scholarly journals Chemotranscriptome analysis indicates the neurotrophic and neuromodulator effects of a citicoline molecule

2020 ◽  
Vol 12 (4) ◽  
pp. 91-99
Author(s):  
I. Yu. Torshin ◽  
O. A. Gromova ◽  
L. V. Stakhovskaya ◽  
V. A. Semenov ◽  
I. A. Shchukin
Keyword(s):  
Neurotrophic Factors ◽  
Cholesterol Metabolism ◽  
Protein Activity ◽  
Cardiac Electrical Activity ◽  
Dopaminergic Agents ◽  
Human Genes ◽  
Antidementia Drugs ◽  
Neuroactive Drugs ◽  
Positive Effect ◽  
Neurotransmitter Metabolism

Objective: to investigate the effect of citicoline (CTC) on gene transcription.Material and methods. Chemotranscriptome analysis of the CTC molecule was carried out on an NPC.TAK model, provided that the cells were incubated with CTC for 24 hours.Results and discussion. CTC dose-dependently affected the transcription of 8,838 out of 12,716 annotated human genes, mainly by increasing the transcription of the genes involved: 1) in the neurotransmitter metabolism of serotonin (n=36), dopamine (n=32), GABA (n=14), and acetylcholine (n=27); 2) in showing the effects of neurotrophic factors (n=152), including nerve growth factor (n=11); 3) in maintaining the cardiovascular system (vasodilation and cardiac electrical activity; a total of 76 genes). CTC reduced the transcription of the genes, whose protein activity supported inflammation (n=86) and cell division (n=656). CTC elevated the expression of 60 genes involved in triglyceride processing and decreased the expression of 51 genes whose proteins were involved in cholesterol metabolism. CTC increased the transcription of the genes involved in the body’s response to various drugs, including antiepileptic drugs (n=20), dopaminergic agents (n=19), antipsychotics (n=38), anxiolytics (n=21), sedatives (n=22), antidepressants (n=35), anesthetics (n=23), and antidementia drugs (n=11).Conclusion. Chemotranscriptome analysis indicated the positive effect of CTC on neurotransmission, neuroprotection, lipid profile, and a higher neuronal susceptibility to other neuroactive drugs.

scholarly journals 2. Beneficial Aspects of Inulin Supplementation as a Fructooligosaccharide Prebiotic in Monogastric Animal Nutrition – A Review

2016 ◽  
Vol 16 (2) ◽  
pp. 315-331 ◽  
Author(s):  
Izabela Kozłowska ◽  
Joanna Marć-Pieńkowska ◽  
Marek Bednarczyk
Keyword(s):  
Cholesterol Metabolism ◽  
Bacterial Species ◽  
Good Condition ◽  
Feed Utilization ◽  
Farm Animals ◽  
Animal Nutrition ◽  
Monogastric Animal ◽  
Host Health ◽  
Daily Body Weight ◽  
Positive Effect

Abstract Inulin is widely used as a prebiotic additive in the nutrition of farm animals and pets. This fructooligosaccharide demonstrates a beneficial effect on host health by stimulating the growth and development of commensal bacterial species inhabiting the large intestine. Used for example in the feeding of piglets, inulin greatly enhances their daily body weight gains and also reduces the risk of anemia (Tako et al., 2008). In poultry, in the case of meat breeds, inulin provides better feed utilization, increases the daily gains and the final carcass weight (Ammerman et al., 1988). In laying hens, it positively stimulates the production of eggs (Chen et al., 2005). The addition of prebiotics in the diet of dogs has a positive effect on the concentration of the end products of sugar and protein fermentation in the colon, thus contributing to the health status and good condition of the animal (Flickinger et al., 2003 b; Middelbos et al., 2007). Moreover, inulin beneficially affects the efficiency of the immune system of the organism (including the anticarcinogenic properties) (Kelly-Quagliana et al., 1998), as well as lipids and the cholesterol metabolism by effectively reducing their concentrations in the blood serum (Grela et al., 2014 a). This paper characterizes inulin as a prebiotic additive in the diet of selected species of monogastric animals. In addition, data about the hypolipidemic and immunostimulatory properties of inulin are presented.

scholarly journals Regular Leisure-Time Physical Activity is Effective in Boosting Neurotrophic Factors and Alleviating Menopause Symptoms

2020 ◽  
Vol 17 (22) ◽  
pp. 8624
Author(s):  
Boram Kim ◽  
Sunghwun Kang
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Body Fat ◽  
Neurotrophic Factors ◽  
Cathepsin B ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Obese Women ◽  
Middle Aged ◽  
Positive Effect

