scholarly journals STUDY OF THYROID DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Sheetal Ratankumar Gatagat
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Diseases ◽  
Endocrine Disorders ◽  
Age Group ◽  
Thyroxine Replacement ◽  
The Impact

Introduction: Metabolic syndrome (MS) is described as insulin resistance, clusters of abnormalities including abdominal obesity, hypertension, hyperglycaemia, increased triglycerides, and decreased high-density lipoprotein cholesterol (HDL-C). In maintaining thermogenesis and metabolic homeostasis Thyroxine and Triidothryronine play an important role. Thyroid is established by thyroid stimulation hormone (TSH). Thyroid hormones up-regulate metabolic pathways relevant to resting energy expenditure, hence obesity and thyroid functions are often correlated. It is still not clear whether these alterations in thyroid hormones are a cause or an effect of obesity. Hypothyroidism is well known to cause diastolic hypertension, endothelial dysfunction, hyperlipidemia and cardiovascular disease. The functions of thyroid affect the components of metabolic syndrome including triglycerides (TG), HDL–cholesterol (HDL-C), blood pressure and plasma glucose. The impact of various degree of thyroid dysfunction on components of metabolic syndrome, however, continues to be debatable. On components of metabolic syndrome, Thyroid dysfunction is also risk factor for ASCVD mediated by the effects of thyroid hormones on glucose metabolism, lipid and blood pressure. In India about onethird of the urban population in large cities has metabolic syndrome with the overall prevalence varying between 11% and 56%. Worldwide Thyroid diseases are most prevalent endocrine disorders. According to various studies it showed that about 42 million people in India suffer from thyroid diseases. Aim: The main aim of this study was to study thyroid dysfunction in metabolic syndrome. Material and Methods: In this study 150 patients with different age group from 20 years to 60 years old were included with metabolic syndrome diagnosed as per IDF criteria. From all the patients who visit hospital as OPD and IPD patients’ detailed history was recorded and also laboratory examination were done. Result: In this study total 150 patients with metabolic syndrome were included in which there were 82 were males and 68 were females.  In this study there were maximum numbers of male patients in comparing with female patients as 43.3% and 54.7% respectively with different age group from 20 years to 60 years old. Out of total patients age group of 35 to 50 years old shows maximum and the age group 50- 60 years old showed least as 37% and 23% respectively. In this study in the age group of 35-50 had abnormal TGL values, compared to the other age groups. While HDL values were low in the 50-60 age group compared to others. Conclusion: Thyroid dysfunction is common in metabolic syndrome patients. The prevalence of hypothyroidism is more common in metabolic syndrome. Therefore early detection and thyroxine replacement could reduce the significant cardiovascular risk. However, there is still a controversy whether the patients with subclinical hypothyroidism would be benefited from thyroxine replacement. Hence Subclinical hypothyroidism should be picked up and treated at the earliest. Keywords: Metabolic syndrome, Thyroid dysfunction, hypothyroidism, HDL

scholarly journals Assessment of Biological Parameters that (Influence) Affect the Quality of Life in a Group of Patients with Metabolic Syndrome

2021 ◽  
Vol 26 (3) ◽  
pp. 18-23
Author(s):  
Ovidiu Boitor ◽  
Laura Ștef ◽  
Gabriela Boţa ◽  
Romeo Mihăilă
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Age Groups ◽  
Hdl Cholesterol ◽  
Biological Data ◽  
Age Group ◽  
Low Hdl ◽  
The Impact

Abstract The study included a group of 42 patients with metabolic syndrome and 32 patients without metabolic syndrome. The following biological data: BMI, blood pressure, type 2 diabetes, low HDL cholesterol levels were statistically compared using the ANOVA test. To assess the impact on quality of life, patients in both groups completed the EQ-5D-3L questionnaire. To verify the statistical confirmation of the results we used the Chi 2 test. In order to correlate the results with the gender and age of the patients, we formed the following age groups 45-54 years, 55-64 years, 65-74 years and over 75 years. We found that the dimensions that affect the quality of life differ depending on the age group as follows: in the 55-64 age group pain / discomfort predominates p = 0.009 and in the 65-74 age group the mobility and self-care dimensions p = 0.043 predominate. We did not obtain statistical confirmation by the Chi 2 test in patients with metabolic syndrome and the variable blood pressure Chi 2 = 5.27 and p = 0.072

scholarly journals Thyroid Dysfunction in Patients with Metabolic Syndrome: A Cross-Sectional, Epidemiological, Pan-India Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Vaishali Deshmukh ◽  
Faraz Farishta ◽  
Milind Bhole
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Overt Hypothyroidism ◽  
Subclinical Hyperthyroidism ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Indian Patients ◽  
Overt Hyperthyroidism

