scholarly journals Disorders of lipid metabolism in subclinical hypothyroidism

2004 ◽  
Vol 50 (3) ◽  
pp. 48-52
Author(s):  
Yu. P. Sych ◽  
V. V. Fadeev ◽  
G. A. Mel'nichenko ◽  
A. L. Syrkin ◽  
A. P. Roitman
Keyword(s):  
Lipid Metabolism ◽  
Thyroid Hormones ◽  
Normal Level ◽  
Subclinical Hypothyroidism ◽  
Elevated Level ◽  
Thyroid Dysfunction ◽  
The Body ◽  
Disorders Of Lipid Metabolism

Subclinical hypothyroidism (SG) is a syndrome caused by a persistent borderline decrease in the level of thyroid hormones in the body, in which a normal level of T4 is determined in combination with a moderately elevated level of TSH. SG is the most common thyroid dysfunction.

THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: THE STATE OF THE PROBLEM AND THE WAYS OF SOLVING

2018 ◽  
Vol 22 (4) ◽  
pp. 40-49 ◽  
Author(s):  
A. R. Volkova ◽  
O. D. Dygun ◽  
B. G. Lukichev ◽  
S. V. Dora ◽  
O. V. Galkina
Keyword(s):  
Chronic Kidney Disease ◽  
Thyroid Gland ◽  
Kidney Disease ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
The Body ◽  
Type I ◽  
Low T3 ◽  
Iodine Excretion

Disturbance of the thyroid function is often detected in patients with different profiles. A special feature of patients with chronic kidney  disease is the higher incidence of various thyroid function  disturbances, especially hypothyroidism. It is known that in patients  with chronic kidney disease (CKD) iodine excretion from the body is  violated, since normally 90% of iodine is excreted in urine.  Accumulation of high concentrations of inorganic iodine leads to the  formation of the Wolf-Chaikoff effect: suppression of iodine  organization in the thyroid gland and disruption of the thyroid  hormones synthesis. Peripheral metabolism of thyroid hormones is  also disturbed, namely, deiodinase type I activity is suppressed and  peripheral conversion of T4 into T3 is inhibited (so-called low T3  syndrome). Therefore, patients with CKD are often diagnosed with  hypothyroidism, and the origin of hypothyroidism is not always  associated with the outcome of autoimmune thyroiditis. The article  presents an overview of a large number of population studies of  thyroid gland dysfunction in patients with CKD, as well as  experimental data specifying the pathogenetic mechanisms of  thyroid dysfunction in patients with CKD. Therapeutic tactics are still  not regulated. However, in a number of studies, replacement therapy with thyroid hormones in patients with CKD had some advantages.

scholarly journals ВЛИЯНИЕ ВЕЩЕСТВА НА ОСНОВЕ ФИБРОИНА ШЕЛКА НА ПОКАЗАТЕЛИ ЛИПИДНОГО ОБМЕНА У КРЫС С ЭКСПЕРИМЕНТАЛЬНОЙ ГИПЕРХОЛЕСТЕРИНЕМИЕЙ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 38-42
Author(s):  
Нишантаев М. К. ◽  
Арифджанов С. З. ◽  
Айходжаев Б. К. ◽  
Юлдашев Н. М.
Keyword(s):  
Lipid Metabolism ◽  
Bile Acid ◽  
Polymer Physics ◽  
The Body ◽  
Hypocholesterolemic Effect ◽  
Bile Acid Sequestrants ◽  
Experimental Hypercholesterolemia ◽  
The Republic ◽  
Academy Of Sciences ◽  
Disorders Of Lipid Metabolism

The article presents the results of a study on the effectiveness of a substance based on silk fibroin, obtained at the Institute of Chemistry and Polymer Physics of the Academy of Sciences of the Republic of Uzbekistan, in eliminating disorders of lipid metabolism in the body. In experiments in rats with experimental hypercholesterolemia, the substance was found to have a cholesterol-lowering property, which is manifested by a decrease in cholesterol level both in blood and in tissues. Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids, which makes it possible to classify this substance as a group of bile acid sequestrants.

scholarly journals Gormony zhirovoy tkani i funktsional'nayaaktivnost' shchitovidnoy zhelezy