Background: The study investigated the effects of regular leisure-time physical activity on the parameters of cognitive function (plasma brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and cathepsin B) and menopausal symptoms (the climacterium, depression, and cognitive impairment) in obese middle-aged women. Methods: All subjects were middle-aged and obese women (n = 52, % body fat > 30%). The participants were divided into premenopausal (PRM) (n = 18, age = 47.56 ± 6.11 years) and postmenopausal (POM) (n = 34, age = 57.79 ± 5.68 years) groups. The participants completed a survey questionnaire related to depression and the climacterium, as well as cognitive tests. Physical activity was performed for 12 weeks. Blood samples from the forearm vein were analyzed after 12 h of fasting. Blood levels of BDNF, NGF, and cathepsin B were analyzed using an R&D kit. Results: Regular leisure-time physical activity had a positive effect on reducing the percentage of body fat in premenopausal and postmenopausal obese women. In addition, the results of the questionnaire showed that regular exercise had a positive effect on body composition caused by lifestyle change and enhanced psychological stability. The BDNF concentration was significantly lower in postmenopausal than in premenopausal obese women. In addition, regular physical activity significantly increased the cathepsin B and NGF levels in postmenopausal obese women. Conclusions: Continuous leisure-time physical activity improved body composition and neurotrophic factors and alleviated menopausal symptoms in obese Korean women.

Modulation of rat visceral pain by brain-derived neurotrophic factors (BDNF)

2010 ◽  
Vol 34 (8) ◽  
pp. S22-S22
Author(s):  
Rong Wei ◽  
Ying Gao ◽  
Xiaoxue Ding ◽  
Ziqi Yue ◽  
Sha Wu ◽  
...  
Keyword(s):  
Neurotrophic Factors ◽  
Visceral Pain

Antidementia Drugs Still Available in the U.K.

2006 ◽  
Vol 39 (7) ◽  
pp. 27
Author(s):  
JONATHAN GARDNER
Keyword(s):  
Antidementia Drugs

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

2016 ◽  
Vol 86 (3-4) ◽  
pp. 127-151 ◽  
Author(s):  
Zeshan Ali ◽  
Zhenbin Wang ◽  
Rai Muhammad Amir ◽  
Shoaib Younas ◽  
Asif Wali ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Review Paper ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Active Role ◽  
Current Review ◽  
Different Types ◽  
Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

Working Memory, Mental Prospection, Time Orientation, and Cognitive Insight

2013 ◽  
Vol 34 (3) ◽  
pp. 159-169 ◽  
Author(s):  
Sevtap Cinan ◽  
Aslı Doğan
Keyword(s):  
Working Memory ◽  
Structural Equation ◽  
Factor Model ◽  
Time Orientation ◽  
Equation Modeling ◽  
Cognitive Insight ◽  
Confirmatory Factor ◽  
Negative Effect ◽  
Positive Effect ◽  
Three Factor

This research is new in its attempt to take future time orientation, morningness orientation, and prospective memory as measures of mental prospection, and to examine a three-factor model that assumes working memory, mental prospection, and cognitive insight are independent but related higher-order cognitive constructs by using confirmatory factor analysis (CFA). The three-factor model produced a good fit to the data. An alternative one-factor model was tested and rejected. The results suggest that working memory and cognitive insight are distinguishable, related constructs, and that both are distinct from, but negatively associated with, mental prospection. In addition, structural equation modeling (SEM) showed that working memory had a strong positive effect on cognitive insight and a moderate negative effect on mental prospection.

Employees’ Critical Thinking, Leaders’ Inspirational Motivation, and Voice Behavior

2018 ◽  
Vol 17 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Jing Jiang ◽  
Ang Gao ◽  
Baiyin Yang
Keyword(s):  
Critical Thinking ◽  
Field Study ◽  
Voice Behavior ◽  
Research And Practice ◽  
Inspirational Motivation ◽  
Positive Effect

Abstract. This study uses implicit voice theory to examine the influence of employees’ critical thinking and leaders’ inspirational motivation on employees’ voice behavior via voice efficacy. The results of a pretest of 302 employees using critical thinking questionnaires and a field study of 273 dyads of supervisors and their subordinates revealed that both employees’ critical thinking and leaders’ inspirational motivation had a positive effect on employees’ voice and that voice efficacy mediates the relationships among employees’ critical thinking, leaders’ inspirational motivation, and employees’ voice. Implications for research and practice are discussed.

Sign in / Sign up

Export Citation Format

Share Document