Background. This study was conducted to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS). Methods. In this cross-sectional study, 432 adults with an established diagnosis of MetS were enrolled across ten centers in India. Anthropometric measurements and vital signs were noted. Blood samples were tested for hemogram, coagulogram, lipid profile, and thyroid function. Fasting plasma glucose (FPG) and fasting plasma insulin were used for the calculation of homeostasis model assessment-estimated insulin resistance (HOMA-IR). Overt hypothyroidism was defined as thyroid-stimulating hormone TSH>4.50 μIU/mL with free thyroxine FT4<0.8 ng/dL and free triiodothyronine FT3<1.4 pg/mL; subclinical hypothyroidism as TSH>4.50 μIU/mL with FT4=0.8-1.8 ng/dL and FT3=1.4-4.4 pg/mL; overt hyperthyroidism as TSH<0.45 μIU/mL with FT4>1.8 ng/dL and FT3>4.4 pg/mL; and subclinical hyperthyroidism as TSH<0.45 μIU/mL with FT4=0.8-1.8 ng/dL and FT3=1.4-4.4 pg/mL. Results. About 121 out of 432 patients (28%) were diagnosed with TD (mean age±SD: 47.9±10.96 years), with women predominance (75% versus 25%). Most patients were in the >45 years of age group (men: 63%; women: 59%). TD was associated with high waist circumference (99.17%), reduced high-density lipoprotein-C (87.60%), raised HOMA-IR (86.78%), systolic blood pressure (77.69%), diastolic blood pressure (59.50%), fasting glucose (58.68%), and triglycerides (33.06%). Overt hypothyroidism was reported in 17.59% (N=76) of patients. Subclinical hypothyroidism, overt hypothyroidism, and subclinical hyperthyroidism were reported in 8.10%, 1.60%, and 0.70% patients with newly occurred TD, respectively. No case of overt hyperthyroidism was present in these patients. Conclusion. Hypothyroidism was the most common TD in Indian patients with MetS. A large proportion of TD cases diagnosed during the study highlight the need for vigilant thyroid screening in patients with MetS in a real-life setting.

scholarly journals Fish Consumption: A Review of Its Effects on Metabolic and Hormonal Health

2021 ◽  
Vol 14 ◽  
pp. 117863882110223
Author(s):  
Carlos O Mendivil
Keyword(s):  
Metabolic Syndrome ◽  
Fish Consumption ◽  
Dietary Habits ◽  
Positive Impact ◽  
Polycystic Ovary ◽  
Scientific Evidence ◽  
Endocrine Disorders ◽  
Omega 3 ◽  
The Metabolic Syndrome ◽  
The Impact

Dietary habits are a major determinant of the risk of chronic disease, particularly metabolic and endocrine disorders. Fish as a food group are a unique source of nutrients with metabolic and hormonal importance including omega-3 fatty acids, iodine, selenium, vitamin D, taurine and carnitine. Fish are also a source of high quality protein and have in general low caloric density. The impact of these nutrients on cardiovascular risk has been extensively reviewed, but the impact of fish on the broader field of endocrine and metabolic health is sometimes not sufficiently appreciated. This article aimed to summarize the impact the effect of regular fish consumption on conditions like the metabolic syndrome, obesity, diabetes, hypothyroidism, polycystic ovary syndrome and the menopausal transition, which are in and of themselves significant causes of morbidity and mortality worldwide. The review revealed that scientific evidence from food science, translational research, epidemiologic studies and interventional trials shows that regular fish consumption has a positive impact on thyroid homeostasis, facilitates maintenance of a healthy body weight, reduces the magnitude of age-associated increases in blood pressure, improves glucose homeostasis helping prevent diabetes and the metabolic syndrome, and has a positive impact on muscle mass preservation among the elderly. These effects are mediated by multiple mechanisms, only some of which have been identified. For most of these effects it holds true that the potential benefits are more substantial when baseline fish consumption is low.

scholarly journals Gormony zhirovoy tkani i funktsional'nayaaktivnost' shchitovidnoy zhelezy

2010 ◽  
Vol 7 (4) ◽  
pp. 8-11 ◽  
Author(s):  
N A Petunina ◽  
N E Al'tshuler ◽  
N G Rakova ◽  
L V Trukhina
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
The Impact ◽  
The Relationship ◽  
Tissue Hormones

The review presents a recent data from the literature on the physiologic and pathophysiologic role of adipose tissue hormones (adiponectin, resistin, leptin). The article details the role of adipocytokines in atherogenesis. It also presents the results of studies depicting the relationship between subclinical hypothyroidism, lipid metabolism and insulin resistance as well as the impact of thyroid dysfunction upon the secretion of adipocytokines.

