We used baseline data from 2 B-vitamin intervention trials that included 6837 patients with ischemic heart disease. Smoking habits were ascertained by interview. Vitamins and metabolites, including the nicotine metabolite cotinine, were measured in plasma and serum by microbiological assays or gas/liquid chromatography–tandem mass spectrometry. Results: The highest circulating concentrations of folate and pyridoxal 5′phosphate (PLP) and lowest concentrations of total plasma homocysteine, a functional marker of folate status, were observed for self-reported never smokers, followed by self-reported ex-smokers and current smokers (Ptrend < 0.001). Cobalamin and its functional marker methylmalonic acid were not associated with smoking status. Based on their low cotinine concentrations, we were able to identify a group of smokers that had abstained from smoking for 3 days or more. Compared with smokers with high plasma cotinine, smokers with low cotinine had significantly higher circulating concentrations of folate, PLP, and riboflavin (all P < 0.005), and this trend continued for ex-smokers, with increasing time since smoking cessation. Conclusions: Smoking lowered circulating concentrations of folate, PLP, and riboflavin, but concentrations increased significantly after a few days of smoking cessation. We propose that short-term effects may be related to acute smoking-induced oxidative stress, whereas the longer-lasting effects among ex-smokers may reflect changes in diet and/or restoration of vitamin concentrations in tissue during the first few months to years after smoking cessation.

scholarly journals Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population

2011 ◽  
Vol 14 (10) ◽  
pp. 1805-1812 ◽  
Author(s):  
Tao Huang ◽  
Katherine L Tucker ◽  
Yu-Chi Lee ◽  
Jimmy W Crott ◽  
Laurence D Parnell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Puerto Rican ◽  
Genetic Polymorphisms ◽  
Genetic Variants ◽  
Pyridoxal Phosphate ◽  
Smoking Status ◽  
Plasma Concentrations ◽  
Lifestyle Factors ◽  
Plasma Homocysteine ◽  
Folate Metabolism

AbstractObjectiveTo investigate genetic and lifestyle factors and their interactions on plasma homocysteine (Hcy) concentrations in the Boston Puerto Rican population.DesignCross-sectional study. Plasma concentrations of Hcy, folate, vitamin B12and pyridoxal phosphate were measured, and genetic polymorphisms were determined. Data on lifestyle factors were collected in interviews.SettingA population survey of health and nutritional measures.SubjectsA total of 994 Puerto Rican men and women residing in the Boston metropolitan area.ResultsSmoking status was positively associated with plasma Hcy. Genetic polymorphismsMTHFR677C→T,FOLH11561C→T,FOLH1rs647370 andPCFT928A→G interacted significantly with smoking for Hcy.MTHFR1298A→C (P= 0·040) andPCFT928A→G (P= 0·002) displayed significant interactions with alcohol intake in determining plasma Hcy. Subjects withPCFT928GGgenotype had significantly higher plasma Hcy concentrations compared with carriers of theAallele (AA+AG;P= 0·030) among non-drinking subjects. When consuming alcohol,GGsubjects had lower plasma Hcy levels compared withAA+AGsubjects. Physical activity interacted significantly withMTR2756A→G in determining plasma Hcy (Pfor interaction = 0·002). Smoking interacted with physical activity for plasma Hcy (Pfor interaction = 0·023).ConclusionsSmoking and drinking were associated plasma Hcy concentrations. Genetic variants involved in folate metabolism further modify the effects of lifestyle on plasma Hcy.

scholarly journals Cigarette Smoking and Competing Risks for Fatal and Nonfatal Cardiovascular Disease Subtypes Across the Life Course

2021 ◽  
Author(s):  
Sadiya S. Khan ◽  
Hongyan Ning ◽  
Arjun Sinha ◽  
John Wilkins ◽  
Norrina B. Allen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cigarette Smoking ◽  
Smoking Status ◽  
The United States ◽  
Years Of Life Lost ◽  
Middle Aged ◽  
Cox Models ◽  
Current Smoking ◽  
Men And Women

