scholarly journals Pulmonary tuberculosis in childhood nephrotic syndrome (A cross sectional study)

2001 ◽  
Vol 41 (2) ◽  
pp. 106
Author(s):  
Taralan Tambunan ◽  
Attila Dewanti ◽  
Bambang Madiyono ◽  
Nastiti N Rahayoe

Childhood tuberculosis persists as an important global health problem. Tuberculosis is one of the commonestimportant complications in children with nephrotic syndrome. Tuberculosis may interfere with the response to steroid therapyand is still being the commonest morbidity cause in children with nephrotic syndrome. To find out the prevalence, clinicalfeatures, and the impact of tuberculosis in children with nephrotic syndrome, a cross sectional study was conducted on 100nephrotic children consisted of 63 males and 37 females at the Cipto Mangunkusumo Hospital from April 1st to October 30th,1999. Pulmonary tuberculosis was detected on 15 cases ( 95% CI : 8% - 22% ) , consisted of 8 boys and 7 girls. Most of themaged 10 – 16 years old (66,6%) and 86,7% were undernourished. The combination of clinical judgement, chest X-ray andMantoux test were helpful in establishing the diagnosis. The majority of tuberculosis cases (80%) were detected on frequentrelapsers and steroid dependent groups of the nephrotic syndrome. A significant correlation were noted in tuberculosis withundernutrition and unfavorable response to steroid (frequent relapser and steroid dependent cases).

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Alfa G. A. Poluan

Abstrak: Tuberkulosis (TB) masih menjadi masalah kesehatan dunia yang utama sampai sekarang. Menurut WHO, Indonesia masih menjadi negara dengan peringkat keempat sebagai penyumbang TB terbesar dengan 400-500 ribu kasus. WHO melaporkan bahwa ada sekitar 327.000 kasus baru TB pada anak dengan usia <15 tahun di seluruh dunia, dan sekitar 65.000 anak meninggal karena TB setiap tahun. Dalam mendiagnosis TB anak perlu dilakukan pemeriksaan uji tuberkulin dan foto toraks. Tujuan penelitian ini adalah untuk mengetahui hubungan gambaran foto toraks dan uji tuberkulin pada anak dengan diagnosis tuberkulosis paru.  Penelitian ini dilakukan di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2012 – Desember 2012. Penelitian ini bersifat analitik observasional menggunakan desain cross sectional dengan data retrospektif. Pengambilan sampel pada penelitian ini menggunakan teknik total sampling. Data yang dikumpulkan diolah dengan menggunakan uji korelasi Kendall’s tau-b. Dari hasil analisa data didapatkan nilai r= -0,408 dengan p= 0,046 (p<0,05). Nilai ini berarti bahwa ada hubungan negatif sedang antara gambaran foto toraks dan uji tuberkulin. Dengan demikian, pemeriksaan foto toraks dan uji tuberkulin harus dilakukan dalam membantu menegakkan diagnosis tuberkulosis paru pada anak. Kata kunci: Foto toraks, uji tuberkulin, tuberkulosis paru, anak    Abstract: Tuberculosis (TB) remains a major global health problem until now. According to WHO, Indonesia has ranked as the fourth largest contributor TB with 400-500 cases. WHO reports that there are approximately 327,000 new cases of TB in children aged <15 years old all over the world, and about 65,000 children die from TB every year. In diagnosing TB in children, tuberculin test and chest x-ray are necessary. The purpose of this research is to determine the relationship between a chest x-ray picture and tuberculin test in children diagnosed with pulmonary tuberculosis. This research was conducted in RSUP Prof. Dr. R. D. Kandou Manado in the period of January 2012 – December 2012. This was an observational analytic research using cross-sectional design with retrospective data. There were 25 children observed in this research. Analysis shows a negative correlation between radiographic picture and tuberculin test (r= -0.408; p= 0.046). Accordingly, chest x-ray examination and tuberculin test should be performed to help justify the diagnosis of pulmonary tuberculosis in children. Key Words: Chest X-ray, Tuberculin test, Pulmonary Tuberculosis, Children


2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Dewi Kartika Turbawaty ◽  
Adhi Kristianto Sugianli ◽  
Arto Yuwono Soeroto ◽  
Budi Setiabudiawan ◽  
Ida Parwati

