THE ELEMENTAL COMPOSITION STUDY OF PLANTS IN THE SIBERIAN FLORA (ALFREDIA CERNUA AND FILI-PENDULA ULMARIA), EXTRACTS AND FRACTIONS TO CREATE DRUGS BASED ON THEM

2019 ◽  
pp. 205-216
Author(s):  
Vladimir Il'ich Otmahov ◽  
Inessa Vladimirovna Shilova ◽  
Elena Vasil'yevna Petrova ◽  
Anastasiya Alekseyevna Loginova ◽  
Evgeniya Sergeyevna Rabtsevich ◽  
...  
Keyword(s):  
Elemental Composition ◽  
Raw Materials ◽  
Absorption Spectrometry ◽  
Atomic Emission ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Emission Spectrometry ◽  
Analytical Control ◽  
Active Substances

Using the methods of arc atomic emission spectrometry (AAES), atomic emission flame photometry (AEFP), atomic absorption spectrometry (AAS) and mass spectrometry (ICP-MS), the elemental composition of the aerial part of widely used in medical practice Alfredia cernua and Filipendula ulmaria, extracts and fractions obtained from them, is investigated. It was shown that not only biologically active substances, but also mineral elements are extracted by extractants, which may be due both to the formation of complexes with biologically active substances and affinity for extractants. Therefore, the elemental composition must be considered as an important component of plant extracts and medicinal products obtained from them. Simultaneously with biologically active substances in ethanol extracts there is an accumulation of not only biogenic, but also toxic elements, which degree of extraction is often higher. It increases even more during the transition from periodic to countercurrent extraction, which allows to obtain extracts with the highest yield of biologically active substances. Since the enriched extract is directly used to obtain the dosage form, a preliminary elemental analysis is necessary. Analytical control of the content of TM is also necessary when choosing the place of growth of plants raw materials, which are used to create medicinal herbal remedies.

scholarly journals Study on domestic market of medicinal products of plant origin

2018 ◽  
pp. 30-36
Author(s):  
V. M. Minarchenko ◽  
A. Yu. Butko
Keyword(s):  
Medicinal Plants ◽  
Raw Materials ◽  
Domestic Market ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Plant Origin ◽  
Resource Base ◽  
Natural Resource Base ◽  
Active Substances

The popularity of herbal remedies and medicines, with the participation of biologically active substances from plants is traditionally high. The annual increase of the domestic market for herbal remedies is due to the preservation and modernization of production capacities for processing of medicinal vegetative raw materials in Ukraine, introduction of modern scientific developments, a large natural resource base of medicinal plants and attracting investments in the development of this industry. The aim of our work was the study of the domestic market of medicines of plant origin, which includes herbal remedies, substances and preparations with the participation of biologically active substances from plants. The object of the study was domestic medicines of plant origin that are registered in Ukraine for 2012–2017. The study used the analytical, statistical methods, and the results of its own resource studies of medicinal plants. Phytopharmaceutical market of Ukraine is actively developing due to the attraction of new types of medicinal plants and expanding the range of medicines. The number of domestic drugs with the participation of biologically active substances from plants has increased by 17.4% compared with 2014. It is established that as of 1 January 2017 in Ukraine was 1 141 the form of medicinal drugs of plant origin. Of them: 645 – domestic products, 496 – foreign. Most of the herbal drugs in the pharmaceutical market of Ukraine are made from wild and cultivated domestic raw materials.

scholarly journals PHYTOCHEMICAL ANALYSIS OF BIOTECHNOLOGICAL RAW MATERIALS OF REPRESENTATIVES OF THE GENUS POTENTILLA L.