2010 ◽  
Vol 7 (4) ◽  
pp. 8-11 ◽  
Author(s):  
N A Petunina ◽  
N E Al'tshuler ◽  
N G Rakova ◽  
L V Trukhina
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
The Impact ◽  
The Relationship ◽  
Tissue Hormones

The review presents a recent data from the literature on the physiologic and pathophysiologic role of adipose tissue hormones (adiponectin, resistin, leptin). The article details the role of adipocytokines in atherogenesis. It also presents the results of studies depicting the relationship between subclinical hypothyroidism, lipid metabolism and insulin resistance as well as the impact of thyroid dysfunction upon the secretion of adipocytokines.

scholarly journals The Clinical Implications of Thyroid Hormones and its Association with Lipid Profile: A Comparative Study from Western Nepal

1970 ◽  
Vol 1 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Ankush Mittal ◽  
Brijesh Sathian ◽  
Arun Kumar ◽  
Nishida Chandrasekharan ◽  
Sanjeev Dwedi
Keyword(s):  
Thyroid Hormones ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Laboratory Tests ◽  
Thyroid Dysfunction ◽  
Reference Range ◽  
Thyroid Disorder ◽  
The Mean ◽  
Tsh Levels

BackgroundThyroid dysfunction is one of the major public health problems in Nepal. Laboratory tests facilitate early diagnosis before clinical features are obvious, increased sensitivity carries the price of decreased diagnostic specificity. Laboratory tests coupled with supportive clinical findings are frequently used to diagnose thyroid dysfunction. Historically, hypercholesterolemia and raised serum low density lipoprotein (LDL) cholesterol levels have been found to be associated with subclinical hypothyroidism. Therefore, assessment of altered lipid profile plays a supportive role in diagnosis of thyroid dysfunction. The aim of our study was to find out the variations of thyroid hormones and lipid profile in hyperthyroidism and hypothyroidism with their clinical implications.Materials and Methods  It was a hospital based retrospective study carried out from the  data  retrieved  from  the  register  maintained  in  the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between 1st July, 2009 and 30th June, 2010. The variables collected were age, gender, T4, T3, TSH, fT4, total cholesterol and triglyceride levels. Descriptive statistics and testing of hypothesis were used for the analysis of data.Results122 out of the 365 subjects selected for the study had some form of thyroid disorder. Of the 122 cases, 40 had hyperthyroidism, 42 had hypothyroidism and the remaining 40 were diagnosed to have subclinical hypothyroidism.  The frequency of thyroid disorders was much higher in females as compared to their male counterparts. The mean value of each variable in cases, except for age, was statistically significant as compared to controls (p=0.001). Elevated levels of total T3 (CI 2.14 to 2.59), T4 (CI 13.00 to 15.30) and fT4 (CI 2.51 to 2.81) associated with decreased TSH levels (CI 0.29 to 0.35) were found in cases of hyperthyroidism. The TSH values (CI 17.05 to 22.85) were markedly increased while T4 and T3 values were found to be less than the reference range in cases of hypothyroidism. There was significant increase in the mean concentration of total cholesterol (CI 268.83 to 289.79) and triglycerides (CI 154.81to 182.05) in cases of hypothyroidism. The fT4 (CI 1.08 to 1.22) levels were in reference range and TSH levels (CI 9.59 to 10.50) were moderately raised in cases of subclinical hypothyroidism.ConclusionThyroid dysfunction is common across all age groups and shows a strong female preponderance in Pokhara valley. It necessitates the measurement of thyroid hormones in women after the age of 50, in pregnancy and after delivery, and in women and men with hypercholesterolemia. Therefore, timely screening and check ups are necessary in order to curtail the problem of undiagnosed cases, giving specific consideration to patients who have high artherogenic profile. This will reduce the risk of future negative health events in older adults.Key Words: Thyroid hormones; Hyperthyroidism; Hypothyroidism; Lipid profile; NepalDOI: 10.3126/nje.v1i1.4102Nepal Journal of Epidemiology 2010;1 (1):11-16

Subclinical hypothyroidism: treat or watch?

