Chorionic gonadotropin regulation of intracellular potassium levels in human blood immunocompetent cells, a role of phases of a menstrual cycle
The effect of chorionic gonadotropin (CG) on intracellular potassium ion( [K+]) levels in human blood immunocompetent cells was studied by taking into account the phases of a menstrual cycle. CG was used in doses of 10, 50, and 100 IU/ml. Plasma photometry was used to measure the level of [K+] ‘ in the fractionated peripheral monocytes and lymphocytes from males, as well as from females in the late follicular and luteal phases of a menstrual cycle. CG used in a dose of 100 IU/ml was found to lower flCf in the monocytes and lymphocytes of males and in a dose of 50 IU in the lymphocytes of females in the luteal phase of a menstrual cycle. The hormone used in large doses stabilized the level of [K+] in both types of cell of female in the follicular phase. It is concluded that CG can modulate the level of [K+] in human peripheral blood immunocompetent cells, and the directionality of its effects depends on a type of hormone-accepting cells and it is determined by a menstrual phase.