Protective effects of Syzygium aromaticum oil (Clove) against acrylamide induced hepatic, renal, and testicular toxicity in rats

2018 ◽  
Vol 6 (1) ◽  
pp. 12 ◽  
Author(s):  
Ashraf Elkomy ◽  
Mohamed Aboubakr ◽  
Samar Ibrahim ◽  
Yasmine Abdelhamid
Keyword(s):  
Oxidative Damage ◽  
Antioxidant Activities ◽  
Protective Role ◽  
Albino Rats ◽  
Syzygium Aromaticum ◽  
Testicular Toxicity ◽  
Protective Effects ◽  
Clove Oil ◽  
Organ Protection ◽  
Testicular Dysfunction

This study aimed to investigate the possible protective role of clove oil against acrylamide induced oxidative damage and impairment of liver, kidney, and testicular functions in albino rats. The apparent oxidative damage was associated with evident hepatic, renal, and testicular dysfunction, which was confirmed in histopathological lesions, and increased serum aspartate aminotransferase and alanine aminotransferase activities. Acrylamide decreased serum total protein and albumin contents; increased urea and creatinine contents. Acrylamide also reduced testosterone concentration. Treatment of acrylamide intoxicated rats with clove oil minimized liver, kidney, and testicular histopathological changes and normalized their functions. Our findings demonstrate that acrylamide is not only associated with hepatotoxicity but also nephrotoxicity and testicular toxicity. Clove oil administration provided substantial organ protection against hepatic, renal, and testicular dysfunction induced by acrylamide, which was possibly mediated through their antioxidant activities.   

scholarly journals Curcumin Produces Protective Effects against Testicular Toxicity Induced By Cadmium in Albino Rats

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
Suman Sharma ◽  
Chetna Ahuja
Keyword(s):  
Young Male ◽  
Cholesterol Content ◽  
Protective Role ◽  
Significant Rise ◽  
Albino Rats ◽  
Testicular Toxicity ◽  
Protective Effects ◽  
Tissue Protein ◽  
Tissue Cholesterol ◽  
Total Tissue

The purpose of our study was to evaluate the preventive effects of supplementation with curcumin (Cur) on Cadmium (Cd) induced testicular damage. Young male Wistar albino rats were divided into five groups; Control, Cd, Cur, Cd+Cur, pre-Cur+Cd. Rats were administered an acute dose of CdCl2 at a concentration of 50 mg/kg bw and Cur at 150 mg/kg bw for 15 days. The activities of the stress indicating enzymes (SOD, CAT) and MDA content as a result of LPO along with the total tissue protein and cholesterol were assessed in the testicular homogenate of rats. A significant reduction in the activities of SOD and CAT with parallel significant upsurge in MDA accompanied by a significant reduction in total tissue protein content and a significant rise in tissue cholesterol was observed in rat testes. Also, the reduction in the testicular weights along with a decline in testosterone concentration was detected. Further, Cur supplementation with Cd significantly upturned the Cd-induced variations in oxidative stress indicating enzymes and amended the testosterone levels, total testicular protein, and cholesterol content. Therefore, it can be concluded that Cur plays a protective role against testicular toxicity produced by a single dose of CdCl2.

Compounds from Ilex paraguariensis extracts have antioxidant effects in the brains of rats subjected to chronic immobilization stress

2017 ◽  
Vol 42 (11) ◽  
pp. 1172-1178 ◽  
Author(s):  
Ana C. Colpo ◽  
Maria Eduarda de Lima ◽  
Marisol Maya-López ◽  
Hemerson Rosa ◽  
Cristina Márquez-Curiel ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Immobilization Stress ◽  
Brain Regions ◽  
Protective Role ◽  
Ilex Paraguariensis ◽  
Protective Effects ◽  
Species Formation ◽  
Lipid And Protein Oxidation ◽  
Response To Stress ◽  
Chronic Immobilization Stress

Immobilization induces oxidative damage to the brain. Ilex paraguariensis extracts (Mate) and their major natural compound, chlorogenic acid (CGA), exert protective effects against reactive oxygen species formation. Here, the effects of Mate and CGA on oxidative damage induced by chronic immobilization stress (CIS) in the cortex, hippocampus, and striatum were investigated. For CIS, animals were immobilized for 6 h every day for 21 consecutive days. Rats received Mate or CGA by intragastric gavage 30 min before every restraint session. Endpoints of oxidative stress (levels of lipid peroxidation, protein carbonylation, and reduced (GSH) and oxidized (GSSG) forms of glutathione) were evaluated following CIS. While CIS increased oxidized lipid and carbonyl levels in all brain regions, CGA (and Mate to a lesser extent) attenuated lipid and protein oxidation as compared with control groups. GSH/GSSG balance showed a tendency to increase in all regions in response to stress and antioxidants. Taken together, our results support a protective role of dietary antioxidants against the neuronal consequences of stress.