Background Cigarette smoking is significantly associated with premature death related and not related to cardiovascular disease (CVD). Whether risk associated with smoking is similar across CVD subtypes and how this translates into years of life lost is not known. Methods and Results We pooled and harmonized individual‐level data from 9 population‐based cohorts in the United States. All participants were free of clinical CVD at baseline with available data on current smoking status, covariates, and CVD outcomes. We examined the association between smoking status and total CVD and CVD subtypes, including fatal and nonfatal coronary heart disease, stroke, congestive heart failure, and other CVD deaths. We performed (1) modified Kaplan–Meier analysis to estimate long‐term risks, (2) adjusted competing Cox models to estimate joint cumulative risks for CVD or noncardiovascular death, and (3) Irwin’s restricted mean to estimate years lived free from and with CVD. Of 106 165 adults, 50.4% were women. Overall long‐term risks for CVD events were 46.0% (95% CI, 44.7–47.3) and 34.7% (95% CI, 33.3–36.0) in middle‐aged men and women, respectively. In middle‐aged men who reported smoking compared with those who did not smoke, competing hazard ratios (HRs) were higher for the first presentation being a fatal CVD event (HR, 1.79 [95% CI, 1.68–1.92]), with a similar pattern among women (HR,1.82 [95% CI, 1.68–1.98]). Smoking was associated with earlier CVD onset by 5.1 and 3.8 years in men and women. Similar patterns were observed in younger and older adults. Conclusions Current smoking was associated with a fatal event as the first manifestation of clinical CVD.

Lowering of Homocysteine Concentrations in Elderly Men and Women

1999 ◽  
Vol 69 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Brönstrup ◽  
Hages ◽  
Pietrzik
Keyword(s):  
Low Dose ◽  
Geometric Mean ◽  
B Vitamins ◽  
Vitamin Supplementation ◽  
Entire Treatment Period ◽  
Men And Women ◽  
Elderly Individuals ◽  
Total Homocysteine ◽  
B Vitamin ◽  
Plasma Total Homocysteine

B-vitamin supplementation has previously been shown to lower the concentration of plasma total homocysteine, a risk factor for cardiovascular disease. Little is known about the homocysteine-lowering effects of low-dose B-vitamins in elderly individuals, who are prone to higher homocysteine levels due to advanced age and a greater frequency of impaired vitamin status. We aimed to identify if and to what extent B-vitamins lower total homocysteine and its subfractions in elderly individuals. Men and women (>= 60 years) received either B-vitamins (400 mug folic acid +1.65 mg pyridoxine +3 mug cyanocobalamin) or a placebo daily for 4 weeks. Subjects in the vitamin group showed a significant decrease in plasma total homocysteine during the first 2 weeks; thereafter, total homocysteine only slightly decreased further resulting in a geometric mean reduction of –16.3% (95% CI: –11.3% to –21.0%) over the entire treatment period. Free homocysteine decreased as well. However, the observed higher ratio of free/total homocysteine after 4 weeks of supplementation suggest a more pronounced reduction in protein-bound homocysteine. Low-dose B-vitamin supplementation is effective in lowering homocysteine in elderly individuals. Further studies are needed to be able to depict the effect of B-vitamin supplementation on different homocysteine subfractions in plasma.

scholarly journals A Daily Cup of Tea or Coffee May Keep You Moving: Association between Tea and Coffee Consumption and Physical Activity

2018 ◽  
Vol 15 (9) ◽  
pp. 1812 ◽  
Author(s):  
Luciana Torquati ◽  
Geeske Peeters ◽  
Wendy Brown ◽  
Tina Skinner
Keyword(s):  
Physical Activity ◽  
Regression Models ◽  
Coffee Consumption ◽  
Future Research ◽  
Caffeine Intake ◽  
Middle Aged ◽  
Coffee Intake ◽  
Metabolic Equivalent ◽  
Major Barrier ◽  
Logistic Regression Models