Impact of sports participation on components of metabolic syndrome in adolescents: ABCD growth study

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Veronica Alves de Menezes ◽  
Wesley Torres ◽  
Eduardo Duarte de Lima Mesquita ◽  
Lucas Gabriel de Moraes Chagas ◽  
Ana Elisa von Ah Morano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Colorimetric Method ◽  
Sports Participation ◽  
Height Velocity ◽  
P Value ◽  
Growth Study ◽  
Small Magnitude ◽  
The Impact ◽  
Moderate Magnitude

Abstract Objectives This study aimed to analyze the impact of sports participation (12 months of practice) on the components of metabolic syndrome (MetS) in both sexes. Methods This is an observational longitudinal study, a part of which is entitled “Analysis of Behaviors of Children During Growth” (ABCD Growth Study), Presidente Prudente, São Paulo, Brazil. The sample was composed of 171 adolescents (112 boys and 59 girls), divided into non-sports and sports groups. High-density lipoprotein-cholesterol (HDL-c), triglycerides, and glucose were analyzed by the colorimetric method of dry chemistry and processed biochemically. Systolic blood pressure and diastolic blood pressure were measured using an automatic device. Body fat was estimated using a densitometry scanner. Results Adolescents who practiced sports were younger (p-value=0.001) and had a lower peak height velocity (p-value=0.001) than the non-sports group. The differences (Δ) after 12 months were of greater magnitude for the sports group when compared to the non-sports group (p-value=0.013), glucose (moderate magnitude in favor of the sports group; p-value=0.001), HDL-c (small magnitude in favor of the sports group; p-value=0.0015), and MetS (moderate magnitude in favor of the sports group; p-value=0.001). Conclusions The practice of sports in adolescents had a protective effect on the metabolic components of MetS.

EVALUATE THE RELATION BETWEEN THYROID DISORDERS AND ABNORMAL UTERINE BLEEDING IN REPRODUCTIVE AGE GROUP : A CROSS SECTIONAL STUDY AT ANMMCH, GAYA, BIHAR

2021 ◽  
pp. 15-16
Author(s):  
Kumari Ragini ◽  
Kumar Sourav ◽  
Lata Shukla Diwedi ◽  
Debarshi Jana
Keyword(s):  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Structural Defects ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Age Group ◽  
Reproductive Age Group

Introduction: Abnormal uterine bleeding (AUB) is a common disorder occurring in reproductive age group females. It can be understood as bleeding that occurs from the uterus outside the normal parameters and there is no structural defects in the genital tract. One of the most common association with AUB is thyroid dysfunctions. Hence this study aimed to see the incidence of thyroid related disorders in AUB and also to assess the menstrual pattern. Material and Methods: 100 women suffering from AUB who presented to OPD of Obstetrics and Gynecology department of Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar were recruited in the study. All females in 19 to 45 years of age group with abnormal uterine bleeding were included excluding those with previously known thyroid disorder, abortion history within 3 months etc. Thyroid function tests were done in all along with ultrasonography of pelvis region. Statistical analysis done. Results: The bleeding abnormality that was found in the most of the women was heavy menstrual bleeding. Women who presented with thyroid dysfunction were 33%. 23% had subclinical hypothyroidism, 6% had hypothyroidism and 4% had hyperthyroidism. Conclusion: Abnormal Uterine Bleeding has strong association with thyroid disorders. Most common type of disorder is subclinical hypothyroidism. Thus all patient of AUB must be evaluated for thyroid dysfunction

scholarly journals Pattern of Metabolic Syndrome in Clinical Practice

1970 ◽  
Vol 10 (2) ◽  
pp. 48-51
Author(s):  
Quazi Tarikul Islam ◽  
Md Azizul Haque ◽  
ASM Shawkat Ali ◽  
ARM Saifuddin Ekram ◽  
Sultana Monira Hussain ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Clinical Practice ◽  
Waist Circumference ◽  
Prospective Study ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Age Group ◽  
Inclusion Criteria