The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

2014 ◽  
Vol 38 (3) ◽  
pp. 774-782 ◽  
Author(s):  
Merve Bacanlı ◽  
Sevtap Aydın ◽  
Gökçe Taner ◽  
Hatice Gül Göktaş ◽  
Tolga Şahin ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Ferulic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Hepato & nephro protective effects of naringenin-loaded tpgs polymeric nanosuspension against cisplatin-induced toxicity

2019 ◽  
Vol 10 (4) ◽  
pp. 2755-2764
Author(s):  
Sumathi Rajamani ◽  
Gobinath Kalyanasundaram ◽  
Tamizharasi Sengodan ◽  
Sivakumar Thangavelu ◽  
Nikhitha K Shanmukhan ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Aqueous Solubility ◽  
Protective Role ◽  
Chemotherapeutic Agents ◽  
Glycol Succinate ◽  
High Pressure Homogenization ◽  
Protective Effects ◽  
Male Wistar Rats ◽  
Nephroprotective Effect

Cisplatin (Cis-Diammineplatinum (II) dichloride/CIS) is one of the most potent chemotherapeutic agents widely used in treatment of various cancers. Naringenin (NAR), a natural flavonoid, protect against CIS-induced injury in rats without hampering CIS beneficial cytotoxic activity. Even though NAR exhibits therapeutic potency, clinical evolution of the molecule is embarrassed because of very less aqueous solubility which corresponds to low availability at the site of the tumor. In our former analysis, nanosuspension of naringenin (NARNS) was developed by the method of high-pressure homogenization. The study had been continued to evaluate the protective role of D-α-Tocopheryl polyethylene glycol succinate (TPGS) coated NARNS, against oxidative stress-induced hepato and nephrotoxicity in male Wistar rats upon CIS treatment. Induction of acute hepato and neprotoxicity was done by intraperitoneal injection (i.p) injection of CIS (7 mg/kg of body weight) and administration of NAR and NARNS. Administration of NARNS virtually suppressed CIS-induced and liver injury evidenced by a reduction of lipid peroxidation level, blood urea nitrogen, serum uric acid, creatinine and elevated enzymatic antioxidant activities of superoxide dismutase, catalase, and glutathione peroxidase in rats liver tissue. Histological studies substantiated the biochemical parameters. The study suggests that NARNS has strong hepato and nephroprotective effect compared to NAR.

scholarly journals The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3064 ◽  
Author(s):  
Yuzhu He ◽  
Byung-gook Kim ◽  
Hye-Eun Kim ◽  
Qiaochu Sun ◽  
Shuhan Shi ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Protective Role ◽  
Related Factor ◽  
Nuclear Factor ◽  
Hacat Cells ◽  
Protective Effects ◽  
Hydroxycinnamic Acid Amides ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE2 levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4/NF-κB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4/NF-κB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties.

Protective role of silymarin and D-penicillamine against lead-induced liver toxicity and oxidative stress

2017 ◽  
Vol 33 (6) ◽  
pp. 512-518 ◽  
Author(s):  
Seyedeh Missagh Jalali ◽  
Hossein Najafzadeh ◽  
Sadegh Bahmei
Keyword(s):  
Liver Toxicity ◽  
Serum Alkaline Phosphatase ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Effects ◽  
Antioxidant Defence ◽  
Antioxidant Defence System ◽  
Pb Exposure ◽  
Group 2

This study was performed to assess hepatotoxicity and alterations in liver antioxidant defence in acute lead (Pb) exposure and the protective effects of silymarin in comparison to D-penicillamine in rats. Forty eight Albino rats were divided in eight groups and received the following treatments in a 10-day experiment – group 1: normal saline as control; group 2: 25-mg/kg Pb acetate, intraperitoneally (IP) for the last 5 days; group 3: 100-mg/kg D-penicillamine, IP for the last 5 days; group 4: 200-mg/kg silymarin, orally for 10 days; and groups 5, 6, 7 and 8: in addition to Pb, they received D-penicillamine, for the last 5 days, silymarin for 10 days, a combination of silymarin for 10 days and D-penicillamine for the last 5 days and silymarin for the last 5 days, respectively. Pb acetate exposure induced significant elevation in serum alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme activities in group 2 compared to control group. Significant reductions in serum total protein and albumin in all Pb-exposed groups and in serum glucose in groups 2, 6 and 8 were also observed. Liver tissue superoxide dismutase and glutathione peroxidase were significantly lower in groups 2 and 8 compared to control group. Silymarin pretreatment and D-penicillamine administration in groups 5, 7 and 8 could significantly lower ALP, ALT and AST and improve liver antioxidant enzymes. Thus, acute Pb exposure induced hepatotoxicity with suppression of liver antioxidant defence system and silymarin, as an antioxidant could alleviate this effect.

