Influence of genetic and comorbid emotional-affective factors on pre-mild cognitive decline in middle-aged patients

Recently, maximum attention has been drawn to the earliest forms of cognitive deficit - pre-mild cognitive decline (PMCD), which includes subjective (SjCD) and subtle cognitive decline (SCD), being the most promising in cognitive decline prevention.Objective: to assess the influence of genetic and comorbid emotional-affective factors on PMCD in middle-aged patients.Patients and methods. The study included 50 middle-aged people (60.76±9.5 years) with cognitive complaints. All patients underwent a cardiovascular assessment, including: biochemistry blood test (lipid profile, urea, glucose, vitamin В12, folic acid, homocysteine, thyroid hormones), duplex scan of the extracranial arteries, blood assay for АРОЕ4 determination, neuropsychological assessment with quantitative neuropsychological methods, emotional-affective background evaluation. In addition, magnetic resonance imaging (MRI) with morphometry of the hippocampus was performed in 20 patients.Results and discussion. Arterial hypertension, diabetes mellitus, and changes in laboratory parameters are significantly were more frequent in patients with SCD than patients with SjCD. The neuropsychological assessment showed maximum differences between SjCD and SCD groups in tests that evaluated reaction time (verbal fluency test, trail making test, part A, digit symbol substitution test, and Munsterberg test). Analysis of neuroimaging parameters revealed a smaller volume of the right hippocampus in APOE4 carriers. patients without depression performed significantly better on memory tasks, when depression was included in the analysis. In addition, patients with depression showed a significantly more pronounced degree of cortical atrophy on MRI.Conclusion. Patients with SCD have lower scores in neuropsychological tests than patients with SjCD. In addition, we observed a high significance of cardiovascular and emotional-affective risk factors in the PMCD development, emphasizing the importance of their evaluation and treatment in the management of patients with PMCD.

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The association between cognitive decline and short-term blood pressure variability in middle-aged patients with primary hypertension — a pilot study

Arterial Hypertension ◽

10.5603/ah.a2018.0013 ◽

2018 ◽

Vol 22 (3) ◽

pp. 135-142

Author(s):

Jakub Baranowski ◽

Karol Klęczar ◽

Marta Sołtysiak ◽

Krystyna Widecka

Keyword(s):

Blood Pressure ◽

Pilot Study ◽

Cognitive Decline ◽

Blood Pressure Variability ◽

Primary Hypertension ◽

Middle Aged ◽

Short Term ◽

Aged Patients

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Clinical-hemodynamic features of ischemic stroke in patients of young age

Ukrains'kyi Visnyk Psykhonevrolohii ◽

10.36927/20790325-v28-is1-2020-6 ◽

2020 ◽

pp. 26-29

Author(s):

Olena Mialovytska ◽

Yaroslav Nebor

Keyword(s):

Ischemic Stroke ◽

Young People ◽

Young Patients ◽

Linear Velocity ◽

Young Age ◽

Left Vertebral Artery ◽

Control Group ◽

Middle Aged ◽

Aged Patients ◽

Aged People

58 patients with ischemic stroke were examined (29 young people — the main group and 29 middle-aged people — control group). Among the examined young patients, cardio embolic subtype of stroke prevailed (66 %), and among middle-aged patients was observed in 10 %. The athe rothrombotic subtype of stroke prevailed in middle-aged people (69 %), and among young people — 24 %. The lacunar subtype of stroke in young people was 3 %, and in middle-aged people — 21 %. Patients of young had such subtypes of strokes as hemodyna mic and hemorheological, which respectively equaled 3 %. In middle age these subtypes of strokes were not observed among the examined patients. In young people the proportion of vascular pools with ische mic stroke was: vertebrobasilar — 41 %, carotid prevailed to some extend — 59 %. In middle-aged people the proportion of strokes prevailed in the carotid pool — 64 %, in the vertebrobasilar it was 29 %. Middle-aged people also had a “combined stroke” (stroke that occurred in several pools at once), it amounted to 7 %. As a result, Doppler study of cerebral vessels proved that in young people linear velocity in the right middle cerebral artery was authentically higher compared with middle-aged patients. At the same time, the linear velocity in middle-aged patients was statistically greater in the left vertebral artery. Keywords: ischemic stroke subtypes, young age, hemodynamic parameters

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Relationship of tooth loss to mild cognitive impairment among middle-aged Mongolians: Mon-Timeline study

Neuroscience Research Notes ◽

10.31117/neuroscirn.v4i4.88 ◽

2021 ◽

Vol 4 (4) ◽

pp. 10-18

Author(s):

Urangoo Ganbaatar ◽

Oyuntuya Gantulga ◽

Puntsagdulam Byambajav ◽

Maralgua Och ◽

Ganjargal Ganburged ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Decline ◽

