The comparative analysis of the effect of environmental toxicants: Bisphenol A, S and F on model plant, fungi and bacteria membranes. The studies on multicomponent systems

2019 ◽  
Vol 289 ◽  
pp. 111136 ◽  
Author(s):  
Katarzyna Hąc-Wydro ◽  
Karolina Połeć ◽  
Marcin Broniatowski
Keyword(s):  
Comparative Analysis ◽  
Bisphenol A ◽  
Environmental Toxicants ◽  
Multicomponent Systems ◽  
Model Plant ◽  
Plant Fungi

scholarly journals The Evaluation of Evidence Bisphenol A Exposure and Human Reproductive Health: A review

2020 ◽  
Vol 1 (1) ◽  
pp. 11-17
Author(s):  
Tomas Jambor ◽  
Eva Kovacikova
Keyword(s):  
Bisphenol A ◽  
Food Packaging ◽  
Sperm Quality ◽  
Reproductive Function ◽  
Epidemiological Studies ◽  
Systematic Research ◽  
Environmental Toxicants ◽  
Spermatozoa Motility ◽  
Increased Risk ◽  
Human Reproductive

Infertility is widespread problem defined as the inability to conceive after one year of unprotected intercourse. One of the most notable factors causing this status is the exposure to environmental contaminants. It is now recognized that many contaminants present in the environment have the ability to interfere in the action of hormones and therefore are termed endocrine disruptors (EDs). Some of these compounds are present in nature, but the majority are artificial and released into the environment by the human activities without any prior knowledge of their impact on ecosystems, animal welfare, or wildlife and human health. Many epidemiological studies have reported a radical growth in the incidence of male infertility, accompanied by decreasing sperm quality, decline in spermatozoa motility, defect in Leydig cell morphology, insufficient activity of steroidogenesis and spermatogenesis. The similar situation was observed in female, when the increased risk for endometriosis, reproductive and other endocrine-related cancer, impaired oocytes, ovarian dysfunction, or irregular menstrual cycle was confirmed. All mentioned consequences have been associated with increasing concentration of bisphenol A (BPA) in the environment. Humans are exposed to BPA not only through specific occupational circumstance, but nowadays more generally also from the ordinary day-to-day domestic and workplace lifestyles. Almost 3.4 million tons per year of BPA is used in a variety common product such as food packaging, household products, epoxy resins, dental sealants and many others. Under these endpoints, apprehensions about the reproductive dysfunctions associated with BPA action are unquestionable. In this review, we address the topic of BPA effects on reproductive function in males and females and emphasize its effects on overall health. A considerably more detailed and systematic research in EDs toxicology is required for a better understanding of risks associated with exposure to environmental toxicants.

scholarly journals Microtubule Cytoskeleton and Spermatogenesis—Lesson From Studies of Toxicant Models

2020 ◽  
Vol 177 (2) ◽  
pp. 305-315 ◽  
Author(s):  
Lingling Wang ◽  
Ming Yan ◽  
Siwen Wu ◽  
Baiping Mao ◽  
Chris K C Wong ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Bisphenol A ◽  
Sertoli Cells ◽  
Environmental Toxicants ◽  
Microtubule Cytoskeleton ◽  
The Past ◽  
Cellular Events ◽  
Per Se ◽  
To Come

Abstract Studies have shown that mammalian testes, in particular the Sertoli cells, are highly susceptible to exposure of environmental toxicants, such as cadmium, perfluorooctanesulfonate, phthalates, 2,5-hexanedione and bisphenol A. However, important studies conducted by reproductive toxicologists and/or biologists in the past have been treated as toxicology reports per se. Yet, many of these studies provided important mechanistic insights on the toxicant-induced testis injury and reproductive dysfunction, relevant to the biology of the testis and spermatogenesis. Furthermore, recent studies have shown that findings obtained from toxicant models are exceedingly helpful tools to unravel the biology of testis function in particular spermatogenesis, including specific cellular events associated with spermatid transport to support spermiogenesis and spermiation. In this review, we critically evaluate some recent data, focusing primarily on the molecular structure and role of microtubules in cellular function, illustrating the importance of toxicant models to unravel the biology of microtubule cytoskeleton in supporting spermatogenesis, well beyond information on toxicology. These findings have opened up some potential areas of research which should be carefully evaluated in the years to come.

scholarly journals Human Excretion of Bisphenol A: Blood, Urine, and Sweat (BUS) Study

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Stephen J. Genuis ◽  
Sanjay Beesoon ◽  
Detlef Birkholz ◽  
Rebecca A. Lobo
Keyword(s):  
Bisphenol A ◽  
Relative Concentration ◽  
Body Burden ◽  
Potential Method ◽  
Environmental Toxicants ◽  
Chemical Contaminant ◽  
Total Body ◽  
Three Body ◽  
Study Participants ◽  
Urine Testing