Pulmonary tuberculosis (TB) is a major global health problem and is one of the top 10 causes of death worldwide. Our study aimed to evaluate the performance of urinary Mycobacterium tuberculosis (Mtb) antigens cocktail (ESAT6, CFP10, and MPT64) compared with culture and microscopy. This descriptive cross-sectional study was conducted in Dr. Hasan Sadikin General Hospital, Bandung, from January 2014 to October 2016. A total of 141 pulmonary tuberculosis patients were included. Sputum samples were examined for acid-fast bacilli (ZN stain) and mycobacterial culture (LJ); the Mtb antigens cocktail was examined in the urine sample. The positivity rate of TB detection from the three methods was as follows: AFB 52/141 (36.9%), culture 50/141 (35.5%), and urinary Mtb antigens cocktail 95/141 (67.4%). Sensitivity, specificity, PPV, and NPV of urinary Mtb antigens cocktail were 68.2%, 33%, 31.6%, and 69.6%, respectively. Validity of combination of both methods with culture as a gold standard yielded sensitivity, specificity, PPV, and NPV of 90%, 28.6%, 40.9%, and 83.8%, respectively. Combination of urinary Mtb antigens cocktail with AFB as a screening test gives a good sensitivity, although the specificity is reduced. Urinary Mtb antigens cocktail can be used as screening test for pulmonary tuberculosis.


2018 ◽  
Vol 31 (3) ◽  
Author(s):  
Jolanta Majer ◽  
Sandra Pyda ◽  
Jerzy Robert Ladny ◽  
Antonio Rodriguez-Nunez ◽  
Lukasz Szarpak

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Agune Ashole Alto ◽  
Wanzahun Godana ◽  
Genet Gedamu

Background. Diarrheal diseases are still one of the major causes of morbidity in under-five children in sub-Saharan Africa. In Ethiopia, diarrhea is responsible for 9% of all deaths and is the major cause of under-five mortality. Objective. To assess the impact of community-led total sanitation and hygiene on the prevalence of diarrheal disease and factors associated among under-five children in Gamo Gofa Zone. Methods. Community-based comparative cross-sectional study design was used to compare the impact of community-led total sanitation and hygiene intervention on under-five diarrheal disease. Multistage sampling method was employed. The data were collected by using pretested structured questionnaires. Data quality was ensured by daily supervision completeness and consistency. The data were coded, entered, and cleaned by using Epi Info version 7 and were analyzed by using SPSS version 20. Bivariate and multivariable analyses were carried out by using binary logistic regression. Significance was declared by using p value of <0.05 and AOR with 95% confidence intervals. Results. The response rate of this study was 93.3%. The overall diarrhea prevalence was 27.5% (CI = (24.06, 30.97)) which was 18.9% (CI = (14.94, 23.2)) in implemented and 36.2%. (CI = (30.41, 41.59)) in nonimplemented woredas. Children whose age was between 12 and 23 months (AOR = 1.6) and greater than 24 months (AOR = 5), availability of handwashing facilities (AOR = 4), disposal of waste in open field (AOR = 9.7), unimproved source of drinking water (AOR = 6.5), using only water for handwashing (AOR = 6), children who started complementary feeding less than 6 months (AOR = 5.6) and greater than 6 months (AOR = 5.2), and utensils used to feed children such as bottle (AOR = 3.9) were the factors positively associated with diarrhea. Conclusion. The overall prevalence of under-five diarrhea was 27.5%. The prevalence was low in CLTSH woredas as compared with non-CLTSH woredas. The study showed that handwashing facility, using only water for handwashing, open refuse disposal, and unimproved source of drinking water among under-five had a statistically significant association with diarrhea occurrence in CLTSH nonimplemented areas. Integrated efforts are needed from the Ministry of Health together with the WASH Project in improving drinking water, handwashing facilities, and solid waste disposal practices.


Physiotherapy ◽  
2019 ◽  
Vol 105 (3) ◽  
pp. 346-353
Author(s):  
Laura M. Mackey ◽  
Catherine Blake ◽  
Maire-Brid Casey ◽  
Camillus K. Power ◽  
Ray Victory ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eman Alshdaifat ◽  
Amer Sindiani ◽  
Wasim Khasawneh ◽  
Omar Abu-Azzam ◽  
Aref Qarqash ◽  
...  

