Childhood Secondhand Smoke Exposure and Risk of Dementia, Alzheimer’s Disease and Stroke in Adulthood: A Prospective Cohort Study

2021 ◽  
pp. 1-6
Author(s):  
S. Zhou ◽  
K. Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondhand Smoke ◽  
Smoking Status ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Heart Study ◽  
Wide Range ◽  
Exposure To Secondhand Smoke

Background: This study aimed to investigate the associations between secondhand smoke exposure and dementia, Alzheimer’s disease (AD) and stroke. Methods: This prospective study analyzed Framingham Offspring (FHS-OS) cohort participants with parents in the original Framingham Heart Study (FHS) cohort with known smoking status during offspring childhood. Surveillance for incident events, including dementia and stroke, among offspring participants exposed to parental smoking up to the age of 18 years commenced at examination 9 through 2014 and continued for approximately 30 years. Results: At baseline, a total of 1683 (56.2%) subjects were not exposed to any secondhand smoke, whereas 670 (22.4%) subjects were exposed to 0-1 packs (20 cigarettes)/day, and 640 (21.4%) were exposed to over 1 pack/day. On follow-up (median: 31 years), 2993 patients developed dementia, including 103 with AD dementia and 315 with stroke. After adjusting for a wide range of established risk factors, participants with the highest exposure to secondhand smoke exhibited increased risks of all dementia, AD dementia and stroke compared with individuals with no exposure [HR 2.86 (2.00-4.09) for dementia; HR 3.13 (1.80-5.42) for AD dementia; HR 1.89 (1.37-2.61) for stroke]. The results remained comparable in the subgroup for individuals with median exposure to secondhand smoke. Conclusion: Exposure to secondhand smoke may be associated with increased risks of dementia, AD dementia and stroke.

scholarly journals Secondhand smoke exposure is associated with increased carotid artery intima-media thickness: The Bogalusa Heart Study

2015 ◽  
Vol 240 (2) ◽  
pp. 374-379 ◽  
Author(s):  
Wei Chen ◽  
Miaoying Yun ◽  
Camilo Fernandez ◽  
Shengxu Li ◽  
Dianjianyi Sun ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Secondhand Smoke ◽  
Intima Media Thickness ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Bogalusa Heart Study ◽  
Media Thickness ◽  
Heart Study

scholarly journals Cigarette Smoking and Secondhand Smoke Exposure Before and After a Tobacco-Free Olympic Policy Period: Qingdao, China

2018 ◽  
Vol 21 (11) ◽  
pp. 1531-1538 ◽  
Author(s):  
Jing Zhao ◽  
Xiaojing Li ◽  
Susan LeRoy Stewart ◽  
Weiguo Gao ◽  
Fei Qi ◽  
...  
Keyword(s):  
Public Policy ◽  
Secondhand Smoke ◽  
Large Scale ◽  
Smoking Prevalence ◽  
Olympic Games ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Before And After ◽  
The Impact ◽  
Exposure To Secondhand Smoke

Abstract Introduction We explored the impact of a temporary tobacco-free public policy for the 2008 Summer Olympics on the smoking prevalence and secondhand smoke exposure among the population of a co-hosting city, Qingdao, China. Methods The Qingdao Diabetes Survey was analyzed for 2006 (n = 4599) and 2009 (n = 4680), which are survey years before and after the tobacco-free Olympics public policy period (July 2007 to January 2009). We analyzed the differences in self-reported smoking prevalence and exposure to secondhand smoke at home and/or workplace, and compared odds of smoking by survey year and of exposure to secondhand smoke among nonsmokers. Results From 2006 to 2009, the male smoking prevalence declined from 51.4% (95% confidence interval [CI] = 49.0% to 53.9%) to 42.6% (95% CI = 40.2% to 45.1%), and the proportion of lighter smokers decreased more. Among nonsmokers, the secondhand smoke exposure rate declined from 62.2% (95% CI = 60.5% to 63.9%) to 56.8% (95% CI = 55.1% to 58.6%). Regression analyses show 34% lower odds of men smoking after Olympics (OR = 0.66, 95% CI = 0.57% to 0.77%). Rural residents and individuals who are not retired were more likely to smoke. Female nonsmokers report 17% less exposure to secondhand smoke after Olympics (OR = 0.83, 95% CI = 0.70% to 0.98%). Urban nonsmokers were more likely to be exposed than their rural counterparts. Conclusions Smoking prevalence among men and secondhand smoke exposure among women significantly decreased in Qingdao, China, after the tobacco-free Olympics public policy period. As only the proportion of lighter smokers decreased, this may help explain why urban nonsmokers reported increased exposure. Unintended increased secondhand smoke exposure and cessation support need to be addressed in large-scale policy campaigns. Implications Hosting the Olympic Games can help to initiate large-scale tobacco-free public policies for hosting cities. Although previous studies have demonstrated reduction in nonsmoker exposure to secondhand smoke, the impact on the hosting city’s smoking prevalence or exposure rates is unclear. After the Olympic Games in Qingdao, China, smoking prevalence among men significantly decreased, mostly due to light smokers. Secondhand smoke exposure at home and/or workplace significantly decreased among female nonsmokers. Urban nonsmokers had an unintended consequence of increased secondhand smoke exposure after the tobacco-free Olympic policy period. Concurrent promotion of cessation support for heavier smokers may be needed.

