scholarly journals THE ROLE OF VITAMIN D IN THE PATHOGENESIS OF CHRONIC NON-COMMUNICABLE DISEASES

2014 ◽  
Vol 17 (3) ◽  
pp. 27-30 ◽  
Author(s):  
L V Egshatyan ◽  
E N Dudinskaya ◽  
O N Tkacheva ◽  
D A Kashtanova
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Vitamin D ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Autoimmune Destruction ◽  
Near Future ◽  
Reduced Risk

This review shows the role of vitamin D in the regulation of not only the level of calcium, but also in the pathogenesis of chronic systemic inflammation, disruption of insulin sensitivity of tissues. The sufficient levels of vitamin D in the blood can lead to reduced risk of developing type 2 diabetes, obesity, autoimmune destruction of pancreatic β-cells, certain cardiometa-bolic risk factors, and therefore cardiovascular disease. Perhaps preparations of vitamin D in the near future may become additional and necessary nutritional substances for correction of insulin resistance, cardiovascular disease, chronic inflammation and prevention of disorders of glucose metabolism.

Role of vitamin D in risk factors of patients with type 2 diabetes mellitus

2020 ◽  
Vol 154 (5) ◽  
pp. 151-156 ◽  
Author(s):  
Qingqing Zhang ◽  
Yucheng Wu ◽  
Yu Lu ◽  
Xiaoqiang Fei
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus

Role of pancreatic-derived factor in type 2 diabetes: evidence from pancreatic β cells and liver

2012 ◽  
Vol 70 (2) ◽  
pp. 100-106 ◽  
Author(s):  
Chunjiong Wang ◽  
Brant R Burkhardt ◽  
Youfei Guan ◽  
Jichun Yang
Keyword(s):  
Type 2 Diabetes ◽  
Β Cells ◽  
Pancreatic Β Cells

scholarly journals A study of the effects of large dose of parenteral vitamin D (D3) on insulin resistance in type 2 DM patients

2017 ◽  
Vol 5 (6) ◽  
pp. 2338
Author(s):  
Vinu Jamwal ◽  
Wani Zahid Hussain ◽  
Abhinav Gupta ◽  
Anil K. Gupta
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Insulin Sensitivity ◽  
Vitamin D3 ◽  
Favourable Effect ◽  
P Value ◽  
Low Grade ◽  
Β Cells ◽  
Pancreatic Β Cells

Background: Over the past decade, vitamin D is more known as a hormone because of its extra - skeletal outcomes in various disease conditions, including diabetes. Most cells, including the pancreatic β-cells, contain the vitamin D receptor and they also have the capability to produce the biologically active 1,25-dihydroxyvitamin D [1,25(OH)2D3] which allows intracrine and paracrine functions. In vitro studies have shown that the active vitamin D metabolite 1,25(OH)2D stimulated insulin release by the pancreatic β-cells. Vitamin D is known to have immune modulatory and anti-inflammatory effects and reduces peripheral insulin resistance by altering low-grade chronic inflammation. This study was done to assess whether supplementation of vitamin D in type 2 diabetes mellitus (T2DM) patients with Vitamin D deficiency has any favourable effect on insulin resistance.Methods: It was a short term interventional study conducted at ASCOMS hospital Jammu including a total of 50 vitamin D deficient [25(OH) D <50 nmol/l] T2DM patients with an in-adequate glycemic control (HbA1c > 7.0%). All the 50 study participants completed the study and there were no changes either in anti-hyperglycemic drugs (including insulin) or antihypertensive drugs being used. After supplementation with a single high dose (600000 IU) of parenteral vitamin D3 changes in HOMA-IR (Homeostasis model assessment insulin resistance) were seen on follow up at 3 months.Results: Vitamin D3 supplementation improved insulin sensitivity, HOMA-IR decreased from 4.05±1.42 to 3.93±1.28 (p =0.011). It decreased equally in males (3.85±1.43 to 3.76±1.30) (p value=0.023) and females (4.24±1.42 to 4.10±1.27) (p value=0.021). HOMA-IR showed negative association with Vitamin D levels both at baseline and after 3 months of follow up.Conclusions: This improvement in insulin sensitivity is evidenced in our study by decrease in fasting insulin levels (FIL) and improvement in fasting blood sugars (FBS). It is due to both direct and indirect effects of Vitamin D3 on both insulin sensitivity and secretion.

RELATIONSHIP BETWEEN VITAMIN D DEFICIENCY AND CARDIOVASCULAR DISEASES (REVIEW)

Vestnik ◽  
2021 ◽  
pp. 40-43
Author(s):  
А.М. Барат ◽  
Г.Д. Жаманбай ◽  
Б.Б. Тельман ◽  
А.Б. Кенесхан ◽  
Д.К. Досиханова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
The World ◽  
Associated Risk Factors