2018 ◽  
pp. 145-154 ◽  
Author(s):  
Людмила (Ljudmila) Ивановна (Ivanovna) Тихомирова (Tihomirova) ◽  
Наталья (Natal'ja) Григорьевна (Grigor'evna) Базарнова (Bazarnova) ◽  
Александра (Aleksandra) Викторовна (Viktorovna) Сысоева (Sysoeva) ◽  
Людмила (Ljudmila) Владимировна (Vladimirovna) Щербакова (Shherbakova)
Keyword(s):  
Elemental Composition ◽  
Chemical Elements ◽  
Raw Materials ◽  
Production Method ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Regenerated Plants ◽  
Active Substances

The genus Potentilla (Potentilla L.) is a member of the family Rosaceae, widespread in temperate, Arctic and Alpine zones of the Northern hemisphere. The genus is known since ancient times for its healing properties. Modern pharmacological studies have confirmed traditional use of the extracts of Potentilla species in various diseases. Phytochemistry representatives of Potentilla L. are poorly understood. Biotechnology for the production of renewable raw materials is only developed for Potentilla alba L.Objective – to conduct phytochemical analysis of biotechnological raw materials and Potentilla alba L. Potentilla fragarioides L., identification of features of the elemental composition and accumulation of biologically active substances in comparison with intact plants.The result of the research developed in biotechnology for the production of biomass of P. fragarioides. The evaluation of the intensity and specificity of accumulation of chemical elements in bodies of regenerated plants of P. alba from the nutrient media in tissue culture. The elements of vigorous accumulation of Ca, Mg, Fe, Mn, Zn, Mo Cu, and the element of a strong accumulation of Co. These features of the elemental composition of plant material P. alba, depending on the production method. Estimated purity, content of water and alcohol-soluble extractives, and certain groups of biologically active substances.It is revealed that white Potentilla and cinquefoil zemlyannikova are the hub of flavonoids and tannins. The incidences of accumulation of biologically active substances in the bloodroot zemljanichnoe exceed the targets set for the white cinquefoil, both traditional and biotechnological raw materials.

scholarly journals COMPARATIVE ANALYSIS OF THE CHEMICAL COMPOSITION OF PLANT RAW MATERIAL IRIS SIBIRICA L.

2017 ◽  
pp. 137-144 ◽  
Author(s):  
Людмила (Ljudmila) Ивановна (Ivanovna) Тихомирова (Tikhomirova) ◽  
Наталья (Natal'ja) Григорьевна (Grigor'evna) Базарнова (Bazarnova) ◽  
Анастасия (Anastasija) Александровна (Aleksandrovna) Синицына (Sinitsyna) ◽  
Ирина (Irina) Владимировна (Vladimirovna) Афанасенкова (Afanasenkova)
Keyword(s):  
Comparative Analysis ◽  
Chemical Composition ◽  
Raw Materials ◽  
Vegetation Period ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Emission Spectrometry ◽  
Siberian Crane ◽  
Active Substances

Species of the genus Iris in the scientific literature, recognized as rich sources of secondary metabolites. However, in chemical terms, Iris sibirica L. is poorly understood. The purpose of this study is a comparative analysis of the chemical composition of plant material of Iris sibirica L. to optimize the timing of collection in the conditions of Altai region.The object used samples of leaves and rhizomes and roots of I. sibirica varieties Cambridge and Sterkh variety, harvested in the vicinity of the city of Novoaltaisk.As a result of these tests the ash content from I. sibirica spring collection 1,3 times more than in autumn. The method of emission spectrometry revealed the presence of 26 elements. Of them macro – 4, microelements and ultramicroelements 8 – 14. Regardless of the variety of plant organs as observed the accumulation of Al. In a raw spring collection piling up Ba and Zn, and in the fall of Sr and Mn. In the studied samples I. sibirica cultivars Siberian crane Cambridge and the concentration of Cu, Pb, Cd, Cr and As exceeded the permissible level for dietary Supplements and tea on plant-basedWith the aim of obtaining flavonoids plant I. sibirica better harvest in the spring, and for optimal coumarins is the autumn collection. Tannins more is accumulated in the rhizomes with roots, and triterpenoid glycosides in the grass. The yield of essential oil from I. sibirica depends on weather conditions of vegetation period, time of procurement of raw materials and on plants and can be increased by 2–3 times.The study of element distribution and synthesized biologically active substances in the process of development of I. sibirica cultivars Siberian crane and Cambridge during the vegetation period has allowed to identify the vegetative phase with maximum accumulation, and organs of plants, accumulation of these biologically active substances.

