Adverse Effects of Environmental Toxicants, Octylphenol and Bisphenol A, on Male Reproductive Functions in Pubertal Rats

Endocrine ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Chandana B. Herath ◽  
Wanzhu Jin ◽  
Gen Watanabe ◽  
Koji Arai ◽  
Akira K. Suzuki ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Environmental Toxicants

scholarly journals Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation

2021 ◽  
Vol 156 ◽  
pp. 106730
Author(s):  
Alexandra Schaffert ◽  
Laura Krieg ◽  
Juliane Weiner ◽  
Rita Schlichting ◽  
Elke Ueberham ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Adipocyte Differentiation ◽  
Human Adipocyte

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Toxicology ◽  
2014 ◽  
Vol 325 ◽  
pp. 133-143 ◽  
Author(s):  
Alice Marmugi ◽  
Frederic Lasserre ◽  
Diane Beuzelin ◽  
Simon Ducheix ◽  
Laurence Huc ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A

scholarly journals Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats

2021 ◽  
pp. 096032712110532
Author(s):  
Manigandan Nagarajan ◽  
Boobalan Raja ◽  
Jeganathan Manivannan
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Thiobarbituric Acid ◽  
Environmental Pollutant ◽  
Ros Generation ◽  
Thiobarbituric Acid Reactive Substances ◽  
Hypertensive Rats ◽  
Liver And Kidney ◽  
Ace Activity ◽  
Safe Dose

Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and “safe” dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period. The results illustrate that a ‘safe’ dose of BPA does not influence the systolic blood pressure (SBP) and levels of circulatory biomarkers of tissue damage. On the other hand, BPA exposure significantly ( p < 0.05) elevates the thiobarbituric acid reactive substances (TBARS) content in plasma and tissues (heart, aorta, liver and kidney) in hypertensive rats when compared with respective control (BPA alone exposed) rats. Similarly, a significant modulation of ROS generation in RBC, plasma nitric oxide (NO) level and angiotensin-converting enzyme (ACE) activity was observed only under hypertensive milieu. In conclusion, the observed adverse effects during ‘safe’ dose of BPA exposure are specific to the hypertensive condition. Therefore, a precise investigation to explore the effects of BPA exposure in vulnerable hypertensive populations is highly suggested.

Adverse Effects of Bisphenol A on Male Reproductive Function

2013 ◽  
pp. 57-82 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Rajamanickam Jubendradass ◽  
Edouard Akono Nantia ◽  
Paul Fewou Moundipa ◽  
Premendu Prakash Mathur
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function

Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice

2019 ◽  
Author(s):  
Yann Malaisé ◽  
Corinne Lencina ◽  
Christel Cartier ◽  
Maïwenn Olier ◽  
Sandrine Ménard ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Immune Responses ◽  
Bisphenol A ◽  
Low Dose ◽  
Intestinal Barrier ◽  
Female Offspring ◽  
Oral Exposure ◽  
Gut Barrier ◽  
Cellular Immune Responses ◽  
Cellular Immune

Abstract Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during perinatal period (gestation and/or lactation). We previously demonstrated that perinatal oral exposure to BPA (via gavage of mothers during gestation and lactation) has long-term consequences on immune response and intestinal barrier functions. Due to its adverse effects on several developmental and physiological processes, BPA was removed from consumer products and replaced by chemical substitutes such as BPS or BPF, that are structurally similar and not well studied compare to BPA. Here, we aimed to compare perinatal oral exposure to these bisphenols (BPs) at two doses (5 and 50 mg/kg body weight (BW)/day (d)) on gut barrier and immune system in female offspring mice at adulthood (Post Natal Day PND70). Methods Pregnant female mice were orally exposed to BPA, BPS or BPF at 5 or 50 μg/kg BW/d from 15th day of gravidity to weaning of pups at PostNatal Day (PND) 21. Gut barrier function and the humoral and cellular immune responses of adult offspring (PND70) were analysed at intestinal and systemic levels. Results In female offspring, perinatal oral BP exposure led to adverse effects on intestinal barrier and immune response that were dependant of the BP nature (A, S or F) and dose of exposure. Stronger impacts were observed with BPS at the dose of 5µg/kg BW/d on inflammatory markers in feces associated with an increase of anti-E. coli IgG, revealing a defect of gut barrier. BPA and BPF exposure induced prominent changes at low dose in offspring mice, in term of gut barrier functions and cellular immune responses, provoking an intestinal and systemic Th1/Th17 inflammation. Conclusion These findings provide, for the first time, a comparative study of long-time consequences of BPA, S and F perinatal exposure by oral route in offspring mice. This work warms that it is mandatory to consider immune markers and dose in risk assessment associated to new BPA’s alternatives. Keywords: Bisphenol A, Bisphenol S, Bisphenol F, Immune responses, Perinatal exposure, Intestine, Th1/Th17, immunoglobulin, cytokines