2021 ◽  
pp. 98-108
Author(s):  
I. A. Tsanava ◽  
S. V. Bulgakova ◽  
A. V. Melikova
Keyword(s):  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Metabolic Disorders ◽  
Reference Range ◽  
Cognitive Disorders ◽  
The Body ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Tsh ◽  
Tsh Levels

Manifest hypothyroidism occurs in more than 5 % of the population, while prevalence of subclinical hypothyroidism is much higher and reaches 15 %. In the practice of an endocrinologist, in most cases, the diagnosis and treatment of manifest hypothyroidism does not raise questions, while subclinical changes in thyroid hormones quite often generate a lot of discussions. The generally accepted reference range for TSH up to 4.50 μIU / ml is in conflict with data showing that more than 95 % of healthy people with euthyroidism have serum TSH levels up to 2.5 μIU / ml. At the same time, a lot of data has been accumulated on the effect of even slightly altered levels of thyroid hormones and TSH on various tissues, organs and systems of the body, especially on the cardiovascular, nervous and reproductive systems. This review analyzes the results of studies aimed at studying the relationship of subclinical hypothyroidism with cardiovascular and metabolic disorders, cognitive disorders, pathology of pregnant women.

Thyroid hormones and thermogenesis: A microcalorimetric study of overall cell metabolism in lymphocytes from patients with different degrees of thyroid dysfunction

1990 ◽  
Vol 123 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Stig Valdemarsson ◽  
Julie Ikomi-Kumm ◽  
Mario Monti
Keyword(s):  
Thyroid Hormones ◽  
Production Rate ◽  
Heat Production ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Subclinical Hyperthyroidism ◽  
Significant Difference ◽  
Heat Production Rate ◽  
Serum Tsh

Abstract. We used microcalorimetry to measure lymphocyte heat production rate in patients with clinical and laboratoy hyperthyroidism (serum TSH ↓, serum FT4 ↑, serum FT3 ↑ ), subclinical hyperthyroidism (serum TSH ↓, serum FT4 ↑, serum FT3=), and subclinical hypothyroidism (serum TSH ↑, serum FT4 ↓, serum FT3=) compared with healthy controls (N= 13). The lymphocyte heat production rate was significantly correlated to the free thyroxine level (r=0.53, p<0.01) and to the free triiodothyronine level (r=0.51, p<0.01) when calculated from pooled data for the three patients groups. The hyperthyroid patients (N = 8) had a significantly increased lymphocyte heat production rate, 3.43±0.25 pW/cell, as compared with 2.31±0.12 pW/cell in the control group (p<0.001). The groups with subclinical hyperthyroidism (N = 7) and subclinical hypothyroidism (N=9) had lymphocyte heat production rates of 2.14±0.11 and 2.56±0.15 pW/cell, respectively, not significantly different from that in the controls. Consistently, there was no significant difference between patients with subclinical hyperthyroidism (N=5) and controls (N=5) with regard to lymphocyte energy production as calculated from separately measured oxygen comsumption rates in vitro, 1.36±0.20 and 1.56±0.12 pW/cell, respectively. Thus microcalorimetry seems to be suitable for studying the influence of thyroid hormones on cellular metabolism. Subclinical thyroid dysfunction does not seem to alter the overall rate of lymphocyte metabolism.

scholarly journals FREQUENCY OF SUBCLINICAL HYPOTHYROIDISM AMONG DIAGNOSED CASES OF CHOLELITHIASIS.

2020 ◽  
Vol 11 (3) ◽  
pp. 46-51
Author(s):  
Riffat Arbab ◽  
Muhammad iqbal Khan ◽  
Abdullah Khan ◽  
Maria Mehmood ◽  
Aisha Arshad ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Stone Formation ◽  
Sphincter Of Oddi ◽  
Cross Sectional Study ◽  
The Body ◽  
Ethical Review ◽  
Medical Institute ◽  
Cross Sectional ◽  
Surgical Department