scholarly journals Possiple Protective Role of Ascorbic Acid on Ethanol Induced Testicular Toxicity in Male Albino Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 49-63
Author(s):  
Sally Ahmed ◽  
Marcelle Haroun ◽  
Nermeen Hassan ◽  
Abeer Sharf El Din ◽  
Sahar Abo El Wafa ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Testicular Toxicity

scholarly journals The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

2021 ◽  
Author(s):  
Ayman Ahmed Bassiouny El-Amawy ◽  
Samir Attia Mohammed Zaahkouk ◽  
Hesham Gamal Abdel Rasheed ◽  
Bassem Elsayed Elaraby Mohammed
Keyword(s):  
Heavy Metals ◽  
Oral Administration ◽  
Antioxidant Defense System ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Toxic Heavy Metals ◽  
Propolis Extract ◽  
Liver And Kidney

Abstract The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

scholarly journals Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats

2021 ◽  
Author(s):  
Peter Folorunsho Ayodele ◽  
Dorcas Ibukun Akinloye ◽  
Adio Jaimiu Akamo ◽  
David Adejare Agboola ◽  
Oluseyi Adeboye Akinloye
Keyword(s):  
Tumor Necrosis ◽  
Ethanol Extract ◽  
Interleukin 10 ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Inflammatory Changes ◽  
Cd Exposure ◽  
Xylopia Aethiopica ◽  
Necrosis Factor

The wide use of cadmium (Cd) in industry causes great environmental health problems to humans and animals. The aim of this study was to investigate the protective effects of Xylopia aethiopica fruit ethanol extract (XAFEE) on cadmium-induced inflammation and dyslipidemia in male albino rats. Thirty albino rats weighing 120–180 g were randomly selected into six groups (n = 5): control rats (administered distilled water only), Cd alone group (10 mg/ kg bw), Cd + 150 mg/kgbw XAFEE, Cd + 300 mg/kgbw XAFEE, 150 mg/kgbw XAFEE and 300 mg /kgbw XAFEE groups after 2-week acclimatization. The experiment lasted for 21 days, after which blood sample was collected by cardiac puncture. Changes in tumor necrosis factor (TNF-α), interleukin 10 (IL-10), total cholesterol (TC), triacylglycerol (TAG), phospholipids and free fatty acids (FFAs) concentrations in serum were determined. The results of the present study indicated that Cd exposure remarkably increased (p < 0.05) the TC, TAG, phospholipids, FFAs and TNF-α concentrations, and significantly decreased IL-10 concentration (p < 0.05). These findings suggest that inflammatory changes and alterations in lipid metabolism might be one of the mechanisms underlying the subtle effects of Cd toxicity, “dyslipidemia.” XAFEE expressed protective role against toxic influence of Cd on affected parameters in rats. The results raised the possibility of Xylopia aethiopica fruit being considered as a condiment in soup, local drinks, supplements or herbs preparations in areas where there are chances of Cd exposure, occupationally or environmentally.

Comparative Protective Effects of N-Acetylcysteine, and Melatonin against Obesity- Induced Testicular Dysfunction in Rats

2020 ◽  
Author(s):  
Sama Salah Khalil ◽  
Joseph Amin Aziz ◽  
Ismail Ahmed Khadiga ◽  
nanees fouad el-malkey
Keyword(s):  
Antioxidant System ◽  
Sperm Count ◽  
Gonadal Hormones ◽  
Immunohistochemical Localization ◽  
Male Rats ◽  
Albino Rats ◽  
Protective Effects ◽  
Testicular Dysfunction ◽  
Factor Α ◽  
Lipid Parameters

N-acetylcysteine (NAC) and melatonin were reported to exert protective effects on testicular tissues. Thus, this study aimed to determine which of these is more efficient against obesity-induced testicular dysfunction in albino rats. Total 32 adult male rats (195 ± 10g) were divided into 4 groups: control, obese rats fed a high-fat diet (HFD), HFD+ NAC (150 mg/kg/d, ip) and HFD+melatonin (10 mg/kg/d, ip) group, for five weeks. Testes and epididymis were weighted. Lipid profile, pituitary-testicular hormones, tumor necrosis factor-α (TNFα), epididymal sperm parameters, testicular oxidant/antioxidant system, testicular and the epididymal histopathology, immunohistochemical localization for androgen receptors (AR) and Bax reaction were analyzed. Administration of NAC or melatonin significantly improved the lipid parameters, gonadal hormones, TNFα level, sperm count and abnormal morphology, oxidant/antioxidant system and the absolute testicular and epididymal mass with an enhancement of testicular architecture, AR expression and apoptosis as compared to that in the obese group. Additionally, as compared to the NAC group, the melanin group had significantly reduced BMI, total cholesterol, triglyceride, and TNFα and increased testosterone, sperm count, motility, superoxide-dismutase activity, mitigated histo-morphometrical changes, BAX expression, and increased testicular AR expression. Therefore, melatonin was more efficient than NAC in affording fortification against HFD-induced testicular dysfunction

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