scholarly journals DETERMINATION OF OPTIMAL EXTRACTION CONDITIONS OF PHENOLIC COMPOUNDS FROM ACORUS CALAMUS LEAVES

2020 ◽  
Vol 3 ◽  
pp. 63-70
Author(s):  
Maksym Yaremenko ◽  
Tetiana Gontova ◽  
Liudmyla Boryak ◽  
Olga Mala ◽  
Oleksiy Andryushayev
Keyword(s):  
Phenolic Compounds ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Extraction Time ◽  
Herbal Remedies ◽  
Acorus Calamus ◽  
Technological Parameters ◽  
Active Substances

From the beginning of its existence and until now, interest in herbal remedies has only grown. Not surprisingly, medicinal herbs are a source of unique combinations of biologically active components that are capable of exhibiting significant pharmacological effects. One of these medicinal plants is Acorus calamus (sweet flag), whose rhizomes have long been used in official and folk medicine, cooking and cosmetology. However, recent studies point to the considerable potential of the aerial part of Acorus calamus as a novel herbal remedy, which is associated with the presence in the leaf of the plant, in addition to essential oil, a considerable amount of substances of phenolic nature. The aim of the research was to determine the optimal conditions for the removal of phenolic compounds from the leaves of Acorus calamus and to determine the technological parameters of raw materials. Materials and methods. During the research, samples of raw materials collected on the territory of Kharkiv region were used, as well as methods that are given in the State Pharmacopoeia of Ukraine. Result. As a result of the research, the extraction conditions at which there was highest content of the extraction of biologically active substances were determined. The extractant, the degree of grinding of the raw material and the optimum extraction time were selected, which allowed to extract almost 80 % of the quantitative content of flavonoids from the raw material. The main technological parameters of Acorus calamus leaves were also determined. The obtained results will be the basis for the development of the technology of obtaining phyto-substance from the leaves of Acorus calamus. Conclusions. The selection of optimal extraction conditions of biologically active compounds from Acorus calamus leaves was carried out. The obtained results show that in order to obtain extracts with the maximum content of biologically active substances (flavonoids), it is advisable to use raw materials with a particle size of 0.5 to 1.0 mm, as an extractant 70 % alcohol and an extraction time of 4 hours.

CONSUMER PROPERTIES OF PASTA WITH POWDER FROM MARIGOLD INFLORESCENCES (TAGETES L.)

2021 ◽  
Vol 40 (4) ◽  
pp. 102-112
Author(s):  
SHAPOVALOVA Nataliia ◽  
VEZHLIVTSEVA Svitlana ◽  
ANTIUSHKO Dmytro
Keyword(s):  
Raw Materials ◽  
Experimental Studies ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Organoleptic Properties ◽  
Biological Value ◽  
Plant Raw Materials ◽  
Active Substances

Background. The deficiency of essential nutrients in the human body is the root cause of reduced efficiency, general resistance of the body to various diseases. That is an urgent problem in the context of the spread of coronavirus infection. In this regard, the search for opportunities to meet the needs of the population in food products that contain biologically active substances (BAS) through the use of high-value and at the same time available plant raw materials is extremely important. Marigolds attract special attention among such raw materials. The aim of the work is to study the chemical composition and evaluate the consumer properties of Tagetes L. varieties, zoned in the Kiev region, to prove the possibility of increasing the biological value of pasta by adding to their recipe powder from marigold inflorescences. Materials and methods. The object of research is pasta of B group (noodles). Inflorescences of marigolds of different varieties gathered during the flowering period in July-September 2019–2020 in the territory of Vasylkiv and Obukhiv districts of Kyiv region, Ukraine were used as enriching plant raw materials. The quality of finished pasta was assessed by organoleptic and physicochemical indexes (moisture content and titratable acidity). The content of mineral elements in the fine powder of marigold inflorescences was determined on the EXHERT-3L device, the quantitative composition and BAS identification – by spectrophotometric analysis on the device Specord-200 Analytic Jena UV-vis. The integrated quality index of pasta products was calculated taking into account the importance factors of individual indexes. Results. Comparing the obtained results, we can state that all the studied varieties – Gold Kopfen, Orange Flame, Hawaii, Equinox are characterized by high biological value, regardless of the area of collection. As a result of calculated and experimental studies it was determined that the addition of 7 % of the supplement does not provide the required supply of vitamins and minerals. Replacing the flour in the recipe by 20 % significantly improves the mineral composition, but deteriorates the taste and aromatic properties of pasta. The most optimal and rational amount of added additive is 15 %, as it improves the organoleptic properties of pasta and enriches their BAS. Conclusion. The usage of non-traditional vegetable raw materials, in particular powder from marigold inflorescences, which is rich in biologically active substances, allows not only to expand the range, improve the quality of finished products, but also increase the biological value of the product. The optimal amount of additive –powder from marigold inflorescences, was defined. It is 15 % by weight of flour in the production of noodles. This concentration allows not only to improve the organoleptic properties, but also to increase the content of biologically active substances – vitamins, micro- and macronutrients. The usage of non-traditional natural raw materials (powder from marigold inflorescences) allows to abandon artificial colorsand give the finished pasta a pleasant colorand aroma.