Дефицит витамина D, а также сердечно-сосудистые заболевания (ССЗ) и связанные с ними факторы риска широко распространены во всем мире и часто возникают одновременно. Давно известно, что витамин D является неотъемлемой частью метаболизма костей, хотя недавние данные свидетельствуют о том, что витамин D играет ключевую роль в патофизиологии других заболеваний, включая сердечно-сосудистые заболевания. В этом обзоре мы стремимся обобщить самые последние данные об участии дефицита витамина D в развитии основных факторов риска сердечно-сосудистых заболеваний: артериальной гипертензии, ожирения и дислипидемии, диабета 2 типа, хронического заболевания почек и эндотелиальной дисфункции. Кроме того, мы приводим самые последние данные наблюдений, а также интервенционные данные о влиянии витамина D на сердечно-сосудистые заболевания. Vitamin D deficiency, as well as cardiovascular disease (CVD) and associated risk factors, are widespread throughout the world and often occur concurrently. Vitamin D has long been known to be an essential part of bone metabolism, although recent evidence suggests that vitamin D plays a key role in the pathophysiology of other diseases, including cardiovascular disease. In this review, we seek to summarize the most recent evidence on the involvement of vitamin D deficiency in the major risk factors for cardiovascular disease: hypertension, obesity and dyslipidemia, type 2 diabetes, chronic kidney disease, and endothelial dysfunction. In addition, we provide the most recent observational data as well as interventional evidence on the effects of vitamin D on cardiovascular disease.

Role of vitamin D in risk factors of patients with type 2 diabetes mellitus

2020 ◽  
Vol 154 (5) ◽  
pp. 151-156
Author(s):  
Qingqing Zhang ◽  
Yucheng Wu ◽  
Yu Lu ◽  
Xiaoqiang Fei
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus

Assessment of the Role of Serum 25-Hydroxy Vitamin D Level on Coronary Heart Disease Risk With Stratification Among Patients With Type 2 Diabetes Mellitus

Angiology ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 86-92
Author(s):  
Abdülbari Bener ◽  
Abdulla O. A. A. Al-Hamaq ◽  
Susu M. Zughaier ◽  
Mustafa Öztürk ◽  
Abdülkadir Ömer
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
25 Hydroxy Vitamin D

We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were included. Information on sociodemographic lifestyle, family history, blood pressure (BP), and coronary heart disease (CHD) complications was collected. Significant differences were found between males and females regarding age-groups ( P = .002), body mass index (BMI; P = .008), physical activity ( P = .010), sheesha smoking ( P = .016), cigarette smoking ( P = .002), hypertension ( P = .050), metabolic syndrome ( P = .026), and CHD ( P = .020). There were significant differences between vitamin D deficiency, insufficiency, and sufficiency in relation to age-group ( P = .002), income ( P = .002), waist circumference ( P = .002), hip circumference ( P = .028), waist–hip ratio ( P = .002), and BMI ( P = .002). Further, mean values of hemoglobin, magnesium, creatinine, hemoglobin A1c (HbA1c), total cholesterol, uric acid, and diastolic BP were significantly higher among patients with vitamin D deficiency compared with those with insufficiency and sufficiency. Multiple logistic regression analysis revealed that 25-hydroxy vitamin D, 25(OH)D, HbA1c, waist circumference, uric acid, duration of T2DM, total cholesterol, systolic and diastolic BP, and BMI were strong predictor risk factors for CHD among patients with T2DM. The present study supports that 25(OH)D may have a direct effect on CHD and on its risk factors.

scholarly journals The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Man Ki Kwok ◽  
Ichiro Kawachi ◽  
David Rehkopf ◽  
Catherine Mary Schooling
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Mendelian Randomization ◽  
Cvd Risk Factors ◽  
Cvd Risk

Abstract Background Cortisol, a steroid hormone frequently used as a biomarker of stress, is associated with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). To clarify whether cortisol causes these outcomes, we assessed the role of cortisol in ischemic heart disease (IHD), ischemic stroke, T2DM, and CVD risk factors using a bi-directional Mendelian randomization (MR) study. Methods Single nucleotide polymorphisms (SNPs) strongly (P < 5 × 10−6) and independently (r2 < 0.001) predicting cortisol were obtained from the CORtisol NETwork (CORNET) consortium (n = 12,597) and two metabolomics genome-wide association studies (GWAS) (n = 7824 and n = 2049). They were applied to GWAS of the primary outcomes (IHD, ischemic stroke and T2DM) and secondary outcomes (adiposity, glycemic traits, blood pressure and lipids) to obtain estimates using inverse variance weighting, with weighted median, MR-Egger, and MR-PRESSO as sensitivity analyses. Conversely, SNPs predicting IHD, ischemic stroke, and T2DM were applied to the cortisol GWAS. Results Genetically predicted cortisol (based on 6 SNPs from CORNET; F-statistic = 28.3) was not associated with IHD (odds ratio (OR) 0.98 per 1 unit increase in log-transformed cortisol, 95% confidence interval (CI) 0.93–1.03), ischemic stroke (0.99, 95% CI 0.91–1.08), T2DM (1.00, 95% CI 0.96–1.04), or CVD risk factors. Genetically predicted IHD, ischemic stroke, and T2DM were not associated with cortisol. Conclusions Contrary to observational studies, genetically predicted cortisol was unrelated to IHD, ischemic stroke, T2DM, or CVD risk factors, or vice versa. Our MR results find no evidence that cortisol plays a role in cardiovascular risk, casting doubts on the cortisol-related pathway, although replication is warranted.

Sign in / Sign up

Export Citation Format

Share Document