Background. Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. There is incomplete understanding of BPA toxicokinetics, and there are no established interventions to eliminate this compound from the human body. Using 20 study participants, this study was designed to assess the relative concentration of BPA in three body fluids—blood, urine, and sweat—and to determine whether induced sweating may be a therapeutic intervention with potential to facilitate elimination of this compound.Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for various environmental toxicants including BPA.Results. BPA was found to differing degrees in each of blood, urine, and sweat. In 16 of 20 participants, BPA was identified in sweat, even in some individuals with no BPA detected in their serum or urine samples.Conclusions. Biomonitoring of BPA through blood and/or urine testing may underestimate the total body burden of this potential toxicant. Sweat analysis should be considered as an additional method for monitoring bioaccumulation of BPA in humans. Induced sweating appears to be a potential method for elimination of BPA.

scholarly journals Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline”

Genetics ◽  
2020 ◽  
Vol 216 (4) ◽  
pp. 879-890
Author(s):  
Beatrix R. Bradford ◽  
Nicole E. Briand ◽  
Nina Fassnacht ◽  
Esabelle D. Gervasio ◽  
Aidan M. Nowakowski ◽  
...  
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Bisphenol A ◽  
Coenzyme Q10 ◽  
Oxidative Dna Damage ◽  
Molecular Mechanisms ◽  
Fluorescent Microscopy ◽  
Environmental Chemicals ◽  
Background Information ◽  
Environmental Toxicants

Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combating their harmful effects. Using the nematode Caenorhabditis elegans, a model with many genetic and physiological similarities to humans, researchers in the Colaiácovo laboratory have identified several molecular mechanisms by which the toxic agent bisphenol A (BPA) interferes with reproduction. Here, we address their recent discovery that a widely available compound, Coenzyme Q10 (CoQ10), can rescue BPA-induced damage. This work is significant in that it poses a low-cost method for improving reproductive success in humans. The goal of this primer is to assist educators and students with navigating the paper entitled “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline.” It is ideally suited for integration into an upper-level undergraduate course such as Genetics, Cell and Molecular Biology, Developmental Biology, or Toxicology. The primer provides background information on the history of BPA, the utility of the C. elegans germ line as a model for studying reproductive toxicity, and research methods including assessment of programmed cell death, fluorescent microscopy applications, and assays to quantify gene expression. Questions for deeper exploration in-class or online are provided.Related article in GENETICS: Hornos Carneiro MF, Shin N, Karthikraj R, Barbosa F Jr, Kannan K, Colaiácovo MP. Antioxidant CoQ10 restores fertility by rescuing bisphenol A-induced oxidative DNA damage in the Caenorhabditis elegans Germline. Genetics 214:381–395.

Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: Implications for toxicity testing paradigms

2013 ◽  
Vol 37 ◽  
pp. 24-30 ◽  
Author(s):  
Oumar Kuzbari ◽  
C. Matthew Peterson ◽  
Michael R. Franklin ◽  
Laura B. Hathaway ◽  
Erica B. Johnstone ◽  
...  
Keyword(s):  
Gene Expression ◽  
Comparative Analysis ◽  
Bisphenol A ◽  
Toxicity Testing ◽  
Relevant Gene

Adverse Effects of Environmental Toxicants, Octylphenol and Bisphenol A, on Male Reproductive Functions in Pubertal Rats

Endocrine ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Chandana B. Herath ◽  
Wanzhu Jin ◽  
Gen Watanabe ◽  
Koji Arai ◽  
Akira K. Suzuki ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Environmental Toxicants

Application of recombinant fluorescent mammalian cells as a toxicity biosensor

2002 ◽  
Vol 46 (3) ◽  
pp. 51-56 ◽  
Author(s):  
E.J. Kim ◽  
Y. Lee ◽  
J.E. Lee ◽  
M.B. Gu
Keyword(s):  
Bisphenol A ◽  
Cell Lines ◽  
Mammalian Cells ◽  
Chinese Hamster ◽  
Ovary Cell ◽  
Environmental Toxicants ◽  
Bacterial Biosensor ◽  
Biosensor System ◽  
Γ Ray ◽  
Ovary Cell Line

With respect to developing a more sensitive biosensor, a recombinant fluorescent Chinese Hamster Ovary cell line was used for the monitoring of various toxicants. Both cell lines, EFC-500 and KFC-A10, were able to detect toxicants sensitively. They were characterized with mitomycin C and γ-ray as genotoxicants and bisphenol A, nonylphenol, ziram and methyl bromide as possible and known EDCs. When compared to each other, the response of KFC-A10 was generally more informative and sensitive. Compared to typical bacterial biosensor systems, these cell lines offered a sensitivity of 2- to 50-fold greater for the tested chemicals. Based on these results, the use of mammalian cells offers a sensitive biosensor system that is not only fast, cheap and reproducible but also capable of monitoring the endocrine-like characteristics of environmental toxicants.

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