scholarly journals Biologically active substances from Achillea nobilis L.

2020 ◽  
Vol 100 (4) ◽  
pp. 52-59
Author(s):  
А.S. Kishkentayeva ◽  
◽  
S.N. Mantler ◽  
М.М. Zhakanov ◽  
S.М. Adekenov ◽  
...  
Keyword(s):  
Climatic Factors ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Component Composition ◽  
Hot Water ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Phytochemical Study ◽  
Plant Raw Materials ◽  
Active Substances

The review summarizes data on biologically active compounds of Achillea nobilis L. and methods of their isolation. From Achillea nobilis L., collected in different places of growth, the following have been isolated: essential oil, the main components of which are monoterpene compounds; sesquiterpene lactones estafiatin, hanphyllin, anobin, chrysartemine A, canin, anolide and tanapartin-β-peroxide; the steroid acetyleucanbin; flavonoids: 3,5-dihydroxy-6,7,8-trimethoxyflavone, 5-hydroxy-3,6,7,4’-tetramethoxyflavone and 5,3’-di-hydroxy-3,6,7,4’-tetramethoxyflavone. It has been determined that the component composition of the essen-tial oil of Achillea nobilis L. largely depends on the soil and climatic factors in the places of its growth, the phase of the growing season and the method of its extraction from plant raw materials, and the extractant used (chloroform, ethanol, hot water, diethyl ether). Antibacterial, antimicrobial, antioxidant, antiparasitic activi-ties are characteristic both for the sums of extractive substances from Achillea nobilis L. and for individual compounds isolated from them. Methods for the isolation of biologically active substances from Achillea nobilis L. for the development of new drug substances are described. The main aim of this work was a com-parative analysis of the available research results on the phytochemical study of Achillea nobilis L.

scholarly journals THE STUDY OF THE DOMINANT GROUPS OF BIOLOGICALLY ACTIVE SUBSTANCES AND BIOELEMENTS IN SOME PLANTS OF THE FAMILY ROSACEAE

2017 ◽  
pp. 145-151
Author(s):  
Ефим (Efim) Авраамович (Avraamovich) Краснов (Krasnov) ◽  
Елена (Elena) Евгеньевна (Evgen'evna) Савельева (Savelyeva) ◽  
Надежда (Nadezhda) Кирилловна (Kirillovna) Рыжакова (Ryzhakova) ◽  
Ярослав (Yaroslav) Евгеньевич (Evgen'evich) Решетов (Reshetov) ◽  
Альбина (Al'bina) Равильевна (Ravil'evna) Гатауллина (Gataullina)
Keyword(s):  
Atomic Emission ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Isolation And Identification ◽  
Leading Role ◽  
Aerial Parts ◽  
Potentilla Anserina ◽  
Rosaceae Family ◽  
Innovative Drugs ◽  
Active Substances

