scholarly journals Prevalence and risk factors for epilepsy in children with spastic cerebral palsy

2016 ◽  
Vol 50 (1) ◽  
pp. 11
Author(s):  
Dedy Rahmat ◽  
Irawan Mangunatmadja ◽  
Bambang Tridjaja ◽  
Taralan Tambunan ◽  
Rulina Suradi
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Palsy ◽  
Central Nervous System Infection ◽  
First Year ◽  
Genetic Syndrome ◽  
Female Ratio ◽  
Increased Risk ◽  
First Year Of Life

Background Epilepsy in cerebral palsy (CP) is usually difficult to treat and can lead to poor prognosis due to increased risk for motor and cognitive disorders. The prevalence and risk factors of epilepsy in children with CP vary among studies.Objective To determine the prevalence and risk factors for epilepsy in spastic CP.Methods We performed a retrospective study using medical records of patients with spastic CP at the Departement of Child Health, Cipto Mangunkusumo Hospital from January 2003 until December 2008. Prevalence ratio was calculated by comparing the prevalence of epilepsy in subjects with and without risk factors. We excluded patients with metabolic disorder, genetic syndrome, and onset of CP after 3 years of age.Results Two hundred thirty six out of 238 spastic CP patients were analyzed. The mean age at diagnosis of spastic CP was 28.8 months. Male to female ratio was 1.4:1. The prevalence of epilepsy in spastic CP was 39%. The risk factors for epilepsy in spastic CP were central nervous system infection, the ocurrence of seizure in the first year of life, and abnormality of EE G.Conclusions The prevalence of epilepsy in spastic CP is 39%. The risk factors for epilepsy in spastic CP are post central nervous system infection, and ocurrence of seizure in the first year of life. [Paediatr Indones. 2010;50:11-7].

Indications for oral hygiene in sick children with cerebral palsy

2020 ◽  
Vol 3 (6) ◽  
pp. 26-27
Author(s):  
Yo. K. Eronov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Palsy ◽  
Brain Injuries ◽  
First Year ◽  
Children With Cerebral Palsy ◽  
The Central Nervous System ◽  
Sick Children ◽  
Serious Disease ◽  
First Year Of Life

Cerebral palsy, one of the diseases of the central nervous system, is a serious disease that is caused by various brain injuries during the first year of life: before, inside and after childbirth. Patients with cerebral palsy lag behind in physical and mental development, and due to their inability to help themselves, this causes not only medical, but also social problems. Proper dental care for sick children with cerebral palsy is one of the measures to prevent diseases of the oral mucosa and its complications

Congenital Cricopharyngeal Achalasia

1977 ◽  
Vol 86 (5) ◽  
pp. 603-610 ◽  
Author(s):  
Timothy J. Reichert ◽  
Charles D. Bluestone ◽  
William K. Sieber ◽  
Sylvan E. Stool ◽  
Anne M. Sieber
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Conservative Management ◽  
Esophageal Motility ◽  
First Year ◽  
Cricopharyngeal Myotomy ◽  
Associated Diseases ◽  
The Central Nervous System ◽  
Esophageal Dysfunction ◽  
First Year Of Life

Fifteen infants with congenital cricopharyngeal achalasia are reviewed. Although most of the patients had symptoms at birth, the diagnosis was frequently not confirmed until later in the first year of life. While four of the infants had only cricopharyngeal achalasia, 11 had associated diseases related to the central nervous system. Those patients without associated diseases improved spontaneously with conservative management; most of the infants with other abnormalities also improved, although their clinical progress was slower and more complicated. In three of the patients, the symptoms were persistent and there were two deaths related to associated diseases. Cricopharyngeal myotomy was performed on two children with only moderate improvement in symptoms. Congenital cricopharyngeal achalasia is more common than formerly recognized. When suspected, an esophagram with tele- or cineradiography is essential to confirm the diagnosis. Esophageal motility studies will quantify changes and also evaluate lower esophageal dysfunction not easily identified on esophagrams.

scholarly journals Adenohypophyseal function in children aged under 1 born to mothers in whom pregnancy was induced

1996 ◽  
Vol 42 (1) ◽  
pp. 9-11
Author(s):  
A. A. Afonin ◽  
V. I. Orlov ◽  
Yu. A. Knyazev ◽  
E. P. Rymanhevskaya ◽  
L. A. Polschikova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Follicle Stimulating Hormone ◽  
First Year ◽  
Polycystic Ovaries ◽  
Somatotropic Hormone ◽  
Hormonal Function ◽  
System A ◽  
The Central Nervous System ◽  
First Year Of Life

A total of 143 children born to mothers who suffered from various forms of endocrine sterility and in whom pregnancy was induced were examined. The levels of somatotropic hormone, prolactin, luteotropic hormone, and follicle-stimulating hormone were measured in the blood on days 1, 3, 6 of life and at the age of 3, 6, and 12 months. The hormones were radioimmunoassayed and measured by imnmnofluorescent methods. The results indicate marked disorders of the adenohypophyseal function in these children, these disorders persisting through the first year of life. The most evident shifts of hormonal parameters are observed in children born to mothers with primary disorders of ovarian hormonal function, particularly so in cases with the polycystic ovaries syndrome, and in children with perinatal involvement of the central nervous system. A high correlation between adenohypophyseal and peripheral gland hormone levels and the concentration of somatotropic hormone was detected.

