scholarly journals A study on curettage pain and hemodynamic parameters of curettage patients: Ketamine or Tramadol?

2018 ◽  
Vol 14 (4) ◽  
pp. 5020
Author(s):  
Hayriye Baltaoğlu Alp ◽  
Sevtap Darçın
Keyword(s):  
Recovery Period ◽  
Systolic Arterial Pressure ◽  
Hemodynamic Parameters ◽  
Hemodynamic Stability ◽  
Pain Scores ◽  
Significant Difference ◽  
Alternative Drug ◽  
Group 2 ◽  
To Receive ◽  
Group 1

Aim: The aim of this study was to compare ketamin(0.5mg/kg)-propofol(1mg/kg) and tramadol(1mg/kg)- propofol(1mg/kg) combination in patients undergoing uterine dilatation and curretage procedure  in terms of total propofol requirement, pain scoring and recovery period of duration .Methods: 100 women under going uterine dilatation and curettage were screened retrospectively after ethical comitee approval. Patients are Dr. Faruk Sükan Doğumevi, Konya, Turkey in January-July 2014 .   Baseline anesthesia was maintained with 1 mg/kg propofol, and the patients were randomly allocated to receive  0.5 mg/kg ketamine (Group 1, n=50) or 1 mg/kg tramadol (Group 2, n=50) there after.  Pain scores, Aldrete scores, and hemodynamic parameters were recorded during and after the surgical procedure. A record was also maintained of any adverse events.Results: When the Aldrete scores at the end of operation, systolic pressures at basal, 0,5,10 minutes,end of op., oxygen saturation at basal,0,5,10 minutes,end of op., diastolic blood pressure at basal,0,5,10 minutes,end of op., heart rates, and visual analogue scores were compared, there was no significant difference between groups (p>0.05) Postoperative heart rate and systolic arterial pressure on beginning were significantly higher in Group 1 compared with Group 2Conclusion: Tramadol might be a better alternative drug rather than ketamine due to better hemodynamic stability and lower respiratory depression rate were seen in patents with it.

scholarly journals Comparison of Two Anesthetic Methods for Intravitreal Ozurdex Injection

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
V. Levent Karabaş ◽  
Berna Özkan ◽  
Çiğdem Akdağ Koçer ◽  
Özgül Altıntaş ◽  
Dilara Pirhan ◽  
...  
Keyword(s):  
Pain Relief ◽  
Pain Score ◽  
Branch Retinal Vein Occlusion ◽  
Subconjunctival Hemorrhage ◽  
Vein Occlusion ◽  
Pain Scores ◽  
Lidocaine Injection ◽  
Group 2 ◽  
To Receive ◽  
Group 1

Purpose. To determine whether subconjunctival lidocaine injection maintains additional anesthetic effect during intravitreal Ozurdex injection.Methods. 63 patients who were diagnosed as central or branch retinal vein occlusion and planned to receive Ozurdex injection for macular edema were prospectively included in the study. The patients were randomized into one of the two anesthetic groups. The first group received topical proparacaine drop and lidocaine applied pledget. The second group received subconjunctival lidocaine injection in addition to the anesthetics in group 1.Results. Mean pain score was1.90±2.39in group 1 and 1.71 ± 2.09 in group 2 (p=0.746). Mean subconjunctival hemorrhage grade was1.67±0.17in group 1 and0.90±0.14in group 2 (p=0.001). There was no relationship between the amount of subconjunctival hemorrhage and pain score of the patients.Conclusions. There was no difference in pain scores between the two anesthetic methods. The addition of subconjunctival lidocaine injection offered no advantage in pain relief compared to lidocaine-applied pledgets.

Intergroup Rhabdomyosarcoma Study-IV: Results for Patients With Nonmetastatic Disease

2001 ◽  
Vol 19 (12) ◽  
pp. 3091-3102 ◽  
Author(s):  
William M. Crist ◽  
James R. Anderson ◽  
Jane L. Meza ◽  
Christopher Fryer ◽  
R. Beverly Raney ◽  
...  
Keyword(s):  
Stage I ◽  
Embryonal Tumors ◽  
Primary Tumor Site ◽  
Free Survival ◽  
Eyelid Tumors ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
To Receive ◽  
Group 1