Abstract BACKGROUND & OBJECTIVE:  Thyroid hormones act as foundation for the normal functioning of all the body hormones and body metabolism. The abnormality of thyroid hormones may lead to deranged lipid metabolism with abnormal relaxation of sphincter of oddi. This will cause stasis of bile in gallbladder and biliary channels leading to stone formation. The objective of the study is to determine the frequency of subclinical hypothyroidism among diagnosed cases of Cholelithiasis. METHODOLOGY: This study was conducted in Surgical Department, Sandman Provincial Hospital Quetta, from January to December 2018. The study has been approved by the ethical review committee of Post Graduate Medical Institute Quetta. It is a cross-sectional study. A total of 193 patients with Cholelithiasis were included in the study. After informed written consent, blood was sent to laboratory for testing the levels of serum TSH, T3 and T4. Samples having TSH values more than 6.0mU/L and serum thyroxin within the normal range 9.0-19.0pmole/L,  were labeled as subclinical hypothyroidism. RESULTS: The data of all the patients between 35 to 62 years of age with Cholelithiasis during the study period was taken and analysis was performed. The inclusion and exclusion criteria were strictly considered. Mean ± SD of age was 47.03±5.401 with C.I (46.26-47.80) years. Out of 193 patients 25 (13%) were male and 168(87%) were female. Subclinical hypothyroidism was found to be in 16 (8.16%) patients and remaining 177(91.70%) patients were found normal. CONCLUSION: It was concluded that the incidence of subclinical hypothyroidism in Cholelithiasis patients is low.

scholarly journals The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients

2020 ◽  
Vol 9 (1) ◽  
pp. 55-62
Author(s):  
L E Zijlstra ◽  
D M van Velzen ◽  
S Simsek ◽  
S P Mooijaart ◽  
M van Buren ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Thyroid Hormones ◽  
Kidney Function ◽  
Thyroid Function ◽  
Primary Endpoint ◽  
Subclinical Hypothyroidism ◽  
Thyroid Disease ◽  
Older Patients ◽  
Thyroid Dysfunction ◽  
Subclinical Hyperthyroidism

Objective Thyroid hormones have been implicated to play a role in cardiovascular disease, along with studies linking thyroid hormone to kidney function. The aim of this study is to investigate whether kidney function modifies the association of subclinical thyroid dysfunction and the risk of cardiovascular outcomes. Methods In total, 5804 patients were included in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). For the current analysis, 426 were excluded because of overt thyroid disease at baseline or 6 months, 266 because of inconsistent thyroid function at baseline and 6 months, 294 because of medication use that could influence thyroid function, and 16 because of missing kidney or thyroid values. Participants with normal fT4 were classified, based on TSH both at inclusion and 6 months, into three groups: subclinical hypothyroidism (TSH >4.5 mIU/L); euthyroidism (TSH = 0.45–4.5 mIU/L); and subclinical hyperthyroidism (TSH <0.45 mIU/L). Strata of kidney function were made based on estimated glomerular filtration rate into three clinically relevant groups: <45, 45–60, and >60 mL/min/1.73 m2. The primary endpoint consists of death from coronary heart disease, non-fatal myocardial infarction and (non)fatal stroke. Results Mean age was 75.3 years, and 49.0% patients were male. Mean follow-up was 3.2 years. Of all participants, 109 subjects (2.2%) had subclinical hypothyroidism, 4573 (94.0%) had euthyroidism, and 182 (3.7%) subclinical hyperthyroidism. For patients with subclinical hypothyroidism, euthyroidism, and subclinical hyperthyroidism, primary outcome occurred in 9 (8.3%), 712 (15.6%), and 23 (12.6%) patients, respectively. No statistically significant relationship was found between subclinical thyroid dysfunction and primary endpoint with adjusted hazard ratios of 0.51 (0.24–1.07) comparing subclinical hyperthyroidism and 0.90 (0.58–1.39) comparing subclinical hypothyroidism with euthyroidism. Neither was this relationship present in any of the strata of kidney function, nor did kidney function interact with subclinical thyroid dysfunction in the association with primary endpoint (P interaction = 0.602 for subclinical hyperthyroidism and 0.388 for subclinical hypothyroidism). Conclusions In this secondary analysis from PROSPER, we found no evidence that the potential association between thyroid hormones and cardiovascular disease is modified by kidney function in older patients with subclinical thyroid dysfunction.

scholarly journals STUDY OF THYROID DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Sheetal Ratankumar Gatagat
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Diseases ◽  
Endocrine Disorders ◽  
Age Group ◽  
Thyroxine Replacement ◽  
The Impact