Considerazioni sulle risultanze statistiche delle malformazioni congenite letali e no in Italia dal 1956 al 1958

1963 ◽  
Vol 12 (3) ◽  
pp. 276-290
Author(s):  
L. Maggiore
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congenital Malformations ◽  
Statistical Data ◽  
First Year ◽  
The Central Nervous System ◽  
First Year Of Life

SUMMARYThe statistical data on the malformation occurred in Italy from 1956 to 1958 have been examined. It has been seen that their number is almost constant (i. e. some 1,500 per year). The ratio of alive malformed to dead malformed is of 3:1, but the number of deaths by congenital malformations increases considerably during the first year of life, mostly due to inner organ malformations, non detectable at birth.50% of the cases of harelip die during the first year of life. The most serious malformations are those concerning the central nervous system, while the most common ones, are those affecting the locomotive apparatus.The number of malformations has not been influenced by the very insufficient diet during the four years of war, neither by the 1957 « asiatic influenza ». The malformation index, furthermore, appears almost constant in the time and in the various regions, showing the highest figure in Lucania and Friuli (3.05) and the lowest ones in Campania (0,89), Sicily and Liguria (1.21).

scholarly journals Varicella Zoster Virus Encephalitis

2019 ◽  
Vol 3 (4) ◽  
pp. 380-382
Author(s):  
Jared Lizzi ◽  
Tyler Hill ◽  
Julian Jakubowski
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Varicella Zoster Virus ◽  
Immunocompromised Patient ◽  
Clinical Suspicion ◽  
The Body ◽  
Varicella Zoster ◽  
Increased Risk ◽  
The Central Nervous System

Varicella zoster virus in the adult patient most commonly presents as shingles. Shingles is a painful vesicular eruption localized to a specific dermatome of the body. One of the potential complications of this infection is involvement of the central nervous system causing encephalitis. An increased risk of this complication is associated with the immunocompromised patient. In this case report, we review the history and physical exam findings that should raise clinical suspicion for varicella zoster encephalitis, as well as the epidemiology, risk factors, treatment, and prognosis of this type of infection.

scholarly journals Risk Factors, Treatment, and Outcome of Central Nervous System Recurrence in Adults With Intermediate-Grade and Immunoblastic Lymphoma

Blood ◽  
1998 ◽  
Vol 91 (4) ◽  
pp. 1178-1184 ◽  
Author(s):  
Koen van Besien ◽  
Chul S. Ha ◽  
Sandy Murphy ◽  
Peter McLaughlin ◽  
Alma Rodriguez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Radiation Treatment ◽  
Large Cell ◽  
Disease Stage ◽  
Extranodal Site ◽  
Immunoblastic Lymphoma ◽  
Kaplan Meier ◽  
Increased Risk

Abstract To evaluate the incidence, risk factors, and outcome of central nervous system (CNS) recurrence in adult patients with non-Hodgkin's lymphoma, we evaluated 605 newly diagnosed patients with large-cell and immunoblastic lymphoma who participated in prospective chemotherapy studies. The Kaplan-Meier estimate of probability of CNS recurrence at 1 year after diagnosis was 4.5% (95% confidence interval [CI], 4.4 to 4.6). Twenty-four patients developed CNS recurrence after a median of 6 months from diagnosis (range, 0 to 44 months). In univariate analysis, an increased risk for CNS recurrence was associated with an advanced disease stage (P = .0014), an increased LDH (P = .0000), the presence of B-symptoms (P = .0037), involvement of more than one extranodal site (P = .0000), poor performance status (P = .0005), and B-cell phenotype (P = .008). Bone marrow involvement (P = .005), involvement of parenchymal organs (P = .03), and involvement of skin, subcutaneous tissue, and muscle (P = .002) were also associated with an increased risk for CNS disease. Multivariate logistic regression analysis identified only involvement of more than one extranodal site (P = .0005) and an increased LDH (P = .0008) as independent predictors of CNS recurrence. Established CNS recurrence had a poor prognosis. Only 1 of 24 patients remains alive and the Kaplan-Meier estimate of probability of survival at 1 year after the diagnosis of CNS recurrence is only 25.3% (95% CI, 6.9 to 43.7). Intrathecal treatment provided symptomatic benefit in only 1 of 6 patients. Radiation treatment provided symptomatic improvement in 6 of 9 patients treated. However, remissions were short and followed by systemic or CNS recurrence. Serum LDH and involvement of more than one extranodal site are independent risk factors for CNS recurrence in patients with large-cell lymphoma. The presence of both risk factors identifies a patient group at high risk for CNS recurrence. Established CNS recurrence can be rapidly fatal. Transient responses occur after radiation treatment.