Physical activity (PA) is an independent predictor of mortality and frailty in middle-aged women, but fatigue remains a major barrier in this group. While caffeine intake has been associated with reduced exertion and perceived fatigue, it is not well understood whether consumption of naturally caffeinated drinks is associated with physical activity. The aim of this study was to determine whether habitual consumption of coffee and tea is associated with participation in physical activity. Women (n = 7580) from the Australian Longitudinal Study on Women’s Health were included in this investigation. Participants reported average tea and coffee intake over the last 12 months and usual PA. Logistic regression models were adjusted for relevant health and lifestyle confounders, and Sobel test was used for mediation analysis. Participants who consumed 1–2 cups of coffee/day were 17% more likely to meet the recommended 500 metabolic equivalent (MET).min/week than women who had <1 cup/day (odds ratio (OR) 1.17, 95% confidence interval (CI) 1.04–1.32). Participants who reported drinking either 1–2 cups or >3 cups/day of tea were 13–26% more likely to meet 500 MET.min/week than those who had <1 cup/day (OR 1.26, 95% CI 1.08–1.46 and OR 1.13, 95% CI 1.01–1.26, respectively). Tiredness and energy mediated associations between intake of coffee (fully) and tea (partially) and PA. Middle-aged women who drink 1–2 cups of coffee or >1 cup of tea/day are more likely to meet the moderate-to-vigorous PA guidelines than those who drink <1 cup/day. Future research is warranted to investigate causality and effects of specific coffee and tea amounts.

scholarly journals Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in British adults aged 19–64 years

2006 ◽  
Vol 96 (6) ◽  
pp. 1116-1124 ◽  
Author(s):  
Christopher W. Thane ◽  
Laura Y. Wang ◽  
W. Andy Coward
Keyword(s):  
Smoking Status ◽  
Geometric Mean ◽  
Plasma Concentrations ◽  
Retinyl Palmitate ◽  
Stepwise Multiple Regression ◽  
Lower Plasma ◽  
Nutrition Survey ◽  
Men And Women ◽  
Nationally Representative ◽  
Variation Explained

Plasma phylloquinone (vitamin K1) concentration from non-fasted blood samples was examined by season, smoking status, socio-demographic factors and phylloquinone intake in a nationally representative sample of 1154 British individuals aged 19–64 years from the 2000–1 National Diet and Nutrition Survey. Geometric mean plasma phylloquinone concentration was 0·94 (95 % CI 0·88, 1·00) nmol/l, with 95 % of values in the range 0·10–8·72 nmol/l. Plasma phylloquinone concentrations of 530 men were significantly higher than those of 624 women (1·13 (95 % CI 1·04, 1·22) v. 0·81 (95 % CI 0·74, 0·88) nmol/l; P < 0·001), independent of other factors. Women aged 19–34 years had significantly lower plasma phylloquinone concentration than their older counterparts. Women were also found to have lower plasma phylloquinone concentrations during summer compared with winter and spring (each P < 0·01). In contrast, plasma phylloquinone concentration in men did not vary significantly by season or any of the socio-demographic or lifestyle factors. Plasma phylloquinone concentrations were positively correlated with phylloquinone intake in men and women (r 0·26 and 0·32 respectively; each P < 0·001). Overall, forward stepwise multiple regression analysis revealed that 8 % of the variation in plasma phylloquinone concentration was explained by phylloquinone intake, with a further 10 % of its variation explained by plasma concentrations of γ-tocopherol (6 %) and retinyl palmitate (4 %). After adjustment for age and corresponding nutrient intakes, plasma phylloquinone concentration was significantly associated (each P < 0·01) with plasma concentrations of total and LDL-cholesterol, α- and γ-tocopherols, retinyl palmitate, β-carotene, lycopene and lutein plus zeaxanthin in men and women.

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