Introduction: Metabolic syndrome (MS) is described as insulin resistance, clusters of abnormalities including abdominal obesity, hypertension, hyperglycaemia, increased triglycerides, and decreased high-density lipoprotein cholesterol (HDL-C). In maintaining thermogenesis and metabolic homeostasis Thyroxine and Triidothryronine play an important role. Thyroid is established by thyroid stimulation hormone (TSH). Thyroid hormones up-regulate metabolic pathways relevant to resting energy expenditure, hence obesity and thyroid functions are often correlated. It is still not clear whether these alterations in thyroid hormones are a cause or an effect of obesity. Hypothyroidism is well known to cause diastolic hypertension, endothelial dysfunction, hyperlipidemia and cardiovascular disease. The functions of thyroid affect the components of metabolic syndrome including triglycerides (TG), HDL–cholesterol (HDL-C), blood pressure and plasma glucose. The impact of various degree of thyroid dysfunction on components of metabolic syndrome, however, continues to be debatable. On components of metabolic syndrome, Thyroid dysfunction is also risk factor for ASCVD mediated by the effects of thyroid hormones on glucose metabolism, lipid and blood pressure. In India about onethird of the urban population in large cities has metabolic syndrome with the overall prevalence varying between 11% and 56%. Worldwide Thyroid diseases are most prevalent endocrine disorders. According to various studies it showed that about 42 million people in India suffer from thyroid diseases. Aim: The main aim of this study was to study thyroid dysfunction in metabolic syndrome. Material and Methods: In this study 150 patients with different age group from 20 years to 60 years old were included with metabolic syndrome diagnosed as per IDF criteria. From all the patients who visit hospital as OPD and IPD patients’ detailed history was recorded and also laboratory examination were done. Result: In this study total 150 patients with metabolic syndrome were included in which there were 82 were males and 68 were females.  In this study there were maximum numbers of male patients in comparing with female patients as 43.3% and 54.7% respectively with different age group from 20 years to 60 years old. Out of total patients age group of 35 to 50 years old shows maximum and the age group 50- 60 years old showed least as 37% and 23% respectively. In this study in the age group of 35-50 had abnormal TGL values, compared to the other age groups. While HDL values were low in the 50-60 age group compared to others. Conclusion: Thyroid dysfunction is common in metabolic syndrome patients. The prevalence of hypothyroidism is more common in metabolic syndrome. Therefore early detection and thyroxine replacement could reduce the significant cardiovascular risk. However, there is still a controversy whether the patients with subclinical hypothyroidism would be benefited from thyroxine replacement. Hence Subclinical hypothyroidism should be picked up and treated at the earliest. Keywords: Metabolic syndrome, Thyroid dysfunction, hypothyroidism, HDL

scholarly journals Thyroid dysfunction in patients of chronic kidney disease

2017 ◽  
Vol 4 (5) ◽  
pp. 1333
Author(s):  
Abhishek Gupta ◽  
Kuldeep K. ◽  
S. K. Virmani ◽  
Mayank Arora
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Past History ◽  
Additional Risk Factor ◽  
Thyroid Disorder ◽  
Cross Sectional ◽  
History Of

Background: Thyroid hormones play a very important role in regulating metabolism, development, protein synthesis, and influencing other hormone functions. CKD has been known to affect the pituitary-thyroid axis and the peripheral metabolism of thyroid hormones. We aimed to study the thyroid dysfunction in patients of chronic kidney disease for the prevalence of subclinical hypothyroidism.Methods: This cross-sectional study was conducted at Chhatrapati Shivaji Subharti Hospital and Medical College, Meerut, Uttar Pradesh, India, over a 2 year period. The study group comprised 100 patients with Chronic kidney disease. Free thyroxine (fT3, fT4) and thyroid-stimulating hormone (TSH) were measured. Patients with family history of thyroid disorder or past history of any medication for thyroid disease or history of any surgery or any radiological intervention to thyroid gland were excluded from the study.Results: Of 100 CKD patients, 25 were found to have subclinical hypothyroidism (SCH) and 75 were euthyroid. The mean age in patients with SCH was 47.72±10.09 and in euthyroid patients was 46.11±14.332. 12 males (48%) and 13 females (52%) patients were found to have subclinical hypothyroidism and 49 male (65%), 26 female (35%) patients were euthyroid. Prevalence of SCH was 25% with a mean TSH level of 8.68± 1.84.Conclusions: We observed a high prevalence of SCH in our CKD patients. SCH is an additional risk factor in CKD patients and the present study finds thyroid dysfunction being SCH to be very common in CKD patients and reveals significant association between CKD progression and thyroid dysfunction.

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