Tooth Loss ◽

Cross Sectional Study ◽

Middle Aged ◽

Significant Interaction Effect ◽

Cross Sectional ◽

Aged People ◽

Relationship Of

Cognitive impairment is common in elderly people, so it is considered an ageing disorder. However, cognitive decline, including dementia, can also occur in middle-aged people. Cognitive impairment is associated with multiple risk factors. We hypothesised that tooth loss might also be a potential risk factor among Mongolians, as oral health problems are one of the significant health issues in Mongolia, especially in middle-aged people. In this cross-sectional study, we used the baseline data from the Mon-Timeline cohort study, including people older than 40 years of age (n=279). The amount of tooth loss was assessed by a trained researcher. Mild cognitive impairment (MCI) was defined as those participants scoring a total of £ 24 points based on the Mini-Mental State Examination (MMSE). Unadjusted analysis showed that having more tooth loss (>10) increased the risk of MCI by an odds ratio of 3.03 (1.49-6.17), as compared with having less tooth loss (£10). Even after adjusting for covariates, the association remained significant, suggesting that tooth loss is associated with MCI risk, independent of age, education, and other socioeconomic factors. There was no significant interaction effect of age in the association between tooth loss and MMSE scores. In conclusion, tooth loss may play a role in developing cognitive decline, especially in the early onset of dementia. Further studies are needed to investigate whether early tooth loss at younger ages is associated with dementia, especially among middle-aged people.

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Diabetes Is Associated with Cognitive Decline in Middle-Aged Patients

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2018.0014 ◽

2018 ◽

Vol 16 (10) ◽

pp. 514-520 ◽

Cited By ~ 2

Author(s):

Michael Palacios-Mendoza ◽

Maria Beatriz Jurado ◽

Ximena Gamboa ◽

Carlos Cevallos ◽

Daniel Moreno-Zambrano ◽

...

Keyword(s):

Cognitive Decline ◽

Middle Aged ◽

Aged Patients

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A Retrospective Analysis of Pain Etiology in Middle-Aged Patients with Peripheral Neuropathy

Medicina ◽

10.3390/medicina57080787 ◽

2021 ◽

Vol 57 (8) ◽

pp. 787

Author(s):

Anna K. Szewczyk ◽

Anna Jamroz-Wiśniewska ◽

Konrad Rejdak

Keyword(s):

Peripheral Neuropathy ◽

Electrophysiological Study ◽

Middle Aged ◽

Aged Patients ◽

Small Fibre Neuropathy ◽

Aged People ◽

Small Fibre ◽

Laboratory Results ◽

And Gender ◽

Internal And External Factors

Background and Objectives: Correct assessment and a multidisciplinary approach appear to be extremely important in preventing peripheral neuropathy and its complications. The purpose of this study was to find the correlations and dissimilarities between different types of peripheral neuropathy, the occurrence of pain, and laboratory results. Materials and Methods: This retrospective study assessed 124 patients who were hospitalized in our neurology department due to various types of sensory or motor disturbances. The patients were eventually diagnosed with peripheral neuropathy, based on the electrophysiological study, anamnesis, physical examination, and laboratory results. The whole group was subjected to statistical analysis. Results: The mean age of patients was over 56 years, with a slight woman predominance. A statistically significant (p < 0.05) relationship between the place of residence and gender was seen, where more men than women live in the rural area, while more women than men live in the urban area. Most often we observed symmetric, sensorimotor, demyelinating, inflammatory, and chronic neuropathy. More than 40% of patients reported pain. A statistically significant correlation between the evolution/severity and the occurrence of pain was seen in subacute type (p < 0.05) and small fibre neuropathy (p < 0.01). Conclusions: A higher incidence of peripheral neuropathy in middle-aged people will become essential in the aging society with lifestyle and chronic disorders. Peripheral neuropathy is slightly more common in women than men and its occurrence may be influenced by work performed or internal and external factors. In the study group, more than 40% of patients reported pain, therefore the pain measurement for each patient should be implemented and repeated at every visit. An assessment of sodium level and, in women, markers of neuroinflammation level in the various types of peripheral neuropathy may be an interesting direction for the future.

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Assessment of Acute Stress Disorder of Young and Middle-Aged Patients With Acute Myocardial Infarction And Analysis of The Influencing Factors

10.21203/rs.3.rs-1185822/v1 ◽

2021 ◽

Author(s):

Minjuan Wu ◽

Wang Wenqin ◽

Zhang Xingwei ◽

Li Junhua

Keyword(s):

Myocardial Infarction ◽

Social Support ◽

Acute Myocardial Infarction ◽

Cardiac Rehabilitation ◽

Stress Disorder ◽

Acute Stress ◽

Acute Stress Disorder ◽

Middle Aged ◽

Aged Patients ◽

Aged People

Abstract Background: Young and middle-aged people are considered a vulnerable group to experience acute stress disorder (ASD) after acute myocardial infarction (AMI). This study aims to explore influencing factors to ASD in young and middle-aged groups.Methods: 190 patients of 18–60 years of age with acute myocardial infarction were enrolled in this study. We assessed the association between ASD and demographic data, adult attachment, and social support.Results: A total of 190 young and middle-aged people were investigated in this study. Among them, 65 cases were positive for acute stress disorder, with a positive rate of 34.21%. Multivariate stepwise regression showed that attachment-related anxiety, distribution of criminal vessels, perceived support, complications, and attachment-related avoidance are the main factors affecting acute stress disorder of young and middle-aged patients with AMI.Conclusions: The incidence of acute stress disorder in young and middle-aged patients with AMI is high. We should strengthen social support and pay attention to the psychological state of patients in the process of follow-up cardiac rehabilitation to improve their ability to deal with acute stress events and actively participate in postoperative cardiac rehabilitation.

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