scholarly journals Factors Associated with Tobacco Smoking in HIV Infected Persons, Brazil: A Cross Sectional Survey

2020 ◽  
Author(s):  
William Sorensen ◽  
Natalia Maria Vieira Pereira-Caldeira ◽  
Julianna Boyle ◽  
Lilian Andreia Fleck-Reinato ◽  
Elucir Gir
Keyword(s):  
Sexual Orientation ◽  
Secondhand Smoke ◽  
Smoking Status ◽  
Smoking Behavior ◽  
Smoke Exposure ◽  
Hiv Care ◽  
Secondhand Smoke Exposure ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Lower Education Level

Abstract Background: The purpose of this study was to assess differences in factors between smoking status of Brazilians living with HIV, as well as assess whether secondhand smoke exposure or sexual orientation was associated with smoking status. Methods: Over 200 HIV infected individuals were convenience sampled. Permission was granted by the Universidade de São Paulo, and trained HIV care nurses conducted the interviews. Results: Two-hundred and five participants were interviewed of whom 39% currently smoked tobacco. Sexual orientation did not associate with smoking categories, but secondhand smoke exposure did. In the ever-smoking model lower education level was more likely to induce smoking behavior and women were 70% more likely to have smoked. In the current-smoking model, attitudes were significant, and women were 75% more likely to be currently smoking. Conclusion: Smoking prevalence is high in HIV-infected persons in Brazil. Comprehensive attention is needed to help individuals successfully quit, including emphasis on secondhand smoking risk awareness and offering coping strategies to prevail over stigma and stress, especially for women.

Association between widespread pain and dementia, Alzheimer’s disease and stroke: a cohort study from the Framingham Heart Study

2021 ◽  
pp. rapm-2021-102733
Author(s):  
Kanran Wang ◽  
Hong Liu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Pain ◽  
Cohort Study ◽  
Framingham Heart Study ◽  
Widespread Pain ◽  
Dementia Risk ◽  
Heart Study ◽  
Alzheimer’S Disease Dementia

Background and objectiveChronic pain may be an early indicator of cognitive decline, but previous studies have not systematically examined the population-level associations between widespread pain and adverse cognitive outcomes and stroke. This study was designed to determine the association between widespread pain, a common subtype of chronic pain, and subsequent dementia, Alzheimer’s disease dementia and stroke.MethodsThis retrospective cohort study used data from the US community-based Framingham Heart Study. Pain status was assessed at a single time point between 1990 and 1994. Widespread pain was determined based on the Framingham Heart Study pain homunculus. Dementia follow-up occurred across a median of 10 years (IQR, 6–13 years) for persons who were dementia free at baseline. Proportional hazard models examined associations between widespread pain and incident dementia, Alzheimer’s disease dementia and stroke.ResultsA total of 347 (14.1%) subjects fulfilled the criteria for widespread pain, whereas 2117 (85.9%) subjects did not. Of 188 cases of incident all-cause dementia, 128 were Alzheimer’s disease dementia. In addition, 139 patients suffered stroke during the follow-up period. After multivariate adjustment including age and sex, widespread pain was associated with 43% increase in all-cause dementia risk (HR: 1.43; 95% CI 1.06 to 1.92), 47% increase in Alzheimer’s disease dementia risk (HR: 1.47; 95% CI 1.13 to 2.20) and 29% increase in stroke risk (HR: 1.29; 95% CI 1.08 to 2.54). Comparable results were shown in the subgroup of individuals over 65 years old.ConclusionWidespread pain was associated with an increased incidence of all-cause dementia, Alzheimer’s disease dementia and stroke.Trial registration numberNCT00005121.