To determine the content of the dominant groups of biologically active substances (tannins, polysaccharides, flavonoids) and bioelements in aerial parts of ten species of the Rosaceae family, which grows in Siberia: Potentilla anserina L., P. longifolia Willd., P. canescens Besser, P. bifurca L., P. tergemina Sojak, P. argentea L., P. goldbachii Rupr., P. sericea Dulac., Agrimonia pilosa Ledeb., Filipendula ulmaria (L.) Maxim. To determine the concentrations of essential and conditionally essential trace elements defined by the method of atomic emission spectroscopy. First identified plants of the genus Potentilla (P. canescens, P. tergemina) and Filipendula (F. ulmaria), accumulate significant quantities of lithium – 14,6, and 11,0 13,3 mg/kg, respectively, making them promising for further studies on the isolation and identification of active substances with the aim of creating innovative drugs. Investigated the content of heavy metals (Pb, Hg, As, Cd), the values of which meets regulatory requirements. Useful properties of the examined species family Rosaceae are determined by the content of biologically active substances (flavonoids, polysaccharides, tannins) and the complex of macro - and micronutrients. It is revealed that a dominant position in the spectrum belongs to the macronutrients potassium, calcium and magnesium (4,300 to 27,000 mg/kg). Among micronutrients the leading role is copper, followed by iron, silicon and manganese having important biological value, in particular, involved in the process of hematopoiesis.

BACKGROUND CONTENT OF TECHNOGENIC AND NATURAL RADIONUCLIDES IN DETOXIFYING AND BIOLOGICALLY ACTIVE SUBSTANCES

2021 ◽  
Vol 1 (2) ◽  
pp. 223-229
Author(s):  
G.А. Zhorov ◽  
◽  
L.L. Zakharova ◽  
V.N. Obryvin ◽  
◽  
...  
Keyword(s):  
Specific Activity ◽  
Raw Materials ◽  
Natural Radionuclides ◽  
Animal Husbandry ◽  
Maximum Level ◽  
Feed Additives ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Radioactive Isotopes ◽  
Active Substances

For correctly assess the effectiveness and safety of the use of sorption-detoxifying agents and feed additives intended for animals receiving feed with an excess content of toxicants, it is necessary to take into account the background levels of radionuclides, toxic elements, pesticides and other technogenic and natural pollutants in the studied substances. The need for such studies is due both to the existence of areas with a naturally elevated level of natural toxicants in the sources of raw materials for the production of additives and drugs, and to the increasing anthropogenic influence, accompanied by the entry of xenobiotics into environmental objects. In series of radiometric studies, the specific activity of technogenic and natural radioactive isotopes (90Sr, 137Cs, 40К, 226Ra, 232Th) in a number of sorption-detoxifying and biologically active substances and preparations used in animal husbandry and veterinary medicine as part of feed additives and pharmacological agents was determined. It was found that in 43% of the studied samples, the level of specific activity of 1,1Sr in 3-90 times higher than allowed by the current standards. The maximum level of 90Sr, equal to (137±9) Bq/kg, was detected in perlite. The specific activity of 137Cs did not exceed the permissible level: in mineral sorbents its amount reached (40±7) Bq/kg, in organic and complex sorbents – (24±4), and in feed additives – (29±8) Bq/kg. The maximum levels of 40K were (1429±83) Bq/ kg in minerals (radionite) and (2613±100) Bq/kg in organic substances (lignohumate). The levels of 226Ra and 232Th did not exceed (153±13) and (79±13) Bq/kg, respectively, and were higher in the mineral samples.

ECDYSTEROIDS IN NATURE AND THEIR PROPERTIES

2019 ◽  
Vol 5 (3) ◽  
pp. 26-28
Author(s):  
Э. Наумова ◽  
E. Naumova ◽  
Б. Валентинов ◽  
B. Valentinov
Keyword(s):  
Raw Materials ◽  
Folk Medicine ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Natural Sources ◽  
Natural Origin ◽  
Adaptogenic Activity ◽  
Active Substances

Ecdysteroids are biologically active substances of natural origin. Their adaptogenic activity, hormone-like and bioregulatory effects used in traditional and folk medicine are known. Sources of raw materials are diverse. Applications depend on the methods of obtaining ecdysteroids and their natural sources.

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