PURPOSE: The study goal was to improve outcome in children with rhabdomyosarcoma by comparing risk-based regimens of surgery, radiotherapy (RT) and chemotherapy. PATIENTS AND METHODS: Eight hundred eighty-three previously untreated eligible patients with nonmetastatic rhabdomyosarcoma entered the Intergroup Rhabdomyosarcoma Study-IV (IRS-IV) (1991 to 1997) after surgery and were randomized treatment by primary tumor site, group (1 to 3), and stage (I to III). Failure-free survival (FFS) rates and survival were the end points used in comparisons between randomized groups and between patient subgroups treated on IRS-III and IRS-IV. Most patients were randomized to receive vincristine and dactinomycin (VA) and cyclophosphamide (VAC, n = 235), or VA and ifosfamide (VAI, n = 222), or vincristine, ifosfamide, and etoposide (VIE, n = 236). Patients with group 3 tumors were randomized to receive conventional RT (C-RT) versus hyperfractionated RT (HF-RT). RESULTS: Overall 3-year FFS and survival were 77% and 86%, respectively. Three-year FFS rates with VAC, VAI, and VIE were 75%, 77%, and 77%, respectively (P = .42). No significant difference in outcome was noted with HF-RT versus C-RT (P = .85 and P = .90, respectively). Overall, patients with embryonal tumors benefited from intensive three-drug chemotherapy in IRS-IV (3-year FFS, 83%). The improvement was seen for patients with stage I or stage II/III, group 1/2 disease, many of whom received VA chemotherapy on IRS-III. Patients with stage 2/3, group 3 disease had similar outcomes on IRS-III and IRS-IV. Three-year FFS for the nonrandomized patient subsets was 75% with renal abnormalities; 81% for paratesticular, group 1 cases; and 91% for group 1/2 orbit or eyelid tumors. Patients with paratesticular primaries had poorer outcomes if they were more than 10 years old (3-year FFS, 63% v 90%). Myelosuppression occurred in most patients, but toxic deaths occurred in less than 1%. CONCLUSION: VAC and VAI or VIE with surgery (with or without RT), are equally effective for patients with local or regional rhabdomyosarcoma and are more effective for embryonal tumors than therapies used previously. Younger patients with group 1 paratesticular embryonal tumors and all patients with group 1/2 orbit or eyelid tumors can usually be cured with VA chemotherapy along with postoperative RT for group 2 disease.

scholarly journals Local Steroid Treatment: An Effective Procedure for Idiopathic Granulomatous Mastitis, Including Complicated Cases

2021 ◽  
Author(s):  
Taha Furkan Ertürk ◽  
Özgür Çakır ◽  
Büşra Yaprak Bayrak ◽  
Abdullah Güneş ◽  
Selahattin Aydemir ◽  
...  
Keyword(s):  
Steroid Treatment ◽  
Maximum Diameter ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Pain Scores ◽  
Surgical Methods ◽  
Significant Difference ◽  
Pre Treatment ◽  
Group 2 ◽  
Group 1

Abstract Purpose To evaluate the effectiveness of treatment with topical and intralesional steroids for idiopathic granulomatous mastitis (IGM) and to compare with surgical methods.Methods Data was retrospectively collected from records. Intralesional steroid injection and topical steroid administration, hereafter referred to as local steroid treatment (LST) were applied in Group 1. Surgery (local excision, wide excision and mastectomy) was performed in Group 2. In Group 1 changes in lesion sizes were recorded and factors complicating treatment were identified. The Numeric Pain Rating Scale was used to determine subjective pain. LST and surgery were compared with regard to: pain before and after the treatment; complication rate; recurrence rate; and treatment cost.Results There were 38 and 48 patients in Group 1 and Group 2, respectively. In the LST group 72 lesions were present and 70 of 72 (97%) responded completely to treatment. Pre-treatment median maximum diameter was 23.50 (15.25-35.25) mm, which regressed to 16 (12-25) mm after the first session. While the pre-treatment pain scores of Group 1 and Group 2 were similar (p=0.756), there was a significant difference in the post-treatment pain scores (p<0.001). No recurrence occurred in any patients in Group 1, while recurrence developed in 15 (31.2%) patients in Group 2 (p<0.001).Conclusion LST is a treatment for IGM that is cheap, with high efficiency, negligible recurrence, and has good esthetic outcome. Our results suggest that LST should be the first-line treatment option for all IGM patients, including complicated cases.

scholarly journals A comparative study of supraglottic airway devices Baska mask and ProSeal-laryngeal mask airway in short gynaecological procedures

2019 ◽  
Vol 8 (1) ◽  
pp. 285
Author(s):  
Ranjith Kumar Kachakayala ◽  
Parmeet Bhatia ◽  
Shalendra Singh ◽  
Deepak Dwivedi
Keyword(s):  
Airway Device ◽  
Supraglottic Airway ◽  
Supraglottic Airway Devices ◽  
Significant Difference ◽  
Study Support ◽  
Group 2 ◽  
Low Incidence ◽  
Airway Devices ◽  
To Receive ◽  
Group 1