scholarly journals Influence of family resources on secondhand smoking in pregnant women: a cross-sectional study in the border and minority urban areas of Northwest China

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jiangyun Chen ◽  
Xinhui Li ◽  
Pengqian Fang
Keyword(s):  
Pregnant Women ◽  
Secondhand Smoke ◽  
Protective Factor ◽  
Smoke Exposure ◽  
Population Characteristics ◽  
Smoking Ban ◽  
Secondhand Smoke Exposure ◽  
Smoking Bans ◽  
Family Resources ◽  
Exposure To Secondhand Smoke

Abstract Background Pregnant women’s exposure to secondhand smoke is a very serious health issue in China. The purpose of our research is to identify factors that predict the probability of exposure to secondhand smoke among pregnant women from the perspective of a family-based open system. Methods From September 2014 to August 2015, Urumqi City, Shihezi City, and Shawan County-level City were sampled according to population characteristics. A revised structured questionnaire based on family resources was adapted for use in this study. Questionnaires were collected via convenience sampling at the hospitals with the largest number of local antenatal clients. A total of 1249 pregnant women of age 18–51 years were investigated. Descriptive statistics were calculated to characterize the participants and study variables. Binary logistic regression was performed to assess the impact of family resources corresponding variables on the likelihood that participants would be exposed to SHS. Both unadjusted and adjusted odds ratios (OR/AOR) [with 95% confidence intervals (CI)] were reported. Results The secondhand smoke exposure rate found in this study was 54.6%. Having good knowledge of the dangers of secondhand smoke had no effect on reducing the prevalence of exposure (P > 0.05). Even pregnant women whose husbands who did not use tobacco or never smoked nearby had a risk of exposure to secondhand smoke [adjusted odds ratio (AOR) 1.568, 95% CI 1.205–2.041] when the data were adjusted for age, gravidity, gestational weeks, knowledge of the dangers of secondhand smoke, location, and work status. Home smoking bans were confirmed to be an important protective factor (AOR 1.710, 95% CI 1.549–1.918); however, only one-third (33.5%) of participants reported having a smoking ban at home. Religion (mainly Islam), as a special external family resource, was a protective factor that reduced secondhand smoke exposure in pregnant women (AOR 0.399, 95% CI 0.312–0.510). Conclusions The effect of family resources on tobacco control should be considered in the development of effective and enduring strategies for indoor smoking bans and smoking cessation.

scholarly journals Secondhand Smoke and CKD

2019 ◽  
Vol 14 (4) ◽  
pp. 515-522 ◽  
Author(s):  
Jong Hyun Jhee ◽  
Young Su Joo ◽  
Youn Kyung Kee ◽  
Su-Young Jung ◽  
Seohyun Park ◽  
...  
Keyword(s):  
Secondhand Smoke ◽  
Smoke Exposure ◽  
Hazard Ratio ◽  
Secondhand Smoke Exposure ◽  
Exposure Group ◽  
Cross Sectional ◽  
Never Smokers ◽  
Cox Analysis ◽  
Sectional Analysis ◽  
Exposure To Secondhand Smoke

Background and objectivesActive smoking is associated with higher risk of various diseases. However, the risk of CKD development in nonsmokers exposed to secondhand smoke is not well elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers.Design, setting, participants, & measurementsA total of 131,196 never-smokers with normal kidney function, who participated in the Korean Genome and Epidemiology Study from 2001 to 2014, were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days per week, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incident CKD development was analyzed in a longitudinal cohort of 1948 participants without CKD at baseline, which was a subset of the main cohort.ResultsThe mean age of participants was 53 years, and 75% were women. Prevalent CKD was observed in 231 (1.8%), 64 (1.7%), and 2280 (2.0%) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week: OR, 1.72; 95% confidence interval [95% CI], 1.30 to 2.27; and ≥3 days per week: OR, 1.44; 95% CI, 1.22 to 1.70). During a mean follow-up of 104 months, CKD occurred in 319 (16%) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days per week: hazard ratio, 1.59; 95% CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95% CI, 1.03 to 2.67).ConclusionsExposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

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