Tumors of the central nervous system in the first year of life

2007 ◽  
Vol 49 (S7) ◽  
pp. 1074-1082 ◽  
Author(s):  
Valerie Larouche ◽  
Annie Huang ◽  
Ute Bartels ◽  
Eric Bouffet
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
First Year ◽  
The Central Nervous System ◽  
First Year Of Life

scholarly journals Features of the recovery period of hypoxic lesion to the central nervous system in children of the first year of life with congenital heart disease

2020 ◽  
Vol 35 (3) ◽  
pp. 53-58
Author(s):  
V. A. Zhelev ◽  
A. S. Pogudina ◽  
E. V. Mikhalev ◽  
A. O. Okorokov ◽  
T. S. Krivonogova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Congenital Heart Disease ◽  
Nervous System ◽  
Heart Disease ◽  
Congenital Heart ◽  
Recovery Period ◽  
First Year ◽  
Resistance Level ◽  
The Central Nervous System ◽  
First Year Of Life

Aim. To study the features of recovery period of hypoxic lesion to the central nervous system (CNS) in children of the first year of life in the presence of congenital heart disease (CHD).Material and Methods. The study involved 80 children born full-term and premature with gestational status of 35–37 weeks with hypoxic damage to the CNS. The main observation group comprised 50 children with CHD (interventricular and atrial septal defects, open ductus arteriosus). All children underwent a comprehensive health assessment, standard echocardiography, and neurosonography at ages of five to seven days and one, three, and six months. Biochemical analysis included assessment of serum neurospecific enolase (NSE), succinate dehydrogenase (SDG), and α-glycerophosphate dehydrogenase (α-GPDH). The control group included 20 full-term newborns without CHD and CNS lesions.Results. The main manifestations in newborns with CHD and hypoxic damage to the CNS were the suppression syndrome, agitation, and hypertension-hydrocephalic syndrome. At the age of six months, a delay in motor development indicators persisted in 35% of children in the main group. The high NSE level in newborns with concomitant septal heart defects was associated with a decrease in the quantitative indicators of neuropsychic development (g = –0.6, p < 0.05). The children with CHD and hypoxic damage to the CNS in the first year of life were significantly more often (p < 0.05) deficient in weight and height. A decrease in the resistance level in the first year of life was observed in 40% of children from the main group, which significantly differed compared with group of children without CHD (p < 0.001). The newborns with hypoxic CNS and CHD lesions had a decrease in the activity of α-GPDH and SDG at the age of five to seven days; the low activity of SDG persisted at the ages of one and six months; the enzyme activity in children of the comparison group was normal (p < 0.05).Conclusion. Children with CHD had the features of clinical course of perinatal damage to the CNS in the acute and recovery periods, a slowdown in the rate of physical and neuropsychic development, a decrease in the resistance level, and impaired functional state of the body. The decreases in the activities of SDG and α-GPDH in children with hypoxic lesions to the CNS in the presence of CHD implied the disturbances in cellular bioenergetics and resulted in inadequate response to external factors.

scholarly journals Effectivenss of complex physical rehabilitation of infants with perinatal central nervous system injury

2016 ◽  
Vol 97 (3) ◽  
pp. 341-346
Author(s):  
T F Schreider ◽  
G V Fedorova ◽  
S N Yakimenko
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Physical Rehabilitation ◽  
Central Nervous System Injury ◽  
First Year ◽  
Tension Index ◽  
Regulatory Systems ◽  
Procedure Duration ◽  
First Year Of Life

Aim. To study the effectiveness of complex physical rehabilitation use in infants with perinatal central nervous system injury.Methods. A complex examination of children with perinatal central nervous system pathology was performed. Based on identified changes, a method of children complex physical rehabilitation was developed, theoretically proved and tested, including manual relaxing massage and anti-gravity gymnastics. The study included 360 children of the first year of life. Massage was performed starting from 3-4 weeks of a child’s life, the procedure duration was 20-25 minutes. Antigravity gymnastics was performed for 3-4 minutes in children aged 1-2 months, 8-10 min - at the age of 3-4 months, 10-15 minutes - at the age of 5-6 months and older. Course consisted of 15-20 procedures, five times a week.Results.. Effectiveness evaluation was conducted in two ways: objective and subjective. Objectively: the positive dynamics of neurological symptoms was reported, symptoms of brain hypoxia, regulatory systems tension index were significantly decreased, the sleep-wake ratio normalized, weight gain occurred. Subjectively: 360 parents of children up to 1 year were interviewed. 93.6±1.3% of the respondents were satisfied with quality of care. Omsk region inhabitants satisfaction was 95.45±1.1% and was higher than in Omsk (93.5±1.3%, pConclusion. The applied method of complex physical rehabilitation of children of the first year of life with perinatal central nervous system injury showed high efficacy in the absence of side effects and may be reproduced in any institutions where rehabilitation measures are performed.

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