scholarly journals The Evaluation of Evidence Bisphenol A Exposure and Human Reproductive Health: A review

2020 ◽  
Vol 1 (1) ◽  
pp. 11-17
Author(s):  
Tomas Jambor ◽  
Eva Kovacikova
Keyword(s):  
Bisphenol A ◽  
Food Packaging ◽  
Sperm Quality ◽  
Reproductive Function ◽  
Epidemiological Studies ◽  
Systematic Research ◽  
Environmental Toxicants ◽  
Spermatozoa Motility ◽  
Increased Risk ◽  
Human Reproductive

Infertility is widespread problem defined as the inability to conceive after one year of unprotected intercourse. One of the most notable factors causing this status is the exposure to environmental contaminants. It is now recognized that many contaminants present in the environment have the ability to interfere in the action of hormones and therefore are termed endocrine disruptors (EDs). Some of these compounds are present in nature, but the majority are artificial and released into the environment by the human activities without any prior knowledge of their impact on ecosystems, animal welfare, or wildlife and human health. Many epidemiological studies have reported a radical growth in the incidence of male infertility, accompanied by decreasing sperm quality, decline in spermatozoa motility, defect in Leydig cell morphology, insufficient activity of steroidogenesis and spermatogenesis. The similar situation was observed in female, when the increased risk for endometriosis, reproductive and other endocrine-related cancer, impaired oocytes, ovarian dysfunction, or irregular menstrual cycle was confirmed. All mentioned consequences have been associated with increasing concentration of bisphenol A (BPA) in the environment. Humans are exposed to BPA not only through specific occupational circumstance, but nowadays more generally also from the ordinary day-to-day domestic and workplace lifestyles. Almost 3.4 million tons per year of BPA is used in a variety common product such as food packaging, household products, epoxy resins, dental sealants and many others. Under these endpoints, apprehensions about the reproductive dysfunctions associated with BPA action are unquestionable. In this review, we address the topic of BPA effects on reproductive function in males and females and emphasize its effects on overall health. A considerably more detailed and systematic research in EDs toxicology is required for a better understanding of risks associated with exposure to environmental toxicants.

scholarly journals Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

2016 ◽  
Vol 10 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Ciro Menale ◽  
Damiano G. Mita ◽  
Nadia Diano ◽  
Sabrina Diano
Keyword(s):  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Adverse Effects ◽  
Bisphenol A ◽  
Estrogenic Activity ◽  
Endocrine Function ◽  
Peripheral Tissues ◽  
Metabolism Regulation

Bisphenol A (BPA) is used as basic chemical compound in the production of polycarbonate food containers or epoxy resins coating metallic cans for food and beverages conservation. Its xeno-estrogenic activity alters endocrine-metabolic pathways modulating glucose metabolism and increasing the risk of developing diabetes, insulin resistance, and obesity. Based on in vitro and in vivo experimental research, here we report some of the major BPA adverse effects on tissues that play a key role in the regulation on the whole body’s metabolism. Evidences have shown that BPA is able to exert its endocrine disrupting action altering glucose metabolism and contributing to the onset of metabolic disorders, acting on liver functions and affecting insulin production by the pancreas. Exposure to BPA has been reported also to modulate glucose utilization in muscles, as well as to interfere with adipose tissue endocrine function. In addition, to peripheral tissues, recent studies have shown that BPA by acting in the Central Nervous System affects neuroendocrine regulation of glucose metabolism, promoting glucose metabolism dysfunction such as glucose intolerance and insulin resistance. Thus, exposure to BPA seems to be an important risk factor in the onset of obesity and metabolic syndrome. However, its mechanisms of action need to be further investigated to provide a major evaluation of risk assessment.

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