1068 randomly sampled adult Bangladeshi people were studied during a period of six months from October 2004 to March 2005. It was a randomized, prospective study. Cases that fulfilled two criteria of metabolic syndrome (MetS) were evaluated to see pattern and types of MetS. Out of 1068 patients, 110 (10.3%) fulfilled the inclusion criteria. 101 (9.4%) cases were labeled as metabolic syndrome according to NCEP ATP III criteria, 09 cases had only two criteria. 40 cases were male & 70 cases were female (M:F= 1:1.8). Mean age of patients with was 44.88, ranging from the age of 20-68 years. Majority (55%) of the patients were in the age group of 30-49 years. Half of the cases had BMI 30-34.9. Mean body weight of male was 85.9 kg and of female was 78.2 kg. Mean waist circumference of male was 41.7 inches and of female 40 inches. Mean HDL for male was 38.3 mg/dL and for female is 40.2 mg/dL. Mean Triglyceride for male was 172.1 and for female was 169.3 mg/dL. Mean total cholesterol for male was 216.7 and for female was 207.6 mg/dL. Mean systolic blood pressure (SBP) for men is 162 mm Hg & diastolic blood pressure (DBP) 99 mm Hg and for female mean SBP 155 and DBP 96 mm Hg. Metabolic syndrome is more prevalent in the 3rd and 4th decade of life in both sexes. It is almost twice common in female than male. Combination of hypertension, obesity & dyslipidemia comprises nearly 40% of its presentation.    doi: 10.3329/jom.v10i2.2813 J MEDICINE 2009; 10 : 48-51

scholarly journals Metabolic Syndrome—Role of Dietary Fat Type and Quantity

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1438 ◽  
Author(s):  
Peter Clifton
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Dietary Fat ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Fasting Insulin ◽  
Polyunsaturated Fat ◽  
Monounsaturated Fat ◽  
The Impact

Background: Metabolic syndrome increases the risk of cardiovascular disease (CVD) over and above that related to type 2 diabetes. The optimal diet for the treatment of metabolic syndrome is not clear. Materials and Methods: A review of dietary interventions in volunteers with metabolic syndrome as well as studies examining the impact of dietary fat on the separate components of metabolic syndrome was undertaken using only recent meta-analyses, if available. Results: Most of the data suggest that replacing carbohydrates with any fat, but particularly polyunsaturated fat, will lower triglyceride(TG), increase high density lipoprotein (HDL) cholesterol, and lower blood pressure, but have no effects on fasting glucose in normal volunteers or insulin sensitivity, as assessed by euglycemic hyperinsulinemic clamps. Fasting insulin may be lowered by fat. Monounsaturated fat (MUFA) is preferable to polyunsaturated fat (PUFA) for fasting insulin and glucose lowering. The addition of 3–4 g of N3 fats will lower TG and blood pressure (BP) and reduce the proportion of subjects with metabolic syndrome. Dairy fat (50% saturated fat) is also related to a lower incidence of metabolic syndrome in cohort studies.

scholarly journals Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 105
Author(s):  
Ilona Górna ◽  
Marta Napierala ◽  
Ewa Florek
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Blood Pressure ◽  
Abdominal Obesity ◽  
Critical Review ◽  
Lifestyle Modifications ◽  
The Metabolic Syndrome ◽  
Arterial Blood ◽  
The Impact

The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.

scholarly journals Study on Thyroid Dysfunction in Patients with Type-2 Diabetes

2020 ◽  
Vol 7 (52) ◽  
pp. 3142-3147
Author(s):  
Senthil Chander ◽  
Kalpana Dev Venkatesan ◽  
Christina Mary Paul
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
General Medicine ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Cross Sectional ◽  
Patients With Diabetes

BACKGROUND Diabetes mellitus is one of the leading endocrine disorders worldwide. Thyroid dysfunction is a common endocrine disorder affecting the general population next to diabetes. The objective of this study was to determine the prevalence of thyroid dysfunction among patients with Type 2 diabetes. METHODS This analytical cross sectional study was conducted from June 2019 to Dec 2019. One hundred and fifty type–2 diabetes patients who attended the outpatient clinic of General Medicine Department, ACS Medical College and Hospital were included in the study. A detailed history and examination was done after getting informed consent. Blood samples were collected and sent to the laboratory for the evaluation of thyroid profile. RESULTS Thyroid dysfunction was found in 27 % of the patients with diabetes. Subclinical hypothyroidism was the most common thyroid dysfunction reported (14.7 %) followed by clinical hypothyroidism (10 %), subclinical hyperthyroidism (2 %) and clinical hyperthyroidism (0.6 %). CONCLUSIONS Thyroid dysfunction is common in patients with type-2 diabetes. A substantial proportion of the diabetic patients with thyroid dysfunction have subclinical hypothyroidism. Unidentified thyroid dysfunction could negatively impact diabetes and its complications. Therefore, early and routine screening of thyroid is recommended in all patients with diabetes to reduce the burden of the disease. KEYWORDS Type-2 Diabetes Mellitus, Thyroid Dysfunction, Hypothyroidism

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