Abstract Background Residency programs have been impacted by the Coronavirus disease 2019 (COVID-19) pandemic. In this study we aim to investigate and evaluate the impact of the pandemic on residents as well as residency training programs. Methods This was a cross-sectional study including a survey of 43 questions prepared on Google forms and electronically distributed among a convenience sample of residents training at a tertiary center in North Jordan during the COVID-19 pandemic. Data were collected in the period between October 30th and November 8th of 2020. The survey included questions that addressed the impact of the pandemic on residents’ health as well as training programs. The study participants included residents in training at KAUH in 2020 and were stratified according to the type of residency program (surgical residents (SRs) and non-surgical residents (NSRs)). Statistical methods included descriptive analysis, Chi-square or Fisher’s exact test, Mann Whitney U test, and Cramer’s V and r statistics as measures of effect sizes. Results Of all 430 residents, 255 (59%) responded to the survey. A total of 17 (7%) of residents reported being infected with COVID-19 and a significant difference was reported between SRs and NSRs (10% vs 4%, V = .124 “small effect” (95% CI; .017–.229), p = 0.048). Approximately, 106 (42%) reported a decrease in the number of staff working at the clinic and 164 (64%) reported limited access to personal protective equipment during the pandemic. On a 4-point Likert scale for the feeling of anxiety, the median was 2 (2–3 IQR) in the NSRs group, vs 2 (1–2 IQR) in the SRs groups, with the NSRs being more likely to feel anxious (r = 0.13 “small effect” (95% CI; 0.007–0.249), p = .044). Similarly, the proportion of residents who reported feeling anxious about an inadequacy of protective equipment in the work area was significantly greater in the NSRs group (90.3% vs 75.2%; V = .201 “small effect” (95% CI; .078–.313), p = .001), as well as the proportion of residents who reported feeling increased stress and anxiety between colleagues being also significantly higher in the NSRs group (88.1% vs 76%; V = .158 “small effect” (95% CI; .032–.279), p = .012). Conclusion The burden of the ongoing pandemic on the mental health status of residents is very alarming and so providing residents with psychological counseling and support is needed. Also, critical implications on the flow of residency training programs have been noticed. This necessitates adapting and adopting smart educational techniques to compensate for such limitations.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sivaporn Gatechompol ◽  
Weerakit Harnpariphan ◽  
Ruamthip Supanan ◽  
Gompol Suwanpimolkul ◽  
Jiratchaya Sophonphan ◽  
...  

Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid preventive therapy (IPT). Methods A cross-sectional study was conducted among prisoners in Klong Prem Central Prison, Bangkok. Participants were screened for active TB by questionnaire and chest X-ray. LTBI was evaluated by Tuberculin skin test (TST) and QuantiFERON-TB Gold Plus (QFTP) among subgroup. Participants with positive TST or QFTP were considered to have LTBI. Participants with LTBI were offered IPT. Results From August 2018–November 2019, 1002 participants were analyzed. All participants were male with a median age of 38 (IQR 32–50) years. LTBI identified by either TST/QFTP was present in 466 (46.5%) participants. TST was positive in 359 (36%) participants. In the subgroup of 294 participants who had both TST and QFTP results, 181/294 (61.6%) tested positive by QFTP. Agreement between TST and QFTP was 55.1% (Kappa = 0.17). The risk factors associated with LTBI were previous incarceration (aOR 1.53, 95%CI, 1.16–2.01, p = 0.002), history of prior active TB (aOR 3.02, 95%CI, 1.74–5.24, p < 0.001) and duration of incarceration ≥10 years (aOR 1.86, 95%CI, 1.24–2.79, p = 0.003). Majority of LTBI participants (82%) agreed to take IPT. Three hundred and 56 (93%) participants completed treatment whereas 27 (7%) participants discontinued IPT due to the side effects of INH. Conclusion This is the first study to evaluate the prevalence of LTBI and feasibility of IPT among Thai prisoners. LTBI prevalence in male prisoners in Thailand is high. LTBI screening and treatment should be implemented together with other preventive components.


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