Background: Baska Mask® (BM) a newer Supraglottic Airway Device (SAD) considered to cause low incidence of Postoperative Pharyngolaryngeal Complications (POPC). This study was designed to assess efficacy, safety and early and late POPC between BM and commonly use ProSeal LMA (PMLA).Methods: Patients between 18 to 60 years of age undergoing elective short gynecological procedures were randomized into two groups, to receive ventilation with either BM (group 1, n=50) or an PMLA (group 2, n=50).Results: There was no significant difference in the ease of insertion for both the devices (p<0.24). There was no significant difference in the number of attempts for both the devices (p<0.69). When compared to PLMA, the time (in seconds) required for insertion of BM was significantly less in duration (20.9 vs. 16) (p<0.0001). Between the two groups significant hemodynamic changes noticed after removal of SGA. The blood staining of device was similar in both groups. Failure to place device, postoperative complication like laryngospasm and bronchospasm did not occur in both BM and PLMA groups.Conclusions: In conclusion, findings of this study support that BM takes significantly shorter placement time and provides a better seal as compared to PLMA but without any reduction in laryngopharyngeal complications.

Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas

1976 ◽  
Vol 45 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Bryce Weir ◽  
Pierre Band ◽  
Raul Urtasun ◽  
Gilles Blain ◽  
Don McLean ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Content Type ◽  
Significant Difference ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
To Receive ◽  
Mean Time ◽  
Grade Iii ◽  
Group 1

✓ Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) received radiation therapy totaling 4000 to 4500 rads in 4 to 5 weeks. Group 2 (13 patients) received 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) 130 mg/sq m orally every 6 weeks. Group 3 (13 patients) received radiation therapy plus CCNU as for Groups 1 and 2. When the disease progressed, patients in Groups 1 and 2 were crossed over to receive CCNU and irradiation respectively. The median survival time in these groups was 188, 259, and 252 days, and the mean survival 263, 262, and 329 days. The median time from diagnosis to crossover (Groups 1 and 2) or to progression (Group 3) was 163, 99, and 220 days, and the mean time was 172, 108, and 231 days. There was no statistically significant difference between the means or medians in any of these situations.

scholarly journals Do depression, anxiety, or stress have any effect on pain scores in patients undergoing colposcopy?

2021 ◽  
Vol 8 (8) ◽  
pp. 480-484
Author(s):  
Muzaffer Seyhan Cikman ◽  
Ismet Gun
Keyword(s):  
Pain Perception ◽  
Gynecologic Oncology ◽  
Patient Characteristics ◽  
Stress Group ◽  
Pain Scores ◽  
Significant Difference ◽  
Parity Number ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: In this study, we evaluated the effect of depression, anxiety, and stress on pain perception during colposcopy. Material and methods: This study was performed at the gynecologic oncology department of Lutfi Kirdar Kartal Education and Research Hospital in Istanbul, Turkey between September 2017 and January 2018. After taking informed consent, Depression Anxiety and Stress Scale (DASS-42) were completed by women who were attended outpatient colposcopy unit. Patients were classified into three groups according to DASS-42 (Group 1: patients without depression, anxiety or stress; Group 2: patients with one or two of depression, anxiety and stress; Group 3: patients with all of depression, anxiety and stress). Patient characteristics were also recorded. The degree of pain perception was evaluated visual analogue scale (VAS) at the end of the procedure. The p values less than 0.05 were considered statistically significant. Results: A total of 116 women were enrolled into this study. There was no statistically significant difference between the groups in terms of age, gravidity, parity, number of gynecologic examination, waiting time, BMI, VAS, having a partner, came alone to clinic, level of education, employment, indication of procedure, number of biopsies, ECC presence (p>0.05). There was no difference between the subgroups in terms of VAS. There was negative correlation between groups and VAS (r=-0.195, p=0.036). Conclusion: According to our findings, depression, anxiety and stress have no impact on pain perception during colposcopy but there is a weak correlation between the absence of depression, anxiety, stress and the pain score.

scholarly journals A Comparative Study to Evaluate the Effect of Honey and Zinc Oxide Eugenol Dressing for the Treatment of Dry Socket: A Double-Blind Randomized Controlled Trial

2021 ◽  
Vol 12 (1) ◽  
pp. 6
Author(s):  
Zafar Ali Khan ◽  
Namdeo Prabhu ◽  
Naseer Ahmed ◽  
Abhishek Lal ◽  
Rakhi Issrani ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Rating Scale ◽  
Verbal Rating Scale ◽  
Dry Socket ◽  
Pain Scores ◽  
Zinc Oxide Eugenol ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Dry socket is a common postoperative complication secondary to any tooth extraction but is more commonly associated with mandibular third molars. Dry socket has been treated with various treatment modalities with different success rates. This study aimed to evaluate the effect of using honey and zinc oxide eugenol as an intra-socket medicament for the treatment of dry sockets. Ninety patients were divided into three groups as follows: Group 1 “honey”: 30 patients; Group 2 “zinc oxide eugenol”: 30 patients; and Group 3 “control”: 30 patients. Pre-medication and post-medication pain scores at different time intervals were measured on a verbal rating scale. The mean ages of the patients in each of the groups were as follows: Group 1: 44.26 ± 14.14; Group 2: 45.30 ± 18.08; and Group 3: 51.93 ± 9.75. As regards verbal rating scale pain scores, a significant difference was noted in patients that belonged to Groups 1 and 2, with an immediate reduction in post-medication pain scores. However, patients belonging to Group 3 reported pain and discomfort for over a week. The use of honey and zinc oxide eugenol resulted in significant immediate post-medication pain scores in patients as compared to the control group. Therefore, both honey and zinc oxide eugenol can be used as treatment options for dry socket patients.

scholarly journals Analgesia following Arthroscopic Knee Surgery. A Controlled Study of Intra-articular Morphine, Bupivacaine or Both Combined

1993 ◽  
Vol 21 (2) ◽  
pp. 201-203 ◽  
Author(s):  
M. M. McSwiney ◽  
G. P. Joshi ◽  
P. Kenny ◽  
S. M. McCarroll
Keyword(s):  
Normal Saline ◽  
Arthroscopic Surgery ◽  
Controlled Study ◽  
Control Group ◽  
Group 4 ◽  
Pain Scores ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

In a double-blind, randomised controlled trial, we studied 40 patients who received one of four intra-articular injections at the end of arthroscopic surgery. Each group contained ten patients. The patients in Group 1 received normal saline 25 ml; those in Group 2 received bupivacaine 0.25% 25 ml; those in Group 3 received morphine 5 mg in normal saline 25 ml; and those in Group 4 received a combination of bupivacaine 0.5% 12.5 ml and 5 mg of morphine made up to 25 ml with normal saline to produce the same bupivacaine concentration as Group 2. At the time the patient awoke, and 30min, Ihr, Ihr 30min, 2hr, 4hr, 8hr, 12hr, and 24hr postoperatively, pain was assessed using a visual analogue scale. The need for supplementary analgesic agents in the first 24 hours was recorded. All pain scores were significantly lower (P< 0.05) in Groups 2, 3 and 4 compared with the control group with the exception of Group 2 at 24 hours. Pain scores were significantly lower (P<0.05) for Group 2 compared with Group 3 for the first 90 minutes postoperatively. At 4, 8, 12 and 24 hours postoperatively the pain scores were significantly lower (P<0.05%) for Group 3 compared with Group 2. Group 4 had the lowest pain scores over the recorded period compared with the other groups. The need for supplemental analgesia was significantly lower (P<0.05) in the treatment Groups 2, 3 and 4 compared to the control Group 1. There was no significant difference in supplemental analgesic requirements between Groups 2, 3 and 4. A combination of bupivacaine and morphine injected intra-articularly following arthroscopy provided superior analgesia compared with that achieved by either drug alone.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Tuberculosis of the meninges and central nervous system. Experience of clinical diagnostics in St. Petersburg for 50 years

MedAlliance ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 14-24
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Errors ◽  
Clinical Diagnostics ◽  
Lethal Outcome ◽  
Significant Difference ◽  
Group 2 ◽  
Allergic Vasculitis ◽  
Tuberculosis Meningitis ◽  
Group 1

The clinic and diagnostics of tuberculosis meningitis (TM) in 926 patients treated in St. Petersburg hospitals in 1965–1994 (group 1) and in 1995–2018 (group 2) is presented. The TM clinic is demonstrated to be determined by the form of tuberculosis and its characteristic generalization nature in the presence of repeated waves of bacteremia and allergic vasculitis of greater or lesser severity. There is clinical peculiarity of TM in primary pulmonary tuberculosis and its early large-focal and late miliar generalization, as well as in hematogenous tuberculosis. In patients of the 1st and 2nd groups the TM clinic shows in some respects a noticeable similarity, in others — a significant difference. Despite the typical symptoms, early diagnosis of TM took place in less than 20% of patients. Clinical examples illustrating the unusual development of TM, contrasting with its usual course, are given. A number of objective and subjective factors contributing to the adverse evolution of TM and its lethal outcome are discussed. These include the peculiarity of modern tuberculosis, especially when associated with HIV infection, as well as medical errors associated with ignorance of the pathogenesis of tuberculosis and failure to comply with the minimum examination for tuberculosis.

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